Nuclear localization of PTEN is regulated by Ca2+ through a tyrosil phosphorylation-independent conformational modification in major vault protein

Cancer Research

Volumn 66, Issue 24, 2006, Pages 11677-11682

  Minaguchi, Takeo ^a   Waite, Kristin A ^a   Eng, Charis ^a,b,c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b TAUSSIG CANCER INSTITUTE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIMYCIN; CALCIUM; IONOPHORE; LUNG RESISTANCE PROTEIN; MANGANESE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P42; PROTEIN P44; SMALL INTERFERING RNA; STEROID RECEPTOR; TYROSINE DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; CELLULAR DISTRIBUTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

APOPTOSIS; BASE SEQUENCE; BREAST NEOPLASMS; CALCIUM; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; DNA PRIMERS; FEMALE; HUMANS; MEMBRANE PROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PLASMIDS; PROTEIN CONFORMATION; PROTEIN TRANSPORT; PTEN PHOSPHOHYDROLASE; RNA, NEOPLASM; RNA, SMALL INTERFERING; TRANSFECTION; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 33846245967     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2240     Document Type: Article

References (29)

1. Waite KA, Eng C. Protean PTEN: form and function. Am J Hum Genet 2002;70:829-44.
2. Li DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 1997;57:2124-9.
3. Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997;15:356-62.
4. Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, Sellers WR. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 2000;20:8969-82.
5. Comer FI, Parent CA. PI 3-kinases and PTEN: how opposites chemoattract. Cell 2002;109:541-4.
6. Eng C. PTEN: one gene, many syndromes. Hum Mutat 2003;22:183-98.
7. Ginn-Pease ME, Eng C. Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells. Cancer Res 2003;63:282-6.
8. Chung JH, Eng C. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res 2005;65:8096-100.
9. Mossink MH, van Zon A, Scheper RJ, Sonneveld P, Wiemer EA. Vaults: a ribonucleoprotein particle involved in drug resistance? Oncogene 2003;22:7458-67.
10. Yu Z, Fotouhi-Ardakani N, Wu L, et al. PTEN associates with the vault particles in HeLa cells. J Biol Chem 2002;277:40247-52.
11. Abbondanza C, Rossi V, Roscigno A, et al. Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell. J Cell Biol 1998;141:1301-10.
12. Kolli S, Zito CI, Mossink MH, Wiemer EA, Bennett AM. The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J Biol Chem 2004;279:29374-85.
13. Yi C, Li S, Chen X et al. Major vault protein, in concert with constitutively photomorphogenic 1, negatively regulates c-Jun-mediated activator protein 1 transcription in mammalian cells. Cancer Res 2005;65:5835-40.
14. Chung JH, Ginn-Pease ME, Eng C. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. Cancer Res 2005;65:4108-16.
15. Ehrnsperger C, Volknandt W. Major vault protein is a substrate of endogenous protein kinases in CHO and PC12 cells. Biol Chem 2001;382:1463-71.
16. 1 arrest followed by apoptosis. Cancer Res 1999;59:5808-14.
17. Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem 2001;276:48627-30.
18. Walker GM. Biotechnological implications of the interactions between magnesium and calcium. Magnes Res 1999;12:303-9.
19. Laurant P, Touyz RM. Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. J Hypertens 2000;18:1177-91.
20. Ikura M, Ames JB. Genetic polymorphism and protein conformational plasticity in the calmodulin superfamily: two ways to promote multifunctionality. Proc Natl Acad Sci U S A 2006;103:1159-64.
21. Liu F, Wagner S, Campbell RB, Nickerson JA, Schiffer CA, Ross AH. PTEN enters the nucleus by diffusion. J Cell Biochem 2005;96:221-34.
22. Adachi M, Fukuda M, Nishida E. Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO J 1999;18:5347-58.
23. Kahl CR, Means AR. Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. Endocr Rev 2003;24:719-36.
24. Schmitt JM, Wayman GA, Nozaki N, Soderling TR. Calcium activation of ERK mediated by calmodulin kinase I. J Biol Chem 2004;279:24064-72.
25. Lin CC, Shyr MH, Chien CS, et al. Thrornbin-stimulated cell proliferation mediated through activation of Ras/Raf/MEK/MAPK pathway in canine cultured tracheal smooth muscle cells. Cell Signal 2002;14:265-75.
26. Rodriguez-Mora OG, LaHair MM, McCubrey JA, Franklin RA. Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells. Cancer Res 2005;65:5408-16.
27. Kim E, Lee S, Mian MF, et al. Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. FEBS J 2006;273:793-804.
28. Murray D, Honig B. Electrostatic control of the membrane targeting of C2 domains. Mol Cell 2002;9:145-54.
29. Stoffler D, Goldie KN, Feja B, Aebi U. Calcium-mediated structural changes of native nuclear pore complexes monitored by time-lapse atomic force microscopy. J Mol Biol 1999;287:741-52.