Regulation of PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) Expression by Estradiol and Progesterone in Human Endometrium

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 10, 2003, Pages 5017-5026

  Guzeloglu Kayisli, Ozlem ^a,b   Kayisli, Umit A ^a,b   Al Rejjal, Rafat ^a   Zheng, Wenxin ^a   Luleci, Guven ^b   Arici, Aydin ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b AKDENIZ UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; PROGESTERONE; STEROID;

ADULT; APOPTOSIS; ARTICLE; BREAST; CELL GROWTH; CELL PROLIFERATION; CHROMOSOME 10; CHROMOSOME DELETION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOMETRIUM; ENDOMETRIUM CELL; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MENSTRUAL CYCLE; PREGNANCY; PRIORITY JOURNAL; PROSTATE; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PTEN GENE; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ADENOCARCINOMA; CELL DIVISION; DECIDUA; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; ESTRADIOL; FEMALE; GENE EXPRESSION; HUMANS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PREGNANCY; PROGESTERONE; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; STROMAL CELLS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0242288646     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030414     Document Type: Article

References (37)

1. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Pue J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R 1997 PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 28:1943-1947
2. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV 1997 Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15:356-362
3. Li DM, Sun H 1997 TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res 57:2124-2129
4. Ali IU, Schriml M, Dean M 1999 Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 91: 1922-1932
5. Bonneau D, Longy M 2000 Mutations of the human PTEN gene. Hum Mutat 16:109-122
6. Maehama T, Taylor GS, Dixon JE 2001 PTEN and myotubular in: novel phosphoinositide phosphatases. Annu Rev Biochem 70:247-279
7. Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK 1998 The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci USA 95:13513-13518
8. Han SY, Kato H, Kato S, Suzuki T, Shibata H, Ishii S, Shiiba K, Matsuno S, Kanamaru R, Ishioka C 2000 Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay. Cancer Res 60: 3147-3151
9. Furnari FB, Lin H, Huang HS, Cavenee WK 1997 Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci USA 94:12479-12484
10. Leslie NR, Downes CP 2002 PTEN: the down side of PI 3-kinase signaling. Cell Signal 14:285-295
11. Tsugawa K, Jones MK, Sugimachi K, Sarfeh IJ, Tarnawski AS 2002 Biological role of phosphatase PTEN in cancer and tissue injury healing. Front Biosci 7:e245-e251
12. Weng L, Brown J, Eng C 2001 PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Hum Mol Genet 10:237-242
13. Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP 1998 Pten is essential for embryonic development and tumour suppression. Nat Genet 19:348-355
14. Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak TW 1998 High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8:1169-1178
15. Hale GE, Hughes CL, Cline JM 2002 Endometrial cancer: hormonal factors, the perimenopausal window of risk, and isoflavones. J Clin Endocrinol Metab 87:3-15
16. Sun H, Enomoto T, Fujita M, Wada H, Yoshino K, Ozaki K, Nakamura T, Murata Y 2001 Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia. Am J Clin Pathol 115:32-38
17. Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Eng C 2000 Changes in endometrial PTEN expression throughout the human menstrual cycle. J Clin Endocrinol Metab 85:2334-2338
18. Vazquez F, Ramaswamy S, Nakamura N, Sellers WR 2000 Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 20: 5010-5018
19. Kayisli UA, Aksu CA, Berkkanoglu M, Arici A 2002 Estrogenicity of isoflavones on human endometrial stromal and glandular cells. J Clin Endocrinol Metab 87:5539-5544
20. Arici A, Head JR, MacDonald PC, Casey ML 1993 Regulation of interleukin-8 gene expression in human endometrial cells in culture. Mol Cell Endocrinol 94:195-204
21. Gilbert SF, Migeon BR 1975 D-valine as a selective agent for normal human and rodent epithelial cells in culture. Cell 5:11-17
22. Birle D, Bottini N, Williams S, Huynh H, deBelle I, Adamson E, Mustelin T 2002 Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. J Immunol 169:286-291
23. Mutter GL 2001 PTEN, a protean tumor suppressor. Am J Pathol 158:1895-1898
24. Waite KA, Eng C 2002 Protean PTEN: form and function. Am J Hum Genet 70:829-844
25. Tseng L, Mazella J 2002 Endometrial cell specific gene activation during implantation and early pregnancy. Front Biosci 7:d1566-d1774
26. Rango UI, Classen Linke CA, Krusche B 1998 The receptive endometrium is characterized by apoptosis in the glands. Hum Reprod 13:3177-3189
27. Simon C, Dominguez F, Remohi J, Pellicer A 2001 Embryonic regulation of endometrial molecules in human implantation. Ann NY Acad Sci 943:1-16
28. Demir R, Kayisli UA, Celik-Ozenci C, Korgun E, Demir-Weusten A, Arici A 2002 Structural differentiation of human uterine luminal and glandular epithelium during early pregnancy: an ultrastructural and immunohistochemical study. Placenta 23:672-684
29. Mutter GL, Ince TA, Baak JP, Kust GA, Zhou XP, Eng C 2001 Molecular identification of latent precancers in histologically normal endometrium. Cancer Res 61:4311-4314
30. Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, Wood J, Ross C, Sawyers CL, Whang YE 2000 Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc Natl Acad Sci USA 97:4233-4238
31. Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR 2001 Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem 276:48627-48630
32. Perren A, Komminoth P, Saremaslani P, Matter C, Feurer S, Lees JA, Heitz PU, Eng C 2000 Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. Am J Pathol 157:1097-1103
33. Lachyankar MB, Sultana N, Schonhoff CM, Mitra P, Poluha W, Lambert S, Quesenberry PJ, Litofsky NS, Recht LD, Nabi R, Miller SJ, Ohta S, Neel BG, Ross AH 2000 A role for nuclear PTEN in neuronal differentiation. J Neurosci 20:1404-1413
34. Whiteman DC, Zhou XP, Cummings MC, Pavey S, Hayward NK, Eng C 2002 Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma. Int J Cancer 99:63-67
35. Miller S, Lou D, Seldin D, Lane W, Neel B 2002 Direct identification of PTEN phosphorylation sites. FEBS Lett 528:145-153
36. Arnold SF, Obourn JD, Jaffe H, Notides AC 1995 Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: consequence on DNA binding. J Steroid Biochem Mol Biol 55:63-72
37. Shiojima I, Walsh K 2002 Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 90:1243-1250