Novel functions for mucosal SIgA

Mucosal Immune Defense: Immunoglobulin A

Volumn , Issue , 2007, Pages 183-202

  Phalipon, Armelle ^a   Corthésy, Blaise ^b  

^a INSTITUT PASTEUR   (France)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 50149112190     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-72232-0_8     Document Type: Chapter

References (99)

1. Anjuère, F., Luci, C., Lebens, M., Rousseau, D., Hervouet, C., Milon, G., Holmgren, J., Ardavin, C., and Czerkinsky, C. (2004). In vivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera toxin. J. Immunol. 173:5103-5111.
2. Biesbrock, A. R., Reddy, M. S., and Levine, M. J. (1991). Interaction of a salivary mucin-secretory immunoglobulin A complex with mucosal pathogens. Infect. Immun. 59:3492-3497.
3. Bollinger, R. R., Everett, M. L., Palestrant, D., Love, S. D., Lin, S. S., and Parker, W. (2003). Human secretory immunoglobulin A may contribute to biofilm formation in the gut. Immunology 109:580-587.
4. Bollinger, R. R., Everett, M. L., Wahl, S. D., Lee, Y. H., Orndorff, P. E., and Parker, W. (2006). Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili. Mol. Immunol. 43:378-387.
5. Bomsel, M., Heyman, M., Hocini, H., Lagaye, S., Belec, L., Dupont, C., and Desgranges, C. (1998). Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM. Immunity 19:277-287.
6. Boren, T., Falk, P., Roth, K. A., Larson, G., and Normark, S. (1993). Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 262:1892-1895.
7. Brière, F., Paliard, X., and De Vries, J. E. (1988). Induction of the receptor for the Fc portion of IgA by secretory IgA on human T cell lines and T cell clones. Eur. J. Immunol. 18:445-450.
8. Brock, S. C., McGraw, P. A., Wright, P. F., Crowe, J. E., Jr. (2002). The human polymeric immunoglobulin receptor facilitates invasion of epithelial cells by Streptococcus pneumoniae in a strain-specific and cell type-specific manner. Infect. Immun. 70:5091-5095.
9. Cebra, J. J. (1999). Influences of microbiota on intestinal immune system development. Am. J. Clin. Nutr. 69:1046S-1051S.
10. Chintalacharuvu, K. R., and Morrison, S. L. (1997). Production of secretory immunoglobulin A by a single mammalian cell. Proc. Natl. Acad. Sci. USA 94:6364-6368.
11. Corthésy, B., Benureau, Y., Perrier, C., Fourgeux, C., Parez, N., Greenberg, H., and Schwartz-Cornil, I. (2006). Rotavirus anti-VP6 secretory IgA contributes to protection via intracellular neutralization but not via immune exclusion. J. Virol. 80:10, 692-10, 699.
12. Corthésy, B., Kaufmann, M., Phalipon, A., Peitsch, M., Neutra, M. R., and Kraehenbuhl, J. P. (1996). A pathogen-specific epitope inserted into recombinant secretory immunoglobulin A is immunogenic by the oral route. J. Biol. Chem. 271:33, 670-33, 677.
13. Costerton, J. W., Lewandowski, Z., Caldwell, D. E., Korber, D. R., and Lappin-Scott, H. M. (1995). Microbial biofilms. Annu. Rev. Microbiol. 49:711-745.
14. Crottet, P., and Corthésy, B. (1998). Secretory component delays the conversion of secretory IgA into antigen-binding competent F (ab') 2: A possible implication for mucosal defense. J. Immunol. 161:5445-5453.
15. Cukrowska, B., Lodinova-Zadnikova, R., Enders, C., Sonnenborn, U., Schulze, J., and Tlaskalova-Hogenova, H. (2002). Specific proliferative and antibody responses of premature infants to intestinal colonization with nonpathogenic probiotic E. coli strain Nissle 1917. Scand. J. Immunol. 55:204-209.
16. Dallas, S. D., and Rolfe, R. D. (1998) Binding of Clostridium difficile toxin A to human milk secretory component. J. Med. Microbiol. 47:879-888.
17. Eberl, G. (2005). Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway? Nat. Rev. Immunol. 5:413-420.
18. Elm, C., Braathen, R., Bergmann, S., Frank, R., Vaerman, J. P., Kaetzel, C. S., Chhatwal, G. S., Johansen, F. E., and Hammerschmidt, S. (2004). Ectodomains 3 and 4 of human polymeric immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. J. Biol. Chem. 279:6296-6304.
19. Fagarasan, S., Muramatsu, M., Suzuki, K., Nagaoka, H., Hiai, H., and Honjo, T. (2002). Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298:1424-1427.
20. Fagarasan, S., and Honjo, T. (2004). Regulation of IgA synthesis at mucosal surfaces. Curr. Opin. Immunol. 16:277-283.
21. Falk, P., Roth, K. A., Boren, T., Westblom, T. U., Gordon, J. I., and Normark, S. (1993). An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium. Proc. Natl. Acad. Sci. USA 90:2035-2039.
22. Fang, H., Elina, T., Heikki, A., and Seppo, S. (2000). Modulation of humoral immune response through probiotic intake. FEMS Immunol. Med. Microbiol. 29:47-52.
23. Favre, L., Spertini, F., and Corthésy, B. (2005). Secretory IgA possesse intrinsic modulatory properties stimulating mucosal and systemic immune responses. J. Immunol. 175:2793-2800.
24. Fernandez, M. I., Pedron, T., Tournebize, R., Olivo-Marin, J. C., Sansonetti, P. J., and Phalipon. (2003). A. Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells. Immunity 18:739-749.
25. Friman, V., Adlerberth, I., Connell, H., Svanborg, C., Hanson, L. A., and Wold, A. E. (1996). Decreased expression of mannose-specific adhesins by Escherichia coli in the colonic microflora of immunoglobulin A-deficient individuals. Infect. Immun. 64:2794-2798.
26. Fujioka, H., Emancipator, S. N., Aikawa, M., Huang, D. S., Blatnik, F., Karban, T., De Fife, K., and Mazanec, M. B. (1998). Immunocytochemical colocalization of specific immunoglobulin A with sendai virus protein in infected polarized epithelium. J. Exp. Med. 188:1223-1229.
27. Fukushima, Y., Kawata, Y., Hara, H., Terada, A., and Mitsuoka, T. (1998). Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int. J. Food Microbiol. 42:39-44.
28. Geissmann, F., Launay, P., Pasquier, B., Lepelletier, Y., Leborgne, M., Lehuen, A., Brousse, N., and Monteiro, R. C. (2001). A subset of human dendritic cells expresses IgA Fc receptor (CD89), which mediates internalization and activation upon crosslinking by IgA complexes. J. Immunol. 166:346-352.
29. Giugliano, L. G., Ribeiro, S. T., Vainstein, M. H., and Ulhoa, C. J. (1995). Free secretory component and lactoferrin of human milk inhibit the adhesion of enterotoxigenic Escherichia coli. J. Med. Microbiol. 42:3-9.
30. Gonnella, P. A., Chen, Y., Inobe, J., Komagata, Y., Quartulli, M., and Weiner, H. L. (1998). In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice. J. Immunol. 160:4708-4718.
31. Hammerschmidt, S., Talay, S. R., Brandtzaeg, P., and Chhatwal, G. S. (1997). SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component. Mol. Microbiol. 25:1113-1124.
32. Hammerschmidt, S., Tillig, M. P., Wolff, S., Vaerman, J. P., and Chhatwal, G. S. (2000). Species-specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif. Mol. Microbiol. 36:726-736.
33. Heystek, H. C., Moulon, C., Woltman, A. M., Garonne, P., and Van Kooten, C. (2002). Human immature dendritic cells efficiently bind and take up secretory IgA without the induction of maturation. J. Immunol. 168:102-107.
34. Hooper, L. V., and Gordon, J. I. (2001). Commensal host-bacterial relationships in the gut. Science 292:1115-1118.
35. Huang, Y. T., Wright, A., Gao, X., Kulick, L., Yan, H., and Lamm, M. E. (2005). Intraepithelial cell neutralization of HIV-1 replication by IgA. J. Immunol. 174:4828-4835.
36. Iwasaki, A., and Kelsall, B. L. (1999). Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med. 190:229-239.
37. Jang, M. H., Kweon, M. N., Iwatani, K., Yamamoto, M., Terahara, K., Sasakawa, C., Suzuki, T., Nochi, T., Yokota, Y., Rennert, P. D., Hiroi, T., Tamagawa, H., Iijima, H., Kunisawa, J., Yuki, Y., and Kiyono, H. (2004). Intestinal villous M cells: An antigen entry site in the mucosal epithelium. Proc. Natl. Acad. Sci. USA 101:6110-6115.
38. Jenkins, S. L., Wang, J., Vazir, M., Vela, J., Sahagun, O., Gabbay, P., Hoang, L., Diaz, R. L., Aranda, R., and Martin, M. G. (2003). Role of passive and adaptive immunity in influencing enterocyte-specific gene expression. Am. J. Physiol:. Gastrointest. Liver Physiol. 285:G714-G725.
39. Kaetzel, C. S. (2001). Polymeric Ig receptor: defender of the fort or Trojan horse? Curr. Biol. 11:R35-R38.
40. Kaetzel, C. S., Robinson, J. K., Chintalacharuvu, K. R., Vaerman, J. P., and Lamm, M. E. (1991). The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA. Proc. Natl. Acad. Sci. USA 88:8796-8800.
41. Kerr, M. A. (1990). The structure and function of human IgA. Biochem. J. 271:285-296.
42. Kiyono, H., McGhee, J. R., Mosteller, L. M., Eldridge, J. H., Koopman, W. J., Kearney, J. F., and Michalek, S. M. (1982). Murine Peyer's patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses. J. Exp. Med. 156:1115-1130.
43. Lamm, M. E. (1997). Interaction of antigens and antibodies at mucosal surfaces. Annu. Rev. Microbiol. 51:311-340.
44. Langley, R., Wines, B., Willoughby, N., Basu, I., Proft, T., and Fraser, J. D. (2005). The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha RI binding and serum killing of bacteria. J. Immunol. 174:2926-2933.
45. Liepke, C., Adermann, K., Raida, M., Magert, H. J., Forssmann, W. G., and Zucht, H. D. (2002). Human milk provides peptides highly stimulating the growth of bifidobacteria. Eur. J. Biochem. 269:712-718.
46. Lindh, E. (2005). Increased resistance of immunoglobulin A dimers to proteolytic degradation after binding of secretory component. J. Immunol. 114:284-286.
47. Lorenz, R. G., and Newberry, R. D. (2004). Isolated lymphoid follicles can function as sites for induction of mucosal immune responses. Ann. NY Acad Sci. 1029:44-57.
48. Lu, L., Lamm, M. E., Li, H., Corthésy, B., and Zhang, J. R. (2003). The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. J. Biol. Chem. 278:48, 178-48, 187.
49. Luo, R., Mann, B., Lewis, W. S., Rowe, A., Heath, R., Stewart, M. L., Hamburger, A. E., Sivakolundu, S., Lacy, E. R., Bjorkman, P. J., Tuomanen, E., and Kriwacki, R. W. (2005). Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. EMBO J. 24:34-43.
50. Macpherson, A. J., Gatto, D., Sainsbury, E., Harriman, G. R., Hengartner, H., and Zinkernagel, R. M. (2000). A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288:2222-2226.
51. Macpherson, A. J., Hunziker, L., McCoy, K., and Lamarre, A. (2001). IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms. Microbes Infect. 3:1021-1035.
52. Macpherson, A. J., and Uhr, T. (2004). Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303:1662-1665.
53. Mantis, N. J., Cheung, M. C., Chintalacharuvu, K. R., Rey, J., Corthésy, B., and Neutra, M. R. (2002). Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor. J. Immunol. 169:1844-1851.
54. Mantis, N. J., Farrant, S. A., and Mehta, S. (2004). Oligosaccharide side chains on human secretory IgA serve as receptors for ricin. J. Immunol. 172:6838-6845.
55. Marshall, L. J., Perks, B., Ferkol, T., and Shute, J. K. (2001). IL-8 released constitutively by primary bronchial epithelial cells in culture forms an inactive complex with secretory component. J. Immunol. 167:2816-2823.
56. Mattu, T. S., Pleass, R. J., Willis, A. C., Kilian, M., Wormald, M. R., Lellouch, A. C., Rudd, P. M., Woof, J. M., and Dwek, R. A. (1998). The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions. J. Biol. Chem. 273:2260-2272.
57. Mazanec, M. B., Kaetzel, C. S., Lamm, M. E., Fletcher, D., and Nedrud, J. G. (1992). Intracellular neutralization of virus by immunoglobulin A antibodies. Proc. Natl. Acad. Sci. USA 89:6901-6905.
58. Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., and Kasper, D. L. (2005). An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122:107-118.
59. Mellman, I., and Steinman, R. M. (2001). Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255-258.
60. Mestecky, J., Russell, M. W., and Elson, C. O. (1999). Intestinal IgA: Novel views on its function in the defence of the largest mucosal surface. Gut 44:2-5.
61. Mostov, K. E., Kraehenbuhl, J. P., and Blobel, G. (1980). Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms. Proc. Natl. Acad. Sci. USA 77:7257-7261.
62. Newburg, D. S. (1999). Human milk glycoconjugates that inhibit pathogens. Curr. Med. Chem. 6:117-127.
63. Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M., Ploegh, H. L., Fox, J. G., Littman, D. R., and Reinecker, H. C. (2005). CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307:254-258.
64. Owen, R. L. (1999). Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches: A personal and historical perspective. Semin. Immunol. 11:157-163.
65. Palestrant, D., Holzknecht, Z. E., Collins, B. H., Parker, W., Miller, S. E., and Bollinger, R. R. (2004). Microbial biofilms in the gut: visualization by electron microscopy and by acridine orange staining. Ultrastruct. Pathol. 28:23-27.
66. Pasquier, B., Launay, P., Kanamaru, Y., Moura, I. C., Pfirsch, S., Ruffie, C., Henin, D., Benhamou, M., Pretolani, M., Blank, U., and Monteiro, R. C. (2005). Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. Immunity 22:31-42.
67. Perrier, C., Sprenger, N., and Corthésy, B. (2006). Glycans on secretory component participate in innate protection against mucosal pathogens. J. Biol. Chem. 281:14, 280-14, 287.
68. Phalipon, A., Cardona, A., Kraehenbuhl, J. P., Edelman, L., Sansonetti, P. J., and Corthésy, B. (2002). Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity 17:107-115.
69. Phalipon, A., and Corthésy, B. (2003). Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins. Trends Immunol. 24:55-58.
70. Poger, M. E., and Lamm, M. E. (1974). Localization of free and bound secretory component in human intestinal epithelial cells. A model for the assembly of secretory IgA. J. Exp. Med. 139:629-642.
71. Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J. P., and Ricciardi-Castagnoli, P. (2001). Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2:361-367.
72. Rey, J., Garin, N., Spertini, F., and Corthésy, B. (2004). Targeting of secretory IgA to Peyer's patch dendritic and T cells after transport by intestinal M cells. J. Immunol. 172:3026-3033.
73. Rhee, K. J., Sethupathi, P., Driks, A., Lanning, D. K., and Knight, K. L. (2004). Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J. Immunol. 172:1118-1124.
74. Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G. M., Nespoli, A., Viale, G., Allavena, P., and Rescigno, M. (2005). Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat. Immunol. 6:507-514.
75. Robinson, J. K., Blanchard, T. G., Levine, A. D., Emancipator, S. N., and Lamm, M. E. (2001). A mucosal IgA-mediated excretory immune system in vivo. J. Immunol. 166:3688-3692.
76. Rosenow, C., Ryan, P., Weiser, J. N., Johnson, S., Fontan, P., Ortqvist, A., and Masure, H. R. (1997). Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae. Mol. Microbiol. 25:819-829.
77. Roy, M. J., and Varvayanis, M. (1987). Development of dome epithelium in gutassociated lymphoid tissues: association of IgA with M cells. Cell Tissue Res. 248:645-651.
78. Royle, L., Roos, A., Harvey, D. J., Wormald, M. R., Van Gijlswijk-Janssen, D., El-Redwan, R. M., Wilson, I. A., Daha, M. R., Dwek, R. A., and Rudd, P. M. (2003). Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. J. Biol. Chem. 278:20, 140-20, 153.
79. Rudd, P. M., Elliott, T., Cresswell, P., Wilson, I. A., and Dwek, R. A. (2001). Glycosylation and the immune system. Science 291:2370-2376.
80. Russell, M. W., Reinholdt, J., and Kilian, M. (1989). Anti-inflammatory activity of human IgA antibodies and their Fab alpha fragments: Inhibition of IgG-mediated complement activation. Eur. J. Immunol. 19:2243-2249.
81. Saltzman, W. M., Radomsky, M. L., Whaley, K. J., and Cone, R. A. (1994). Antibody diffusion in human cervical mucus. Biophys. J. 66:508-515.
82. Sandor, M., Waldschmidt, T. J., Williams, K. R., and Lynch, R. G. (1990). IgA-induced avidity maturation of IgA Fc receptors on murine T lymphocytes. J. Immunol. 144:4562-4570.
83. Schneeman, T. A., Bruno, M. E., Schjerven, H., Johansen, F. E., Chady, L., and Kaetzel, C. S. (2005). Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: Linking innate and adaptive immune responses. J. Immunol. 175:376-384.
84. Schroten, H., Stapper, C., Plogmann, R., Kohler, H., Hacker, J., and Hanisch, F. G. (1998). Fab-independent antiadhesion effects of secretory immunoglobulin A on S-fimbriated Escherichia coli are mediated by sialyloligosaccharides. Infect. Immun. 66:3971-3973.
85. Shroff, K. E., Meslin, K., and Cebra, J. J. (1995). Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect. Immun. 63:3904-3913.
86. Stoel, M., Jiang, H. Q., Van Diemen, C. C., Bun, J. C., Dammers, P. M., Thurnheer, M. C., Kroese, F. G., Cebra, J. J., and Bos, N. A. (2005). Restricted IgA repertoire in both B-1 and B-2 cell-derived gut plasmablasts. J. Immunol. 174:1046-1054.
87. Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T., and Fagarasan, S. (2004). Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl. Acad. Sci. USA 101:1981-1986.
88. Suzuki, K., Oida, T., Hamada, H., Hitotsumatsu, O., Watanabe, M., Hibi, T., Yamamoto, H., Kubota, E., Kaminogawa, S., and Ishikawa, H. (2000). Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis. Immunity 13:691-702.
89. Tejada-Simon, M. V., Lee, J., Ustunol, Z., and Pestka, J. J. (1999). Ingestion of yogurt containing Lactobacillus acidophilus and Bifidobacterium to potentiate immunoglobulin A responses to cholera toxin in mice. J. Dairy Sci. 82:649-660.
90. Umesaki, Y., and Setoyama, H. (2000). Structure of the intestinal flora responsible for development of the gut immune system in a rodent model. Microbes Infect. 2:1343-1351.
91. Underdown, B. J., De Rose, J., Koczekan, K., Socken, D., and Weicker, J. (1977). Isolation of human secretory component by affinity chromatography on IgM-sepharose. Immunochemistry 14:111-118.
92. Van Der Waaij, L. A., Limburg, P. C., Mesander, G., and Van Der Waaij, D. (1996). In vivo IgA coating of anaerobic bacteria in human faeces. Gut 38:348-354.
93. Weltzin, R., Lucia-Jandris, P., Michetti, P., Fields, B. N., Kraehenbuhl, J. P., and Neutra, M. R. (1989). Binding and transepithelial transport of immunoglobulins by intestinal M cells: Demonstration using monoclonal IgA antibodies against enteric viral proteins. J. Cell. Biol. 108:1673-1685.
94. Williamson, E., Bilsborough, J. M., and Viney, J. L. (2002). Regulation of mucosal dendritic cell function by receptor activator of NF-kappa B (RANK)/RANK ligand interactions: impact on tolerance induction. J. Immunol. 169:3606-3612.
95. Wold, A. E., Mestecky, J., Tomana, M., Kobata, A., Ohbayashi, H., Endo, T., and Eden, C. S. (1990). Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli type 1 fimbrial lectin. Infect. Immun. 58:3073-3077.
96. Wu, H. Y., and Weiner, H. L. (2003). Oral tolerance. Immunol. Res. 28:265-284.
97. Yoshida, M., Claypool, S. M., Wagner, J. S., Mizoguchi, E., Mizoguchi, A., Roopenian, D. C., Lencer, W. I., and Blumberg, R. S. (2004). Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20:769-783.
98. Zhang, J. R., Mostov, K. E., Lamm, M. E., Nanno, M., Shimida, S., Ohwaki, M., and Tuomanen, E. (2000). The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells. Cell 102:827-837.
99. Zhou, F, Kraehenbuhl, J. P., and Neutra, M. R. (1995). Mucosal IgA response to rectally administered antigen formulated in IgA-coated liposomes. Vaccine 13:637-644.