In vivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera toxin

Journal of Immunology

Volumn 173, Issue 8, 2004, Pages 5103-5111

  Anjuère, Fabienne ^a,e   Luci, Carmelo ^a   Lebens, Michael ^b   Rousseau, Déborah ^a   Hervouet, Catherine ^a   Milon, Geneviève ^c   Holmgren, Jan ^b   Ardavin, Carlos ^d   Czerkinsky, Cecil ^a  

^a INSERM   (France)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c INSTITUT PASTEUR   (France)

^d CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^e UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CCL20 CHEMOKINE; CD8 ANTIGEN; CHEMOKINE; CHOLERA TOXIN; GLYCOPROTEIN P 15095; IMMUNOLOGICAL ADJUVANT; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG POTENCY; FEMALE; IMMUNOSTIMULATION; IN VIVO STUDY; INTESTINE EPITHELIUM; LEUKOCYTE MIGRATION; MESENTERY LYMPH NODE; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TH2 CELL;

EID: 6344288797     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.8.5103     Document Type: Article

References (35)

1. Czerkinsky, C., F. Anjuere, J. R. McGhee, A. George-Chandy, J. Holmgren, M.-P. Kieny, K. Fujiyashi, J. Mestecky, V. Pierrefite-Carle, C. Rask, and J. B. Sun. 2000. Mucosal immunity and tolerance: relevance to vaccine development. Immunol. Rev. 170:197.
2. Weiner, H. L. 2000. Oral tolerance, an active immunologic process mediated by multiple mechanisms. J. Clin. Invest. 106:935.
3. Elson, C. O., and W. Ealding. 1984. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J. Immunol. 133:2892.
4. Holmgren, J., N. Lycke, and C. Czerkinsky. 1993. Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems. Vaccine 11:1179.
5. Lycke, N., and J. Holmgren. 1986. Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens. Immunology 59:301.
6. Xu-Amano, J., H. Kiyono, R. J. Jackson, H. F. Staats, K. Fujihashi, P. D. Burrows, C. O. Elson, S. Pillai, and J. R. McGhee. 1993. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J. Exp. Med. 178:1309.
7. Holmgren, J. 1981. Actions of cholera toxin and the prevention and treatment of cholera. Nature 292:413.
8. Steinman, R. M., and M. C. Nussenzweig. 2002. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA 99:351.
9. Banchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebecque, Y. T. Liu, B. Pulendran, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:767.
10. Anjuère, F., P. Martín, I. Ferrero, M. López, G. Martínez del Hoyo, N. Wright, and C. Ardavín. 1999. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes and skin of the mouse. Blood 93:590.
11. Martin, P., S. Ruiz Ruiz, G. M. del Hoyo, F. Anjuère, H. Hernandez Vargas, M. Lopez-Bravo, and C. Ardavin. 2002. Dramatic increase in lymph node dendritic cell number during infection by the mouse mammary tumor virus occurs by CD62L-dependent blood-borne DC recruitment. Blood 99:1282.
12. + dendritic cells: tissue-dependent differences offset CD8α-related dendritic cell heterogeneity. J. Immunol. 33:2007.
13. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180:25.
14. Lebens, M., S. Johansson, J. Osek, M. Lindblad, and J. Holmgren. 1993. Large-scale production of Vibrio cholerae toxin B subunit for use in oral vaccines. Biotechnology 11:1574.
15. Witholt, B., M. Boekhout, M. Brock, J. Kingma, H. V. Heerikhuizen, and W. Leisgang. 1976. An efficient and reproducible procedure for the formation of spheroplasts from variously grown Escherichi coli. Anal. Biochem. 74:160.
16. Anjuère, F., and C. Ardavín. 2001. Isolation of mouse thymic dendritic cells. In Dendritic Cell Protocols. S. Robinson and A. Stagg, eds. Humana, Totowa, NJ, p. 23.
17. Becksteadt, J. M. 1994. A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues. J. Histochem. Cytochem. 42:737.
18. Villavedra, M., H. Carol, M. Hjulstrom, J. Holmgren, and C. Czerkinsky. 1997. PERFEXT: a direct method for quantitative assessment of cytokine production in vivo at the local level. Res. Immunol. 148:257.
19. 4-integrins in lymphocyte homing to mucosal tissues in vivo. J. Immunol. 152:3282.
20. + dendritic cell population in mouse Peyer's patches. Eur. J. Immunol. 26:1801.
21. Kelsall, B. L., and W. Strober. 1996. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J. Exp. Med. 183:237.
22. Anjuère, F., A. George-Chandy, F. Audant, D. Rousseau, J. Holmgren, and C. Czerkinsky. 2003. Transcutaneous immunization with cholera toxin B subunit adjuvant suppresses IgE antibody responses via selective induction of Th1 immune responses. J. Immunol. 170:1586.
23. p) integrins on mouse lymphocytes: relevance to the mucosal immune system. Eur. J. Immunol. 21:2591.
24. 7 integrin. Nature 372:190.
25. Maric, I., P. G. Holt, M. H. Perdue, and J. Bienenstock. 1996. Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine. J. Immunol. 15:1408.
26. Becker, C., S. Wirtz, M. Blessing, J. Pirhonen, D. Strand, O. Bechthold, J. Frick, P. R. Galle, I. Autenrieth, and M. F. Neurath. 2003. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J. Clin. Invest. 112:693.
27. Sierro, F., B. Dubois, A. Coste, D. Kaiserlian, J. P. Kraehenbuhl, and J. C. Sirard. 2001. Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc. Natl. Acad. Sci. USA 98:13722.
28. + T cells in vivo. J. Immunol. 169:3914.
29. Gagliardi M. C., F. Sallusto, M. Marinaro, A. Langenkamp, A. Lanzavecchia, and M. T. De Magistris. 2000. Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming. Eur. J. Immunol. 30:2394.
30. George-Chandy, A., K. Eriksson, M. Lebens, I. Nordstrom, E. Schon, and J. Holmgren. 2001. Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen-presenting cells. Infect. Immun. 69:5716.
31. Lavelle, E. C., E. McNeela, M. E. Armstrong, O. Leavy, S. C. Higgins, and K. H. Mills. 2003. Cholera toxin promotes the induction of regulatory T cells specific for bystander antigens by modulating dendritic cell activation. J. Immunol. 171:2384.
32. + dendritic cell phenotype upon maturation by CD40 ligation. J. Leukocyte Biol. 67:206.
33. Rescigno, M., M. Urbano, B. Valzasina, M. Francolini, G. Rotta, R. Bonasio, F. Granucci, J.-P. Krahenbuhl, and P. Ricciardi-Castagnoli. 2001. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2:361.
34. Yamamoto, M., P. Rennert, J. R. McGhee, M. N. Kweon, S. Yamamoto, T. Dohi, S. Otake, H. Bluethmann, K. Fujihashi, and H. Kiyono. 2000. Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. J. Immunol. 164:5184.
35. Alpan, O., G. Rudomen, and P. Matzinger. 2001. The role of dendritic cells, B cells, and M cells in gut-oriented immune responses. J. Immunol. 166:4843.