Structure of the intestinal flora responsible for development of the gut immune system in a rodent model

Microbes and Infection

Volumn 2, Issue 11, 2000, Pages 1343-1351

  Umesaki, Yoshinori ^a   Setoyama, Hiromi ^a  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

Development; Gut immune system; Intestinal flora; Segmented filametous bacteria

Indexed keywords

IMMUNOGLOBULIN A;

BACTERIAL COLONIZATION; DIGESTIVE SYSTEM; HOST; IMMUNE RESPONSE; IMMUNE SYSTEM; INTESTINE FLORA; INTESTINE MUCOSA; LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; REVIEW;

EID: 0033774143     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(00)01288-0     Document Type: Review

References (76)

1. Microbial ecology of the gastrointestinal tract
2. Expansion of alpha beta T-cell receptor bearing intestinal lymphocytes after microbial colonization in germ-free mice and its independence from thymus
3. Relationship between the development of the intestinal IgA immune system and the establishment of microbial flora in the digestive tract of young holoxenic mice
4. Effect of the gastrointestinal microflora on induction and maintenance of oral tolerance to ovalbumin in C3H/HeJ mice
5. The absence of gut flora, the doses of antigen ingested and aging affect the long-term peripheral tolerance induced by ovalbumin feeding in mice
6. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance
7. Impaired superoxide production in peripheral blood neutrophils of germ-free rats
8. Ontogeny of macrophage function to release superoxide anion in conventional and germfree mice
9. Lysosomal enzyme activity in pulmonary alveolar macrophages from conventional, germfree, monoassociated, conventionalized rats
10. Molecular analysis of the composition of the bifidobacterial and lactobacillus microflora of humans
11. Effects of fecal microorganisms and their chloroform-resistant variants derived from mice, rats, humans on immunological and physiological characteristics of the intestine in ex-germ-free mice
12. Characteristic fecal flora of NC mice
13. Habitat, succession, attachment, morphology of segmented, filamentous microbes indigenous to the murine gastrointestinal tract
14. The attachment of filamentous segmented microorganisms to the distal ileum wall of the mouse: A scanning and transmission electron microscopy study
15. Segmented filamentous bacteria are indigenous bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in ex-germ-free mouse
16. Indigenous, normal, autochtonous flora of the gastrointestinal tract
17. Immunity of Cryptosporidium muris infection in mice expressed through gut CD4+ intraepithelial lymphocytes
18. Intraepithelial lymphocytes traffic to the intestine and enhance resistance to Toxoplasma gondii oral infection
19. Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain-dependent and determined by T cells expressing gamma delta T-cell antigen receptors
20. Differential roles of segmented filamentous bacteria and closttidia in development of the intestinal immune system
21. Microbial colonization influences composition and T cell receptor Vβ repertoire of intraepithelial lymphocytes in rat intestine
22. Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine
23. The exanpsion and selection of T cell receptor alpha beta intestinal intraepithelial T cell clones
24. Two gut intraepithelial lymphocyte populations with different T cell receptors: A role for the gut epithelium in T cell differentiation
25. Different use of T cell receptor transducing molecules on two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation
26. The anatomical basis of intestinal immunity
27. Generation of intestinal T cells from progenitors residing in gut cryptopatches
28. T cell progenitors in the murine small intestine
29. Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor lineage
30. Selection and expansion of CD8α/α+ T cell receptor α/β+ intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules
31. Cutting edge: TCR αβ (+) CD8αα (+) T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC Class I molecules
32. Development of CD8 α/α and CD8α/β T cells in major histocompatibility complex class I-deficient mice
33. Differential induction of major histocompatibity complex class II molecules on the mouse intestine by bacterial colonization
34. Proliferative recruitment of intraepithelial lymphocytes after microbial colonization of germ-free mice
35. Regional variation in the proliferative rate and life span of αβ TCR + and γδ TCR + intrepithelial lymphocytes in the murine small intestine
36. A step-wise expansion of intestinal intraepithelial lymphocytes in association with microbial colonization is defined by sensitivity to cyclosporin A
37. Predominant T-cell receptor Vβ usage of intraepithelial lymphocytes during the immune response to enteric reovirus infection
38. Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection
39. Abrupt induction of GDP-fucose: Asialo GM1 fucosyltransferase in the small intestine after conventionalization of germ-free mice
40. γδTCR-bearing intraepithelial lymphocytes regulate class II major histocompatibility complex molecule expression on the mouse small intestinal epithelium
41. The intestinal epithelial cell: Processing and presentation of antigen to the mucosal immune system
42. Effects of age, strain, social hierarchy on colonization of autochtonous segmented filamentous bacteria in the ileum of mice
43. Development and cytolytic function of intestinal intraepithelial lymphocytes in antigen-minimized mice
44. Characterization of clostridia isolated from feces of limited flora mice and their effect on caecal size when associated with germ-free mice
45. Filamentous microbes indigenous to the murine small bowel: A scanning electron microscopic study of their morphology and attachment to the epithelium
46. Interactions between gut-associated lymphoid tissue and colonization levels of indigenous, segmented, filamentous bacteria in the small intestine of mice
47. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes
48. Intestinal epithelial cells both express and respond to interleukin 15
49. Interleukin-15 preferentially promotes the growth of intestinal epithelial lymphocytes bearing gamma delta T cell receptor in mice
50. An interleukin-7 internet for intestinal intraepithelilal T cell development: Knock out ligand or receptor reveal differences in the immunodeficient state
51. Local hormone networks and intestinal T cell homeostasis
52. Influence of intesinal bacterial flora on cytokine (IL-1, IL-6, TNF-α) production by mouse peritoneal macrophages
53. Butyrate as a differentiating agent: Pharmacokinetics, analogues and current status
54. Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice
55. Quantification of antigen-specific immunoglobulin A after oral booster immunization with ovalbumin in mice mono-associated with segmented filamentous bacteria or Clostridium inncuum
56. Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system
57. Release of the soluble co-receptor (protein Fv) of secretory immunoglobulins after colonization of axenic rats by the human gut microflora
58. Relationship between interdigestive motility and secretion of immunoglobulin A in human proximal small intestine
59. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut
60. Regional specialization in the mucosal immune system: What happens in the microcompartments?
61. Habitat, succession, attachment, morphology of segmented, filamentous microbes indigenous to the murine gastrointestinal tract
62. The attachment of filamentous segmented microorganisms to the distal ileum wall of the mouse: A scanning and transmission electron microscopy study
63. A model of host-microbial interactions in an open ecosystem
64. Probiotics in human health
65. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense
66. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
67. Interleukin-10-deficient mice develop chronic enterocolitis
68. T cell receptor-αβ-deficient mice fail to develop colitis in the absence of microbial environment
69. Inflammatory bowel disease-like enteritis and cecitis in a senescence-accelerated mouse (SAM) P1/Yit strain
70. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, arthritis in HLA-B27/human β2 microglobulin transgenic rats
71. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-dificient mice
72. Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice
73. Intestinal, segmented, filamentous bacteria in a wide range of vertebrate species