IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms

Microbes and Infection

Volumn 3, Issue 12, 2001, Pages 1021-1035

  Macpherson, Andrew J ^a   Hunziker, Lukas ^a   McCoy, Kathy ^a   Lamarre, Alain ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Bacteria; IgA; Intestinal mucosa; Viruses

Indexed keywords

IMMUNOGLOBULIN A;

B LYMPHOCYTE; BACTERIAL COLONIZATION; BACTERIAL IMMUNITY; BILE; CELL CULTURE; CELL TYPE; CELLULAR DISTRIBUTION; EXPERIMENTAL MODEL; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IN VIVO STUDY; INTESTINE BLOOD FLOW; INTESTINE FLORA; INTESTINE INFECTION; INTESTINE LYMPH; INTESTINE MUCOSA; LYMPH FLOW; MILK; NEWBORN PERIOD; PATHOGENICITY; PEYER PATCH; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW; ROTAVIRUS; SURFACE PROPERTY;

MAMMALIA;

EID: 0034802944     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(01)01460-5     Document Type: Review

References (119)

1. Developmental microbial ecology of the neonatal gastrointestinal tract
2. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins
3. Transepithelial transport of immunoglobulins
4. Intravascular and mucosal immunoglobulin A: Two separate but related systems of immune defense?
5. Epithelial transcytosis of monomeric IgA and IgG cross-linked through antigen to polymeric IgA. A role for monomeric antibodies in the mucosal immune system
6. The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: A local defense function for IgA
7. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria
8. Intestinal and circulating antibody-forming cells in IgA-deficient individuals after oral cholera vaccination
9. Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other immunoglobulin isotypes
10. Rapid active transport of immunoglobulin A from blood to bile
11. Rapid disappearance from serum of intravenously injected rat myeloma IgA and its secretion into bile
12. Identification of secretory component as an IgA receptor on rat hepatocytes
13. Secretory component as the receptor for polymeric IgA on rat hepatocytes
14. The membrane receptor for polymeric immunoglobulin is structurally related to secretory component. Isolation and characterization of membrane secretory component from rabbit liver and mammary gland
15. Selective transport of polymeric immunoglobulin A in bile. Quantitative relationships of monomeric and polymeric immunoglobulin A, immunoglobulin M, and other proteins in serum, bile, and saliva
16. A comparative study of the biliary secretion of human dimeric and monomeric IgA in the rat and in man
17. IgA in human bile and liver
18. IgA plasma cells in biliary mucosa: A likely source of locally synthesized IgA in human hepatic bile
19. Gall bladder: The predominant source of bile IgA in man?
20. Receptor-mediated binding and uptake of immunoglobulin A by human liver
21. Plasma cells and epithelial immunoglobulins in the mouse mammary gland during pregnancy and lactation
22. Metabolism of immunoglobulin A in lactating mice: Origins of immunoglobulin A in milk
23. Origin of IgA-secreting plasma cells in the mammary gland
24. Organ and isotype distribution of plasma cells producing specific antibody after oral immunization: Evidence for a generalized secretory immune system
25. GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism
26. Cellular distribution, regulation, and biochemical nature of an Fc alpha receptor in humans
27. Bispecific molecules directed to the Fc receptor for IgA (Fc alpha RI, CD89) and tumor antigens efficiently promote cell-mediated cytotoxicity of tumor targets in whole blood
28. Fc alpha receptors mediate release of tumour necrosis factor-alpha and interleukin-6 by human monocytes following receptor aggregation
29. FcalphaRI-positive liver Kupffer cells: Reappraisal of the function of immunoglobulin A in immunity
30. The route of recirculation of lymphocytes in the rat
31. Selective migration of lymphocytes within the mouse small intestine
32. The gut-associated lymphoid system: Nature and properties of the large dividing cells
33. Peyer's patches: An enriched source of precursors for IgA-producing immunocytes in the rabbit
34. The origin and antigen-dependent distribution of IgA-containing cells in the intestine
35. Cellular kinetics of the intestinal immune response to cholera toxoid in rats
36. Early appearance of 'natural' mucosal IgA responses and germinal centers in suckling mice developing in the absence of maternal antibodies
37. B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development
38. The 'Ly-1 B' cell subpopulation in normal immunodefective, and autoimmune mice
39. Progenitors for Ly-1 B cells are distinct from progenitors for other B cells
40. Normal, autoimmune, and malignant CD5+ B cells: The Ly-1 B lineage?
41. Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment
42. Repetitive usage of immunoglobulin VH and D gene segments in CD5+ Ly-1 B clones of (NZB x NZW)F1 mice
43. The repertoire of IgM in normal mice is largely independent of external antigenic contact
44. Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice
45. Positive selection of natural autoreactive B cells
46. TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo
47. Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage
48. Many of the IgA producing plasma cells in the murine gut are derived from self-replenishing precursors in the peritoneal cavity
49. IgA production in MHC class II-deficient mice is primarily a function of B-1a cells
50. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
51. Leu-1+ (CD5+) B cells. A major lymphoid subpopulation in human fetal spleen: Phenotypic and functional studies
52. CD5+ B lymphocytes, polyreactive antibodies and the human B-cell repertoire
53. Rheumatoid factor secretion from human Leu-1+ B cells
54. Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated Vh region genes
55. Characteristics of IgVH genes used by human intestinal plasma cells from childhood
56. Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells
57. Peyer's patches, gut IgA plasma cells and thymic function: Study in nude mice bearing thymic grafts
58. Protection against cholera toxin after oral immunisation is thymus dependent and associated with intestinal production of neutralising IgA antitoxin
59. Transforming growth factor β specifically enhances IgA production by lipopolysaccharide stimulated murine B lymphocytes
60. Regulation of IgA differentiation in CH12LX B cells by lymphokines: IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA
61. Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells
62. IL-6 is a potent cofactor of IL-1 in IgM synthesis and of IL-5 in IgA synthesis
63. Interleukin 10 and transforming growth factor beta cooperate to induce anti- CD40-activated naive human B cells to secrete immunoglobulin
64. Molecular genetic features reflecting the preference for isotype switching to IgA expression by Peyer's patch germinal center B cells
65. Dendritic cell dependent expression of IgA by clones in T/B microcultures
66. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin
67. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen
68. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin
69. Intestinal mucosal memory and presence of memory cells in lamina propria and Peyer's patches in mice 2 years after oral immunization with cholera toxin
70. Paradoxical IgA immunity in CD4-deficient mice
71. Lack of J chain inhibits the transport of gut IgA and abrogates the development of intestinal antitoxic protection
72. Impaired mucosal immune responses in interleukin 4-targeted mice
73. Requirements for B7-CD28 costimulation in mucosal IgA responses: Paradoxes observed in CTLA4-H gamma 1 transgenic mice
74. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
75. Interleukin-10-deficient mice develop chronic enterocolitis
76. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
77. Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice
78. Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses
79. Oral vaccination with immune stimulating complexes
80. The role of interleukin-6 in mucosal IgA antibody responses in vivo
81. IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection
82. Poliovirus antibody response in serum and nasal secretions following intranasal inoculation with inactivated poliovaccine
83. Induction of mucosal immunity by inactivated poliovirus vaccine is dependent on previous mucosal contact with live virus
84. Antibody response in serum and nasopharynx after naturally acquired and vaccine-induced infection with rubella virus
85. Immunity to rotavirus infection in mice
86. Analyses of homologous rotavirus infection in the mouse model
87. Comparison of mucosal and systemic humoral immune responses and subsequent protection in mice orally inoculated with a homologous or a heterologous rotavirus
88. Recovery from chronic rotavirus infection in mice with severe combined immunodeficiency: Virus clearance mediated by adoptive transfer of immune CD8+ T lymphocytes
89. Role of B cells and cytotoxic T lymphocytes in clearance of and immunity to rotavirus infection in mice
90. Effector functions of antibody and CD8+ cells in resolution of rotavirus infection and protection against reinfection in mice
91. Protection of the villus epithelial cells of the small intestine from rotavirus infection does not require immunoglobulin A
92. Immunity to rotavirus in T cell deficient mice
93. Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity
94. Passive transfer of local immunity to influenza-virus infection by IgA antibody
95. Immunoglobulin A mediation of murine nasal anti-influenza virus immunity
96. Antibody responses and protection in mice immunized orally against influenza virus
97. Cross-protection against influenza-A virus-infection by passively transferred respiratory-tract IgA antibodies to different hemagglutinin molecules
98. Rapid recovery of lung histology correlates with clearance of influenza virus by specific CD8+ cytotoxic T cells
99. Do L3T4+ T cells act as effector cells in protection against influenza virus infection
100. Mechanism of protective immunity against influenza virus infection in mice without antibodies
101. Mechanisms of heterosubtypic immunity to lethal influenza A virus infection in fully immunocompetent, T cell-depleted, beta2-microglobulin-deficient, and J chain-deficient mice
102. Mucosal immunity to influenza without IgA: An IgA knockout mouse model
103. IgA immunodeficiency leads to inadequate Th cell priming and increased susceptibility to influenza virus infection
104. New model for analysis of mucosal immunity: Intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection
105. Monoclonal immunoglobulin-A antibody-directed against serotype-specific epitope of Shigella flexneri lipopolysaccharide protects against murine experimental shigellosis
106. Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization
107. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut
108. Role of maternal antibody in the induction of virus specific and bystander IgA responses in Peyer's patches of suckling mice
109. Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice
110. N
111. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line
112. Evidence for protection by breast-feeding against infant deaths from infectious diseases in Brazil
113. Case-control study of risk of dehydrating diarrhoea in infants in vulnerable period after full weaning
114. Protective effect of breast feeding against infection
115. Early diet of preterm infants and development of allergic or atopic disease: Randomised prospective study
116. Relation of infant diet to childhood health: Seven year follow up of cohort of children in Dundee infant feeding study
117. Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria