Comparison of cell lines for stable production of fucose-negative antibodies with enhanced ADCC

Biotechnology and Bioengineering

Volumn 94, Issue 4, 2006, Pages 680-688

  Kanda, Yutaka ^a   Yamane Ohnuki, Naoko ^a   Sakai, Naoto ^a   Yamano, Kazuya ^a   Nakano, Ryosuke ^a   Inoue, Miho ^a   Misaka, Hirofumi ^a   Iida, Shigeru ^a   Wakitani, Masako ^a   Konno, Yoshinobu ^a   Yano, Keiichi ^a   Shitara, Kenya ^a   Hosoi, Shinji ^a   Satoh, Mitsuo ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Antibody dependent cellular cytotoxicity; CHO cells; Fucose negative antibody production; FUT8 knockout; Lec13; Ms704; Serum free fed batch culture; YB2 0

Indexed keywords

BIOREACTORS; CARBOHYDRATES; CELL CULTURE; CELLS; SYNTHESIS (CHEMICAL);

ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY (ADCC); CHO CELLS; FUCOSE-NEGATIVE ANTIBODY PRODUCTION; FUT8 KNOCKOUT; LEC13; MS704; SERUM-FREE FED-BATCH CULTURE; YB2/0;

ANTIBODIES;

FUCOSE;

ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; BIOREACTOR; CELL CLONE; CELL CULTURE; CELL DIFFERENTIATION; COMPARATIVE STUDY; CONTROLLED STUDY; HOST CELL; HYBRIDOMA; LENTIL; METHODOLOGY; NONHUMAN; PH; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIBODY FORMATION; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL LINE; CHO CELLS; CRICETINAE; CULTURE MEDIA, SERUM-FREE; DNA, COMPLEMENTARY; FUCOSE; FUCOSYLTRANSFERASES; GENE DELETION; MONOSACCHARIDES; OLIGOSACCHARIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

CRICETULUS GRISEUS; LENS CULINARIS;

EID: 33646724042     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.20880     Document Type: Article

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