Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 819, Issue 2, 2005, Pages 203-218

  Beck, Alain ^a   Bussat, Marie Claire ^a   Zorn, Nathalie ^b   Robillard, Virginie ^a   Klinguer Hamour, Christine ^a   Chenu, Stéphane ^a   Goetsch, Liliane ^a   Corvaïa, Nathalie ^a   Van Dorsselaer, Alain ^b   Haeuw, Jean François ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b CNRS   (France)

Author keywords

CHO cells; Glycopeptide mapping; Insulin like growth factor 1 receptor; NS0 cells; Peptide mapping; Recombinant monoclonal antibodies

Indexed keywords

AMINO ACIDS; ANTIBODIES; CELLS; CHARACTERIZATION; ENZYMES; HYDROPHOBICITY; MASS SPECTROMETRY; MODIFICATION;

AMINO ACID SEQUENCES; MICROSEQUENCING; MONOCLONAL ANTIBODY; PEPTIDE MAPPING;

LIQUID CHROMATOGRAPHY;

AMINO ACID; ARGININE CARBOXYPEPTIDASE; ASPARAGINE; CATION; DISULFIDE; ENZYME; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; LYSINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 7H2HM; MONOCLONAL ANTIBODY A2CHM; PAPAIN; PEPTIDE; PYROGLUTAMIC ACID; RECEPTOR ANTIBODY; SOMATOMEDIN C RECEPTOR; TRYPSIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANALYTIC METHOD; ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; DISULFIDE BOND; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME DEGRADATION; GLYCOSYLATION; HEAVY CHAIN; HYDROPHOBICITY; INTERMETHOD COMPARISON; INTRON; ION EXCHANGE CHROMATOGRAPHY; ISOELECTRIC FOCUSING; LIGHT CHAIN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE MAPPING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN VARIANT; QUANTITATIVE ANALYSIS; QUANTUM YIELD; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 20244385589     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2004.06.052     Document Type: Article

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