The conformational switch from the factor X zymogen to protease state mediates exosite expression and prothrombinase assembly

Journal of Biological Chemistry

Volumn 283, Issue 27, 2008, Pages 18627-18635

  Toso, Raffaella ^a   Zhu, Hua ^a   Camire, Rodney M ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BIOCHEMISTRY; KETONES; SODIUM; SODIUM CHLORIDE;

ACTIVE SITES; CATALYTIC DOMAINS; CATALYTIC SITES; CONFORMATIONAL SWITCHES; IN LINES; INTRAMOLECULAR ACTIVATIONS; N TERMINUSES; PROTHROMBINASE; SERINE PROTEASES; STRUCTURAL PLASTICITIES; SURFACE LOOPS;

BINDING SITES;

ARGININE; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; ENZYME PRECURSOR; GLUTAMIC ACID; GLYCINE; PROTEINASE; PROTHROMBIN; SODIUM; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5A; PROTHROMBINASE COMPLEX;

ALLOSTERISM; ARTICLE; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN VARIANT; REGULATORY MECHANISM; AMINOACYLATION; BINDING SITE; ENZYME ACTIVATION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; ENZYME ACTIVATION; ENZYME PRECURSORS; FACTOR V; FACTOR VA; FACTOR XA; HUMANS; MUTAGENESIS; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SODIUM; TRANSFER RNA AMINOACYLATION;

EID: 49649122047     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802205200     Document Type: Article

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