Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 13, 2007, Pages 5306-5311

  Kirchhofer, Daniel ^a   Lipari, Michael T ^a   Santell, Lydia ^a   Billeci, Karen L ^a   Maun, Henry R ^a   Sandoval, Wendy N ^a   Moran, Paul ^a   Ridgway, John ^a   Eigenbrot, Charles ^a   Lazarus, Robert A ^a  

^a GENENTECH INC   (United States)

Author keywords

Allosteric regulation; Cancer; Receptor tyrosine kinase; Signal transduction; Trypsin

Indexed keywords

MUTANT PROTEIN; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SERINE PROTEINASE; SCATTER FACTOR RECEPTOR;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING SITE; CELL MIGRATION; CELL PROLIFERATION; CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ENGINEERING; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; CHO CELL; CRICETULUS; DRUG ANTAGONISM; HAMSTER; METABOLISM; METHODOLOGY; NEOPLASM; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; ANIMALS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; HEPATOCYTE GROWTH FACTOR; HUMANS; NEOPLASMS; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MET; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION;

EID: 34248335027     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700184104     Document Type: Article

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