Regions remote from the site of cleavage determine macromolecular substrate recognition by the prothrombinase complex

Journal of Biological Chemistry

Volumn 273, Issue 17, 1998, Pages 10709-10718

  Betz, Andreas ^a,b   Krishnaswamy, Sriram ^a,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; FIBRINOGEN; LOW MOLECULAR WEIGHT HEPARIN; PROTHROMBIN; THROMBIN;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; COMPETITIVE INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; MACROMOLECULE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BINDING, COMPETITIVE; CATTLE; ENZYME PRECURSORS; FACTOR V; FACTOR X; FACTOR XA; FLUORESCENCE POLARIZATION; HIRUDINS; HYDROLYSIS; KINETICS; PEPTIDE FRAGMENTS; PROTHROMBIN; SUBSTRATE SPECIFICITY; THROMBIN;

EID: 0032562804     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.17.10709     Document Type: Article

References (62)

1. Schechter, I., and Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162
2. Bode, W., Mayr, I., Baumann, U., Huber, R., Stone, S. R., and Hofsteenge, J. (1989) EMBO J. 8, 3467-3475
3. Fenton, J. W., II, Landis, B. H., Walz, D. A., and Finlayson, J. S. (1977) in Chemistry and Biology of Thrombin (Fenton, J. W., II, Lundblad, R. L., and Mann, K. G., eds) pp. 43-70, Ann Arbor Science, Ann Arbor, MI
4. Boissel, J. P., Le Bonniec, B., Rabiet, M. J., Labie, D., and Elion, J. (1984) J. Biol. Chem. 259, 5691-5697
5. Hofsteenge, J., Braun, P. J., and Stone, S. R. (1988) Biochemistry 27, 2144-2151
6. Mann, K. G., Jenny, R. J., and Krishnaswamy, S. (1988) Annu. Rev. Biochem. 57, 915-956
7. Mann, K. G., Nesheim, M. E., Church, W. R., Haley, P., and Krishnaswamy, S. (1990) Blood 76, 1-16
8. Kalafatis, M., Swords, N. A., Rand, M. D., and Mann, K. G. (1994) Biochim. Biophys. Acta 1227, 113-129
9. Padmanabhan, K., Padmanabhan, K. P., Tulinsky, A., Park, C. H., Bode, W., Huber, R., Blankenship, D. T., Cardin, A. D., and Kisiel, W. (1993) J. Mol. Biol. 232, 947-966
10. Nesheim, M. E., Eid, S., and Mann, K. G. (1981) J. Biol. Chem. 256, 9874-9882
11. Walker, R. K., and Krishnaswamy, S. (1993) J. Biol. Chem. 268, 13920-13929
12. Ellis, V., Scully, M. F., and Kakkar, V. V. (1984) Biochemistry 23, 5882-5887
13. Krishnaswamy, S., Vlasuk, G. P., and Bergum, P. W. (1994) Biochemistry 33, 7897-7907
14. Betz, A., Vlasuk, G. P., Bergum, P. W., and Krishnaswamy, S. (1997) Biochemistry 36, 181-191
15. Walker, R. K., and Krishnaswamy, S. (1994) J. Biol. Chem. 269, 27441-27450
16. Krishnaswamy, S., and Walker, R. K. (1997) Biochemistry 36, 3319-3330
17. Krishnaswamy, S., and Betz, A. (1997) Biochemistry 36, 12080-12086
18. Lundblad, R. L., Kingdon, H. S., and Mann, K. G. (1976) Methods Enzymol. 45, 156-176
19. Lottenberg, R., and Jackson, C. M. (1983) Biochim. Biophys. Acta 742, 558-564
20. Higgins, D. L., and Mann, K. G. (1983) J. Biol. Chem. 258, 6503-6508
21. Gomori, G. (1942) J. Lab. Clin. Med. 27, 955-960
22. Stone, S. R., and Maraganore, J. M. (1993) Methods Enzymol. 223, 312-336
23. Krishnaswamy, S., Mann, K. G., and Nesheim, M. E. (1986) J. Biol. Chem. 261, 8977-8984
24. Jesty, J., and Nemerson, Y. (1976) Methods Enzymol. 45, 95-107
25. Krishnaswamy, S., Church, W. R., Nesheim, M. E., and Mann, K. G. (1987) J. Biol. Chem. 262, 3291-3299
26. Chase, T., Jr., and Shaw, E. (1967) Methods Enzymol. 19, 20-27
27. Krishnaswamy, S., and Mann, K. G. (1988) J. Biol. Chem. 263, 5714-5723
28. Laroche, Y., Storme, V., De Meutter, J., Messens, J., and Lauwereys, M. (1994) Bio/Technology 12, 1119-1124
29. Matthias, F. R., Reinicke, R., and Heene, D. L. (1977) Thrombosis Res. 10, 365-384
30. Baugh, R. J., and Krishnaswamy, S. (1996) J. Biol. Chem. 271, 16126-16134
31. Mann, K. G., Elion, J., Butkowski, R. J., Downing, M., and Nesheim, M. E. (1981) Methods Enzymol. 80, 286-302
32. Brezniak, D. V., Brower, M. S., Witting, J. I., Walz, D. A., and Fenton, J. W., II (1990) Biochemistry 29, 3536-3542
33. Laemmli, U. K. (1970) Nature 227, 680-685
34. Jackson, C. M., Johnson, T. F., and Hanahan, D. J. (1968) Biochemistry 7, 4492-4505
35. Fujikawa, K., Coan, M. H., Legas, M. E., and Davie, E. W. (1974) Biochemistry 13, 5290-5299
36. Laue, T. M., Johnson, A. E., Esmon, C. T., and Yphantis, D. A. (1984) Biochemistry 23, 1339-1348
37. Fassman, G. D. (1975) Handbook of Biochemistry and Molecular Biology. Proteins, Vol. II, 3rd ed., CRC Press, Cleveland, OH
38. Gill, S. C., and von Hippel, P. H. (1989) Anal. Biochem. 182, 319-326
39. Bock, P. E. (1988) Biochemistry 27, 6633-6639
40. Krishnaswamy, S., Nesheim, M. E., Pryzdial, E. L., and Mann, K. G. (1993) Methods Enzymol. 222, 260-280
41. Bock, P. E., Craig, P. A., Olson, S. T., and Singh, P. (1989) Arch. Biochem. Biophys. 273, 375-388
42. Krishnaswamy, S. (1990) J. Biol. Chem. 265, 3708-3718
43. Lakowicz, J. R. (1983) Principles of Fluorescence Spectroscopy, Plenum Press, New York
44. Bevington, P. R. (1969) Data Reduction and Error Analysis in the Physical Sciences, McGraw-Hill, New York
45. Straume, M., and Johnson, M. L. (1992) Methods Enzymol. 210, 87-105
46. Segel, I. H. (1975) Enzyme Kinetics: Behaviour and Analysis of Rapid Equilibrium and Steady State Enzyme Systems, John Wiley & Sons, New York
47. Olson, S. T., Bock, P. E., and Sheffer, R. (1991) Arch. Biochem. Biophys. 286, 533-545
48. Nesheim, M. E., Kettner, C., Shaw, E., and Mann, K. G. (1981) J. Biol. Chem. 256, 6537-6540
49. Krishnaswamy, S., Jones, K. C., and Mann, K. G. (1988) J. Biol. Chem. 263, 3823-3834
50. Stubbs, M. T., and Bode, W. (1995) Trends Biochem. Sci. 20, 23-28
51. Vijayalakshmi, J., Padmanabhan, K. P., Mann, K. G., and Tulinsky, A. (1994) Protein Sci. 3, 2254-2271
52. Lewis, S. D., Brezniak, D. V., Fenton, J. W., and Shafer, J. A. (1992) Protein Sci. 1, 998-1006
53. Olson, S. T., Halvorson, H. R., and Bjork, I. (1991) J. Biol. Chem. 266, 6342-6352
54. Liu, L. W., Ye, J., Johnson, A. E., and Esmon, C. T. (1991) J. Biol. Chem. 266, 23633-23636
55. Bock, P. E., Olson, S. T., and Bjork, I. (1997) J. Biol. Chem. 272, 19837-19845
56. Fredenburgh, J. C., Stafford, A. R., and Weitz, J. I. (1997) J. Biol. Chem. 272, 25493-25499
57. Lai, M. T., Di Cera, E., and Shafer, J. A. (1997) J. Biol. Chem. 272, 30275-30282
58. Gitel, S. N., Owen, W. G., Esmon, C. T., and Jackson, C. M. (1973) Proc. Natl. Acad. Sci. U. S. A. 70, 1344-1348
59. Esmon, C. T., and Jackson, C. M. (1974) J. Biol. Chem. 249, 7791-7797
60. Church, W. R., Messier, T. L., Tucker, M. M., and Mann, K. G. (1988) Blood 72, 1911-1921
61. Brandstetter, H., Kuhne, A., Bode, W., Huber, R., von der Saal, W., Wirthensohn, K., and Engh, R. A. (1996) J. Biol. Chem. 271, 29988-29992
62. Rezaie, A. R., and Esmon, C. T. (1995) J. Biol. Chem. 270, 16176-16181