Removal of B-domain sequences from factor V rather than specific proteolysis underlies the mechanism by which cofactor function is realized

Journal of Biological Chemistry

Volumn 279, Issue 20, 2004, Pages 21643-21650

  Toso, Raffaella ^a   Camire, Rodney M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOASSAY; BIOLOGICAL MEMBRANES; CELLS; CONFORMATIONS; FLUORESCENCE;

KINETIC ASSAYS; PROCOAGULANT ACTIVITY;

ENZYMES;

ARGININE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5; PROCOAGULANT; PROTEIN PRECURSOR;

ARTICLE; CELL FUNCTION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DERIVATIZATION; HUMAN; HYPOTHESIS; MEMBRANE BINDING; MOLECULAR INTERACTION; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; SEQUENCE ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELL LINE; CRICETINAE; FACTOR V; FACTOR VA; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE;

EID: 2442655492     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402107200     Document Type: Article

References (61)

1. Mann, K. G., Nesheim, M. E., Church, W. R., Haley, P. E., and Krishnaswamy, S. (1990) Blood 76, 1-16
2. Mann, K. G., and Kalafatis, M. (2002) Blood 101, 20-30
3. Ortel, T. L., Kane, W. H., and Keller, F. G. (1995) in Molecular Basis of Thrombosis and Hemostasis (High, K. A., and Roberts, H. R., eds) pp. 119-146, Marcel Dekker, New York
4. Nesheim, M. E., Taswell, J. B., and Mann, K. G. (1979) J. Biol. Chem. 254, 10952-10962
5. Foster, W. B., Nesheim, M. E., and Mann, K. G. (1983) J. Biol. Chem. 258, 13970-13977
6. Suzuki, K., Dahlbäck, B., and Stenflo, J. (1982) J. Biol. Chem. 257, 6556-6564
7. Guinto, E. R., and Esmon, C. T. (1984) J. Biol. Chem. 259, 13986-13992
8. Esmon, C. T., Owen, W. G., Duiguid, D., and Jackson, C. M. (1973) Biochim. Biophys. Acta 310, 289-294
9. Esmon, C. T. (1979) J. Biol. Chem. 254, 964-973
10. Nesheim, M. E., and Mann, K. G. (1979) J. Biol. Chem. 254, 1326-1334
11. Jenny, R. J., Pittman, D. D., Toole, J. J., Kriz, R. W., Aldape, R. A., Hewick, R. M., Kaufman, R. J., and Mann, K. G. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 4846-4850
12. Khan, A. M., and James, M. N. G. (1998) Protein Sci. 7, 815-836
13. Coughlin, S. R. (2000) Nature 407, 258-264
14. Doolittle, R. F. (2003) J. Thromb. Haemostasis 1, 1559-1565
15. Keller, F. G., Ortel, T. L., Quinn-Allen, M. A., and Kane, W. H. (1995) Biochemistry 34, 4118-4124
16. Thorelli, E., Kaufman, R. J., and Dahlbäck, B. (1997) Eur. J. Biochem. 247, 12-20
17. Steen, M., and Dahlbäck, B. (2002) J. Biol. Chem. 277, 38424-38430
18. Camire, R. M., Kalafatis, M., and Tracy, P. B. (1998) Biochemistry 37, 11896-11906
19. Kalafatis, M., Beck, D. O., and Mann, K. G. (2004) J. Biol. Chem. 278, 33550-33561
20. Kobe, B., and Kemp, B. E. (1999) Nature 402, 373-376
21. Kane, W. H., Devore-Carter, D., and Ortel, T. L. (1990) Biochemistry 29, 6762-6768
22. Nesheim, M. E., Foster, W. B., Hewick, R., and Mann, K. G. (1984) J. Biol. Chem. 259, 3187-3196
23. Marquette, K. A., Pittman, D. D., and Kaufman, R. J. (1995) Blood 86, 3026-3034
24. Kalafatis, M., and Mann, K. G. (1997) Arterioscler. Thromb. Vasc. Biol. 17, 620-627
25. Lottenberg, R., and Jackson, C. M. (1983) Biochim. Biophys. Acta 742, 558-564
26. Higgins, D. L., and Mann, K. G. (1983) J. Biol. Chem. 258, 6503-6508
27. Gomori, G. (1942) J. Lab. Clin. Med. 27, 955-960
28. Baugh, R., and Krishnaswamy, S. (1996) J. Biol. Chem. 271, 16126-16134
29. Buddai, S. K., Toulokhonova, L., Bergum, P. W., Vlasuk, G. P., and Krishnaswamy, S. (2002) J. Biol. Chem. 277, 26689-26698
30. Katzmann, J. A., Nesheim, M. E., Hibbard, L. S., and Mann, K. G. (1981) Proc. Natl. Acad. Sci. U. S.A. 78, 162-166
31. Kalafatis, M., Krishnaswamy, S., Rand, M. D., and Mann, K. G. (1993) Methods Enzymol. 222, 224-236
32. Mann, K. G., Elion, J., Butkowski, R. J., Downing, M., and Nesheim, M. E. (1981) Methods Enzymol. 80, 286-302
33. Mann, K. G. (1976) Methods Enzymol. 45, 123-156
34. Lundblad, R. L., Kingdon, H. S., and Mann, K. G. (1976) Methods Enzymol. 45, 156-176
35. Di Scipio, R. G., Hermodson, M. A., Yates, S. G., and Davie, E. W. (1977) Biochemistry 16, 698-706
36. Kaufman, R. J., Davies, M. V., Wasley, L. C., and Michnick, D. (1991) Nucleic Acids Res. 19, 4485-4490
37. Horton, R. M., Hunt, H. D., Ho, S. N., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 61-68
38. Sandberg, H., Almstedt, A., Brandt, J., Gray, E., Holmquist, L., Oswaldsson, U., Sebring, S., and Mikaelsson, M. (2001) Thromb. Haemostasis 85, 93-100
39. Stafford, W. F. (1992) Anal. Biochem. 203, 295-301
40. Babul, J., and Stellwagen, E. (1969) Anal. Biochem. 28, 216-221
41. Betz, A., and Krishnaswamy, S. (1998) J. Biol. Chem. 273, 10709-10718
42. Krishnaswamy, S., and Walker, R. K. (1997) Biochemistry 36, 3319-3330
43. Camire, R. M. (2002) J. Biol. Chem. 277, 37863-37870
44. Bevington, P. R., and Robinson, K. D. (1992) Data Reduction and Error Analysis for the Physical Sciences, McGraw-Hill, New York
45. Straume, M., and Johnson, M. L. (1992) Methods Enzymol. 210, 87-105
46. Krishnaswamy, S. (1990) J. Biol. Chem. 265, 3708-3718
47. Segal, I. H. (1975) Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady State Enzyme Systems, John Wiley & Sons, Inc., New York
48. Mann, K. G., Hockin, M. F., Begin, K. J., and Kalafatis, M. (1997) J. Biol. Chem. 272, 20678-20683
49. Krishnaswamy, S., and Mann, K. G. (1988) J. Biol. Chem. 263, 5714-5723
50. Laue, T. M., Johnson, A. E., Esmon, C. T., and Yphantis, D. A. (1984) Biochemistry 23, 1339-1348
51. Kim, S. W., Ortel, T. L., Quinn-Allen, M. A., Yoo, L., Worfolk, L., Zhai, X., Lentz, B. R., and Kane, W. H. (1999) Biochemistry 38, 11448-11454
52. Chen, J., Ishii, M., Wang, L., Ishii, K., and Coughlin, S. R. (1994) J. Biol. Chem. 269, 16041-16045
53. Eaton, D. L., Wood, W. I., Eaton, D., Hass, P. E., Hollingshead, P., Wion, K. L., Mather, J., Lawn, R. M., Vehar, G. A., and Gorman, C. (1986) Biochemistry 25, 8343-8347
54. Toole, J. J., Pittman, D. D., Orr, E. C., Murtha, P., Wasley, L. C., and Kaufman, R. J. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 5939-5942
55. Pittman, D. D., Alderman, E. M., Tomkinson, K. N., Wang, J. H., Giles, A. R., and Kaufman, R. J. (1993) Blood 81, 2925-2935
56. Donath, M.-J. S. H., Laaf, R. T. M., Biessels, P. T. M., Lenting, P. J., van de Loo, J., van Mourik J. A., Voorberg J., and Mertens K. (1995) Biochem. J. 312, 49-55
57. Pipe, S. W., and Kaufman, R. J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 11851-11856
58. Pittman, D. D., and Kaufman, R. J. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 2429-2433
59. Kemball-Cook, G., Tuddenham, E. G., and Wacey A. I. (1998) Nucleic Acids Res. 26, 216-219
60. Monkovic, D. D., and Tracy, P. B. (1990) Biochemistry 29, 1118-1128
61. Bruin, T., Sturk, A., Ten Cate, J. W., and Cath, M. (1987) Eur. J. Biochem. 170, 305-310