Activating a zymogen without proteolytic processing: Mutation of Lys15 and Asn194 activates trypsinogen

Biochemistry

Volumn 37, Issue 46, 1998, Pages 16201-16210

  Pasternak, Annette ^b   Liu, Xiaolin ^b   Lin, Tiao Yin ^a,b   Hedstrom, Lizbeth ^b  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; ENZYME PRECURSOR; HISTIDINE; ISOLEUCINE; LYSINE; PHENYLALANINE; SERINE PROTEINASE; TRYPSIN; TRYPSINOGEN;

ARTICLE; BINDING AFFINITY; HYDROLYSIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

ANIMALS; APROTININ; ASPARAGINE; ASPARTIC ACID; CATTLE; COUMARINS; ENZYME ACTIVATION; ENZYME STABILITY; HISTIDINE; HYDROLYSIS; LYSINE; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PHENYLALANINE; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY; TRYPSIN; TRYPSINOGEN;

EID: 0032542024     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980951d     Document Type: Article

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