메뉴 건너뛰기




Volumn 1, Issue 4, 2008, Pages 547-558

TGF-β1 as a therapeutic target for pulmonary fibrosis and COPD

Author keywords

Emphysema; Pulmonary fibrosis; Stem cells; TGf ; Therapeutic target

Indexed keywords

ACETYLCYSTEINE; APOPTOSIS INHIBITOR; CONNECTIVE TISSUE GROWTH FACTOR; DECORIN; GELATINASE B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTEGRIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RECEPTOR BLOCKING AGENT; SEMAPHORIN; SEMAPHORIN 7A; SMAD3 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 49449094115     PISSN: 17512433     EISSN: None     Source Type: Journal    
DOI: 10.1586/17512433.1.4.547     Document Type: Review
Times cited : (10)

References (118)
  • 1
    • 0036587571 scopus 로고    scopus 로고
    • Transforming growth factor β signal transduction
    • Dennler S, Goumans MJ, ten Dijke P. Transforming growth factor β signal transduction. J. Leukoc. Biol. 71(5), 731-740 (2002).
    • (2002) J. Leukoc. Biol , vol.71 , Issue.5 , pp. 731-740
    • Dennler, S.1    Goumans, M.J.2    ten Dijke, P.3
  • 2
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-β
    • Letterio JJ, Roberts AB. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16, 137-161 (1998).
    • (1998) Annu. Rev. Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 3
    • 0030427867 scopus 로고    scopus 로고
    • Signal transduction by members of the transforming growth factor-β superfamily
    • Attisano L, Wrana JL. Signal transduction by members of the transforming growth factor-β superfamily. Cytokine Growth Factor Rev. 7(4), 327-339 (1996).
    • (1996) Cytokine Growth Factor Rev , vol.7 , Issue.4 , pp. 327-339
    • Attisano, L.1    Wrana, J.L.2
  • 4
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-β signals
    • Massague J. How cells read TGF-β signals. Nat. Rev. Mol. Cell Biol. 1(3), 169-178 (2000).
    • (2000) Nat. Rev. Mol. Cell Biol , vol.1 , Issue.3 , pp. 169-178
    • Massague, J.1
  • 5
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-β signaling through Smads
    • Feng XH, Derynck R. Specificity and versatility in TGF-β signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659-693 (2005).
    • (2005) Annu. Rev. Cell Dev. Biol , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 6
    • 0029995587 scopus 로고    scopus 로고
    • Transforming growth factor-β1-deficient mice: Identification of isoform-specific activities in vivo
    • Letterio JJ, Roberts AB. Transforming growth factor-β1-deficient mice: identification of isoform-specific activities in vivo. J. Leukoc. Biol. 59(6), 769-774 (1996).
    • (1996) J. Leukoc. Biol , vol.59 , Issue.6 , pp. 769-774
    • Letterio, J.J.1    Roberts, A.B.2
  • 7
    • 3543109115 scopus 로고    scopus 로고
    • Early growth response gene 1-mediated apoptosis is essential for transforming growth factor β1-induced pulmonary fibrosis
    • Lee CG, Cho SJ, Kang MJ et al. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor β1-induced pulmonary fibrosis. J. Exp. Med. 200(3), 377-389 (2004).
    • (2004) J. Exp. Med , vol.200 , Issue.3 , pp. 377-389
    • Lee, C.G.1    Cho, S.J.2    Kang, M.J.3
  • 8
    • 0005588573 scopus 로고    scopus 로고
    • Interstitial lung disease: A clinical overview and general approach
    • Fishman AP, Elias JA, Fishman JA et al, Eds, McGraw-Hill Inc, NY, USA
    • Raghu G. Interstitial lung disease: a clinical overview and general approach. In: Fishman's Pulmonary Diseases and Disorders. Fishman AP, Elias JA, Fishman JA et al. (Eds). McGraw-Hill Inc., NY, USA 1037-1053 (1998).
    • (1998) Fishman's Pulmonary Diseases and Disorders , pp. 1037-1053
    • Raghu, G.1
  • 9
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • Hogg JC, Chu F, Utokaparch S et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350(26), 2645-2653 (2004).
    • (2004) N. Engl. J. Med , vol.350 , Issue.26 , pp. 2645-2653
    • Hogg, J.C.1    Chu, F.2    Utokaparch, S.3
  • 10
    • 0037320195 scopus 로고    scopus 로고
    • Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease
    • Fabbri LM, Romagnoli M, Corbetta L et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 167(3), 418-424 (2003).
    • (2003) Am. J. Respir. Crit. Care Med , vol.167 , Issue.3 , pp. 418-424
    • Fabbri, L.M.1    Romagnoli, M.2    Corbetta, L.3
  • 11
  • 12
    • 0036199723 scopus 로고    scopus 로고
    • The economic impact of chronic obstructive pulmonary disease
    • Faulkner MA, Hilleman DE. The economic impact of chronic obstructive pulmonary disease. Expert Opin. Pharmacother. 3(3), 219-228 (2002).
    • (2002) Expert Opin. Pharmacother , vol.3 , Issue.3 , pp. 219-228
    • Faulkner, M.A.1    Hilleman, D.E.2
  • 13
    • 0036676669 scopus 로고    scopus 로고
    • The burden of chronic obstructive pulmonary disease
    • Vermeire P. The burden of chronic obstructive pulmonary disease. Respir. Med. 96(Suppl. C), S3-S10 (2002).
    • (2002) Respir. Med , vol.96 , Issue.SUPPL. C
    • Vermeire, P.1
  • 14
    • 33646799069 scopus 로고    scopus 로고
    • Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data
    • Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367(9524), 1747-1757 (2006).
    • (2006) Lancet , vol.367 , Issue.9524 , pp. 1747-1757
    • Lopez, A.D.1    Mathers, C.D.2    Ezzati, M.3    Jamison, D.T.4    Murray, C.J.5
  • 15
    • 34548222188 scopus 로고    scopus 로고
    • Global burden of COPD: Risk factors, prevalence, and future trends
    • Mannino DM, Buist AS. Global burden of COPD: risk factors, prevalence, and future trends. Lancet 370(9589), 765-773 (2007).
    • (2007) Lancet , vol.370 , Issue.9589 , pp. 765-773
    • Mannino, D.M.1    Buist, A.S.2
  • 16
    • 2942729608 scopus 로고    scopus 로고
    • Management of chronic obstructive pulmonary disease
    • Sutherland ER, Cherniack RM. Management of chronic obstructive pulmonary disease. N. Engl. J. Med. 350(26), 2689-2697 (2004).
    • (2004) N. Engl. J. Med , vol.350 , Issue.26 , pp. 2689-2697
    • Sutherland, E.R.1    Cherniack, R.M.2
  • 17
    • 33747835877 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Epidemiology, pathophysiology, pathogenesis, clinical course management and rehabilitation
    • Fishman AP Ed, McGraw-Hill Inc, NY, USA
    • Senior RM. Chronic obstructive pulmonary disease: epidemiology, pathophysiology, pathogenesis, clinical course management and rehabilitation. In: Fishman's Manual of Pulmonary Diseases and Disorders. Fishman AP (Ed.). McGraw-Hill Inc., NY, USA 118-142 (2002).
    • (2002) Fishman's Manual of Pulmonary Diseases and Disorders , pp. 118-142
    • Senior, R.M.1
  • 18
    • 0001889863 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Epidemiology, pathophysiology, and pathogenesis
    • Fishman AP, Elias JA, Fishman JA et al, Eds, McGraw-Hill Inc, NY, USA
    • Senior RM, Shapiro SD. Chronic obstructive pulmonary disease: epidemiology, pathophysiology, and pathogenesis. In: Fishman's Pulmonary Diseases and Disorders. Fishman AP, Elias JA, Fishman JA et al. (Eds). McGraw-Hill Inc., NY, USA 659-681 (1998).
    • (1998) Fishman's Pulmonary Diseases and Disorders , pp. 659-681
    • Senior, R.M.1    Shapiro, S.D.2
  • 21
    • 0033968434 scopus 로고    scopus 로고
    • Apoptosis and formation of peroxynitrite in the lungs of patients with obliterative bronchiolitis
    • Hansen PR, Holm AM, Svendseri UG, Olsen PS, Andersen CB. Apoptosis and formation of peroxynitrite in the lungs of patients with obliterative bronchiolitis. J. Heart Lung Transplant. 19(2), 160-166 (2000).
    • (2000) J. Heart Lung Transplant , vol.19 , Issue.2 , pp. 160-166
    • Hansen, P.R.1    Holm, A.M.2    Svendseri, U.G.3    Olsen, P.S.4    Andersen, C.B.5
  • 22
    • 0033406743 scopus 로고    scopus 로고
    • Cellular and connective tissue changes in alveolar septal walls in emphysema
    • Vlahovic G, Russell ML, Mercer RR, Crapo JD. Cellular and connective tissue changes in alveolar septal walls in emphysema. Am. J. Respir. Crit. Care Med. 160(6), 2086-2092 (1999).
    • (1999) Am. J. Respir. Crit. Care Med , vol.160 , Issue.6 , pp. 2086-2092
    • Vlahovic, G.1    Russell, M.L.2    Mercer, R.R.3    Crapo, J.D.4
  • 23
    • 0038465920 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade
    • Tuder RM, Zhen L, Cho CY et al. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am. J. Respir. Cell Mol. Biol. 29(1), 88-97 (2003).
    • (2003) Am. J. Respir. Cell Mol. Biol , vol.29 , Issue.1 , pp. 88-97
    • Tuder, R.M.1    Zhen, L.2    Cho, C.Y.3
  • 24
    • 0034474704 scopus 로고    scopus 로고
    • Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?
    • MacNee W, Rahman I. Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease? Trends Mol. Med. 7(2), 55-62 (2001).
    • (2001) Trends Mol. Med , vol.7 , Issue.2 , pp. 55-62
    • MacNee, W.1    Rahman, I.2
  • 25
    • 0033660171 scopus 로고    scopus 로고
    • Inhibition of VEGF receptors causes lung cell apoptosis and emphysema
    • Kasahara Y, Tuder RM, Taraseviciene-Stewart L et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest. 106(11), 1311-1319 (2000).
    • (2000) J. Clin. Invest , vol.106 , Issue.11 , pp. 1311-1319
    • Kasahara, Y.1    Tuder, R.M.2    Taraseviciene-Stewart, L.3
  • 26
    • 0035077330 scopus 로고    scopus 로고
    • Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema
    • Kasahara Y, Tuder RM, Cool CD et al. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am. J. Respir. Crit. Care Med. 163(3 Pt 1), 737-744 (2001).
    • (2001) Am. J. Respir. Crit. Care Med , vol.163 , Issue.3 PART 1 , pp. 737-744
    • Kasahara, Y.1    Tuder, R.M.2    Cool, C.D.3
  • 27
    • 0038070219 scopus 로고    scopus 로고
    • Alveolar wall apoptosis causes lung destruction and emphysematous changes
    • Aoshiba K, Yokohori N, Nagai A. Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am. J. Respir. Cell Mol. Biol. 28(5), 555-562 (2003).
    • (2003) Am. J. Respir. Cell Mol. Biol , vol.28 , Issue.5 , pp. 555-562
    • Aoshiba, K.1    Yokohori, N.2    Nagai, A.3
  • 28
    • 0034949094 scopus 로고    scopus 로고
    • Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema
    • Majo J, Ghezzo H, Cosio MG. Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. Eur. Respir. J. 17(5), 946-953 (2001).
    • (2001) Eur. Respir. J , vol.17 , Issue.5 , pp. 946-953
    • Majo, J.1    Ghezzo, H.2    Cosio, M.G.3
  • 29
    • 0034101866 scopus 로고    scopus 로고
    • Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD
    • Segura-Valdez L, Pardo A, Gaxiola M et al. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest 117(3), 684-694 (2000).
    • (2000) Chest , vol.117 , Issue.3 , pp. 684-694
    • Segura-Valdez, L.1    Pardo, A.2    Gaxiola, M.3
  • 30
    • 1242306658 scopus 로고    scopus 로고
    • Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema
    • Yokohori N, Aoshiba K, Nagai A. Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest 125(2), 626-632 (2004).
    • (2004) Chest , vol.125 , Issue.2 , pp. 626-632
    • Yokohori, N.1    Aoshiba, K.2    Nagai, A.3
  • 32
    • 20444368841 scopus 로고    scopus 로고
    • Role of cathepsin S-depenaent epithelial cell apoptosis in γ interferon-induced alveolar remodeling and pulmonary emphysema
    • In Press
    • Zheng T, Kang MJ, Crothers K et al. Role of cathepsin S-depenaent epithelial cell apoptosis in γ interferon-induced alveolar remodeling and pulmonary emphysema. J. Immunol. (2005) (In Press).
    • (2005) J. Immunol
    • Zheng, T.1    Kang, M.J.2    Crothers, K.3
  • 33
    • 17044453955 scopus 로고    scopus 로고
    • Increased expression of transforming growth factor-β1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    • Takizawa H, Tanaka M, Takami K et al. Increased expression of transforming growth factor-β1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am. J. Respir. Crit. Care Med. 163(6), 1476-1483 (2001).
    • (2001) Am. J. Respir. Crit. Care Med , vol.163 , Issue.6 , pp. 1476-1483
    • Takizawa, H.1    Tanaka, M.2    Takami, K.3
  • 34
    • 0346726049 scopus 로고    scopus 로고
    • Expression of transforming growth factor β1 in bronchial biopsies in asthma and COPD
    • Kokturk N, Tatlicioglu T, Memis L, Akyurek N, Akyol G. Expression of transforming growth factor β1 in bronchial biopsies in asthma and COPD. J. Asthma 40(8), 887-893 (2003).
    • (2003) J. Asthma , vol.40 , Issue.8 , pp. 887-893
    • Kokturk, N.1    Tatlicioglu, T.2    Memis, L.3    Akyurek, N.4    Akyol, G.5
  • 35
    • 0037373277 scopus 로고    scopus 로고
    • Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
    • Neptune ER, Frischmeyer PA, Arking DE et al. Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome. Nat. Genet. 33(3), 407-411 (2003).
    • (2003) Nat. Genet , vol.33 , Issue.3 , pp. 407-411
    • Neptune, E.R.1    Frischmeyer, P.A.2    Arking, D.E.3
  • 36
    • 4344653389 scopus 로고    scopus 로고
    • SMAD-signaling in chronic obstructive pulmonary disease: Transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke
    • Springer J, Scholz FR, Peiser C, Groneberg DA, Fischer A. SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol. Chem. 385(7), 649-653 (2004).
    • (2004) Biol. Chem , vol.385 , Issue.7 , pp. 649-653
    • Springer, J.1    Scholz, F.R.2    Peiser, C.3    Groneberg, D.A.4    Fischer, A.5
  • 37
    • 0037435009 scopus 로고    scopus 로고
    • Loss of integrin α(v)β6-mediated TGF-β activation causes MMP12-dependent emphysema
    • Morris DG, Huang X, Kaminski N et al. Loss of integrin α(v)β6-mediated TGF-β activation causes MMP12-dependent emphysema. Nature 422(6928), 169-173 (2003).
    • (2003) Nature , vol.422 , Issue.6928 , pp. 169-173
    • Morris, D.G.1    Huang, X.2    Kaminski, N.3
  • 38
    • 3242799550 scopus 로고    scopus 로고
    • Smad3 null mice develop airspace enlargement and are resistant to TGF-β-mediated pulmonary fibrosis
    • Bonniaud P, Kolb M, Galt T et al. Smad3 null mice develop airspace enlargement and are resistant to TGF-β-mediated pulmonary fibrosis. J. Immunol. 173(3), 2099-2108 (2004).
    • (2004) J. Immunol , vol.173 , Issue.3 , pp. 2099-2108
    • Bonniaud, P.1    Kolb, M.2    Galt, T.3
  • 39
    • 1242329185 scopus 로고    scopus 로고
    • Transforming growth factor-β1 genotype and susceptibility to chronic obstructive pulmonary disease
    • Wu L, Chau J, Young RP et al. Transforming growth factor-β1 genotype and susceptibility to chronic obstructive pulmonary disease. Thorax 59 (2), 126-129 (2004).
    • (2004) Thorax , vol.59 , Issue.2 , pp. 126-129
    • Wu, L.1    Chau, J.2    Young, R.P.3
  • 40
    • 34249057411 scopus 로고    scopus 로고
    • Semaphorin 7A plays a critical role in TGF-β1-induced pulmonary fibrosis
    • Kang HR, Lee CG, Homer RJ, Elias JA. Semaphorin 7A plays a critical role in TGF-β1-induced pulmonary fibrosis. J. Exp. Med. 204(5), 1083-1093 (2007).
    • (2007) J. Exp. Med , vol.204 , Issue.5 , pp. 1083-1093
    • Kang, H.R.1    Lee, C.G.2    Homer, R.J.3    Elias, J.A.4
  • 41
    • 34147099468 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-β1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12
    • Kang HR, Cho SJ, Lee CG, Homer RJ, Elias JA. Transforming growth factor (TGF)-β1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. J. Biol. Chem. 282(10), 7723-7732 (2007).
    • (2007) J. Biol. Chem , vol.282 , Issue.10 , pp. 7723-7732
    • Kang, H.R.1    Cho, S.J.2    Lee, C.G.3    Homer, R.J.4    Elias, J.A.5
  • 42
    • 40649126575 scopus 로고    scopus 로고
    • P21 regulates TGF-β1-induced pulmonary responses via a TNF-α-signaling pathway
    • Yamasaki M, Kang HR, Homer RJ et al. P21 regulates TGF-β1-induced pulmonary responses via a TNF-α-signaling pathway. Am. J. Respir. Cell Mol. Biol. 38(3), 346-353 (2008).
    • (2008) Am. J. Respir. Cell Mol. Biol , vol.38 , Issue.3 , pp. 346-353
    • Yamasaki, M.1    Kang, H.R.2    Homer, R.J.3
  • 43
    • 0036936550 scopus 로고    scopus 로고
    • Roles for insulin-like growth factor I and transforming growth factor-β in fibrotic lung disease
    • Krein PM, Winston BW. Roles for insulin-like growth factor I and transforming growth factor-β in fibrotic lung disease. Chest 122(6 Suppl.), 289S-293S (2002).
    • (2002) Chest , vol.122 , Issue.6 SUPPL.
    • Krein, P.M.1    Winston, B.W.2
  • 44
    • 0035895243 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy
    • Selman M, King TE, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann. Intern. Med. 134(2), 136-151 (2001).
    • (2001) Ann. Intern. Med , vol.134 , Issue.2 , pp. 136-151
    • Selman, M.1    King, T.E.2    Pardo, A.3
  • 45
    • 0030076509 scopus 로고    scopus 로고
    • TGF-β 1, but not TGF-β 2 or TGF-β 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: An immunohistochemical study
    • Khalil N, O'Connor RN, Flanders KC, Unruh H. TGF-β 1, but not TGF-β 2 or TGF-β 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am. J. Respir. Cell Mol. Biol. 14(2), 131-138 (1996).
    • (1996) Am. J. Respir. Cell Mol. Biol , vol.14 , Issue.2 , pp. 131-138
    • Khalil, N.1    O'Connor, R.N.2    Flanders, K.C.3    Unruh, H.4
  • 46
    • 0035181092 scopus 로고    scopus 로고
    • Regulation of the effects of TGF-β 1 by activation of latent TGF-β 1 and differential expression of TGF-β receptors (T β R-I and T β R-II) in idiopathic pulmonary fibrosis
    • Khalil N, Parekh TV, O'Connor R et al. Regulation of the effects of TGF-β 1 by activation of latent TGF-β 1 and differential expression of TGF-β receptors (T β R-I and T β R-II) in idiopathic pulmonary fibrosis. Thorax 56(12), 907-915 (2001).
    • (2001) Thorax , vol.56 , Issue.12 , pp. 907-915
    • Khalil, N.1    Parekh, T.V.2    O'Connor, R.3
  • 47
    • 0041677660 scopus 로고    scopus 로고
    • Release of biologically active TGF-(β) 1 by alveolar epithelial cells results in pulmonary fibrosis
    • In press
    • Xu YD, Hua J, Mui A et al. Release of biologically active TGF-(β) 1 by alveolar epithelial cells results in pulmonary fibrosis. Am. J. Physiol. (Lung Cell Mol. Physiol.) (2003) (In press).
    • (2003) Am. J. Physiol. (Lung Cell Mol. Physiol.)
    • Xu, Y.D.1    Hua, J.2    Mui, A.3
  • 48
    • 0033844731 scopus 로고    scopus 로고
    • A CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the rat
    • Yehualaeshet T, O'Connor R, Begleiter A et al. A CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the rat. Am. J. Respir. Cell Mol. Biol. 23(2), 204-212 (2000).
    • (2000) Am. J. Respir. Cell Mol. Biol , vol.23 , Issue.2 , pp. 204-212
    • Yehualaeshet, T.1    O'Connor, R.2    Begleiter, A.3
  • 49
    • 0032719815 scopus 로고    scopus 로고
    • Transient gene transfer and expression of Smad7 prevents bleomycin-induccd lung fibrosis in mice
    • Nakao A, Fujii M, Matsumura R et al. Transient gene transfer and expression of Smad7 prevents bleomycin-induccd lung fibrosis in mice. J. Clin. Invest. 104(1), 5-11 (1999).
    • (1999) J. Clin. Invest , vol.104 , Issue.1 , pp. 5-11
    • Nakao, A.1    Fujii, M.2    Matsumura, R.3
  • 50
    • 0030800795 scopus 로고    scopus 로고
    • Adenovector-mediated gene transfer of active transforming growth factor-β1 induces prolonged severe fibrosis in rat lung
    • Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-β1 induces prolonged severe fibrosis in rat lung. J. Clin. Invest. 100(4), 768-776 (1997).
    • (1997) J. Clin. Invest , vol.100 , Issue.4 , pp. 768-776
    • Sime, P.J.1    Xing, Z.2    Graham, F.L.3    Csaky, K.G.4    Gauldie, J.5
  • 51
    • 0037241857 scopus 로고    scopus 로고
    • Re-evaluation of fibrogenic cytokines in lung fibrosis
    • Kelly M, Kolb M, Bonniaud P, Gauldie J. Re-evaluation of fibrogenic cytokines in lung fibrosis. Curr. Pharm. Des. 9(1), 39-49 (2003).
    • (2003) Curr. Pharm. Des , vol.9 , Issue.1 , pp. 39-49
    • Kelly, M.1    Kolb, M.2    Bonniaud, P.3    Gauldie, J.4
  • 52
    • 0036335052 scopus 로고    scopus 로고
    • Increased circulating levels of soluble Fas ligand are correlated with disease activity in patients with fibrosing lung diseases
    • Kuwano Y, Maeyama T, Inoshima I et al. Increased circulating levels of soluble Fas ligand are correlated with disease activity in patients with fibrosing lung diseases. Respirology 7(1), 15-21 (2002).
    • (2002) Respirology , vol.7 , Issue.1 , pp. 15-21
    • Kuwano, Y.1    Maeyama, T.2    Inoshima, I.3
  • 53
    • 0032622244 scopus 로고    scopus 로고
    • The involvement of Fas-Fas ligand pathway in fibrosing lung diseases
    • Kuwano K, Miyazaki H, Hagimoto N et al. The involvement of Fas-Fas ligand pathway in fibrosing lung diseases. Am. J. Respir. Cell Mol. Biol. 20(1), 53-60 (1999).
    • (1999) Am. J. Respir. Cell Mol. Biol , vol.20 , Issue.1 , pp. 53-60
    • Kuwano, K.1    Miyazaki, H.2    Hagimoto, N.3
  • 54
    • 0030215822 scopus 로고    scopus 로고
    • P21 Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis
    • Kuwano K, Kunitake R, Kawasaki M et al. P21 Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 154(2 Pt 1), 477-483 (1996).
    • (1996) Am. J. Respir. Crit. Care Med , vol.154 , Issue.2 PART 1 , pp. 477-483
    • Kuwano, K.1    Kunitake, R.2    Kawasaki, M.3
  • 55
    • 0032717522 scopus 로고    scopus 로고
    • Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis
    • Kuwano K, Hagimoto N, Kawasaki M et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J. Clin. Invest. 104(1), 13-19 (1999).
    • (1999) J. Clin. Invest , vol.104 , Issue.1 , pp. 13-19
    • Kuwano, K.1    Hagimoto, N.2    Kawasaki, M.3
  • 56
    • 0036231985 scopus 로고    scopus 로고
    • Transforming growth factor-β1: Its anti-inflammatory and pro-fibrotic effects
    • Ling E, Robinson DS. Transforming growth factor-β1: its anti-inflammatory and pro-fibrotic effects. Clin. Exp. Allergy 32(2), 175-178 (2002).
    • (2002) Clin. Exp. Allergy , vol.32 , Issue.2 , pp. 175-178
    • Ling, E.1    Robinson, D.S.2
  • 57
    • 0036124599 scopus 로고    scopus 로고
    • Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation
    • Flanders KC, Sullivan CD, Fujii M et al. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am. J. Pathol. 160(3), 1057-1068 (2002).
    • (2002) Am. J. Pathol , vol.160 , Issue.3 , pp. 1057-1068
    • Flanders, K.C.1    Sullivan, C.D.2    Fujii, M.3
  • 58
    • 0035501062 scopus 로고    scopus 로고
    • TGF-β signaling in cancer - a double-edged sword
    • Akhurst RJ, Derynck R. TGF-β signaling in cancer - a double-edged sword. Trends Cell Biol. 11 (11), S44-S51 (2001).
    • (2001) Trends Cell Biol , vol.11 , Issue.11
    • Akhurst, R.J.1    Derynck, R.2
  • 59
    • 0034927240 scopus 로고    scopus 로고
    • Is Smad3 a major player in signal transduction pathways leading to fibrogenesis?
    • Roberts AB, Piek E, Bottinger EP et al. Is Smad3 a major player in signal transduction pathways leading to fibrogenesis? Chest 120(1 Suppl.), 43S-47S (2001).
    • (2001) Chest , vol.120 , Issue.1 SUPPL.
    • Roberts, A.B.1    Piek, E.2    Bottinger, E.P.3
  • 60
    • 0026751479 scopus 로고
    • Differential effect of transforming growth factor β on the synthesis of Th1- and Th2-like lymphokines by human T lymphocytes
    • Fargeas C, Wu CY, Nakajima T et al. Differential effect of transforming growth factor β on the synthesis of Th1- and Th2-like lymphokines by human T lymphocytes. Eur. J. Immunol. 22(8), 2173-2176 (1992).
    • (1992) Eur. J. Immunol , vol.22 , Issue.8 , pp. 2173-2176
    • Fargeas, C.1    Wu, C.Y.2    Nakajima, T.3
  • 61
    • 0029149596 scopus 로고
    • Control of CD4 effector fate: Transforming growth factor β1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion
    • Zhang X, Giangreco L, Broome HE, Dargan CM, Swain SL. Control of CD4 effector fate: transforming growth factor β1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. J. Exp. Med. 182(3), 699-709 (1995).
    • (1995) J. Exp. Med , vol.182 , Issue.3 , pp. 699-709
    • Zhang, X.1    Giangreco, L.2    Broome, H.E.3    Dargan, C.M.4    Swain, S.L.5
  • 62
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β(1)
    • Lee CG, Homer RJ, Zhu Z et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β(1). J. Exp. Med. 194(6), 809-821 (2001).
    • (2001) J. Exp. Med , vol.194 , Issue.6 , pp. 809-821
    • Lee, C.G.1    Homer, R.J.2    Zhu, Z.3
  • 63
    • 0034178260 scopus 로고    scopus 로고
    • TGF-β1 and radiation fibrosis: A master switch and a specific therapeutic target?
    • Martin M, Lefaix J, Delanian S. TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target? Int. J. Radiat. Oncol. Biol. Phys. 47(2), 277-290 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol. Phys , vol.47 , Issue.2 , pp. 277-290
    • Martin, M.1    Lefaix, J.2    Delanian, S.3
  • 65
    • 0034977190 scopus 로고    scopus 로고
    • TGF-β is a critical mediator of acute lung injury
    • Pittet JF, Griffiths MJ, Geiser T et al. TGF-β is a critical mediator of acute lung injury. J. Clin. Invest. 107(12), 1537-1544 (2001).
    • (2001) J. Clin. Invest , vol.107 , Issue.12 , pp. 1537-1544
    • Pittet, J.F.1    Griffiths, M.J.2    Geiser, T.3
  • 66
    • 0035701641 scopus 로고    scopus 로고
    • Negative effect of transforming growth factor-β-1 on intestinal anastomotic tissue regeneration
    • Fukuda H, Motohiro T, Nakai K et al. Negative effect of transforming growth factor-β-1 on intestinal anastomotic tissue regeneration. Eur. Surg. Res. 33(5-6), 388-394 (2001).
    • (2001) Eur. Surg. Res , vol.33 , Issue.5-6 , pp. 388-394
    • Fukuda, H.1    Motohiro, T.2    Nakai, K.3
  • 67
    • 0036317623 scopus 로고    scopus 로고
    • Development, characterization, and wound healing of the keratin 14 promoted transforming growth factor-β1 transgenic mouse
    • Chan T, Ghahary A, Demare J et al. Development, characterization, and wound healing of the keratin 14 promoted transforming growth factor-β1 transgenic mouse. Wound Repair Regen. 10(3), 177-187 (2002).
    • (2002) Wound Repair Regen , vol.10 , Issue.3 , pp. 177-187
    • Chan, T.1    Ghahary, A.2    Demare, J.3
  • 68
    • 0037092499 scopus 로고    scopus 로고
    • Resistance of keratinocytes to TGFβ-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds
    • Amendt C, Mann A, Schirmacher P, Blessing M. Resistance of keratinocytes to TGFβ-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds. J. Cell Sci. 115(Pt 10), 2189-2198 (2002).
    • (2002) J. Cell Sci , vol.115 , Issue.PART 10 , pp. 2189-2198
    • Amendt, C.1    Mann, A.2    Schirmacher, P.3    Blessing, M.4
  • 69
    • 3543107212 scopus 로고    scopus 로고
    • Fibrotic disease and the T(H) 1/T(H) 2 paradigm
    • Wynn TA. Fibrotic disease and the T(H) 1/T(H) 2 paradigm. Nat. Rev. Immunol. 4(8), 583-594 (2004).
    • (2004) Nat. Rev. Immunol , vol.4 , Issue.8 , pp. 583-594
    • Wynn, T.A.1
  • 70
    • 4644225081 scopus 로고    scopus 로고
    • IL-13 activates a mechanism of tissue fibrosis that is completely TGF-β independent
    • Kaviratne M, Hesse M, Leusink M et al. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-β independent. J. Immunol. 173(6), 4020-4029 (2004).
    • (2004) J. Immunol , vol.173 , Issue.6 , pp. 4020-4029
    • Kaviratne, M.1    Hesse, M.2    Leusink, M.3
  • 71
    • 2342482002 scopus 로고    scopus 로고
    • Nitric oxide in health and disease of the respiratory system
    • Ricciardolo FL, Sterk PJ, Gaston B, Folkerts G. Nitric oxide in health and disease of the respiratory system. Physiol. Rev. 84(3), 731-765 (2004).
    • (2004) Physiol. Rev , vol.84 , Issue.3 , pp. 731-765
    • Ricciardolo, F.L.1    Sterk, P.J.2    Gaston, B.3    Folkerts, G.4
  • 72
    • 7044229899 scopus 로고    scopus 로고
    • The development of emphysema in cigarette smoke exposed mice is strain dependent
    • Guerassimov A, Hoshino Y, Takubo Y et al. The development of emphysema in cigarette smoke exposed mice is strain dependent. Am. J. Respir. Crit. Care Med. 170(9), 974-980 (2004).
    • (2004) Am. J. Respir. Crit. Care Med , vol.170 , Issue.9 , pp. 974-980
    • Guerassimov, A.1    Hoshino, Y.2    Takubo, Y.3
  • 73
    • 0035984567 scopus 로고    scopus 로고
    • Differences in the fibrogenic response after transfer of active transforming growth factor-β1 gene to lungs of 'fibrosis-prone' and 'fibrosis-resistant' mouse strains
    • Kolb M, Bonniaud P, Galt T et al. Differences in the fibrogenic response after transfer of active transforming growth factor-β1 gene to lungs of 'fibrosis-prone' and 'fibrosis-resistant' mouse strains. Am. J. Respir. Cell Mol. Biol. 27(2), 141-150 (2002).
    • (2002) Am. J. Respir. Cell Mol. Biol , vol.27 , Issue.2 , pp. 141-150
    • Kolb, M.1    Bonniaud, P.2    Galt, T.3
  • 74
    • 0029895964 scopus 로고    scopus 로고
    • Inheritance of susceptibility to bleomycin-induced pulmonary fibrosis in the mouse
    • Haston CK, Amos CI, King TM, Travis EL. Inheritance of susceptibility to bleomycin-induced pulmonary fibrosis in the mouse. Cancer Res. 56(11), 2596-2601 (1996).
    • (1996) Cancer Res , vol.56 , Issue.11 , pp. 2596-2601
    • Haston, C.K.1    Amos, C.I.2    King, T.M.3    Travis, E.L.4
  • 75
    • 0036667985 scopus 로고    scopus 로고
    • Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice
    • Haston CK, Wang M, Dejournett RE et al. Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice. Hum. Mol. Genet. 11(16), 1855-1863 (2002).
    • (2002) Hum. Mol. Genet , vol.11 , Issue.16 , pp. 1855-1863
    • Haston, C.K.1    Wang, M.2    Dejournett, R.E.3
  • 76
    • 0036645068 scopus 로고    scopus 로고
    • Universal and fadiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis
    • Haston CK, Zhou X, Gumbiner-Russo L et al. Universal and fadiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis. Cancer Res. 62(13), 3782-3788 (2002).
    • (2002) Cancer Res , vol.62 , Issue.13 , pp. 3782-3788
    • Haston, C.K.1    Zhou, X.2    Gumbiner-Russo, L.3
  • 77
    • 18744434746 scopus 로고    scopus 로고
    • Mapping susceptibility genes for the induction of pulmonary fibrosis in mice
    • Barth RK, Hanchett LA, Baecher-Allan CM. Mapping susceptibility genes for the induction of pulmonary fibrosis in mice. Chest 121 (3 Suppl.), 21S (2002).
    • (2002) Chest , vol.121 , Issue.3 SUPPL.
    • Barth, R.K.1    Hanchett, L.A.2    Baecher-Allan, C.M.3
  • 78
    • 0019945992 scopus 로고
    • Lung fibrosis and emphysema: Divergent responses to a common injury?
    • Niewoehner DE, Hoidal JR. Lung fibrosis and emphysema: divergent responses to a common injury? Science 217(4557), 359-360 (1982).
    • (1982) Science , vol.217 , Issue.4557 , pp. 359-360
    • Niewoehner, D.E.1    Hoidal, J.R.2
  • 80
    • 0037097680 scopus 로고    scopus 로고
    • TGF-β 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells
    • Hagimoto N, Kuwano Y, Inoshima I et al. TGF-β 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells. J. Immunol. 168(12), 6470-6478 (2002).
    • (2002) J. Immunol , vol.168 , Issue.12 , pp. 6470-6478
    • Hagimoto, N.1    Kuwano, Y.2    Inoshima, I.3
  • 81
    • 34447116385 scopus 로고    scopus 로고
    • The regulatory role of TGF-β in airway remodeling in asthma
    • Makinde T, Murphy RF, Agrawal DK. The regulatory role of TGF-β in airway remodeling in asthma. Immunol. Cell Biol. 85(5), 348-356 (2007).
    • (2007) Immunol. Cell Biol , vol.85 , Issue.5 , pp. 348-356
    • Makinde, T.1    Murphy, R.F.2    Agrawal, D.K.3
  • 82
    • 33645241270 scopus 로고    scopus 로고
    • Proapoptotic bid is required for pulmonary fibrosis
    • Budinger GR, Mutlu GM, Eisenbart J et al. Proapoptotic bid is required for pulmonary fibrosis. Proc. Natl Acad. Sci. USA 103(12), 4604-4609 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.12 , pp. 4604-4609
    • Budinger, G.R.1    Mutlu, G.M.2    Eisenbart, J.3
  • 83
    • 33847040423 scopus 로고    scopus 로고
    • Gene transfer ofhepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis
    • Gazdhar A, Fachinger P, van Leer C et al. Gene transfer ofhepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis. Am. J Physiol. Lung Cell. Mol. Physiol. 292(2), L529-L536 (2007).
    • (2007) Am. J Physiol. Lung Cell. Mol. Physiol , vol.292 , Issue.2
    • Gazdhar, A.1    Fachinger, P.2    van Leer, C.3
  • 84
    • 33745472563 scopus 로고    scopus 로고
    • Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis
    • Marchand-Adam S, Fabre A, Mailleux AA et al. Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis. Am J. Respir. Crit. Care Med. 174(1), 58-66 (2006).
    • (2006) Am J. Respir. Crit. Care Med , vol.174 , Issue.1 , pp. 58-66
    • Marchand-Adam, S.1    Fabre, A.2    Mailleux, A.A.3
  • 85
    • 33745860364 scopus 로고    scopus 로고
    • Transgenic modeling of transforming growth factor-β(1): Role of apoptosis in fibrosis and alveolar remodeling
    • Lee CG, Kang HR, Homer RJ, Chupp, G, Elias JA. Transgenic modeling of transforming growth factor-β(1): role of apoptosis in fibrosis and alveolar remodeling. Proc. Am. Thorac Soc. 3(5), 418-423 (2006).
    • (2006) Proc. Am. Thorac Soc , vol.3 , Issue.5 , pp. 418-423
    • Lee, C.G.1    Kang, H.R.2    Homer, R.J.3    Chupp, G.4    Elias, J.A.5
  • 86
    • 34248389630 scopus 로고    scopus 로고
    • Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-β (TGF-β) and α-actomyosin (α SMA), important mediators of radiation-induced pneumopathy and lung fibrosis
    • Molteni A, Wolfe LF, Ward WF et al. Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-β (TGF-β) and α-actomyosin (α SMA), important mediators of radiation-induced pneumopathy and lung fibrosis. Curr. Pharm. Des. 13(13), 1307-1316 (2007).
    • (2007) Curr. Pharm. Des , vol.13 , Issue.13 , pp. 1307-1316
    • Molteni, A.1    Wolfe, L.F.2    Ward, W.F.3
  • 87
    • 33751207110 scopus 로고    scopus 로고
    • VEGF, a prosurvival factor, acts in concert with TGF-β1 to induce endothelial cell apoptosis
    • Ferrari G, Pintucci G, Seghezzi G et al. VEGF, a prosurvival factor, acts in concert with TGF-β1 to induce endothelial cell apoptosis. Proc. Natl Acad. Sci. USA 103(46), 17260-17265 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.46 , pp. 17260-17265
    • Ferrari, G.1    Pintucci, G.2    Seghezzi, G.3
  • 88
    • 39549091069 scopus 로고    scopus 로고
    • VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma
    • Maharaj AS, Wilshe TE, Saint-Geniez M et al. VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma. J. Exp. Med. 205(2), 491-501 (2008).
    • (2008) J. Exp. Med , vol.205 , Issue.2 , pp. 491-501
    • Maharaj, A.S.1    Wilshe, T.E.2    Saint-Geniez, M.3
  • 89
    • 41049094560 scopus 로고    scopus 로고
    • Endoglin in angiogenesis and vascular diseases
    • Ten Dijke P, Goumans MJ, Pardali E. Endoglin in angiogenesis and vascular diseases. Angiogenesis 11 (1), 79-89 (2008).
    • (2008) Angiogenesis , vol.11 , Issue.1 , pp. 79-89
    • Ten Dijke, P.1    Goumans, M.J.2    Pardali, E.3
  • 90
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn TA. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214(2), 199-210 (2008).
    • (2008) J. Pathol , vol.214 , Issue.2 , pp. 199-210
    • Wynn, T.A.1
  • 91
    • 0037314229 scopus 로고    scopus 로고
    • New insights into the pathogenesis of asthma
    • Elias JA, Lee CG, Zheng T et al. New insights into the pathogenesis of asthma. J. Clin. Invest. 111(3), 291-297 (2003).
    • (2003) J. Clin. Invest , vol.111 , Issue.3 , pp. 291-297
    • Elias, J.A.1    Lee, C.G.2    Zheng, T.3
  • 93
    • 33646914221 scopus 로고    scopus 로고
    • The role of circulating fibrocytes in fibrosis
    • Quan TE, Cowper SE, Bucala R. The role of circulating fibrocytes in fibrosis. Curr. Rheumatol. Rep. 8(2), 145-150 (2006).
    • (2006) Curr. Rheumatol. Rep , vol.8 , Issue.2 , pp. 145-150
    • Quan, T.E.1    Cowper, S.E.2    Bucala, R.3
  • 94
    • 34547960749 scopus 로고    scopus 로고
    • The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses
    • Bellini A, Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab. Invest. 87(9), 858-870 (2007).
    • (2007) Lab. Invest , vol.87 , Issue.9 , pp. 858-870
    • Bellini, A.1    Mattoli, S.2
  • 95
    • 0038544594 scopus 로고    scopus 로고
    • Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma
    • Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J. Immunol. 171(1), 380-389 (2003).
    • (2003) J. Immunol , vol.171 , Issue.1 , pp. 380-389
    • Schmidt, M.1    Sun, G.2    Stacey, M.A.3    Mori, L.4    Mattoli, S.5
  • 96
    • 22144461325 scopus 로고    scopus 로고
    • Nawshad A, Lagamba D, Polad A, Hay ED. Transforming growth factor-β signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs 1790-2, 11-23 (2005).
    • Nawshad A, Lagamba D, Polad A, Hay ED. Transforming growth factor-β signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs 1790-2), 11-23 (2005).
  • 97
    • 33748375828 scopus 로고    scopus 로고
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    • Kim KK, Kugler MC, Wolters PJ et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc. Natl Acad. Sci. USA 103(35), 13180-13185 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.35 , pp. 13180-13185
    • Kim, K.K.1    Kugler, M.C.2    Wolters, P.J.3
  • 98
    • 34548411746 scopus 로고    scopus 로고
    • TGF-β-induced EMT: Mechanisms and implications for fibrotic lung disease
    • Willis BC, Borok Z. TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease. Am. J. Physiol Lung Cell. Mol. Physiol. 293(3), L525-534 (2007).
    • (2007) Am. J. Physiol Lung Cell. Mol. Physiol , vol.293 , Issue.3
    • Willis, B.C.1    Borok, Z.2
  • 99
    • 16844371760 scopus 로고    scopus 로고
    • A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition
    • Yang J, Dai C, Liu Y. A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. J. Am. Soc. Nephrol. 16(1), 69-78 (2005).
    • (2005) J. Am. Soc. Nephrol , vol.16 , Issue.1 , pp. 69-78
    • Yang, J.1    Dai, C.2    Liu, Y.3
  • 100
    • 14844290237 scopus 로고    scopus 로고
    • Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney
    • Zeisberg M, Shah AA, Kalluri R. Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J. Biol. Chem. 280(9), 8094-8100 (2005).
    • (2005) J. Biol. Chem , vol.280 , Issue.9 , pp. 8094-8100
    • Zeisberg, M.1    Shah, A.A.2    Kalluri, R.3
  • 101
    • 33745855458 scopus 로고    scopus 로고
    • Neutrophil elastase: Mediator of extracellular matrix destruction and accumulation
    • Chua F, Laurent GJ. Neutrophil elastase: mediator of extracellular matrix destruction and accumulation. Proc. Am. Thorac Soc. 3(5), 424-427 (2006).
    • (2006) Proc. Am. Thorac Soc , vol.3 , Issue.5 , pp. 424-427
    • Chua, F.1    Laurent, G.J.2
  • 102
    • 37549027570 scopus 로고    scopus 로고
    • Transforming growth factor-β activation in the lung: Focus on fibrosis and reactive oxygen species
    • Koli K, Myllarniemi M, Keski-Oja J, Kinnula VL. Transforming growth factor-β activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid. Redox Signal. 10(2), 333-342 (2008).
    • (2008) Antioxid. Redox Signal , vol.10 , Issue.2 , pp. 333-342
    • Koli, K.1    Myllarniemi, M.2    Keski-Oja, J.3    Kinnula, V.L.4
  • 103
    • 28244500027 scopus 로고    scopus 로고
    • Antioxidant therapy for idiopathic pulmonary fibrosis
    • Hunninghake GW. Antioxidant therapy for idiopathic pulmonary fibrosis. N. Engl. J. Med. 353(21), 2285-2287 (2005).
    • (2005) N. Engl. J. Med , vol.353 , Issue.21 , pp. 2285-2287
    • Hunninghake, G.W.1
  • 104
    • 33747756116 scopus 로고    scopus 로고
    • Promising pharmacologic innovations in treating pulmonary fibrosis
    • Bhatr N, Baran CP, Allen J, Magro C, Marsh CB. Promising pharmacologic innovations in treating pulmonary fibrosis. Curr. Opin. Pharmacol. 6(3), 284-292 (2006).
    • (2006) Curr. Opin. Pharmacol , vol.6 , Issue.3 , pp. 284-292
    • Bhatr, N.1    Baran, C.P.2    Allen, J.3    Magro, C.4    Marsh, C.B.5
  • 105
    • 0142085920 scopus 로고    scopus 로고
    • Cytokine regulation of pulmonary fibrosis in scleroderma
    • Atamas SP, White B. Cytokine regulation of pulmonary fibrosis in scleroderma. Cytokine Growth Factor Rev. 14(6), 537-550 (2003).
    • (2003) Cytokine Growth Factor Rev , vol.14 , Issue.6 , pp. 537-550
    • Atamas, S.P.1    White, B.2
  • 106
    • 33744935771 scopus 로고    scopus 로고
    • Targeting genes for treatment in idiopathic pulmonary fibrosis: Challenges and opportunities, promises and pitfalls
    • Ask K, Martin GE, Kolb M, Gauldie J. Targeting genes for treatment in idiopathic pulmonary fibrosis: challenges and opportunities, promises and pitfalls. Proc. Am. Thorac Soc. 3(4), 389-393 (2006).
    • (2006) Proc. Am. Thorac Soc , vol.3 , Issue.4 , pp. 389-393
    • Ask, K.1    Martin, G.E.2    Kolb, M.3    Gauldie, J.4
  • 107
    • 33845358419 scopus 로고    scopus 로고
    • Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: Interaction with hepatocyte growth factor
    • Zhang A, Wang MH, Dong Z, Yang T. Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: interaction with hepatocyte growth factor. Am. J. Physiol. Renal Physiol. 291(6), F1323-F1331 (2006).
    • (2006) Am. J. Physiol. Renal Physiol , vol.291 , Issue.6
    • Zhang, A.1    Wang, M.H.2    Dong, Z.3    Yang, T.4
  • 108
    • 33846556197 scopus 로고    scopus 로고
    • Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)-β1-induced collagen synthesis
    • Sandulache VC, Parekh A, Li-Korotky H, Dohar JE, Hebda PA. Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)-β1-induced collagen synthesis. Wound Repair Regen. 15(1), 122-133 (2007).
    • (2007) Wound Repair Regen , vol.15 , Issue.1 , pp. 122-133
    • Sandulache, V.C.1    Parekh, A.2    Li-Korotky, H.3    Dohar, J.E.4    Hebda, P.A.5
  • 109
    • 34548498378 scopus 로고    scopus 로고
    • Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase
    • Dunkern TR, Feurstein D, Rossi GA. Sabatini F, Hatzelmann A. Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase. Eur. J. Pharmacol. 572(1), 12-22 (2007).
    • (2007) Eur. J. Pharmacol , vol.572 , Issue.1 , pp. 12-22
    • Dunkern, T.R.1    Feurstein, D.2    Rossi, G.A.3    Sabatini, F.4    Hatzelmann, A.5
  • 110
    • 33746215177 scopus 로고    scopus 로고
    • Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling
    • Shim YM, Zhu Z, Zheng T et al. Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling. J. Immunol. 177(3), 1918-1924 (2006).
    • (2006) J. Immunol , vol.177 , Issue.3 , pp. 1918-1924
    • Shim, Y.M.1    Zhu, Z.2    Zheng, T.3
  • 111
    • 0035083956 scopus 로고    scopus 로고
    • Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin
    • Kolb M, Margetts PJ, Galt T et al. Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin. Am. J. Respir. Crit. Care Med. 163(3 Pt 1), 770-777 (2001).
    • (2001) Am. J. Respir. Crit. Care Med , vol.163 , Issue.3 PART 1 , pp. 770-777
    • Kolb, M.1    Margetts, P.J.2    Galt, T.3
  • 112
    • 49049110677 scopus 로고    scopus 로고
    • Integrins and the activation of latent transforming growth factor β1 - an intimate relationship
    • Epub ahead of print
    • Wipff PJ, Hinz B. Integrins and the activation of latent transforming growth factor β1 - an intimate relationship. Eur. J. Cell Biol. (2008) (Epub ahead of print).
    • (2008) Eur. J. Cell Biol
    • Wipff, P.J.1    Hinz, B.2
  • 113
    • 34247612439 scopus 로고    scopus 로고
    • New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: A potential role for stem cells in the lung parenchyma and implications for therapy
    • Gharaee-Kermani M, Gyetko MR, Hu B, Phan SH. New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy. Pharm. Res. 24(5), 819-841 (2007).
    • (2007) Pharm. Res , vol.24 , Issue.5 , pp. 819-841
    • Gharaee-Kermani, M.1    Gyetko, M.R.2    Hu, B.3    Phan, S.H.4
  • 114
    • 0346094380 scopus 로고    scopus 로고
    • Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema
    • Ishizawa K, Kubo H, Yamada M et al. Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema. FEBS Lett. 556(1-3), 249-252 (2004).
    • (2004) FEBS Lett , vol.556 , Issue.1-3 , pp. 249-252
    • Ishizawa, K.1    Kubo, H.2    Yamada, M.3
  • 115
    • 0035805055 scopus 로고    scopus 로고
    • Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    • Krause DS, Theise ND, Collector MI et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105 (3), 369-377 (2001).
    • (2001) Cell , vol.105 , Issue.3 , pp. 369-377
    • Krause, D.S.1    Theise, N.D.2    Collector, M.I.3
  • 116
    • 1642454668 scopus 로고    scopus 로고
    • Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury
    • Yamada M, Kubo H, Kobayashi S et al. Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J. Immunol. 172(2), 1266-1272 (2004).
    • (2004) J. Immunol , vol.172 , Issue.2 , pp. 1266-1272
    • Yamada, M.1    Kubo, H.2    Kobayashi, S.3
  • 117
    • 24344448730 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells in repair of the injured lung
    • Rojas M, Xu J, Woods CR et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am. J. Respir. Cell Mol. Biol. 33(2), 145-152 (2005).
    • (2005) Am. J. Respir. Cell Mol. Biol , vol.33 , Issue.2 , pp. 145-152
    • Rojas, M.1    Xu, J.2    Woods, C.R.3
  • 118
    • 0037478581 scopus 로고    scopus 로고
    • Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    • Ortiz LA, Gambelli F, McBride C et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc. Natl Acad. Sci. USA 100(14), 8407-8411 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.14 , pp. 8407-8411
    • Ortiz, L.A.1    Gambelli, F.2    McBride, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.