Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine Superfund site: In vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes

Toxicological Sciences

Volumn 60, Issue 1, 2001, Pages 77-91

  Bello, Susan M ^a,b   Franks, Diana G ^a   Stegeman, John J ^a   Hahn, Mark E ^a  

^a WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Ah receptor; Cytochrome P4501A1; Dioxin; Fish; Polychlorinated biphenyls (PCBs); Resistance

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4 NITROPHENOL; AROMATIC HYDROCARBON; AROMATIC HYDROCARBON RECEPTOR; BETA NAPHTHOFLAVONE; CELL PROTEIN; CYTOCHROME P450 1A1; ETHOXYRESORUFIN DEETHYLASE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; POLYCHLORINATED BIPHENYL; XENOBIOTIC AGENT;

ANIMAL TISSUE; ARTICLE; ATLANTIC OCEAN; CHEMOSENSITIVITY; CONCENTRATION (PARAMETERS); CONTAMINATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SUBSTRATE; FISH; GENE INDUCTION; GILL; GONAD; HEART; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; KIDNEY PARENCHYMA; LIVER; LIVER CELL CULTURE; MARINE ENVIRONMENT; MEASUREMENT; MULTIPLE CHEMICAL SENSITIVITY; NONHUMAN; POPULATION; PROTEIN INDUCTION; RNA TRANSLATION; SIGNAL TRANSDUCTION; SPLEEN; UNITED STATES;

ANIMALS; BENZOFURANS; BETA-NAPHTHOFLAVONE; BODY WEIGHT; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; DRUG TOLERANCE; ENZYME INDUCTION; FEMALE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; GONADS; HAZARDOUS WASTE; HEPATOCYTES; KILLIFISHES; LIVER; MALE; MICROSOMES; ORGAN SIZE; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN;

ANIMALIA; FUNDULUS HETEROCLITUS; GADUS MORHUA;

EID: 0035094766     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/60.1.77     Document Type: Article

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