Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism

Toxicology and Applied Pharmacology

Volumn 217, Issue 3, 2006, Pages 308-321

  Incardona, John P ^a   Day, Heather L ^a   Collier, Tracy K ^a   Scholz, Nathaniel L ^a  

^a NORTHWEST FISHERIES SCIENCE CENTER   (United States)

Author keywords

Cardiotoxicity; Fish development; Fossil fuels; Hepatotoxicity; Mixture toxicity; Non point source pollution

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BENZ[A]ANTHRACENE; CHRYSENE; CYTOCHROME P450 1A; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCULATION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYOTOXICITY; ENVIRONMENTAL EXPOSURE; HYDROPHOBICITY; LARVA; LIVER TOXICITY; METABOLISM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; TISSUE SPECIFICITY; TOXICITY; ZEBRA FISH;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BENZ(A)ANTHRACENES; CHRYSENES; CYTOCHROME P-450 CYP1A1; EMBRYO, NONMAMMALIAN; ENZYME INDUCTION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART DEFECTS, CONGENITAL; LARVA; LIVER; MORPHOLINES; OLIGONUCLEOTIDES, ANTISENSE; POLYCYCLIC HYDROCARBONS, AROMATIC; PROTEIN ISOFORMS; PYRENES; RECEPTORS, ARYL HYDROCARBON; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

DANIO RERIO;

EID: 33845223174     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.09.018     Document Type: Article

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