Inhibition of CYP1A enzymes by α-naphthoflavone causes both synergism and antagonism of retene toxicity to rainbow trout (Oncorhynchus mykiss)

Aquatic Toxicology

Volumn 81, Issue 3, 2007, Pages 275-285

  Hodson, Peter V ^a   Qureshi, Kashif ^a   Noble, Cameron A J ^a   Akhtar, Parveen ^a   Brown, R Stephen ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Alpha naphthoflavone; CYP1A; Fish; Metabolism; PAH; Retene; Toxicity

Indexed keywords

7 ISOPROPYL 1 METHYLPHENANTHRENE; ALPHA NAPHTHOFLAVONE; CYTOCHROME P450 1A; PHENANTHRENE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ANTAGONISM; CHEMICAL POLLUTANT; DOSE-RESPONSE RELATIONSHIP; ENZYME ACTIVITY; INHIBITION; METABOLISM; METABOLITE; MORTALITY; PAH; PIGMENT; POLLUTION EXPOSURE; SALMONID; SYNERGISM; TOXICITY;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME METABOLISM; HYDROXYLATION; LARVA; METABOLITE; MORTALITY; NONHUMAN; OXYGENATION; PREVALENCE; PRIORITY JOURNAL; RAINBOW TROUT; REGULATORY MECHANISM; TOXICITY; TOXIN ANALYSIS;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZOFLAVONES; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A1; DRUG INTERACTIONS; ENZYME INDUCTION; ENZYME INHIBITORS; FISH DISEASES; LARVA; METHANOL; ONCORHYNCHUS MYKISS; PHENANTHRENES; WATER POLLUTANTS, CHEMICAL;

ONCORHYNCHUS MYKISS;

EID: 33847047436     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2006.12.012     Document Type: Article

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