The aryl hydrocarbon receptor. Studies using the AHR-null mice

Drug Metabolism and Disposition

Volumn 26, Issue 12, 1998, Pages

  Gonzalez, Frank J ^a   Fernandez Salguero, Pedro ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; APOPTOSIS; CARCINOGENESIS; ENVIRONMENTAL EXPOSURE; GROWTH REGULATION; HOMEOSTASIS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TOXIN ANALYSIS;

ANIMALS; MICE; MICE, INBRED STRAINS; RECEPTORS, ARYL HYDROCARBON; TETRACHLORODIBENZODIOXIN;

ANIMALIA; MAMMALIA;

EID: 0032447116     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (11)

1. Abholt BD and Birnbaum LS (1990) TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD. Toxicol Appl Pharmacol 106:418-432.
2. Abbott BD, Harris MW and Birnbaum LS (1992) Comparisons of the effects of TCDD and hydrocortisone on growth factor expression provide insight into their interaction in the embryonic mouse palate. Teratology 45:35-53.
3. Andreola F, Fernandez-Salguero PM, Chiantore MV, Petkovich MP, Gonzalez FJ and De Luca LM (1997) Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism. Cancer Res 57:2835-2838.
4. Ashok M, Turner C and Wilson TG (1998) Insect juvenile hormone resistance gene homology with the bHLH-PAS family of transcriptional regulators [sec comments], Proc Natl Acad Sci USA 95:2761-2766.
5. Bryant PL, Clark GC, Probst MR and Abbott BD (1997) Effects of TCDD on Ah receptor, ARNT, EGF, and TGF-alpha expression in embryonic mouse urinary tract. Teratology 55:326-337.
6. Chen YH and Tukey RH (1996) Protein kinase C modulates regulation of the CYP1 A1 gene by the aryl hydrocarbon receptor. J Biol Chem 271:26261-26266.
7. Ciolino HP, Wang TT and Yeh GC (1998) Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. Cancer Res 58:2754-2760.
8. Couture LA, Abbott BD and Birnbaum LS (1990) A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances toward understanding the mechanism. Teratology 42:619-627.
9. Dohr O and Abel J (1997) Transforming growth factor-betal coregulates mRNA expression of aryl hydrocarbon receptor and cell-cycle-regulating genes in human cancer cell lines. Biochem Biophys Res Commun 241:86-91.
10. Dohr O, Sinning R, Vogel C, Munzel P and Abel J (1997) Effect of transforming growth factor-betal on expression of aryl hydrocarbon receptor and genes of Ah gene battery: clues for independent down-regulation in A549 cells. Mol Pharmacol 51:703-710.
11. Fernandez-Salguero P, Pineau T, Hilbert DM, McPhail T, Lee SS, Kimura S, Nebert DW, Rudikoff S, Ward JM and Gonzalez FJ (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor [see comments]. Science 268:722-726.