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Volumn 1783, Issue 9, 2008, Pages 1605-1612

Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes

Author keywords

Articular chondrocyte; Promoter analysis; RNA interference; Smad; Tissue inhibitor of metalloproteinases 3; Transforming growth factor beta

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSFORMING GROWTH FACTOR BETA1; 6,7 DIMETHYL 2 (2E) 3 (1 METHYL 2 PHENYL 1H PYRROLO(2,3 B)PYRIDIN 3 YL PROP 2 ENOYL) 1,2,3,4 TETRAHYDROISOQUINOLINE HYDROCHLORIDE; 6,7-DIMETHYL-2-(2E)-3-(1-METHYL-2-PHENYL-1H-PYRROLO(2,3-B)PYRIDIN-3-YL-PROP-2-ENOYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE; ISOQUINOLINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA;

EID: 49149123259     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2008.04.005     Document Type: Article
Times cited : (41)

References (60)
  • 1
    • 0038639763 scopus 로고    scopus 로고
    • Aggrecanases and cartilage matrix degradation
    • Nagase H., and Kashiwagi M. Aggrecanases and cartilage matrix degradation. Arthritis Res. Ther. 5 (2003) 94-103
    • (2003) Arthritis Res. Ther. , vol.5 , pp. 94-103
    • Nagase, H.1    Kashiwagi, M.2
  • 4
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein G.S. Evolving concepts of rheumatoid arthritis. Nature 423 (2003) 356-361
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 5
    • 16344376594 scopus 로고    scopus 로고
    • Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads
    • Verdier M.P., Seite S., Guntzer K., Pujol J.P., and Boumediene K. Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads. Rheumatol. Int. 25 (2005) 118-124
    • (2005) Rheumatol. Int. , vol.25 , pp. 118-124
    • Verdier, M.P.1    Seite, S.2    Guntzer, K.3    Pujol, J.P.4    Boumediene, K.5
  • 8
    • 0025729912 scopus 로고
    • Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals
    • Brandes M.E., Allen J.B., Ogawa Y., and Wahl S.M. Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals. J. Clin. Invest. 87 (1991) 1108-1113
    • (1991) J. Clin. Invest. , vol.87 , pp. 1108-1113
    • Brandes, M.E.1    Allen, J.B.2    Ogawa, Y.3    Wahl, S.M.4
  • 10
    • 0025283586 scopus 로고
    • Transforming growth factor-beta and cellular immune responses in synovial fluids
    • Lotz M., Kekow J., and Carson D.A. Transforming growth factor-beta and cellular immune responses in synovial fluids. J. Immunol. 144 (1990) 4189-4194
    • (1990) J. Immunol. , vol.144 , pp. 4189-4194
    • Lotz, M.1    Kekow, J.2    Carson, D.A.3
  • 13
    • 0346220031 scopus 로고    scopus 로고
    • Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis
    • Scharstuhl A., Vitters E.L., van der Kraan P.M., and van den Berg W.B. Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis. Arthritis Rheum. 48 (2003) 3442-3451
    • (2003) Arthritis Rheum. , vol.48 , pp. 3442-3451
    • Scharstuhl, A.1    Vitters, E.L.2    van der Kraan, P.M.3    van den Berg, W.B.4
  • 14
    • 0042622575 scopus 로고    scopus 로고
    • Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees
    • Mi Z., Ghivizzani S.C., Lechman E., Glorioso J.C., Evans C.H., and Robbins P.D. Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res. Ther. 5 (2003) R132-R139
    • (2003) Arthritis Res. Ther. , vol.5
    • Mi, Z.1    Ghivizzani, S.C.2    Lechman, E.3    Glorioso, J.C.4    Evans, C.H.5    Robbins, P.D.6
  • 15
    • 34248181957 scopus 로고    scopus 로고
    • Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair
    • Pagnotto M.R., Wang Z., Karpie J.C., Ferretti M., Xiao X., and Chu C.R. Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair. Gene Ther. 14 (2007) 804-813
    • (2007) Gene Ther. , vol.14 , pp. 804-813
    • Pagnotto, M.R.1    Wang, Z.2    Karpie, J.C.3    Ferretti, M.4    Xiao, X.5    Chu, C.R.6
  • 16
    • 0036800192 scopus 로고    scopus 로고
    • Metalloproteinase inhibitors: biological actions and therapeutic opportunities
    • Baker A.H., Edwards D.R., and Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J. Cell Sci. 115 (2002) 3719-3727
    • (2002) J. Cell Sci. , vol.115 , pp. 3719-3727
    • Baker, A.H.1    Edwards, D.R.2    Murphy, G.3
  • 17
    • 34250348783 scopus 로고    scopus 로고
    • Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1
    • Lee M.H., Atkinson S., and Murphy G. Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1. J. Biol. Chem. 282 (2007) 6887-6898
    • (2007) J. Biol. Chem. , vol.282 , pp. 6887-6898
    • Lee, M.H.1    Atkinson, S.2    Murphy, G.3
  • 18
    • 0035853456 scopus 로고    scopus 로고
    • Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)
    • Hashimoto G., Aoki T., Nakamura H., Tanzawa K., and Okada Y. Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4). FEBS Lett. 494 (2001) 192-195
    • (2001) FEBS Lett. , vol.494 , pp. 192-195
    • Hashimoto, G.1    Aoki, T.2    Nakamura, H.3    Tanzawa, K.4    Okada, Y.5
  • 19
    • 0345735683 scopus 로고    scopus 로고
    • TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors
    • Gendron C., Kashiwagi M., Hughes C., Caterson B., and Nagase H. TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors. FEBS Lett. 555 (2003) 431-436
    • (2003) FEBS Lett. , vol.555 , pp. 431-436
    • Gendron, C.1    Kashiwagi, M.2    Hughes, C.3    Caterson, B.4    Nagase, H.5
  • 20
    • 25444445358 scopus 로고    scopus 로고
    • Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme
    • Wei S., Kashiwagi M., Kota S., Xie Z., Nagase H., and Brew K. Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme. J. Biol. Chem. 280 (2005) 32877-32882
    • (2005) J. Biol. Chem. , vol.280 , pp. 32877-32882
    • Wei, S.1    Kashiwagi, M.2    Kota, S.3    Xie, Z.4    Nagase, H.5    Brew, K.6
  • 22
    • 0037093362 scopus 로고    scopus 로고
    • Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme
    • Lee M.H., Verma V., Maskos K., Nath D., Knauper V., Dodds P., Amour A., and Murphy G. Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme. Biochem. J. 364 (2002) 227-234
    • (2002) Biochem. J. , vol.364 , pp. 227-234
    • Lee, M.H.1    Verma, V.2    Maskos, K.3    Nath, D.4    Knauper, V.5    Dodds, P.6    Amour, A.7    Murphy, G.8
  • 23
    • 19544382895 scopus 로고    scopus 로고
    • Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis
    • Mahmoodi M., Sahebjam S., Smookler D., Khokha R., and Mort J.S. Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis. Am. J. Pathol. 166 (2005) 1733-1740
    • (2005) Am. J. Pathol. , vol.166 , pp. 1733-1740
    • Mahmoodi, M.1    Sahebjam, S.2    Smookler, D.3    Khokha, R.4    Mort, J.S.5
  • 24
    • 33947175117 scopus 로고    scopus 로고
    • Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice
    • Sahebjam S., Khokha R., and Mort J.S. Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice. Arthritis Rheum. 56 (2007) 905-909
    • (2007) Arthritis Rheum. , vol.56 , pp. 905-909
    • Sahebjam, S.1    Khokha, R.2    Mort, J.S.3
  • 25
    • 0142218538 scopus 로고    scopus 로고
    • Metalloproteinases, inflammation, and rheumatoid arthritis
    • Mohammed F.F., Smookler D.S., and Khokha R. Metalloproteinases, inflammation, and rheumatoid arthritis. Ann. Rheum. Dis. 62 Suppl 2 (2003) ii43-ii47
    • (2003) Ann. Rheum. Dis. , vol.62 , Issue.SUPPL. 2
    • Mohammed, F.F.1    Smookler, D.S.2    Khokha, R.3
  • 27
    • 36448936383 scopus 로고    scopus 로고
    • TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility
    • Schmierer B., and Hill C.S. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat. Rev., Mol. Cell Biol. 8 (2007) 970-982
    • (2007) Nat. Rev., Mol. Cell Biol. , vol.8 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 28
    • 33847736357 scopus 로고    scopus 로고
    • Expression and function of TbetaRII-B, a variant of the type II TGF-beta receptor, in human chondrocytes
    • Parker W.L., Finnson K.W., Soe-Lin H., Knaus P., and Philip A. Expression and function of TbetaRII-B, a variant of the type II TGF-beta receptor, in human chondrocytes. Osteoarthr. Cartil. 15 (2007) 442-453
    • (2007) Osteoarthr. Cartil. , vol.15 , pp. 442-453
    • Parker, W.L.1    Finnson, K.W.2    Soe-Lin, H.3    Knaus, P.4    Philip, A.5
  • 29
    • 0032970436 scopus 로고    scopus 로고
    • Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification
    • Sakou T., Onishi T., Yamamoto T., Nagamine T., Sampath T., and Ten Dijke P. Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification. J. Bone Miner. Res. 14 (1999) 1145-1152
    • (1999) J. Bone Miner. Res. , vol.14 , pp. 1145-1152
    • Sakou, T.1    Onishi, T.2    Yamamoto, T.3    Nagamine, T.4    Sampath, T.5    Ten Dijke, P.6
  • 30
    • 0035795409 scopus 로고    scopus 로고
    • TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    • Yang X., Chen L., Xu X., Li C., Huang C., and Deng C.X. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J. Cell Biol. 153 (2001) 35-46
    • (2001) J. Cell Biol. , vol.153 , pp. 35-46
    • Yang, X.1    Chen, L.2    Xu, X.3    Li, C.4    Huang, C.5    Deng, C.X.6
  • 31
    • 2942564047 scopus 로고    scopus 로고
    • Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species
    • Li W.Q., Qureshi H.Y., Liacini A., Dehnade F., and Zafarullah M. Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species. Free Radic. Biol. Med. 37 (2004) 196-207
    • (2004) Free Radic. Biol. Med. , vol.37 , pp. 196-207
    • Li, W.Q.1    Qureshi, H.Y.2    Liacini, A.3    Dehnade, F.4    Zafarullah, M.5
  • 32
    • 16344380409 scopus 로고    scopus 로고
    • TGF-beta-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor
    • Qureshi H.Y., Sylvester J., El Mabrouk M., and Zafarullah M. TGF-beta-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor. J. Cell. Physiol. 203 (2005) 345-352
    • (2005) J. Cell. Physiol. , vol.203 , pp. 345-352
    • Qureshi, H.Y.1    Sylvester, J.2    El Mabrouk, M.3    Zafarullah, M.4
  • 33
    • 34250623251 scopus 로고    scopus 로고
    • Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes
    • Qureshi H.Y., Ahmad R., Sylvester J., and Zafarullah M. Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes. Cell. Signal. 19 (2007) 1643-1651
    • (2007) Cell. Signal. , vol.19 , pp. 1643-1651
    • Qureshi, H.Y.1    Ahmad, R.2    Sylvester, J.3    Zafarullah, M.4
  • 34
    • 0031899837 scopus 로고    scopus 로고
    • Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding gene
    • Zeng Y., Rosborough R.C., Li Y., Gupta A.R., and Bennett J. Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding gene. Dev. Dyn. 211 (1998) 228-237
    • (1998) Dev. Dyn. , vol.211 , pp. 228-237
    • Zeng, Y.1    Rosborough, R.C.2    Li, Y.3    Gupta, A.R.4    Bennett, J.5
  • 35
    • 0141793857 scopus 로고    scopus 로고
    • The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells
    • Fu Y., O'Connor L.M., Shepherd T.G., and Nachtigal M.W. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem. Biophys. Res. Commun. 310 (2003) 391-397
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 391-397
    • Fu, Y.1    O'Connor, L.M.2    Shepherd, T.G.3    Nachtigal, M.W.4
  • 36
    • 31044448265 scopus 로고    scopus 로고
    • Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression
    • Jinnin M., Ihn H., and Tamaki K. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol. Pharmacol. 69 (2006) 597-607
    • (2006) Mol. Pharmacol. , vol.69 , pp. 597-607
    • Jinnin, M.1    Ihn, H.2    Tamaki, K.3
  • 38
    • 33748659352 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation
    • Blaney Davidson E.N., Vitters E.L., van der Kraan P.M., and van den Berg W.B. Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation. Ann. Rheum. Dis. 65 (2006) 1414-1421
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 1414-1421
    • Blaney Davidson, E.N.1    Vitters, E.L.2    van der Kraan, P.M.3    van den Berg, W.B.4
  • 39
    • 0036234366 scopus 로고    scopus 로고
    • Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development
    • Ito Y., Bringas Jr. P., Mogharei A., Zhao J., Deng C., and Chai Y. Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development. Dev. Dyn. 224 (2002) 69-78
    • (2002) Dev. Dyn. , vol.224 , pp. 69-78
    • Ito, Y.1    Bringas Jr., P.2    Mogharei, A.3    Zhao, J.4    Deng, C.5    Chai, Y.6
  • 41
    • 14844303713 scopus 로고    scopus 로고
    • Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment
    • Furumatsu T., Tsuda M., Taniguchi N., Tajima Y., and Asahara H. Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment. J. Biol. Chem. 280 (2005) 8343-8350
    • (2005) J. Biol. Chem. , vol.280 , pp. 8343-8350
    • Furumatsu, T.1    Tsuda, M.2    Taniguchi, N.3    Tajima, Y.4    Asahara, H.5
  • 44
    • 0035907240 scopus 로고    scopus 로고
    • Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
    • Verrecchia F., Chu M.L., and Mauviel A. Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J. Biol. Chem. 276 (2001) 17058-17062
    • (2001) J. Biol. Chem. , vol.276 , pp. 17058-17062
    • Verrecchia, F.1    Chu, M.L.2    Mauviel, A.3
  • 45
    • 28244454171 scopus 로고    scopus 로고
    • Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway
    • Akool E.-S., Doller A., Muller R., Gutwein P., Xin C., Huwiler A., Pfeilschifter J., and Eberhardt W. Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway. J. Biol. Chem. 280 (2005) 39403-39416
    • (2005) J. Biol. Chem. , vol.280 , pp. 39403-39416
    • Akool, E.-S.1    Doller, A.2    Muller, R.3    Gutwein, P.4    Xin, C.5    Huwiler, A.6    Pfeilschifter, J.7    Eberhardt, W.8
  • 46
    • 0034943365 scopus 로고    scopus 로고
    • Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites
    • Tardif G., Reboul P., Dupuis M., Geng C., Duval N., Pelletier J.P., and Martel-Pelletier J. Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites. J. Rheumatol. 28 (2001) 1631-1639
    • (2001) J. Rheumatol. , vol.28 , pp. 1631-1639
    • Tardif, G.1    Reboul, P.2    Dupuis, M.3    Geng, C.4    Duval, N.5    Pelletier, J.P.6    Martel-Pelletier, J.7
  • 47
    • 33646361074 scopus 로고    scopus 로고
    • Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells
    • Leivonen S.K., Ala-Aho R., Koli K., Grenman R., Peltonen J., and Kahari V.M. Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells. Oncogene 25 (2006) 2588-2600
    • (2006) Oncogene , vol.25 , pp. 2588-2600
    • Leivonen, S.K.1    Ala-Aho, R.2    Koli, K.3    Grenman, R.4    Peltonen, J.5    Kahari, V.M.6
  • 48
    • 0035914339 scopus 로고    scopus 로고
    • Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3
    • Yuan W., and Varga J. Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3. J. Biol. Chem. 276 (2001) 38502-38510
    • (2001) J. Biol. Chem. , vol.276 , pp. 38502-38510
    • Yuan, W.1    Varga, J.2
  • 49
    • 0030613262 scopus 로고    scopus 로고
    • Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling
    • Souchelnytskyi S., Tamaki K., Engstrom U., Wernstedt C., Ten Dijke P., and Heldin C.H. Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J. Biol. Chem. 272 (1997) 28107-28115
    • (1997) J. Biol. Chem. , vol.272 , pp. 28107-28115
    • Souchelnytskyi, S.1    Tamaki, K.2    Engstrom, U.3    Wernstedt, C.4    Ten Dijke, P.5    Heldin, C.H.6
  • 50
    • 0036894454 scopus 로고    scopus 로고
    • Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage
    • Bau B., Haag J., Schmid E., Kaiser M., Gebhard P.M., and Aigner T. Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage. J. Bone Miner. Res. 17 (2002) 2141-2150
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 2141-2150
    • Bau, B.1    Haag, J.2    Schmid, E.3    Kaiser, M.4    Gebhard, P.M.5    Aigner, T.6
  • 51
    • 0034695483 scopus 로고    scopus 로고
    • Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling
    • Sirard C., Kim S., Mirtsos C., Tadich P., Hoodless P.A., Itie A., Maxson R., Wrana J.L., and Mak T.W. Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. J. Biol. Chem. 275 (2000) 2063-2070
    • (2000) J. Biol. Chem. , vol.275 , pp. 2063-2070
    • Sirard, C.1    Kim, S.2    Mirtsos, C.3    Tadich, P.4    Hoodless, P.A.5    Itie, A.6    Maxson, R.7    Wrana, J.L.8    Mak, T.W.9
  • 52
    • 0032491478 scopus 로고    scopus 로고
    • Smad4/DPC4 and Smad3 mediate transforming growth factor-beta (TGF-beta) signaling through direct binding to a novel TGF-beta-responsive element in the human plasminogen activator inhibitor-1 promoter
    • Song C.Z., Siok T.E., and Gelehrter T.D. Smad4/DPC4 and Smad3 mediate transforming growth factor-beta (TGF-beta) signaling through direct binding to a novel TGF-beta-responsive element in the human plasminogen activator inhibitor-1 promoter. J. Biol. Chem. 273 (1998) 29287-29290
    • (1998) J. Biol. Chem. , vol.273 , pp. 29287-29290
    • Song, C.Z.1    Siok, T.E.2    Gelehrter, T.D.3
  • 53
    • 23944485929 scopus 로고    scopus 로고
    • Smad4 is required for the normal organization of the cartilage growth plate
    • Zhang J., Tan X., Li W., Wang Y., Wang J., Cheng X., and Yang X. Smad4 is required for the normal organization of the cartilage growth plate. Dev. Biol. 284 (2005) 311-322
    • (2005) Dev. Biol. , vol.284 , pp. 311-322
    • Zhang, J.1    Tan, X.2    Li, W.3    Wang, Y.4    Wang, J.5    Cheng, X.6    Yang, X.7
  • 54
    • 1642403894 scopus 로고    scopus 로고
    • Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1
    • Jinnin M., Ihn H., Asano Y., Yamane K., Trojanowska M., and Tamaki K. Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1. Oncogene 23 (2004) 1656-1667
    • (2004) Oncogene , vol.23 , pp. 1656-1667
    • Jinnin, M.1    Ihn, H.2    Asano, Y.3    Yamane, K.4    Trojanowska, M.5    Tamaki, K.6
  • 56
    • 0034704076 scopus 로고    scopus 로고
    • Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1
    • Datta P.K., Blake M.C., and Moses H.L. Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1. J. Biol. Chem. 275 (2000) 40014-40019
    • (2000) J. Biol. Chem. , vol.275 , pp. 40014-40019
    • Datta, P.K.1    Blake, M.C.2    Moses, H.L.3
  • 57
    • 15444375634 scopus 로고    scopus 로고
    • SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells
    • Tsukada S., Westwick J.K., Ikejima K., Sato N., and Rippe R.A. SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. J. Biol. Chem. 280 (2005) 10055-10064
    • (2005) J. Biol. Chem. , vol.280 , pp. 10055-10064
    • Tsukada, S.1    Westwick, J.K.2    Ikejima, K.3    Sato, N.4    Rippe, R.A.5
  • 58
    • 0038175448 scopus 로고    scopus 로고
    • Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling
    • Ungefroren H., Lenschow W., Chen W.B., Faendrich F., and Kalthoff H. Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling. J. Biol. Chem. 278 (2003) 11041-11049
    • (2003) J. Biol. Chem. , vol.278 , pp. 11041-11049
    • Ungefroren, H.1    Lenschow, W.2    Chen, W.B.3    Faendrich, F.4    Kalthoff, H.5
  • 59
    • 0035957924 scopus 로고    scopus 로고
    • Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells
    • Watanabe H., de Caestecker M.P., and Yamada Y. Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells. J. Biol. Chem. 276 (2001) 14466-14473
    • (2001) J. Biol. Chem. , vol.276 , pp. 14466-14473
    • Watanabe, H.1    de Caestecker, M.P.2    Yamada, Y.3


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