Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factorβ-mediated Meckel's cartilage development

Developmental Dynamics

Volumn 224, Issue 1, 2002, Pages 69-78

  Ito, Yoshihiro ^a   Bringas Jr , Pablo ^a   Mogharei, Ali ^a   Zhao, Jingsong ^a   Deng, Chuxia ^b   Chai, Yang ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Meckel's cartilage; Smad2; Smad7; TGF signaling

Indexed keywords

SMAD PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROGENESIS; CONTROLLED STUDY; CRANIOFACIAL DEVELOPMENT; DNA SYNTHESIS; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; NEURAL CREST; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CARTILAGE; CHONDROCYTES; CULTURE MEDIA, SERUM-FREE; CULTURE TECHNIQUES; DNA-BINDING PROTEINS; EMBRYO; FEMALE; MANDIBLE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURAL CREST; PREGNANCY; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; SKULL; SMAD2 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEINS; ZEBRAFISH PROTEINS;

MALLEUS;

EID: 0036234366     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.10088     Document Type: Article

References (51)

1. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
2. Skeletal tissue and transforming growth factor beta
3. Specific transforming growth factor-β subtypes regulate embryonic mouse Meckel's cartilage and tooth development
4. An early mandibular organ culture model developed to study cranial neural crest cell migration and molecular regulation of first branchial arch morphogenesis
5. Inhibition of transforming growth factor-β type II receptor signaling accelerates tooth formation in mouse first branchial arch explants
6. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
7. Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins
8. The triple origin of skull in higher vertebrates: A study in quail-chick chimeras
9. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
10. Expression of Smadl and Smad2 during embryogenesis suggests a role in organ development
11. Madr2 maps to 18q21 and encodes a TGF-β-regulated Mad-related protein that is functionally mutated in colorectal carcinoma
12. The role of effectors of the activin signaling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development
13. Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: Signaling by BMPs and TGF-betas
14. All for one and one for all: Condensations and the initiation of skeletal development
15. The Mad-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
16. MADR1, a Mad-related protein that functions in BMP2 signaling pathways
17. Smad6 inhibits signaling by the TGF-β superfamily
18. Overexpression of Smad2 reveals its concerted action with Smad 4 in regulating TGF-β-mediated epidermal homeostasis
19. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation
20. The TGF-β family mediator Smadl is phosphorylated directly and activated functionally by the BMP receptor kinase
21. A human Mad protein acting as a BMP-regulated transcriptional activator
22. TGF-β signal transduction
23. TGFβ Signaling in growth control, cancer, and heritable disorders
24. Regulation of mandibular growth and morphogenesis
25. Positive and negative regulation of TGF-β signaling
26. TGF-β receptor-mediated signaling through Smad2, Smad3, and Smad4
27. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling
28. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
29. The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissue
30. Smad2 role in mesoderm formation, left-right patterning and craniofacial development
31. Immunohistochemical localization of TGFβ1, TGFβ2, and TGFβ3 in the mouse embryo: Expression patterns suggest multiple roles during embryonic development
32. Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification
33. TGFβ2 knockout mice have multiple developmental defects that are nonoverlapping with other TGFβ knockout phenotypes
34. Positionally-dependent chondrogenesis induced by BMP4 is co-regulated by Sox9 and Msx2
35. Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta
36. Ventrally emigrating neural tube cells contribute to the formation of Meckel's and quadrate cartilage
37. Generalized lacZ expression with the ROSA26 Cre reporter strain
38. Peptide growth factors are multifunctional
39. Participation of Smad2, Smad3, and Smad4 in transforming growth factor beta (TGF-beta)-induced activation of Smad7. The TGF-beta response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation
40. Smad5 induces ventral fates in Xenopus Embryo
41. Closure of lens vesicle
42. Vascular Mads: Two novel Mad-related genes selectively inducible by flow in human vascular endothelium
43. Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β
44. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
45. Functions of mammalian Smad genes are revealed by targeted gene disruption in mice
46. Regulation of Smad activity
47. Alternatively spliced variant of Smad2 Lacking Exon 3
48. No evidence for ventrally migrating neural tube cells from the mid- and hindbrain
49. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T-cell responsiveness to TGF-β
50. Receptor-associated Mad homologues as effectors of the TGF-β response
51. Smad7 is a TGF-β-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis