메뉴 건너뛰기




Volumn 15, Issue 4, 2007, Pages 442-453

Expression and function of TβRII-B, a variant of the type II TGF-β receptor, in human chondrocytes

Author keywords

Cartilage; Chondrocytes; Osteoarthritis; T RII B; TGF receptors

Indexed keywords

COLLAGEN TYPE 2; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2 B; UNCLASSIFIED DRUG; TGFBR2 PROTEIN, HUMAN;

EID: 33847736357     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2006.10.006     Document Type: Article
Times cited : (24)

References (55)
  • 1
    • 0032976180 scopus 로고    scopus 로고
    • From cartilage metabolism to clinics: the role of cytokines and growth factors in cartilage destruction in osteoarthritis and rheumatoid arthritis
    • Van den Berg W.B. From cartilage metabolism to clinics: the role of cytokines and growth factors in cartilage destruction in osteoarthritis and rheumatoid arthritis. J Rheumatol 58 (1999) 136-141
    • (1999) J Rheumatol , vol.58 , pp. 136-141
    • Van den Berg, W.B.1
  • 2
    • 0035992496 scopus 로고    scopus 로고
    • Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders
    • Grimaud E., Heymann D., and Redini F. Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders. Cytokine Growth Factor Rev 13 (2002) 241-257
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 241-257
    • Grimaud, E.1    Heymann, D.2    Redini, F.3
  • 3
    • 0036644328 scopus 로고    scopus 로고
    • Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair
    • Scharstuhl A., Glansbeek H.L., van Beuningen H.M., Vitters E.L., van der Kraan P.M., and van den Berg W.B. Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair. J Immunol 169 (2002) 507-514
    • (2002) J Immunol , vol.169 , pp. 507-514
    • Scharstuhl, A.1    Glansbeek, H.L.2    van Beuningen, H.M.3    Vitters, E.L.4    van der Kraan, P.M.5    van den Berg, W.B.6
  • 4
    • 0030727351 scopus 로고    scopus 로고
    • Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
    • Serra R., Johnson M., Filvaroff E.H., LaBorde J., Sheehan D.M., Derynck R., et al. Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol 139 (1997) 541-552
    • (1997) J Cell Biol , vol.139 , pp. 541-552
    • Serra, R.1    Johnson, M.2    Filvaroff, E.H.3    LaBorde, J.4    Sheehan, D.M.5    Derynck, R.6
  • 5
    • 0035795409 scopus 로고    scopus 로고
    • TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    • Yang X., Chen L., Xu X., Li C., Huang C., and Deng C.X. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol 153 (2001) 35-46
    • (2001) J Cell Biol , vol.153 , pp. 35-46
    • Yang, X.1    Chen, L.2    Xu, X.3    Li, C.4    Huang, C.5    Deng, C.X.6
  • 6
    • 0032910482 scopus 로고    scopus 로고
    • The long-term effect of a short course of transforming growth factor-beta1 on rat articular cartilage
    • Itayem R., Mengarelli-Widholm S., and Reinholt F.P. The long-term effect of a short course of transforming growth factor-beta1 on rat articular cartilage. Apmis 107 (1999) 183-192
    • (1999) Apmis , vol.107 , pp. 183-192
    • Itayem, R.1    Mengarelli-Widholm, S.2    Reinholt, F.P.3
  • 7
    • 0033986279 scopus 로고    scopus 로고
    • Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections
    • van Beuningen H.M., Glansbeek H.L., van der Kraan P.M., and van den Berg W.B. Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections. Osteoarthritis Cartilage 8 (2000) 25-33
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 25-33
    • van Beuningen, H.M.1    Glansbeek, H.L.2    van der Kraan, P.M.3    van den Berg, W.B.4
  • 9
    • 0022978337 scopus 로고
    • Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta
    • Seyedin S.M., Thompson A.Y., Bentz H., Rosen D.M., McPherson J.M., Conti A., et al. Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta. J Biol Chem 261 (1986) 5693-5695
    • (1986) J Biol Chem , vol.261 , pp. 5693-5695
    • Seyedin, S.M.1    Thompson, A.Y.2    Bentz, H.3    Rosen, D.M.4    McPherson, J.M.5    Conti, A.6
  • 10
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y., and Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 (2003) 685-700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 11
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-beta-Smad signalling
    • ten Dijke P., and Hill C.S. New insights into TGF-beta-Smad signalling. Trends Biochem Sci 9 (2004) 265-273
    • (2004) Trends Biochem Sci , vol.9 , pp. 265-273
    • ten Dijke, P.1    Hill, C.S.2
  • 12
    • 0030039921 scopus 로고    scopus 로고
    • A human transforming growth factor-b type II receptor that contains an insertion in the extracellular domain
    • Hirai R., and Fujita T. A human transforming growth factor-b type II receptor that contains an insertion in the extracellular domain. Exp Cell Res 223 (1996) 135-141
    • (1996) Exp Cell Res , vol.223 , pp. 135-141
    • Hirai, R.1    Fujita, T.2
  • 13
    • 0027276765 scopus 로고
    • Betaglycan presents ligand to the TGF beta signaling receptor
    • Lopez-Casillas F., Wrana J.L., and Massague J. Betaglycan presents ligand to the TGF beta signaling receptor. Cell 73 (1993) 1435-1444
    • (1993) Cell , vol.73 , pp. 1435-1444
    • Lopez-Casillas, F.1    Wrana, J.L.2    Massague, J.3
  • 14
    • 0033135695 scopus 로고    scopus 로고
    • Ectodomain cleavage and shedding of the type III transforming growth factor-beta receptor in lung membranes effect of temperature, ligand binding and membrane solubilization
    • Philip A., Hannah R., and O'Connor-McCourt M. Ectodomain cleavage and shedding of the type III transforming growth factor-beta receptor in lung membranes effect of temperature, ligand binding and membrane solubilization. Eur J Biochem 261 (1999) 618-628
    • (1999) Eur J Biochem , vol.261 , pp. 618-628
    • Philip, A.1    Hannah, R.2    O'Connor-McCourt, M.3
  • 15
    • 0028057726 scopus 로고
    • Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta
    • Yamashita H., Ichijo H., Grimsby S., Moren A., ten Dijke P., and Miyazono K. Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta. J Biol Chem 269 (1994) 1995-2001
    • (1994) J Biol Chem , vol.269 , pp. 1995-2001
    • Yamashita, H.1    Ichijo, H.2    Grimsby, S.3    Moren, A.4    ten Dijke, P.5    Miyazono, K.6
  • 16
    • 0032484022 scopus 로고    scopus 로고
    • Role of endoglin in cellular responses to transforming growth factor-beta. A comparative study with betaglycan
    • Letamendia A., Lastres P., Botella L.M., Raab U., Langa C., Velasco B., et al. Role of endoglin in cellular responses to transforming growth factor-beta. A comparative study with betaglycan. J Biol Chem 273 (1998) 33011-33019
    • (1998) J Biol Chem , vol.273 , pp. 33011-33019
    • Letamendia, A.1    Lastres, P.2    Botella, L.M.3    Raab, U.4    Langa, C.5    Velasco, B.6
  • 17
    • 0037047426 scopus 로고    scopus 로고
    • Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II
    • Guerrero-Esteo M., Sanchez-Elsner T., Letamendia A., and Bernabeu C. Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. J Biol Chem 277 (2002) 29197-29209
    • (2002) J Biol Chem , vol.277 , pp. 29197-29209
    • Guerrero-Esteo, M.1    Sanchez-Elsner, T.2    Letamendia, A.3    Bernabeu, C.4
  • 18
    • 0033605704 scopus 로고    scopus 로고
    • Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart
    • Brown C.B., Boyer A.S., Runyan R.B., and Barnett J.V. Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Science 283 (1999) 2080-2082
    • (1999) Science , vol.283 , pp. 2080-2082
    • Brown, C.B.1    Boyer, A.S.2    Runyan, R.B.3    Barnett, J.V.4
  • 19
    • 0029066003 scopus 로고
    • Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor beta 2
    • Sankar S., Mahooti-Brooks N., Centrella M., McCarthy T.L., and Madri J.A. Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor beta 2. J Biol Chem 270 (1995) 13567-13572
    • (1995) J Biol Chem , vol.270 , pp. 13567-13572
    • Sankar, S.1    Mahooti-Brooks, N.2    Centrella, M.3    McCarthy, T.L.4    Madri, J.A.5
  • 20
    • 0035254335 scopus 로고    scopus 로고
    • Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor
    • Rotzer D., Roth M., Lutz M., Lindemann D., Sebald W., and Knaus P. Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. EMBO J 20 (2001) 480-490
    • (2001) EMBO J , vol.20 , pp. 480-490
    • Rotzer, D.1    Roth, M.2    Lutz, M.3    Lindemann, D.4    Sebald, W.5    Knaus, P.6
  • 21
    • 2542425404 scopus 로고    scopus 로고
    • In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2
    • del Re E., Babitt J.L., Pirani A., Schneyer A.L., and Lin H.Y. In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2. J Biol Chem 279 (2004) 22765-22772
    • (2004) J Biol Chem , vol.279 , pp. 22765-22772
    • del Re, E.1    Babitt, J.L.2    Pirani, A.3    Schneyer, A.L.4    Lin, H.Y.5
  • 22
    • 12244276347 scopus 로고    scopus 로고
    • Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGFbeta receptor independent manner
    • Parker W.L., Goldring M.B., and Philip A. Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGFbeta receptor independent manner. J Bone Miner Res 18 (2003) 289-302
    • (2003) J Bone Miner Res , vol.18 , pp. 289-302
    • Parker, W.L.1    Goldring, M.B.2    Philip, A.3
  • 23
    • 0030856858 scopus 로고    scopus 로고
    • Characterization of a 60-kDa cell surface-associated transforming growth factor-beta binding protein that can interfere with transforming growth factor-beta receptor binding
    • Piek E., Franzen P., Heldin C.H., and ten Dijke P. Characterization of a 60-kDa cell surface-associated transforming growth factor-beta binding protein that can interfere with transforming growth factor-beta receptor binding. J Cell Physiol 173 (1997) 447-459
    • (1997) J Cell Physiol , vol.173 , pp. 447-459
    • Piek, E.1    Franzen, P.2    Heldin, C.H.3    ten Dijke, P.4
  • 25
    • 0035233899 scopus 로고    scopus 로고
    • Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases
    • Souchelnytskyi S., Ronnstrand L., Heldin C.H., and ten Dijke P. Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases. Methods Mol Biol 124 (2001) 107-120
    • (2001) Methods Mol Biol , vol.124 , pp. 107-120
    • Souchelnytskyi, S.1    Ronnstrand, L.2    Heldin, C.H.3    ten Dijke, P.4
  • 26
    • 0028328915 scopus 로고
    • Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay
    • Hollander A.P., Heathfield T.F., Webber C., Iwata Y., Bourne R., Rorabeck C., et al. Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J Clin Invest 93 (1994) 1722-1732
    • (1994) J Clin Invest , vol.93 , pp. 1722-1732
    • Hollander, A.P.1    Heathfield, T.F.2    Webber, C.3    Iwata, Y.4    Bourne, R.5    Rorabeck, C.6
  • 27
    • 0028172988 scopus 로고
    • Successful immortalization of human chondrocytes exhibiting stable expression of cartilage-specific type II collagen
    • Goldring M.B., Birkhead J.R., Suen L.-F., Yamin R., Mizuno S., Glowacki J., et al. Successful immortalization of human chondrocytes exhibiting stable expression of cartilage-specific type II collagen. J Clin Invest 94 (1994) 2307-2316
    • (1994) J Clin Invest , vol.94 , pp. 2307-2316
    • Goldring, M.B.1    Birkhead, J.R.2    Suen, L.-F.3    Yamin, R.4    Mizuno, S.5    Glowacki, J.6
  • 28
    • 0009588168 scopus 로고    scopus 로고
    • Morgan J.R., and Yarmush M. (Eds), Humana Press Inc., Totowa, NJ
    • Robbins J.R., and Goldring M.B. In: Morgan J.R., and Yarmush M. (Eds). Methods in Molecular Medicine (1997), Humana Press Inc., Totowa, NJ 173-192
    • (1997) Methods in Molecular Medicine , pp. 173-192
    • Robbins, J.R.1    Goldring, M.B.2
  • 30
    • 0025356905 scopus 로고
    • Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat
    • Gruppuso P.A., Mead J.E., and Fausto N. Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat. Cancer Res 50 (1990) 1464-1469
    • (1990) Cancer Res , vol.50 , pp. 1464-1469
    • Gruppuso, P.A.1    Mead, J.E.2    Fausto, N.3
  • 31
    • 0026537831 scopus 로고
    • Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase
    • Lin H.Y., Wang X.F., Ng-Eaton E., Weinberg R.A., and Lodish H.F. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell 68 (1992) 775-785
    • (1992) Cell , vol.68 , pp. 775-785
    • Lin, H.Y.1    Wang, X.F.2    Ng-Eaton, E.3    Weinberg, R.A.4    Lodish, H.F.5
  • 32
    • 0033851028 scopus 로고    scopus 로고
    • Endoglin expression on human microvascular endothelial cells association with betaglycan and formation of higher order complexes with TGF-beta signalling receptors
    • Wong S.H., Hamel L., Chevalier S., and Philip A. Endoglin expression on human microvascular endothelial cells association with betaglycan and formation of higher order complexes with TGF-beta signalling receptors. Eur J Biochem 267 (2000) 5550-5560
    • (2000) Eur J Biochem , vol.267 , pp. 5550-5560
    • Wong, S.H.1    Hamel, L.2    Chevalier, S.3    Philip, A.4
  • 33
    • 0025021804 scopus 로고
    • Induction and autocrine receptor binding of transforming growth factor-beta 2 during terminal differentiation of primary mouse keratinocytes
    • Glick A.B., Danielpour D., Morgan D., Sporn M.B., and Yuspa S.H. Induction and autocrine receptor binding of transforming growth factor-beta 2 during terminal differentiation of primary mouse keratinocytes. Mol Endocrinol 4 (1990) 46-52
    • (1990) Mol Endocrinol , vol.4 , pp. 46-52
    • Glick, A.B.1    Danielpour, D.2    Morgan, D.3    Sporn, M.B.4    Yuspa, S.H.5
  • 34
    • 0025370836 scopus 로고
    • Identification of disulfide-linked transforming growth factor-beta 1-specific binding proteins in rat glomeruli
    • MacKay K., Robbins A.R., Bruce M.D., and Danielpour D. Identification of disulfide-linked transforming growth factor-beta 1-specific binding proteins in rat glomeruli. J Biol Chem 265 (1990) 9351-9356
    • (1990) J Biol Chem , vol.265 , pp. 9351-9356
    • MacKay, K.1    Robbins, A.R.2    Bruce, M.D.3    Danielpour, D.4
  • 36
    • 33845631481 scopus 로고    scopus 로고
    • Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes
    • Finnson K.W., Tam B.Y., Liu K., Marcoux A., Lepage P., Roy S., et al. Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes. FASEB J 20 (2006) 1525-1527
    • (2006) FASEB J , vol.20 , pp. 1525-1527
    • Finnson, K.W.1    Tam, B.Y.2    Liu, K.3    Marcoux, A.4    Lepage, P.5    Roy, S.6
  • 37
    • 0033166197 scopus 로고    scopus 로고
    • Human chondrocyte culture models for studying cyclooxygenase expression and prostaglandin regulation of collagen gene expression
    • Goldring M.B., and Berenbaum F. Human chondrocyte culture models for studying cyclooxygenase expression and prostaglandin regulation of collagen gene expression. Osteoarthritis Cartilage 7 (1999) 386-388
    • (1999) Osteoarthritis Cartilage , vol.7 , pp. 386-388
    • Goldring, M.B.1    Berenbaum, F.2
  • 38
    • 0034326794 scopus 로고    scopus 로고
    • Proteoglycan production by immortalized human chondrocyte cell lines cultured under conditions that promote expression of the differentiated phenotype
    • Kokenyesi R., Tan L., Robbins J.R., and Goldring M.B. Proteoglycan production by immortalized human chondrocyte cell lines cultured under conditions that promote expression of the differentiated phenotype. Arch Biochem Biophys 383 (2000) 79-90
    • (2000) Arch Biochem Biophys , vol.383 , pp. 79-90
    • Kokenyesi, R.1    Tan, L.2    Robbins, J.R.3    Goldring, M.B.4
  • 39
    • 0034064619 scopus 로고    scopus 로고
    • Integrin expression by primary and immortalized human chondrocytes: evidence of a differential role for alpha1beta1 and alpha2 beta1 integrins in mediating chondrocyte adhesion to types II and VI collagen
    • Loeser R.F., Sadiev S., Tan L., and Goldring M.B. Integrin expression by primary and immortalized human chondrocytes: evidence of a differential role for alpha1beta1 and alpha2 beta1 integrins in mediating chondrocyte adhesion to types II and VI collagen. Osteoarthritis Cartilage 8 (2000) 96-105
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 96-105
    • Loeser, R.F.1    Sadiev, S.2    Tan, L.3    Goldring, M.B.4
  • 40
    • 0033791689 scopus 로고    scopus 로고
    • Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1beta
    • Robbins J.R., Thomas B., Tan L., Choy B., Arbiser J.L., Berenbaum F., et al. Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1beta. Arthritis Rheum 43 (2000) 2189-2201
    • (2000) Arthritis Rheum , vol.43 , pp. 2189-2201
    • Robbins, J.R.1    Thomas, B.2    Tan, L.3    Choy, B.4    Arbiser, J.L.5    Berenbaum, F.6
  • 41
    • 0031960132 scopus 로고    scopus 로고
    • Endoglin, a component of the TGF-beta receptor system, is a differentiation marker of human choriocarcinoma cells
    • Letamendia A., Lastres P., Almendro N., Raab U., Buhring H.J., Kumar S., et al. Endoglin, a component of the TGF-beta receptor system, is a differentiation marker of human choriocarcinoma cells. Int J Cancer 76 (1998) 541-546
    • (1998) Int J Cancer , vol.76 , pp. 541-546
    • Letamendia, A.1    Lastres, P.2    Almendro, N.3    Raab, U.4    Buhring, H.J.5    Kumar, S.6
  • 42
    • 0035827581 scopus 로고    scopus 로고
    • Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts
    • Piek E., Ju W.J., Heyer J., Escalante-Alcalde D., Stewart C.L., Weinstein M., et al. Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem 276 (2001) 19945-19953
    • (2001) J Biol Chem , vol.276 , pp. 19945-19953
    • Piek, E.1    Ju, W.J.2    Heyer, J.3    Escalante-Alcalde, D.4    Stewart, C.L.5    Weinstein, M.6
  • 43
    • 0034194304 scopus 로고    scopus 로고
    • Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation
    • Choy L., Skillington J., and Derynck R. Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol 149 (2000) 667-682
    • (2000) J Cell Biol , vol.149 , pp. 667-682
    • Choy, L.1    Skillington, J.2    Derynck, R.3
  • 44
    • 0031149506 scopus 로고    scopus 로고
    • Species-specific expression of type II TGF-beta receptor isoforms by articular chondrocytes: effect of proteoglycan depletion and aging
    • Glansbeek H.L., van der Kraan P.M., Lafeber F.P., Vitters E.L., and van den Berg W.B. Species-specific expression of type II TGF-beta receptor isoforms by articular chondrocytes: effect of proteoglycan depletion and aging. Cytokine 9 (1997) 347-351
    • (1997) Cytokine , vol.9 , pp. 347-351
    • Glansbeek, H.L.1    van der Kraan, P.M.2    Lafeber, F.P.3    Vitters, E.L.4    van den Berg, W.B.5
  • 45
    • 8144230707 scopus 로고    scopus 로고
    • Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
    • Lebrin F., Goumans M.J., Jonker L., Carvalho R.L., Valdimarsdottir G., Thorikay M., et al. Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J 23 (2004) 4018-4028
    • (2004) EMBO J , vol.23 , pp. 4018-4028
    • Lebrin, F.1    Goumans, M.J.2    Jonker, L.3    Carvalho, R.L.4    Valdimarsdottir, G.5    Thorikay, M.6
  • 46
    • 0030728295 scopus 로고    scopus 로고
    • Distinct endocytic responses of heteromeric and homomeric transforming growth factor beta receptors
    • Anders R.A., Arline S.L., Dore J.J., and Leof E.B. Distinct endocytic responses of heteromeric and homomeric transforming growth factor beta receptors. Mol Biol Cell 8 (1997) 2133-2143
    • (1997) Mol Biol Cell , vol.8 , pp. 2133-2143
    • Anders, R.A.1    Arline, S.L.2    Dore, J.J.3    Leof, E.B.4
  • 47
    • 0029010192 scopus 로고
    • Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors
    • Chen R.H., Moses H.L., Maruoka E.M., Derynck R., and Kawabata M. Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors. J Biol Chem 270 (1995) 12235-12241
    • (1995) J Biol Chem , vol.270 , pp. 12235-12241
    • Chen, R.H.1    Moses, H.L.2    Maruoka, E.M.3    Derynck, R.4    Kawabata, M.5
  • 48
    • 0028171082 scopus 로고
    • Reconstitution and transphosphorylation of TGF-beta receptor complexes
    • Ventura F., Doody J., Liu F., Wrana J.L., and Massague J. Reconstitution and transphosphorylation of TGF-beta receptor complexes. EMBO J 13 (1994) 5581-5589
    • (1994) EMBO J , vol.13 , pp. 5581-5589
    • Ventura, F.1    Doody, J.2    Liu, F.3    Wrana, J.L.4    Massague, J.5
  • 49
    • 17544376741 scopus 로고    scopus 로고
    • Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors
    • Feng X.H., and Derynck R. Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors. J Biol Chem 271 (1996) 13123-13129
    • (1996) J Biol Chem , vol.271 , pp. 13123-13129
    • Feng, X.H.1    Derynck, R.2
  • 50
    • 0033605117 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces formation of a dithiothreitol-resistant type I/Type II receptor complex in live cells
    • Wells R.G., Gilboa L., Sun Y., Liu X., Henis Y.I., and Lodish H.F. Transforming growth factor-beta induces formation of a dithiothreitol-resistant type I/Type II receptor complex in live cells. J Biol Chem 274 (1999) 5716-5722
    • (1999) J Biol Chem , vol.274 , pp. 5716-5722
    • Wells, R.G.1    Gilboa, L.2    Sun, Y.3    Liu, X.4    Henis, Y.I.5    Lodish, H.F.6
  • 51
    • 0034194584 scopus 로고    scopus 로고
    • Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2
    • Abdalla S.A., Pece-Barbara N., Vera S., Tapia E., Paez E., Bernabeu C., et al. Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2. Hum Mol Genet 9 (2000) 1227-1237
    • (2000) Hum Mol Genet , vol.9 , pp. 1227-1237
    • Abdalla, S.A.1    Pece-Barbara, N.2    Vera, S.3    Tapia, E.4    Paez, E.5    Bernabeu, C.6
  • 53
    • 0034021776 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors
    • Gilboa L., Nohe A., Geissendorfer T., Sebald W., Henis Y.I., and Knaus P. Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. Mol Biol Cell 11 (2000) 1023-1035
    • (2000) Mol Biol Cell , vol.11 , pp. 1023-1035
    • Gilboa, L.1    Nohe, A.2    Geissendorfer, T.3    Sebald, W.4    Henis, Y.I.5    Knaus, P.6
  • 54
    • 0033601179 scopus 로고    scopus 로고
    • Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription
    • Engel M.E., McDonnell M.A., Law B.K., and Moses H.L. Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J Biol Chem 274 (1999) 37413-37420
    • (1999) J Biol Chem , vol.274 , pp. 37413-37420
    • Engel, M.E.1    McDonnell, M.A.2    Law, B.K.3    Moses, H.L.4
  • 55
    • 0026496172 scopus 로고
    • TGF beta signals through a heteromeric protein kinase receptor complex
    • Wrana J.L., Attisano L., Carcamo J., Zentella A., Doody J., Laiho M., et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71 (1992) 1003-1014
    • (1992) Cell , vol.71 , pp. 1003-1014
    • Wrana, J.L.1    Attisano, L.2    Carcamo, J.3    Zentella, A.4    Doody, J.5    Laiho, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.