Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3

Gene Therapy

Volumn 10, Issue 3, 2003, Pages 234-242

  van der Laan, W H ^a,b   Quax, P H A ^a   Seemayer, C A ^c   Huisman, L G M ^a   Pieterman, E J ^b   Grimbergen, J M ^a   Verheijen, J H ^a   Breedveld, F C ^b   Gay, R E ^c   Gay, S ^c   Huizinga, T W J ^b   Pap, T ^c,d  

^a TNO   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c University Hospital   (Switzerland)

^d OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Fibroblasts; Invasion; Rheumatoid arthritis; TIMP 1; TIMP 3

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; MARIMASTAT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

CARTILAGE DEGENERATION; CELL COUNT; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; FIBROBLAST; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; JOINT DESTRUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SCID MOUSE; SYNOVIOCYTE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; ARTHRITIS, RHEUMATOID; CARTILAGE, ARTICULAR; CELL DIVISION; FIBROBLASTS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; MATRIX METALLOPROTEINASES; MICE; MICE, SCID; SYNOVIAL MEMBRANE; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-3; TRANSDUCTION, GENETIC;

ADENOVIRIDAE; ANIMALIA;

EID: 0037319185     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301871     Document Type: Review

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