The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism

Trends in Endocrinology and Metabolism

Volumn 11, Issue 7, 2000, Pages 281-285

  Kaestner, Klaus H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; NUCLEAR FACTOR; TRANSCRIPTION FACTOR;

DIET RESTRICTION; GENE EXPRESSION; GLUCONEOGENESIS; GLYCOLYSIS; HORMONAL REGULATION; HUMAN; HYPOGLYCEMIA; LIVER; MAMMAL; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN STRUCTURE; REVIEW; TRANSCRIPTION REGULATION;

EID: 0033843072     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(00)00271-X     Document Type: Review

References (44)

1. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes
2. Liver-enriched transcription factors and hepatocyte differentiation
3. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo
4. Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
5. Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm
6. The formation and maintenance of the definitive endoderm lineage in the mouse: Involvement of HNF3/forkhead proteins
7. HNF-3A, a hepatocyteenriched transcription factor of novel structure is regulated transcriptionally
8. Hepatocyte nuclear factor 3α belongs to a gene family in mammalsthat is homologous to the Drosophila homeotic gene fork head
9. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo
10. The fork head domain: A novel DNA binding motif of eukaryotic transcription factors?
11. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone HS
12. Unified nomenclature for the winged helix/forkhead transcription factors
13. Hepatocyte nuclear factor 3 β contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein
14. Analysis of hepatocyte nuclear factor-3 β protein domains required for transcriptional activation and nuclear targeting
15. Position and orientation of the globular domain of linker histone H5 on the nucleosome
16. Prolonged glucocorticoid exposure dephosphorylates histone Hl and inactivates the MMTV promoter
17. Somatic linker histones cause loss of mesodermal competence in Xenopus
18. Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome
19. Regulation of a transcription factor network required for differentiation and metabolism
20. Inactivation of the winged helix transcription factor HNF3α affects glucose homeostasis and islet glucagon gene expression in vivo
21. Binding sites for hepatocyte nuclear factor 3β or 3γ and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase
22. Hepatocyte nuclear factor 3β is involved in pancreatic betacell-specific transcription of the pdx-1 gene
23. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1
24. Pancreatic β cellspecific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3β sites
25. Glucagon gene expression is negatively regulated by hepatocyte nuclear factor 3β
26. Metabolic control of gene expression: In vivo studies with transgenic mice
27. Hormone response domains in gene transcription
28. Glucocorticolds and insulin regulate expression of the human gene for insulin-like growth factorbinding protein-1 through proximal promoter elements
29. Antiglucocorticoid activity of hepatocyte nuclear factor-6
30. Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes
31. Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive, elements
32. Glucocorticoids are insufficient for neonatal gene induction in the liver
33. Sequential expression of HNF-3 β and HNF-3 α by embryonic organizing centers: The dorsal lip/node, notochord and floor plate
34. HNF-3 β is essential for node and notochord formation in mouse development
35. The wingedhelix transcription factor HNF-3 β is required for notochord development in the mouse embryo
36. A functional dichotomy in hepatocyte specification and maintenance revealed by liver-specific inactivation of the hepatocyte nuclear factor 3β (Foxa2) gene
37. Targeted disruption of the gene encoding hepatocyte nuclear factor 3γ results in reduced transcription of hepatocyte-specific genes
38. Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3α-deficient mice
39. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
40. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
41. Insulin-promoterfactor 1 is required for pancreas development in mice
42. Assignment of the human genes for hepatocyte nuclear factor 3-α, -β, and -γ (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4
43. Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 β and mutation screening in Japanese subjects with maturity-onset diabetes of the young
44. Glucagon deficiency causing severe neonatal hypoglycemia in a patient with normal insulin secretion