Identification of novel small molecule enhancers of protein production by cultured mammalian cells

Biotechnology and Bioengineering

Volumn 100, Issue 6, 2008, Pages 1193-1204

  Allen, Martin J ^a   Boyce, James P ^a   Trentalange, Michael T ^a   Treiber, David L ^a   Rasmussen, Brian ^a   Tillotson, Benjamin ^a   Davis, Raymond ^a   Reddy, Pranhitha ^a  

^a AMGEN INC   (United States)

Author keywords

CHO; Hybridoma; Monoclonal antibody; Protein production; Small molecule enhancer

Indexed keywords

AROMATIC CARBOXYLIC ACIDS; CELL CULTURE MEDIUM; CELL-BASED; CHINESE HAMSTER OVARY CELLS; CHO; CONTROL CULTURES; EXPRESSION ENHANCEMENT; HYBRIDOMA; HYBRIDOMA CELLS; HYDROXAMIC ACIDS; MAMMALIAN CELLS; MONOCLONAL ANTIBODY; MRNA LEVELS; PRODUCTION SYSTEMS; PROTEIN PRODUCTION; PROTEIN PRODUCTIONS; RECOMBINANT PROTEIN EXPRESSIONS; RECOMBINANT PROTEINS; REPORTER PROTEIN; SMALL MOLECULE ENHANCER; SMALL MOLECULES; SODIUM BUTYRATE; TRANSCRIPTIONAL ACTIVATIONS;

ACIDS; ACTIVATION ANALYSIS; ALLERGIES; ANIMAL CELL CULTURE; ANTIBODIES; AROMATIC COMPOUNDS; ARSENIC COMPOUNDS; BOTTLES; CARBOXYLIC ACIDS; CELLS; CHEMICAL REACTORS; CHLORINE COMPOUNDS; CYTOLOGY; DOPING (ADDITIVES); ELECTRIC ENERGY STORAGE; MAMMALS; MANUFACTURE; MERGERS AND ACQUISITIONS; MOLECULES; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; PROTEINS; SODIUM; SURFACE PLASMON RESONANCE;

CELL CULTURE;

ACETAMIDE; AROMATIC CARBOXYLIC ACID; HYDROXAMIC ACID; MESSENGER RNA; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL CLONE; CELL CULTURE; CELL GROWTH; CHO CELL; FEMALE; HYBRIDOMA CELL CULTURE; MAMMAL CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TRANSCRIPTION INITIATION;

ACETAMIDES; ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; FEMALE; FLUORESCENT DYES; GENE EXPRESSION; GENETIC ENHANCEMENT; HEXANOIC ACIDS; HYBRIDOMAS; HYDROCARBONS, AROMATIC; HYDROXAMIC ACIDS; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATION (GENETICS);

CRICETULUS GRISEUS; MAMMALIA;

EID: 48649104369     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21839     Document Type: Article

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