High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor

Biotechnology and Bioengineering

Volumn 51, Issue 6, 1996, Pages 725-729

  Xie, Liangzhi ^a   Wang, Daniel I C ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

bioreactor control; fed batch; high antibody; high density; medium design

Indexed keywords

BATCH CELL CULTURE; CELLS; CHEMICAL VARIABLES CONTROL; GLUCOSE; MATHEMATICAL MODELS; MONOCLONAL ANTIBODIES;

FED BATCH; HIGH ANTIBODY; HIGH DENSITY; LACTATE; MEDIUM DESIGN;

BIOREACTORS;

AMMONIA; GLUCOSE; IMMUNOGLOBULIN G; LACTIC ACID; MONOCLONAL ANTIBODY; TRACE METAL;

ANTIBODY PRODUCTION; ARTICLE; BIOREACTOR; CELL DENSITY; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; FETAL CALF SERUM; GLUCOSE INTAKE; HYBRIDOMA; NUTRIENT;

EID: 9444286985     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19960920)51:6<725::AID-BIT12>3.0.CO;2-C     Document Type: Article

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