Activation of NOD2 in vivo induces IL-1β production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling

Journal of Leukocyte Biology

Volumn 84, Issue 2, 2008, Pages 529-536

  Rosenzweig, H L ^a   Martin, T M ^a,b   Planck, S R ^a,b   Galster, K ^a   Jann, M M ^c   Davey, M P ^b,c   Kobayashi, K ^d   Flavell, R A ^e   Rosenbaum, J T ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokines; Transgenic knockout mice

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MURAMYL DIPEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; EYE INFLAMMATION; FEMALE; IN VIVO STUDY; LEUKOCYTE ADHERENCE; LEUKOCYTE ROLLING; MOUSE; NEUTROPHIL; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; PROTEIN FUNCTION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CASPASE 1; DISEASE MODELS, ANIMAL; EYE; EYE DISEASES; FEMALE; INFLAMMATION; INTERLEUKIN-1BETA; MICE; MICE, INBRED BALB C; NOD2 SIGNALING ADAPTOR PROTEIN;

BACTERIA (MICROORGANISMS); MUS;

EID: 48649100466     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0108015     Document Type: Article

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