A review of the influence of aqueous humor on immunity

Ocular Immunology and Inflammation

Volumn 11, Issue 4, 2003, Pages 231-241

  Taylor, Andrew W ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

Adaptive immunity; Immune privilege; Immunosuppression; Innate immunity; Neuroimmunomodulation

Indexed keywords

ALPHA INTERMEDIN; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; SOMATOSTATIN; TRANSFORMING GROWTH FACTOR BETA2; VASOACTIVE INTESTINAL POLYPEPTIDE;

AQUEOUS HUMOR; EYE INFLAMMATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; PATHOGENESIS; REVIEW; T LYMPHOCYTE; TH1 CELL;

AQUEOUS HUMOR; HUMANS; IMMUNE SYSTEM; IMMUNITY; IMMUNOSUPPRESSION;

EID: 0348140680     PISSN: 09273948     EISSN: None     Source Type: Journal    
DOI: 10.1076/ocii.11.4.231.18269     Document Type: Review

References (46)

1. Barker CF, Billingham RE. Immunologically privileged sites. Adv Immunol. 1977;25:1-54.
2. Medawar P. Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol. 1948;29:58-69.
3. Taylor AW. Neuroimmunomodulation in immune privilege: role of neuropeptides in ocular immunosuppression (Revised). Neuroimmunomodulation. 2002;10: 189-198.
4. Taylor AW. Ocular immunosuppressive microenvironment. Chem Immunol. 1999;73:72-89.
5. Streilein JW. Immunoregulatory mechanisms of the eye. Prog Retin Eye Res. 1999;18:357-370.
6. Niederkorn JY. Immune privilege in the anterior chamber of the eye. Crit Rev Immunol. 2002;22:13-46.
7. Taylor AW, Streilein JW, Cousins SW Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. J Immunol. 1994;153:1080-1086.
8. Taylor AW, Yee DG. Somatostatin is an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci. 2003;44:2644-2649.
9. Taylor AW, Streilein JW, Cousins SW Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor. Curr Eye Res. 1992;11:1199-1206.
10. Star RA, Rajora N, Huang J, et al. Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone. Proc Natl Acad Sci USA. 1995;92:8016-8020.
11. Taylor AW, Yee DG, Streilein JW. Suppression of nitric oxide generated by inflammatory macrophages by calcitonin gene-related peptide in aqueous humor. Invest Ophthalmol Vis Sci. 1998;89:1372-1378.
12. Caspi RR, Sun B, Agarwal RK, et al. T cell mechanisms in experimental autoimmune uveoretinitis: susceptibility is a function of the cytokine response profile. Eye. 1997; 11(Pt 2):209-212.
13. Cher DJ, Mosmann TR. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J Immunol. 1987;138:3688-3694.
14. Buchanan KL, Murphy JW. Kinetics of cellular infiltration and cytokine production during the efferent phase of a delayed-type hypersensitivity reaction. Immunology. 1997;90:189-197.
15. Dutton RW, Bradley LM, Swain SL. T cell memory. Annu Rev Immunol. 1998;16:201-223.
16. Kaiser CJ, Ksander BR, Streilein JW. Inhibition of lymphocyte proliferation by aqueous humor. Reg Immunol. 1989;2:42-49.
17. Cousins SW, Trattler WB, Streilein JW Immune privilege and suppression of immunogenic inflammation in the anterior chamber of the eye. Curr Eye Res. 1991;10:287-297.
18. Granstein RD, Staszewski R, Knisely TL, et al. Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation. J Immunol. 1990;144:3021-3027.
19. Cousins SW, McCabe MM, Danielpour D, et al. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci. 1991:32: 2201-2211.
20. Taylor AW. Immunoregulation of the ocular effector responses by soluble factors in aqueous humor. Reg Immunol. 1994;6:52-57.
21. Taylor AW, Alard P, Yee DG, et al. Aqueous humor induces transforming growth factor-beta (TGF-beta)-producing regulatory T-cells. Curr Eye Res. 1997;16:900-908.
22. Nishida T, Taylor AW. Specific aqueous humor factors induce activation of regulatory T cells. Invest Ophthalmol Vis Sci. 1999;40: 2268-2274.
23. Weiner HL. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev. 2001;182:207-214.
24. Taylor A, Namba K. In vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH). Immunol Cell Biol. 2001:79:358-367.
25. Namba K, Kitaichi N, Nishida T, et al. Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta2. J Leukocyte Biol. 2002:72:946-952.
26. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2:675-680.
27. Akira S, Hemmi H. Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett. 2003;85:85-95.
28. Akira S. Mammalian toll-like receptors. Curr Opin Immunol. 2003;15:5-11.
29. Schnare M, Barton GM, Holt AC, et al. Toll-like receptors control activation of adaptive immune responses. Nat Immunol. 2001;2: 947-950.
30. Qi H, Denning TL, Soong L. Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T-cell cytokine profiles. Infect Immun. 2003;71:3337-3342.
31. Triantafilou M, Triantafilou K. Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol. 2002;23: 301-304.
32. Re F, Strominger JL. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem. 2001; 276:37692-37699.
33. Taylor AW, Streilein JW, Cousins SW. Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. Neuroimmunomodulation. 1994; 1:188-194.
34. Streilein JW, Masli S, Takeuchi M, et al. The eye's view of antigen presentation. Hum Immunol. 2002; 63:435-443.
35. Wilbanks GA, Streilein JW Fluids from immune privileged sites endow macrophages with the capacity to induce antigen-specific immune deviation via a mechanism involving transforming growth factor-beta. Eur J Immunol. 1992;22:1031-1036.
36. Takeuchi M, Alard P, Verbik D, et al. Anterior chamber-associated immune deviation-inducing cells activate T cells, and rescue them from antigen-induced apoptosis. Immunology. 1999;98:576-583.
37. Masli S, Turpie B, Hecker KH, et al. Expression of thrombospondin in TGFbeta-treated APCs and its relevance to their immune deviation-promoting properties. J Immunol. 2002;168:2264-2273.
38. Liu Y, Dana MR, Tewari V, et al. Immune response to intragraft antigen in draining lymph nodes after corneal transplantation is mediated by interleukin-12. J Interferon Cytokine Res. 2001;21: 813-819.
39. Liu Y, Hamrah P, Zhang Q, et al. Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts. J Exp Med. 2002;195:259-268.
40. Perez VL, Biuckians AJ, Streilein JW. In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye. Ocul Immunol Inflamm. 2000;8:9-24.
41. Haynes RJ, McElveen JE, Dua HS, et al. Expression of human beta-defensins in intraocular tissues. Invest Ophthalmol Vis Sci. 2000;41: 3026-3031.
42. Mc NN, Van R, Tuchin OS, et al. Ocular surface epithelia express mRNA for human beta defensin-2. Exp Eye Res. 1999;69:483-490.
43. Lehmann OJ, Hussain IR, Watt PJ. Investigation of beta defensin gene expression in the ocular anterior segment by semiquantitative RT-PCR. Br J Ophthalmol. 2000;84: 523-526.
44. McDermott AM, Redfern RL, Zhang B, et al. Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003;44:1859-1865.
45. Uchio E, Kijima M, Ishioka M, et al. Suppression of actively induced experimental autoimmune uveoretinitis by CD4+ T cells. Graefes Arch Clin Exp Ophthalmol. 1997;235:97-102.
46. Taylor AW, Yee DG, Nishida T, et al. Neuropeptide regulation of immunity. The immunosuppressive activity of alpha-melanocyte-stimulating hormone (alpha-MSH). Ann NY Acad Sci. 2000;917:239-247.