Regulation of Bile Acid Synthesis by the Nuclear Receptor Rev-erbα

Gastroenterology

Volumn 135, Issue 2, 2008, Pages

  Duez, Hélène ^a,b,c   van der Veen, Jelske N ^d   Duhem, Christian ^a,b   Pourcet, Benoît ^a,b,c   Touvier, Thierry ^a,b,c   Fontaine, Coralie ^a,b,c   Derudas, Bruno ^a,b   Baugé, Eric ^a,b   Havinga, Rick ^d   Bloks, Vincent W ^d   Wolters, Henk ^d   van der Sluijs, Fjodor H ^d   Vennström, Björn ^e   Kuipers, Folkert ^d   Staels, Bart ^a,b,c  

^a INSTITUT PASTEUR DE LILLE   (France)

^b INSERM   (France)

^c UNIV LILLE   (France)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; E4BP4 PROTEIN; MESSENGER RNA; REV ERBALPHA PROTEIN; SMALL HETERODIMER PARTNER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; BILE FLOW; CHROMATIN IMMUNOPRECIPITATION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOWN REGULATION; FECES ANALYSIS; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 48549102407     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.05.035     Document Type: Article

References (50)

1. Russell D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72 (2003) 137-174
2. Kuipers F., Stroeve J.H., Caron S., et al. Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. Curr Opin Lipidol 18 (2007) 289-297
3. Sinal C.J., Tohkin M., Miyata M., et al. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102 (2000) 731-744
4. Watanabe M., Houten S.M., Wang L., et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 113 (2004) 1408-1418
5. Angelin B., Eriksson M., and Rudling M. Bile acids and lipoprotein metabolism: a renaissance for bile acids in the post-statin era?. Curr Opin Lipidol 10 (1999) 269-274
6. Kast H.R., Nguyen C.M., Sinal C.J., et al. Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. Mol Endocrinol 15 (2001) 1720-1728
7. Kuipers F., Claudel T., Sturm E., et al. The farnesoid X receptor (FXR) as modulator of bile acid metabolism. Rev Endocr Metab Disord 5 (2004) 319-326
8. Russell D.W., and Setchell K.D. Bile acid biosynthesis. Biochemistry 31 (1992) 4737-4749
9. Inagaki T., Choi M., Moschetta A., et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2 (2005) 217-225
10. Li J., Pircher P.C., Schulman I.G., et al. Regulation of complement C3 expression by the bile acid receptor FXR. J Biol Chem 280 (2005) 7427-7434
11. Lu T.T., Makishima M., Repa J.J., et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 6 (2000) 507-515
12. Goodwin B., Jones S.A., Price R.R., et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6 (2000) 517-526
13. Staudinger J.L., Goodwin B., Jones S.A., et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A 98 (2001) 3369-3374
14. Gupta S., Stravitz R.T., Dent P., et al. Down-regulation of cholesterol 7α-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. J Biol Chem 276 (2001) 15816-15822
15. Wang L., Lee Y.K., Bundman D., et al. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell 2 (2002) 721-731
16. Holt J.A., Luo G., Billin A.N., et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev 17 (2003) 1581-1591
17. Peet D.J., Turley S.D., Ma W., et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR α. Cell 93 (1998) 693-704
18. Hayhurst G.P., Lee Y.H., Lambert G., et al. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21 (2001) 1393-1403
19. Sundseth S.S., and Waxman D.J. Hepatic P-450 cholesterol 7α-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback. J Biol Chem 265 (1990) 15090-15095
20. Kai M., Eto T., Kondo K., et al. Synchronous circadian rhythms of mRNA levels and activities of cholesterol 7α-hydroxylase in the rabbit and rat. J Lipid Res 36 (1995) 367-374
21. Li Y.C., Wang D.P., and Chiang J.Y. Regulation of cholesterol 7α-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7α-hydroxylase mRNA. J Biol Chem 265 (1990) 12012-12019
22. Noshiro M., Nishimoto M., and Okuda K. Rat liver cholesterol 7α-hydroxylase. Pretranslational regulation for circadian rhythm. J Biol Chem 265 (1990) 10036-10041
23. Panda S., Antoch M.P., Miller B.H., et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109 (2002) 307-320
24. Lavery D.J., and Schibler U. Circadian transcription of the cholesterol 7α-hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev 7 (1993) 1871-1884
25. Noshiro M., Kawamoto T., Furukawa M., et al. Rhythmic expression of DEC1 and DEC2 in peripheral tissues:DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP. Genes Cells 9 (2004) 317-329
26. Noshiro M., Usui E., Kawamoto T., et al. Multiple mechanisms regulate circadian expression of the gene for cholesterol 7α-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis. J Biol Rhythms 22 (2007) 299-311
27. Harding H.P., and Lazar M.A. The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat. Mol Cell Biol 15 (1995) 4791-4802
28. Yin L., Wu N., Curtin J.C., et al. Rev-erbα, a heme sensor that coordinates metabolic and circadian pathways. Science 318 (2007) 1786-1789
29. Raghuram S., Stayrook K.R., Huang P., et al. Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ. Nat Struct Mol Biol 14 (2007) 1207-1213
30. Vu-Dac N., Chopin-Delannoy S., Gervois P., et al. The nuclear receptors peroxisome proliferator-activated receptor α and Rev-erbα mediate the species-specific regulation of apolipoprotein A-I expression by fibrates. J Biol Chem 273 (1998) 25713-25720
31. Raspe E., Duez H., Mansen A., et al. Identification of Rev-erbα as a physiological repressor of apoC-III gene transcription. J Lipid Res 43 (2002) 2172-2179
32. Fontaine C., Dubois G., Duguay Y., et al. The orphan nuclear receptor Rev-Erbα is a peroxisome proliferator-activated receptor (PPAR) γ target gene and promotes PPARγ-induced adipocyte differentiation. J Biol Chem 278 (2003) 37672-37680
33. Wang J., and Lazar M.A. Bifunctional role of Rev-erbα in adipocyte differentiation. Mol Cell Biol 28 (2008) 2213-2220
34. Pircher P., Chomez P., Yu F., et al. Aberrant expression of myosin isoforms in skeletal muscles from mice lacking the rev-erbAalpha orphan receptor gene. Am J Physiol Regul Integr Comp Physiol 288 (2005) R482-R490
35. Chomez P., Neveu I., Mansen A., et al. Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(α) orphan receptor. Development 127 (2000) 1489-1498
36. Preitner N., Damiola F., Lopez-Molina L., et al. The orphan nuclear receptor REV-ERBZα controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110 (2002) 251-260
37. Kuipers F., van Ree J.M., Hofker M.H., et al. Altered lipid metabolism in apolipoprotein E-deficient mice does not affect cholesterol balance across the liver. Hepatology 24 (1996) 241-247
38. Mashige F., Imai K., and Osuga T. A simple and sensitive assay of total serum bile acids. Clin Chim Acta 70 (1976) 79-86
39. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37 (1959) 911-917
40. Böttcher C., van Gent C.M., and Pries C. A rapid and sensitive sub-micro phosphorus determination. Anal Chim Acta 24 (1961) 203-204
41. Gamble W., Vaughan M., Kruth H.S., et al. Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells. J Lipid Res 19 (1978) 1068-1070
42. Setchell K.D., Lawson A.M., Tanida N., et al. General methods for the analysis of metabolic profiles of bile acids and related compounds in feces. J Lipid Res 24 (1983) 1085-1100
43. Makishima M., Okamoto A.Y., Repa J.J., et al. Identification of a nuclear receptor for bile acids. Science 284 (1999) 1362-1365
44. Adelmant G., Begue A., Stehelin D., et al. A functional Rev-erbα responsive element located in the human Rev-erbα promoter mediates a repressing activity. Proc Natl Acad Sci U S A 93 (1996) 3553-3558
45. Issemann I., and Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347 (1990) 645-650
46. Claudel T., Sturm E., Duez H., et al. Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. J Clin Invest 109 (2002) 961-971
47. Schwarz M., Lund E.G., Setchell K.D., et al. Disruption of cholesterol 7α-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7α-hydroxylase. J Biol Chem 271 (1996) 18024-18031
48. Kerr T.A., Saeki S., Schneider M., et al. Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell 2 (2002) 713-720
49. Post S.M., Duez H., Gervois P.P., et al. Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-α-mediated down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression. Arterioscler Thromb Vasc Biol 21 (2001) 1840-1845
50. Ueda H.R., Chen W., Adachi A., et al. A transcription factor response element for gene expression during circadian night. Nature 418 (2002) 534-539