메뉴 건너뛰기




Volumn 24, Issue 1, 1996, Pages 241-247

Altered lipid metabolism in apolipoprotein E-deficient mice does not affect cholesterol balance across the liver

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LATHOSTEROL; LIPID; LIVER ENZYME; MESSENGER RNA; PHOSPHOLIPID; STEROL 27 HYDROXYLASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 0029893226     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v24.pm0008707269     Document Type: Article
Times cited : (77)

References (59)
  • 1
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988;240:622-630.
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 2
    • 0020537615 scopus 로고
    • Lipoprotein receptors and cholesterol homeostasis
    • Mahley RW, Innerarity TL. Lipoprotein receptors and cholesterol homeostasis Biochim Biophys Acta 1983;737:197-222.
    • (1983) Biochim Biophys Acta , vol.737 , pp. 197-222
    • Mahley, R.W.1    Innerarity, T.L.2
  • 3
    • 0027990682 scopus 로고
    • Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans
    • Ji Z-S, Fazio S, Lee Y-L, Mahley RW. Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans. J Biol Chem 1994;269:2764-2772.
    • (1994) J Biol Chem , vol.269 , pp. 2764-2772
    • Ji, Z.-S.1    Fazio, S.2    Lee, Y.-L.3    Mahley, R.W.4
  • 4
    • 0022350033 scopus 로고
    • Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
    • Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 1985; 76:1501-1513.
    • (1985) J Clin Invest , vol.76 , pp. 1501-1513
    • Boyles, J.K.1    Pitas, R.E.2    Wilson, E.3    Mahley, R.W.4    Taylor, J.M.5
  • 5
    • 0023280054 scopus 로고
    • Lipoproteins and their receptors in the central nervous system: Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E (LDL) receptors in the brain
    • Pitas RE, Boyles JK, Lee SH, Hui DY, Weisgraber KH. Lipoproteins and their receptors in the central nervous system: characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E (LDL) receptors in the brain. J Biol Chem 1987;262:14352-14360.
    • (1987) J Biol Chem , vol.262 , pp. 14352-14360
    • Pitas, R.E.1    Boyles, J.K.2    Lee, S.H.3    Hui, D.Y.4    Weisgraber, K.H.5
  • 6
    • 0028898620 scopus 로고
    • Effects of apoprotein E on intracellular metabolism of model triglyceride-rich particles are distinct from effects on cell particle uptake
    • Schwiegelshohn B, Presley JF, Gorecki M, Vogel T, Carpentier YA, Maxfield FR, Deckelbaum RJ. Effects of apoprotein E on intracellular metabolism of model triglyceride-rich particles are distinct from effects on cell particle uptake. J Biol Chem 1995;270:1761-1769.
    • (1995) J Biol Chem , vol.270 , pp. 1761-1769
    • Schwiegelshohn, B.1    Presley, J.F.2    Gorecki, M.3    Vogel, T.4    Carpentier, Y.A.5    Maxfield, F.R.6    Deckelbaum, R.J.7
  • 7
    • 0001225364 scopus 로고
    • Type III hyperlipoproteinemia (dysbetalipoproteinemia): The role of apolipoprotein E in normal and abnormal lipoprotein metabolism
    • Scriver CR, Beaudet AL, Sly WS, Valle D, eds. New York: McGraw-Hill
    • Mahley RW, Rall SC Jr. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The metabolic basis of inherited disease. Ed 6. New York: McGraw-Hill, 1989:1195-1213.
    • (1989) The Metabolic Basis of Inherited Disease. Ed 6 , pp. 1195-1213
    • Mahley, R.W.1    Rall Jr., S.C.2
  • 9
    • 0024579909 scopus 로고
    • A young type III hyperlipoproteinemic patient associated with apolipoprotein E deficiency
    • Mabuchi H, Itoh H, Takeda M, Kajinami K, Wakasugi T, Koizumi J, Takeda R, et al. A young type III hyperlipoproteinemic patient associated with apolipoprotein E deficiency. Metabolism 1989;38:115-119.
    • (1989) Metabolism , vol.38 , pp. 115-119
    • Mabuchi, H.1    Itoh, H.2    Takeda, M.3    Kajinami, K.4    Wakasugi, T.5    Koizumi, J.6    Takeda, R.7
  • 10
    • 0023393613 scopus 로고
    • Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype
    • Kesäniemi YA, Ehnholm C, Miettinen TA. Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype. J Clin Invest 1987;80:578-581.
    • (1987) J Clin Invest , vol.80 , pp. 578-581
    • Kesäniemi, Y.A.1    Ehnholm, C.2    Miettinen, T.A.3
  • 11
    • 0025975883 scopus 로고
    • Lathosterol level in plasma is elevated in type III hyperlipoproteinemia, but not in non-type III subjects with apolipoprotein E2/2 phenotype, nor in type IIa or IIb hyperlipoproteinemia
    • 1991
    • Kempen HJM, Gevers Leuven JA, van der Voort HA, de Knijff P, Havekes L. Lathosterol level in plasma is elevated in type III hyperlipoproteinemia, but not in non-type III subjects with apolipoprotein E2/2 phenotype, nor in type IIa or IIb hyperlipoproteinemia. Metabolism 1991;40:231-235, 1991.
    • (1991) Metabolism , vol.40 , pp. 231-235
    • Kempen, H.J.M.1    Gevers Leuven, J.A.2    Van Der Voort, H.A.3    De Knijff, P.4    Havekes, L.5
  • 12
    • 0023639025 scopus 로고
    • Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver
    • Björkhem I, Miettinen TA, Reihner E, Ewerth S, Angelin B, Einarsson K. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. J Lipid Res 1987;28:1137-1143.
    • (1987) J Lipid Res , vol.28 , pp. 1137-1143
    • Björkhem, I.1    Miettinen, T.A.2    Reihner, E.3    Ewerth, S.4    Angelin, B.5    Einarsson, K.6
  • 14
    • 0025261056 scopus 로고
    • Bile acid metabolism in familial dysbetalipoproteinemia: Studies in subjects with the apolipoprotein E-2/2 phenotype
    • Angelin B, Holmquist L, Leijd B, Einarsson K. Bile acid metabolism in familial dysbetalipoproteinemia: studies in subjects with the apolipoprotein E-2/2 phenotype. Eur J Clin Invest 1990;20:143-149.
    • (1990) Eur J Clin Invest , vol.20 , pp. 143-149
    • Angelin, B.1    Holmquist, L.2    Leijd, B.3    Einarsson, K.4
  • 16
    • 0020441532 scopus 로고
    • The hepatobiliary axis and lipoprotein metabolism: Effects of bile acid sequestrants and ileal bypass surgery
    • Packard CJ, Sheperd J. The hepatobiliary axis and lipoprotein metabolism: effects of bile acid sequestrants and ileal bypass surgery. J Lipid Res 1982;23:1081-1098.
    • (1982) J Lipid Res , vol.23 , pp. 1081-1098
    • Packard, C.J.1    Sheperd, J.2
  • 18
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    • Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992;258:468-471.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 19
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • Plump AS, Smith JD, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft JG, Rubin EM, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 1992;71:343-353.
    • (1992) Cell , vol.71 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3    Aalto-Setälä, K.4    Walsh, A.5    Verstuyft, J.G.6    Rubin, E.M.7
  • 20
    • 0025794067 scopus 로고
    • Use of determinations of 7-lathosterol (5-alpha-cholest-7-en-3-beta-ol) and other cholesterol precursors in serum in the study and treatment of disturbances of sterol metabolism, particularly cerebrotendinous xanthomatosis
    • Wolthers BG, Walrecht HT, van der Molen JC, Nagel GT, van Doormaal JJ, Wijnandts PM. Use of determinations of 7-lathosterol (5-alpha-cholest-7-en-3-beta-ol) and other cholesterol precursors in serum in the study and treatment of disturbances of sterol metabolism, particularly cerebrotendinous xanthomatosis. J Lipid Res 1991;32:603-612.
    • (1991) J Lipid Res , vol.32 , pp. 603-612
    • Wolthers, B.G.1    Walrecht, H.T.2    Van Der Molen, J.C.3    Nagel, G.T.4    Van Doormaal, J.J.5    Wijnandts, P.M.6
  • 21
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can Biochem Biophys 1959;37:911-917.
    • (1959) Can Biochem Biophys , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 22
    • 0025327769 scopus 로고
    • Short- and long-term effects of biliary drainage on hepatic cholesterol metabolism in the rat
    • Smit MJ, Temmerman AM, Havinga R, Kuipers F, Vonk RJ. Short- and long-term effects of biliary drainage on hepatic cholesterol metabolism in the rat. Biochem J 1991;269:781-788.
    • (1991) Biochem J , vol.269 , pp. 781-788
    • Smit, M.J.1    Temmerman, A.M.2    Havinga, R.3    Kuipers, F.4    Vonk, R.J.5
  • 23
    • 0023054482 scopus 로고
    • Lipoproteins and liposomes as in vivo cholesterol vehicles in the rat: Preferential use of cholesterol carried by small unilamellar liposomes for the formation of muricholic acids
    • Kuipers F, Spanjer HH, Havinga R, Scherphof GL, Vonk RJ. Lipoproteins and liposomes as in vivo cholesterol vehicles in the rat: preferential use of cholesterol carried by small unilamellar liposomes for the formation of muricholic acids. Biochim Biophys Acta 1986;876:559-566.
    • (1986) Biochim Biophys Acta , vol.876 , pp. 559-566
    • Kuipers, F.1    Spanjer, H.H.2    Havinga, R.3    Scherphof, G.L.4    Vonk, R.J.5
  • 24
    • 0018161396 scopus 로고
    • Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells
    • Gamble W, Vaughan M, Kruth MS, Avignan J. Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells. J Lipid Res 1978;19:1068-1071.
    • (1978) J Lipid Res , vol.19 , pp. 1068-1071
    • Gamble, W.1    Vaughan, M.2    Kruth, M.S.3    Avignan, J.4
  • 25
    • 50549164858 scopus 로고
    • A rapid and sensitive sub-micro phosphorus determination
    • Böttcher CFJ, van Gent CM, Pries C. A rapid and sensitive sub-micro phosphorus determination. Anal Chim Acta 1961;24:203-204.
    • (1961) Anal Chim Acta , vol.24 , pp. 203-204
    • Böttcher, C.F.J.1    Van Gent, C.M.2    Pries, C.3
  • 26
    • 0027457961 scopus 로고
    • Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by bile acids in primary monolayer cultures of rat hepatocytes
    • Twisk J, Lehmann EM, Princen HMG. Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by bile acids in primary monolayer cultures of rat hepatocytes. Biochem J 1993; 290:685-691.
    • (1993) Biochem J , vol.290 , pp. 685-691
    • Twisk, J.1    Lehmann, E.M.2    Princen, H.M.G.3
  • 28
    • 0024394549 scopus 로고
    • Cloning, structure and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme
    • Andersson S, Davis DL, Dahlbäck H, Jörnvall H, Russell DW. Cloning, structure and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem 1989;264:8222-8229.
    • (1989) J Biol Chem , vol.264 , pp. 8222-8229
    • Andersson, S.1    Davis, D.L.2    Dahlbäck, H.3    Jörnvall, H.4    Russell, D.W.5
  • 29
    • 0021141736 scopus 로고
    • Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme a reductase, a glycoprotein of endoplasmic reticulum
    • Chin DW, Gil G, Russell DW, Liscum L, Luskey KL, Basu SK, Okayama H, et al. Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum. Nature 1984;308:613-617.
    • (1984) Nature , vol.308 , pp. 613-617
    • Chin, D.W.1    Gil, G.2    Russell, D.W.3    Liscum, L.4    Luskey, K.L.5    Basu, S.K.6    Okayama, H.7
  • 31
    • 0026002682 scopus 로고
    • Dietary fish oil-induced changes in intrahepatic cholesterol transport and bile acid synthesis in rats
    • Smit MJ, Temmerman AM, Wolters H, Kuipers F, Beynen AC, Vonk RJ. Dietary fish oil-induced changes in intrahepatic cholesterol transport and bile acid synthesis in rats. J Clin Invest 1991;88:943-951.
    • (1991) J Clin Invest , vol.88 , pp. 943-951
    • Smit, M.J.1    Temmerman, A.M.2    Wolters, H.3    Kuipers, F.4    Beynen, A.C.5    Vonk, R.J.6
  • 32
    • 0018396215 scopus 로고
    • Improved methods for the assay and activation of 3-hydroxy-3-methylglutaryl Coenzyme A reductase
    • Philipp BW, Shapiro DJ. Improved methods for the assay and activation of 3-hydroxy-3-methylglutaryl Coenzyme A reductase. J Lipid Res 1979; 20:588-593.
    • (1979) J Lipid Res , vol.20 , pp. 588-593
    • Philipp, B.W.1    Shapiro, D.J.2
  • 33
    • 0019542952 scopus 로고
    • Effect of dispersion of cholesterol in Triton WR-1339 on acyl CoA:cholesterol acyltransferase in rat liver microsomes
    • Billheimer JT, Tavani D, Nes WR. Effect of dispersion of cholesterol in Triton WR-1339 on acyl CoA:cholesterol acyltransferase in rat liver microsomes. Anal Biochem 1981;111:331-335.
    • (1981) Anal Biochem , vol.111 , pp. 331-335
    • Billheimer, J.T.1    Tavani, D.2    Nes, W.R.3
  • 35
    • 0025045782 scopus 로고
    • Potential bile acid precursors in plasma-possible indicators of biosynthetic pathways to cholic and chnodeoxycholic acids in man
    • Axelsson M, Sjövall J. Potential bile acid precursors in plasma-possible indicators of biosynthetic pathways to cholic and chnodeoxycholic acids in man. J Steroid Biochem 1990;36:631-640.
    • (1990) J Steroid Biochem , vol.36 , pp. 631-640
    • Axelsson, M.1    Sjövall, J.2
  • 36
    • 0025845457 scopus 로고
    • Cyclosporine A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis
    • Princen HMG, Meijer P, Wolthers BG, Vonk RJ, Kuipers F. Cyclosporine A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis. Biochem J 1991;275:501-505.
    • (1991) Biochem J , vol.275 , pp. 501-505
    • Princen, H.M.G.1    Meijer, P.2    Wolthers, B.G.3    Vonk, R.J.4    Kuipers, F.5
  • 37
    • 0028850779 scopus 로고
    • Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes
    • Twisk J, de Wit E, Princen HMG. Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes. Biochem J 1995;305:505-511.
    • (1995) Biochem J , vol.305 , pp. 505-511
    • Twisk, J.1    De Wit, E.2    Princen, H.M.G.3
  • 38
    • 0028907388 scopus 로고
    • New insights into the mechanism of bile acid-induced biliary lipid secretion
    • Verkade HJ, Vonk RJ, Kuipers F. New insights into the mechanism of bile acid-induced biliary lipid secretion. HEPATOLOGY 1995;21:1174-1189.
    • (1995) Hepatology , vol.21 , pp. 1174-1189
    • Verkade, H.J.1    Vonk, R.J.2    Kuipers, F.3
  • 41
    • 77956841570 scopus 로고
    • Mechanism of bile acid biosynthesis in mammalian liver
    • Danielsson H, Sjövall J, eds. Amsterdam: Elsevier
    • Björkhem I. Mechanism of bile acid biosynthesis in mammalian liver. In: Danielsson H, Sjövall J, eds. New comprehensive biochemistry. Vol 12. Sterols and Bile Acids. Amsterdam: Elsevier, 1985:231-272.
    • (1985) New Comprehensive Biochemistry. Vol 12. Sterols and Bile Acids , vol.12 , pp. 231-272
    • Björkhem, I.1
  • 42
    • 0023840871 scopus 로고
    • Studies on the link between HMG-CoA reductase and cholesterol 7α-hydroxylase in rat liver
    • Björkhem I, Akerlund JE. Studies on the link between HMG-CoA reductase and cholesterol 7α-hydroxylase in rat liver. J Lipid Res 1988;29:136-143.
    • (1988) J Lipid Res , vol.29 , pp. 136-143
    • Björkhem, I.1    Akerlund, J.E.2
  • 43
    • 0022506757 scopus 로고
    • Effects of mevinolin in rat liver: Evidence for a lack of coupling between synthesis of hydroxymethylglutaryl-CoA-reductase and cholesterol 7α-hydroxylase activity
    • Björkhem I. Effects of mevinolin in rat liver: evidence for a lack of coupling between synthesis of hydroxymethylglutaryl-CoA-reductase and cholesterol 7α-hydroxylase activity. Biochim Biophys Acta 1986;877:43-49.
    • (1986) Biochim Biophys Acta , vol.877 , pp. 43-49
    • Björkhem, I.1
  • 44
    • 0342912311 scopus 로고
    • Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers
    • Singer II, Kawka DW, Kazazis DM, Alberts AW, Chen JS, Huff JW, Ness GC. Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers. Proc Natl Acad Sci U S A 1984;81:5556-5560.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 5556-5560
    • Singer, I.I.1    Kawka, D.W.2    Kazazis, D.M.3    Alberts, A.W.4    Chen, J.S.5    Huff, J.W.6    Ness, G.C.7
  • 45
    • 0023918754 scopus 로고
    • Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin
    • Li AC, Tanaka RD, Callaway K, Fogelman AM, Edwards PA. Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin. J Lipid Res 1988;29:781-796.
    • (1988) J Lipid Res , vol.29 , pp. 781-796
    • Li, A.C.1    Tanaka, R.D.2    Callaway, K.3    Fogelman, A.M.4    Edwards, P.A.5
  • 47
    • 0025847766 scopus 로고
    • Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acid synthesis
    • Ugele B, Kempen HJM, Gebhardt R, Meijer P, Burger HJ, Princen HMG. Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acid synthesis. Biochem J 1991;276:73-77.
    • (1991) Biochem J , vol.276 , pp. 73-77
    • Ugele, B.1    Kempen, H.J.M.2    Gebhardt, R.3    Meijer, P.4    Burger, H.J.5    Princen, H.M.G.6
  • 48
    • 0027363563 scopus 로고
    • Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to complete absence of phospholipid from bile and to liver disease
    • Smit JJM, Schinkel AH, Oude Elferink RPJ, Groen AK, Wagenaar E, van Deemter L, Mol CAAM, et al. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to complete absence of phospholipid from bile and to liver disease. Cell 1993;75:451-462.
    • (1993) Cell , vol.75 , pp. 451-462
    • Smit, J.J.M.1    Schinkel, A.H.2    Oude Elferink, R.P.J.3    Groen, A.K.4    Wagenaar, E.5    Van Deemter, L.6    Mol, C.A.A.M.7
  • 50
    • 0019430146 scopus 로고
    • The contribution of newly synthetized cholesterol to biliary cholesterol in the rat
    • Turley SD, Dietschy JM. The contribution of newly synthetized cholesterol to biliary cholesterol in the rat. J Biol Chem 1981;256:2438-2446.
    • (1981) J Biol Chem , vol.256 , pp. 2438-2446
    • Turley, S.D.1    Dietschy, J.M.2
  • 51
    • 0020700248 scopus 로고
    • Alteration of the degree of biliary cholesterol saturation in the hamster and rat by manipulation of the pools of preformed and newly synthesized cholesterol
    • Turley SD, Spady DK, Dietschy JM. Alteration of the degree of biliary cholesterol saturation in the hamster and rat by manipulation of the pools of preformed and newly synthesized cholesterol. Gastroenterology 1983; 84:253-264.
    • (1983) Gastroenterology , vol.84 , pp. 253-264
    • Turley, S.D.1    Spady, D.K.2    Dietschy, J.M.3
  • 52
    • 0027290832 scopus 로고
    • Changes in biliary lipid secretion during normal development and diurnal cycling in the rat
    • Robins SJ, Fasulo JM, Lessard PD, Patton GM. Changes in biliary lipid secretion during normal development and diurnal cycling in the rat. J Lipid Res 1993;34:1445-1450.
    • (1993) J Lipid Res , vol.34 , pp. 1445-1450
    • Robins, S.J.1    Fasulo, J.M.2    Lessard, P.D.3    Patton, G.M.4
  • 53
    • 0023679756 scopus 로고
    • Simvastatin, a competitive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bile
    • Duane WC, Hunninghake DB, Freeman ML, Pooler PA, Schlasner LA, Gebhard RL. Simvastatin, a competitive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bile. HEPATOLOGY 1988; 8:1147-1150.
    • (1988) Hepatology , vol.8 , pp. 1147-1150
    • Duane, W.C.1    Hunninghake, D.B.2    Freeman, M.L.3    Pooler, P.A.4    Schlasner, L.A.5    Gebhard, R.L.6
  • 54
    • 0025913072 scopus 로고
    • Role of cholesterol synthesis in the regulation of bile acid synthesis and biliary cholesterol secretion in humans
    • Mitchell JC, Stone BG, Logan GM, Duane WC. Role of cholesterol synthesis in the regulation of bile acid synthesis and biliary cholesterol secretion in humans. J Lipid Res 1991;32:1143-1149.
    • (1991) J Lipid Res , vol.32 , pp. 1143-1149
    • Mitchell, J.C.1    Stone, B.G.2    Logan, G.M.3    Duane, W.C.4
  • 55
    • 0024462420 scopus 로고
    • Inappropriate hepatic cholesterol synthesis expands the cellular pool of sterol available for recruitment by bile acids in the rat
    • Bilhartz LE, Spady DK, Dietschy JM. Inappropriate hepatic cholesterol synthesis expands the cellular pool of sterol available for recruitment by bile acids in the rat. J Clin Invest 1989;84:1181-1187.
    • (1989) J Clin Invest , vol.84 , pp. 1181-1187
    • Bilhartz, L.E.1    Spady, D.K.2    Dietschy, J.M.3
  • 56
    • 0022256566 scopus 로고
    • Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism
    • Suckling KE, Stange EF. Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 1985;26:647-671.
    • (1985) J Lipid Res , vol.26 , pp. 647-671
    • Suckling, K.E.1    Stange, E.F.2
  • 57
    • 0027375270 scopus 로고
    • Inefficient degradation of triglyceride-rich lipoprotein by HepG2 cells is due to a retarded transport to the lysosomal compartment
    • Lombardi P, Mulder M, van der Boom H, Frants RR, Havekes LM. Inefficient degradation of triglyceride-rich lipoprotein by HepG2 cells is due to a retarded transport to the lysosomal compartment. J Biol Chem 1993; 268:26113-26119.
    • (1993) J Biol Chem , vol.268 , pp. 26113-26119
    • Lombardi, P.1    Mulder, M.2    Van Der Boom, H.3    Frants, R.R.4    Havekes, L.M.5
  • 58
    • 0026338739 scopus 로고
    • The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targetting of β-VLDL in mouse peritoneal macrophages
    • Tabas I, Myers JN, Innerarity TL, Xu X-X, Arnold K, Boyles J, Maxfield FR. The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targetting of β-VLDL in mouse peritoneal macrophages. J Cell Biol 1991;115:1547-1560.
    • (1991) J Cell Biol , vol.115 , pp. 1547-1560
    • Tabas, I.1    Myers, J.N.2    Innerarity, T.L.3    Xu, X.-X.4    Arnold, K.5    Boyles, J.6    Maxfield, F.R.7
  • 59
    • 0027164253 scopus 로고
    • Dietary cholesterol stimulates hepatic biosynthesis of triglyceride and reduces oxidation of fatty acids in the rat
    • Fungwe TV, Cagen LM, Cook GA, Wilcox HG, Heimberg M. Dietary cholesterol stimulates hepatic biosynthesis of triglyceride and reduces oxidation of fatty acids in the rat. J Lipid Res 1993;34:933-941.
    • (1993) J Lipid Res , vol.34 , pp. 933-941
    • Fungwe, T.V.1    Cagen, L.M.2    Cook, G.A.3    Wilcox, H.G.4    Heimberg, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.