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Volumn 20, Issue 4, 2008, Pages 383-388

Intracellular DNA sensors in immunity

Author keywords

[No Author keywords available]

Indexed keywords

BAFILOMYCIN A1; CATHELICIDIN; CHLOROQUINE; DNA B; DNA VACCINE; DOUBLE STRANDED DNA; INTERFERON; INTERLEUKIN 1BETA; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOTRANSFERASE; SINGLE STRANDED DNA; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 48549091581     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2008.05.009     Document Type: Review
Times cited : (41)

References (49)
  • 1
    • 0343185886 scopus 로고
    • Foreign nucleic acids as the stimulus to make interferon
    • Isaacs A., Cox R.A., and Rotem Z. Foreign nucleic acids as the stimulus to make interferon. Lancet 2 (1963) 113-116
    • (1963) Lancet , vol.2 , pp. 113-116
    • Isaacs, A.1    Cox, R.A.2    Rotem, Z.3
  • 2
    • 0001311171 scopus 로고
    • Inhibition of virus multiplication by foreign nucleic acid
    • Rotem Z., Cox R.A., and Isaacs A. Inhibition of virus multiplication by foreign nucleic acid. Nature 197 (1963) 564-566
    • (1963) Nature , vol.197 , pp. 564-566
    • Rotem, Z.1    Cox, R.A.2    Isaacs, A.3
  • 3
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
    • Tokunaga T., Yamamoto H., Shimada S., Abe H., Fukuda T., Fujisawa Y., Furutani Y., Yano O., Kataoka T., Sudo T., et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Cancer Inst 72 (1984) 955-962
    • (1984) J Natl Cancer Inst , vol.72 , pp. 955-962
    • Tokunaga, T.1    Yamamoto, H.2    Shimada, S.3    Abe, H.4    Fukuda, T.5    Fujisawa, Y.6    Furutani, Y.7    Yano, O.8    Kataoka, T.9    Sudo, T.10
  • 6
    • 0037443644 scopus 로고    scopus 로고
    • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    • Hemmi H., Kaisho T., Takeda K., and Akira S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol 170 (2003) 3059-3064
    • (2003) J Immunol , vol.170 , pp. 3059-3064
    • Hemmi, H.1    Kaisho, T.2    Takeda, K.3    Akira, S.4
  • 9
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson D.B., and Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24 (2006) 93-103
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 10
    • 12344290452 scopus 로고    scopus 로고
    • Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
    • Yoshida H., Okabe Y., Kawane K., Fukuyama H., and Nagata S. Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol 6 (2005) 49-56
    • (2005) Nat Immunol , vol.6 , pp. 49-56
    • Yoshida, H.1    Okabe, Y.2    Kawane, K.3    Fukuyama, H.4    Nagata, S.5
  • 11
  • 12
    • 38949093002 scopus 로고    scopus 로고
    • TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    • This report is the first evidence that DNA vaccine immunogenicity is controlled by the newly identified TLR9-independent, TBK1-mediated innate immune response to dsDNA, and that was independent of DAI, recently identified as a cytosolic sensor for DNA.
    • Ishii K.J., Kawagoe T., Koyama S., Matsui K., Kumar H., Kawai T., Uematsu S., Takeuchi O., Takeshita F., Coban C., et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451 (2008) 725-729. This report is the first evidence that DNA vaccine immunogenicity is controlled by the newly identified TLR9-independent, TBK1-mediated innate immune response to dsDNA, and that was independent of DAI, recently identified as a cytosolic sensor for DNA.
    • (2008) Nature , vol.451 , pp. 725-729
    • Ishii, K.J.1    Kawagoe, T.2    Koyama, S.3    Matsui, K.4    Kumar, H.5    Kawai, T.6    Uematsu, S.7    Takeuchi, O.8    Takeshita, F.9    Coban, C.10
  • 14
    • 41349106548 scopus 로고    scopus 로고
    • TLR9 as a key receptor for the recognition of DNA
    • Kumagai Y., Takeuchi O., and Akira S. TLR9 as a key receptor for the recognition of DNA. Adv Drug Deliv Rev 60 (2008) 795-804
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 795-804
    • Kumagai, Y.1    Takeuchi, O.2    Akira, S.3
  • 15
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda K., Ohba Y., Yanai H., Negishi H., Mizutani T., Takaoka A., Taya C., and Taniguchi T. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1    Ohba, Y.2    Yanai, H.3    Negishi, H.4    Mizutani, T.5    Takaoka, A.6    Taya, C.7    Taniguchi, T.8
  • 16
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • O'Neill L.A., and Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7 (2007) 353-364
    • (2007) Nat Rev Immunol , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 17
  • 19
    • 35348918191 scopus 로고    scopus 로고
    • Structural requirements and applications of inhibitory oligodeoxyribonucleotides
    • Ashman R.F., and Lenert P. Structural requirements and applications of inhibitory oligodeoxyribonucleotides. Immunol Res 39 (2007) 4-14
    • (2007) Immunol Res , vol.39 , pp. 4-14
    • Ashman, R.F.1    Lenert, P.2
  • 20
    • 40249088259 scopus 로고    scopus 로고
    • The DNA sugar backbone 2′ deoxyribose determines toll-like receptor 9 activation
    • This report demonstrated that the sugar-backbone, not the bases of DNA binds to TLR9 and is sufficient as a ligand to act as a 'mild agonist', and that this agonistic activity is further enhanced by the presence of a CpG motif.
    • Haas T., Metzger J., Schmitz F., Heit A., Muller T., Latz E., and Wagner H. The DNA sugar backbone 2′ deoxyribose determines toll-like receptor 9 activation. Immunity 28 (2008) 315-323. This report demonstrated that the sugar-backbone, not the bases of DNA binds to TLR9 and is sufficient as a ligand to act as a 'mild agonist', and that this agonistic activity is further enhanced by the presence of a CpG motif.
    • (2008) Immunity , vol.28 , pp. 315-323
    • Haas, T.1    Metzger, J.2    Schmitz, F.3    Heit, A.4    Muller, T.5    Latz, E.6    Wagner, H.7
  • 21
    • 39349090624 scopus 로고    scopus 로고
    • Nucleic acid recognition receptors in autoimmunity
    • Krug A. Nucleic acid recognition receptors in autoimmunity. Handb Exp Pharmacol 183 (2008) 129-151
    • (2008) Handb Exp Pharmacol , vol.183 , pp. 129-151
    • Krug, A.1
  • 22
    • 34948862264 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    • •] expands the list of factor(s) that can modify the self-nonself moiety of DNA, thereby influencing TLR9-mediated descrimination between microbial (nonself) DNA and host (self) DNA.
    • •] expands the list of factor(s) that can modify the self-nonself moiety of DNA, thereby influencing TLR9-mediated descrimination between microbial (nonself) DNA and host (self) DNA.
    • (2007) Nature , vol.449 , pp. 564-569
    • Lande, R.1    Gregorio, J.2    Facchinetti, V.3    Chatterjee, B.4    Wang, Y.H.5    Homey, B.6    Cao, W.7    Wang, Y.H.8    Su, B.9    Nestle, F.O.10
  • 23
    • 33845284823 scopus 로고    scopus 로고
    • Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis
    • Lee J., Mo J.H., Shen C., Rucker A.N., and Raz E. Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis. Curr Opin Gastroenterol 23 (2007) 27-31
    • (2007) Curr Opin Gastroenterol , vol.23 , pp. 27-31
    • Lee, J.1    Mo, J.H.2    Shen, C.3    Rucker, A.N.4    Raz, E.5
  • 24
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    • Barton G.M., Kagan J.C., and Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol 7 (2006) 49-56
    • (2006) Nat Immunol , vol.7 , pp. 49-56
    • Barton, G.M.1    Kagan, J.C.2    Medzhitov, R.3
  • 25
    • 34247484007 scopus 로고    scopus 로고
    • The interaction between the ER membrane protein UNC93B and TLR3, 7 and 9 is crucial for TLR signaling
    • Brinkmann M.M., Spooner E., Hoebe K., Beutler B., Ploegh H.L., and Kim Y.M. The interaction between the ER membrane protein UNC93B and TLR3, 7 and 9 is crucial for TLR signaling. J Cell Biol 177 (2007) 265-275
    • (2007) J Cell Biol , vol.177 , pp. 265-275
    • Brinkmann, M.M.1    Spooner, E.2    Hoebe, K.3    Beutler, B.4    Ploegh, H.L.5    Kim, Y.M.6
  • 26
    • 40749098665 scopus 로고    scopus 로고
    • UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
    • Kim Y.M., Brinkmann M.M., Paquet M.E., and Ploegh H.L. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452 (2008) 234-238
    • (2008) Nature , vol.452 , pp. 234-238
    • Kim, Y.M.1    Brinkmann, M.M.2    Paquet, M.E.3    Ploegh, H.L.4
  • 28
    • 42949151457 scopus 로고    scopus 로고
    • PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon
    • Watarai H., Sekine E., Inoue S., Nakagawa R., Kaisho T., and Taniguchi M. PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon. Proc Natl Acad Sci U S A 105 (2008) 2993-2998
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2993-2998
    • Watarai, H.1    Sekine, E.2    Inoue, S.3    Nakagawa, R.4    Kaisho, T.5    Taniguchi, M.6
  • 30
    • 34547434301 scopus 로고    scopus 로고
    • Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells
    • Cheng G., Zhong J., Chung J., and Chisari F.V. Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Proc Natl Acad Sci U S A 104 (2007) 9035-9040
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 9035-9040
    • Cheng, G.1    Zhong, J.2    Chung, J.3    Chisari, F.V.4
  • 33
    • 33646592188 scopus 로고    scopus 로고
    • The specific and essential role of MAVS in antiviral innate immune responses
    • Sun Q., Sun L., Liu H.H., Chen X., Seth R.B., Forman J., and Chen Z.J. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24 (2006) 633-642
    • (2006) Immunity , vol.24 , pp. 633-642
    • Sun, Q.1    Sun, L.2    Liu, H.H.3    Chen, X.4    Seth, R.B.5    Forman, J.6    Chen, Z.J.7
  • 36
    • 39149116674 scopus 로고    scopus 로고
    • NLR, the nucleotide-binding domain leucine-rich repeat containing gene family
    • Ye Z., and Ting J.P. NLR, the nucleotide-binding domain leucine-rich repeat containing gene family. Curr Opin Immunol 20 (2008) 3-9
    • (2008) Curr Opin Immunol , vol.20 , pp. 3-9
    • Ye, Z.1    Ting, J.P.2
  • 37
    • 40449097257 scopus 로고    scopus 로고
    • The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    • This report demonstrated that the dsDNA in the cytoplasm activates inflammasome by triggering ASC-dependent caspase-1 activation, resulting in the secretion of IL-1 beta.
    • Muruve D.A., Petrilli V., Zaiss A.K., White L.R., Clark S.A., Ross P.J., Parks R.J., and Tschopp J. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452 (2008) 103-107. This report demonstrated that the dsDNA in the cytoplasm activates inflammasome by triggering ASC-dependent caspase-1 activation, resulting in the secretion of IL-1 beta.
    • (2008) Nature , vol.452 , pp. 103-107
    • Muruve, D.A.1    Petrilli, V.2    Zaiss, A.K.3    White, L.R.4    Clark, S.A.5    Ross, P.J.6    Parks, R.J.7    Tschopp, J.8
  • 42
  • 44
    • 36248988008 scopus 로고    scopus 로고
    • Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    • Yang Y.G., Lindahl T., and Barnes D.E. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131 (2007) 873-886
    • (2007) Cell , vol.131 , pp. 873-886
    • Yang, Y.G.1    Lindahl, T.2    Barnes, D.E.3
  • 47
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • Christensen S.R., Shupe J., Nickerson K., Kashgarian M., Flavell R.A., and Shlomchik M.J. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25 (2006) 417-428
    • (2006) Immunity , vol.25 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 48
    • 35748964708 scopus 로고    scopus 로고
    • Toll-like receptors 7, 8 and 9: linking innate immunity to autoimmunity
    • Krieg A.M., and Vollmer J. Toll-like receptors 7, 8 and 9: linking innate immunity to autoimmunity. Immunol Rev 220 (2007) 251-269
    • (2007) Immunol Rev , vol.220 , pp. 251-269
    • Krieg, A.M.1    Vollmer, J.2
  • 49
    • 34249707811 scopus 로고    scopus 로고
    • TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    • Baccala R., Hoebe K., Kono D.H., Beutler B., and Theofilopoulos A.N. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med 13 (2007) 543-551
    • (2007) Nat Med , vol.13 , pp. 543-551
    • Baccala, R.1    Hoebe, K.2    Kono, D.H.3    Beutler, B.4    Theofilopoulos, A.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.