-
1
-
-
0343185886
-
Foreign nucleic acids as the stimulus to make interferon
-
Isaacs A., Cox R.A., and Rotem Z. Foreign nucleic acids as the stimulus to make interferon. Lancet 2 (1963) 113-116
-
(1963)
Lancet
, vol.2
, pp. 113-116
-
-
Isaacs, A.1
Cox, R.A.2
Rotem, Z.3
-
2
-
-
0001311171
-
Inhibition of virus multiplication by foreign nucleic acid
-
Rotem Z., Cox R.A., and Isaacs A. Inhibition of virus multiplication by foreign nucleic acid. Nature 197 (1963) 564-566
-
(1963)
Nature
, vol.197
, pp. 564-566
-
-
Rotem, Z.1
Cox, R.A.2
Isaacs, A.3
-
3
-
-
0021256125
-
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
-
Tokunaga T., Yamamoto H., Shimada S., Abe H., Fukuda T., Fujisawa Y., Furutani Y., Yano O., Kataoka T., Sudo T., et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Cancer Inst 72 (1984) 955-962
-
(1984)
J Natl Cancer Inst
, vol.72
, pp. 955-962
-
-
Tokunaga, T.1
Yamamoto, H.2
Shimada, S.3
Abe, H.4
Fukuda, T.5
Fujisawa, Y.6
Furutani, Y.7
Yano, O.8
Kataoka, T.9
Sudo, T.10
-
4
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct B-cell activation
-
Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., Koretzky G.A., and Klinman D.M. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-549
-
(1995)
Nature
, vol.374
, pp. 546-549
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
Waldschmidt, T.J.4
Bishop, G.A.5
Teasdale, R.6
Koretzky, G.A.7
Klinman, D.M.8
-
5
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., et al. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
-
6
-
-
0037443644
-
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
-
Hemmi H., Kaisho T., Takeda K., and Akira S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol 170 (2003) 3059-3064
-
(2003)
J Immunol
, vol.170
, pp. 3059-3064
-
-
Hemmi, H.1
Kaisho, T.2
Takeda, K.3
Akira, S.4
-
7
-
-
0033515098
-
Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
-
Suzuki K., Mori A., Ishii K.J., Saito J., Singer D.S., Klinman D.M., Krause P.R., and Kohn L.D. Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. Proc Natl Acad Sci U S A 96 (1999) 2285-2290
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 2285-2290
-
-
Suzuki, K.1
Mori, A.2
Ishii, K.J.3
Saito, J.4
Singer, D.S.5
Klinman, D.M.6
Krause, P.R.7
Kohn, L.D.8
-
8
-
-
29244471275
-
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
-
Ishii K.J., Coban C., Kato H., Takahashi K., Torii Y., Takeshita F., Ludwig H., Sutter G., Suzuki K., Hemmi H., et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 7 (2006) 40-48
-
(2006)
Nat Immunol
, vol.7
, pp. 40-48
-
-
Ishii, K.J.1
Coban, C.2
Kato, H.3
Takahashi, K.4
Torii, Y.5
Takeshita, F.6
Ludwig, H.7
Sutter, G.8
Suzuki, K.9
Hemmi, H.10
-
9
-
-
30444450839
-
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
-
Stetson D.B., and Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24 (2006) 93-103
-
(2006)
Immunity
, vol.24
, pp. 93-103
-
-
Stetson, D.B.1
Medzhitov, R.2
-
10
-
-
12344290452
-
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
-
Yoshida H., Okabe Y., Kawane K., Fukuyama H., and Nagata S. Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol 6 (2005) 49-56
-
(2005)
Nat Immunol
, vol.6
, pp. 49-56
-
-
Yoshida, H.1
Okabe, Y.2
Kawane, K.3
Fukuyama, H.4
Nagata, S.5
-
11
-
-
33750465224
-
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
-
Kawane K., Ohtani M., Miwa K., Kizawa T., Kanbara Y., Yoshioka Y., Yoshikawa H., and Nagata S. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443 (2006) 998-1002
-
(2006)
Nature
, vol.443
, pp. 998-1002
-
-
Kawane, K.1
Ohtani, M.2
Miwa, K.3
Kizawa, T.4
Kanbara, Y.5
Yoshioka, Y.6
Yoshikawa, H.7
Nagata, S.8
-
12
-
-
38949093002
-
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
-
This report is the first evidence that DNA vaccine immunogenicity is controlled by the newly identified TLR9-independent, TBK1-mediated innate immune response to dsDNA, and that was independent of DAI, recently identified as a cytosolic sensor for DNA.
-
Ishii K.J., Kawagoe T., Koyama S., Matsui K., Kumar H., Kawai T., Uematsu S., Takeuchi O., Takeshita F., Coban C., et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451 (2008) 725-729. This report is the first evidence that DNA vaccine immunogenicity is controlled by the newly identified TLR9-independent, TBK1-mediated innate immune response to dsDNA, and that was independent of DAI, recently identified as a cytosolic sensor for DNA.
-
(2008)
Nature
, vol.451
, pp. 725-729
-
-
Ishii, K.J.1
Kawagoe, T.2
Koyama, S.3
Matsui, K.4
Kumar, H.5
Kawai, T.6
Uematsu, S.7
Takeuchi, O.8
Takeshita, F.9
Coban, C.10
-
13
-
-
34250698370
-
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
-
Latz E., Verma A., Visintin A., Gong M., Sirois C.M., Klein D.C., Monks B.G., McKnight C.J., Lamphier M.S., Duprex W.P., et al. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 8 (2007) 772-779
-
(2007)
Nat Immunol
, vol.8
, pp. 772-779
-
-
Latz, E.1
Verma, A.2
Visintin, A.3
Gong, M.4
Sirois, C.M.5
Klein, D.C.6
Monks, B.G.7
McKnight, C.J.8
Lamphier, M.S.9
Duprex, W.P.10
-
14
-
-
41349106548
-
TLR9 as a key receptor for the recognition of DNA
-
Kumagai Y., Takeuchi O., and Akira S. TLR9 as a key receptor for the recognition of DNA. Adv Drug Deliv Rev 60 (2008) 795-804
-
(2008)
Adv Drug Deliv Rev
, vol.60
, pp. 795-804
-
-
Kumagai, Y.1
Takeuchi, O.2
Akira, S.3
-
15
-
-
17844380477
-
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
-
Honda K., Ohba Y., Yanai H., Negishi H., Mizutani T., Takaoka A., Taya C., and Taniguchi T. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040
-
(2005)
Nature
, vol.434
, pp. 1035-1040
-
-
Honda, K.1
Ohba, Y.2
Yanai, H.3
Negishi, H.4
Mizutani, T.5
Takaoka, A.6
Taya, C.7
Taniguchi, T.8
-
16
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
O'Neill L.A., and Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7 (2007) 353-364
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.1
Bowie, A.G.2
-
17
-
-
33750064259
-
Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program
-
Negishi H., Fujita Y., Yanai H., Sakaguchi S., Ouyang X., Shinohara M., Takayanagi H., Ohba Y., Taniguchi T., and Honda K. Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci U S A 103 (2006) 15136-15141
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 15136-15141
-
-
Negishi, H.1
Fujita, Y.2
Yanai, H.3
Sakaguchi, S.4
Ouyang, X.5
Shinohara, M.6
Takayanagi, H.7
Ohba, Y.8
Taniguchi, T.9
Honda, K.10
-
18
-
-
33947717604
-
Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells
-
Schmitz F., Heit A., Guggemoos S., Krug A., Mages J., Schiemann M., Adler H., Drexler I., Haas T., Lang R., et al. Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells. Eur J Immunol 37 (2007) 315-327
-
(2007)
Eur J Immunol
, vol.37
, pp. 315-327
-
-
Schmitz, F.1
Heit, A.2
Guggemoos, S.3
Krug, A.4
Mages, J.5
Schiemann, M.6
Adler, H.7
Drexler, I.8
Haas, T.9
Lang, R.10
-
19
-
-
35348918191
-
Structural requirements and applications of inhibitory oligodeoxyribonucleotides
-
Ashman R.F., and Lenert P. Structural requirements and applications of inhibitory oligodeoxyribonucleotides. Immunol Res 39 (2007) 4-14
-
(2007)
Immunol Res
, vol.39
, pp. 4-14
-
-
Ashman, R.F.1
Lenert, P.2
-
20
-
-
40249088259
-
The DNA sugar backbone 2′ deoxyribose determines toll-like receptor 9 activation
-
This report demonstrated that the sugar-backbone, not the bases of DNA binds to TLR9 and is sufficient as a ligand to act as a 'mild agonist', and that this agonistic activity is further enhanced by the presence of a CpG motif.
-
Haas T., Metzger J., Schmitz F., Heit A., Muller T., Latz E., and Wagner H. The DNA sugar backbone 2′ deoxyribose determines toll-like receptor 9 activation. Immunity 28 (2008) 315-323. This report demonstrated that the sugar-backbone, not the bases of DNA binds to TLR9 and is sufficient as a ligand to act as a 'mild agonist', and that this agonistic activity is further enhanced by the presence of a CpG motif.
-
(2008)
Immunity
, vol.28
, pp. 315-323
-
-
Haas, T.1
Metzger, J.2
Schmitz, F.3
Heit, A.4
Muller, T.5
Latz, E.6
Wagner, H.7
-
21
-
-
39349090624
-
Nucleic acid recognition receptors in autoimmunity
-
Krug A. Nucleic acid recognition receptors in autoimmunity. Handb Exp Pharmacol 183 (2008) 129-151
-
(2008)
Handb Exp Pharmacol
, vol.183
, pp. 129-151
-
-
Krug, A.1
-
22
-
-
34948862264
-
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
-
•] expands the list of factor(s) that can modify the self-nonself moiety of DNA, thereby influencing TLR9-mediated descrimination between microbial (nonself) DNA and host (self) DNA.
-
•] expands the list of factor(s) that can modify the self-nonself moiety of DNA, thereby influencing TLR9-mediated descrimination between microbial (nonself) DNA and host (self) DNA.
-
(2007)
Nature
, vol.449
, pp. 564-569
-
-
Lande, R.1
Gregorio, J.2
Facchinetti, V.3
Chatterjee, B.4
Wang, Y.H.5
Homey, B.6
Cao, W.7
Wang, Y.H.8
Su, B.9
Nestle, F.O.10
-
23
-
-
33845284823
-
Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis
-
Lee J., Mo J.H., Shen C., Rucker A.N., and Raz E. Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis. Curr Opin Gastroenterol 23 (2007) 27-31
-
(2007)
Curr Opin Gastroenterol
, vol.23
, pp. 27-31
-
-
Lee, J.1
Mo, J.H.2
Shen, C.3
Rucker, A.N.4
Raz, E.5
-
24
-
-
29244450802
-
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
-
Barton G.M., Kagan J.C., and Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol 7 (2006) 49-56
-
(2006)
Nat Immunol
, vol.7
, pp. 49-56
-
-
Barton, G.M.1
Kagan, J.C.2
Medzhitov, R.3
-
25
-
-
34247484007
-
The interaction between the ER membrane protein UNC93B and TLR3, 7 and 9 is crucial for TLR signaling
-
Brinkmann M.M., Spooner E., Hoebe K., Beutler B., Ploegh H.L., and Kim Y.M. The interaction between the ER membrane protein UNC93B and TLR3, 7 and 9 is crucial for TLR signaling. J Cell Biol 177 (2007) 265-275
-
(2007)
J Cell Biol
, vol.177
, pp. 265-275
-
-
Brinkmann, M.M.1
Spooner, E.2
Hoebe, K.3
Beutler, B.4
Ploegh, H.L.5
Kim, Y.M.6
-
26
-
-
40749098665
-
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
-
Kim Y.M., Brinkmann M.M., Paquet M.E., and Ploegh H.L. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452 (2008) 234-238
-
(2008)
Nature
, vol.452
, pp. 234-238
-
-
Kim, Y.M.1
Brinkmann, M.M.2
Paquet, M.E.3
Ploegh, H.L.4
-
27
-
-
34247236200
-
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
-
•].
-
•].
-
(2007)
Nat Immunol
, vol.8
, pp. 487-496
-
-
Tian, J.1
Avalos, A.M.2
Mao, S.Y.3
Chen, B.4
Senthil, K.5
Wu, H.6
Parroche, P.7
Drabic, S.8
Golenbock, D.9
Sirois, C.10
-
28
-
-
42949151457
-
PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon
-
Watarai H., Sekine E., Inoue S., Nakagawa R., Kaisho T., and Taniguchi M. PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon. Proc Natl Acad Sci U S A 105 (2008) 2993-2998
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2993-2998
-
-
Watarai, H.1
Sekine, E.2
Inoue, S.3
Nakagawa, R.4
Kaisho, T.5
Taniguchi, M.6
-
29
-
-
38849127573
-
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis
-
Asagiri M., Hirai T., Kunigami T., Kamano S., Gober H.J., Okamoto K., Nishikawa K., Latz E., Golenbock D.T., Aoki K., et al. Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science 319 (2008) 624-627
-
(2008)
Science
, vol.319
, pp. 624-627
-
-
Asagiri, M.1
Hirai, T.2
Kunigami, T.3
Kamano, S.4
Gober, H.J.5
Okamoto, K.6
Nishikawa, K.7
Latz, E.8
Golenbock, D.T.9
Aoki, K.10
-
30
-
-
34547434301
-
Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells
-
Cheng G., Zhong J., Chung J., and Chisari F.V. Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Proc Natl Acad Sci U S A 104 (2007) 9035-9040
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 9035-9040
-
-
Cheng, G.1
Zhong, J.2
Chung, J.3
Chisari, F.V.4
-
31
-
-
33845986012
-
Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication
-
Opitz B., Vinzing M., van Laak V., Schmeck B., Heine G., Gunther S., Preissner R., Slevogt H., N'Guessan P.D., Eitel J., et al. Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. J Biol Chem 281 (2006) 36173-36179
-
(2006)
J Biol Chem
, vol.281
, pp. 36173-36179
-
-
Opitz, B.1
Vinzing, M.2
van Laak, V.3
Schmeck, B.4
Heine, G.5
Gunther, S.6
Preissner, R.7
Slevogt, H.8
N'Guessan, P.D.9
Eitel, J.10
-
32
-
-
33745814424
-
Essential role of IPS-1 in innate immune responses against RNA viruses
-
Kumar H., Kawai T., Kato H., Sato S., Takahashi K., Coban C., Yamamoto M., Uematsu S., Ishii K.J., Takeuchi O., et al. Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med 203 (2006) 1795-1803
-
(2006)
J Exp Med
, vol.203
, pp. 1795-1803
-
-
Kumar, H.1
Kawai, T.2
Kato, H.3
Sato, S.4
Takahashi, K.5
Coban, C.6
Yamamoto, M.7
Uematsu, S.8
Ishii, K.J.9
Takeuchi, O.10
-
33
-
-
33646592188
-
The specific and essential role of MAVS in antiviral innate immune responses
-
Sun Q., Sun L., Liu H.H., Chen X., Seth R.B., Forman J., and Chen Z.J. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24 (2006) 633-642
-
(2006)
Immunity
, vol.24
, pp. 633-642
-
-
Sun, Q.1
Sun, L.2
Liu, H.H.3
Chen, X.4
Seth, R.B.5
Forman, J.6
Chen, Z.J.7
-
34
-
-
34547143110
-
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Takaoka A., Wang Z., Choi M.K., Yanai H., Negishi H., Ban T., Lu Y., Miyagishi M., Kodama T., Honda K., et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448 (2007) 501-505
-
(2007)
Nature
, vol.448
, pp. 501-505
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
Yanai, H.4
Negishi, H.5
Ban, T.6
Lu, Y.7
Miyagishi, M.8
Kodama, T.9
Honda, K.10
-
35
-
-
44449157593
-
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
-
Wang Z., Choi M.K., Ban T., Yanai H., Negishi H., Lu Y., Tamura T., Takaoka A., Nishikura K., and Taniguchi T. Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci U S A 105 (2008) 5477-5482
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 5477-5482
-
-
Wang, Z.1
Choi, M.K.2
Ban, T.3
Yanai, H.4
Negishi, H.5
Lu, Y.6
Tamura, T.7
Takaoka, A.8
Nishikura, K.9
Taniguchi, T.10
-
36
-
-
39149116674
-
NLR, the nucleotide-binding domain leucine-rich repeat containing gene family
-
Ye Z., and Ting J.P. NLR, the nucleotide-binding domain leucine-rich repeat containing gene family. Curr Opin Immunol 20 (2008) 3-9
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 3-9
-
-
Ye, Z.1
Ting, J.P.2
-
37
-
-
40449097257
-
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
-
This report demonstrated that the dsDNA in the cytoplasm activates inflammasome by triggering ASC-dependent caspase-1 activation, resulting in the secretion of IL-1 beta.
-
Muruve D.A., Petrilli V., Zaiss A.K., White L.R., Clark S.A., Ross P.J., Parks R.J., and Tschopp J. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452 (2008) 103-107. This report demonstrated that the dsDNA in the cytoplasm activates inflammasome by triggering ASC-dependent caspase-1 activation, resulting in the secretion of IL-1 beta.
-
(2008)
Nature
, vol.452
, pp. 103-107
-
-
Muruve, D.A.1
Petrilli, V.2
Zaiss, A.K.3
White, L.R.4
Clark, S.A.5
Ross, P.J.6
Parks, R.J.7
Tschopp, J.8
-
38
-
-
34548031870
-
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
-
Fernandes-Alnemri T., Wu J., Yu J.W., Datta P., Miller B., Jankowski W., Rosenberg S., Zhang J., and Alnemri E.S. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 14 (2007) 1590-1604
-
(2007)
Cell Death Differ
, vol.14
, pp. 1590-1604
-
-
Fernandes-Alnemri, T.1
Wu, J.2
Yu, J.W.3
Datta, P.4
Miller, B.5
Jankowski, W.6
Rosenberg, S.7
Zhang, J.8
Alnemri, E.S.9
-
39
-
-
35348934890
-
Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants
-
Yu J.W., Fernandes-Alnemri T., Datta P., Wu J., Juliana C., Solorzano L., McCormick M., Zhang Z., and Alnemri E.S. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol Cell 28 (2007) 214-227
-
(2007)
Mol Cell
, vol.28
, pp. 214-227
-
-
Yu, J.W.1
Fernandes-Alnemri, T.2
Datta, P.3
Wu, J.4
Juliana, C.5
Solorzano, L.6
McCormick, M.7
Zhang, Z.8
Alnemri, E.S.9
-
40
-
-
0034114882
-
Features of systemic lupus erythematosus in Dnase1-deficient mice
-
Napirei M., Karsunky H., Zevnik B., Stephan H., Mannherz H.G., and Moroy T. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat Genet 25 (2000) 177-181
-
(2000)
Nat Genet
, vol.25
, pp. 177-181
-
-
Napirei, M.1
Karsunky, H.2
Zevnik, B.3
Stephan, H.4
Mannherz, H.G.5
Moroy, T.6
-
41
-
-
0034939627
-
Mutation of DNASE1 in people with systemic lupus erythematosus
-
Yasutomo K., Horiuchi T., Kagami S., Tsukamoto H., Hashimura C., Urushihara M., and Kuroda Y. Mutation of DNASE1 in people with systemic lupus erythematosus. Nat Genet 28 (2001) 313-314
-
(2001)
Nat Genet
, vol.28
, pp. 313-314
-
-
Yasutomo, K.1
Horiuchi, T.2
Kagami, S.3
Tsukamoto, H.4
Hashimura, C.5
Urushihara, M.6
Kuroda, Y.7
-
42
-
-
3242672339
-
Gene-targeted mice lacking the Trex1 (DNase III) 3′ → 5′ DNA exonuclease develop inflammatory myocarditis
-
Morita M., Stamp G., Robins P., Dulic A., Rosewell I., Hrivnak G., Daly G., Lindahl T., and Barnes D.E. Gene-targeted mice lacking the Trex1 (DNase III) 3′ → 5′ DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol 24 (2004) 6719-6727
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6719-6727
-
-
Morita, M.1
Stamp, G.2
Robins, P.3
Dulic, A.4
Rosewell, I.5
Hrivnak, G.6
Daly, G.7
Lindahl, T.8
Barnes, D.E.9
-
43
-
-
34548327158
-
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus
-
Lee-Kirsch M.A., Gong M., Chowdhury D., Senenko L., Engel K., Lee Y.A., de Silva U., Bailey S.L., Witte T., Vyse T.J., et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet 39 (2007) 1065-1067
-
(2007)
Nat Genet
, vol.39
, pp. 1065-1067
-
-
Lee-Kirsch, M.A.1
Gong, M.2
Chowdhury, D.3
Senenko, L.4
Engel, K.5
Lee, Y.A.6
de Silva, U.7
Bailey, S.L.8
Witte, T.9
Vyse, T.J.10
-
44
-
-
36248988008
-
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
-
Yang Y.G., Lindahl T., and Barnes D.E. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131 (2007) 873-886
-
(2007)
Cell
, vol.131
, pp. 873-886
-
-
Yang, Y.G.1
Lindahl, T.2
Barnes, D.E.3
-
45
-
-
34447132813
-
Fen1 mutations result in autoimmunity, chronic inflammation and cancers
-
Zheng L., Dai H., Zhou M., Li M., Singh P., Qiu J., Tsark W., Huang Q., Kernstine K., Zhang X., et al. Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat Med 13 (2007) 812-819
-
(2007)
Nat Med
, vol.13
, pp. 812-819
-
-
Zheng, L.1
Dai, H.2
Zhou, M.3
Li, M.4
Singh, P.5
Qiu, J.6
Tsark, W.7
Huang, Q.8
Kernstine, K.9
Zhang, X.10
-
46
-
-
22944490869
-
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
-
Christensen S.R., Kashgarian M., Alexopoulou L., Flavell R.A., Akira S., and Shlomchik M.J. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 202 (2005) 321-331
-
(2005)
J Exp Med
, vol.202
, pp. 321-331
-
-
Christensen, S.R.1
Kashgarian, M.2
Alexopoulou, L.3
Flavell, R.A.4
Akira, S.5
Shlomchik, M.J.6
-
47
-
-
33748472865
-
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
-
Christensen S.R., Shupe J., Nickerson K., Kashgarian M., Flavell R.A., and Shlomchik M.J. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25 (2006) 417-428
-
(2006)
Immunity
, vol.25
, pp. 417-428
-
-
Christensen, S.R.1
Shupe, J.2
Nickerson, K.3
Kashgarian, M.4
Flavell, R.A.5
Shlomchik, M.J.6
-
48
-
-
35748964708
-
Toll-like receptors 7, 8 and 9: linking innate immunity to autoimmunity
-
Krieg A.M., and Vollmer J. Toll-like receptors 7, 8 and 9: linking innate immunity to autoimmunity. Immunol Rev 220 (2007) 251-269
-
(2007)
Immunol Rev
, vol.220
, pp. 251-269
-
-
Krieg, A.M.1
Vollmer, J.2
-
49
-
-
34249707811
-
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
-
Baccala R., Hoebe K., Kono D.H., Beutler B., and Theofilopoulos A.N. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med 13 (2007) 543-551
-
(2007)
Nat Med
, vol.13
, pp. 543-551
-
-
Baccala, R.1
Hoebe, K.2
Kono, D.H.3
Beutler, B.4
Theofilopoulos, A.N.5
|