-
1
-
-
0001359591
-
Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
-
Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 1990;2:279-89.
-
(1990)
Plant Cell
, vol.2
, pp. 279-289
-
-
Napoli, C.1
Lemieux, C.2
Jorgensen, R.3
-
2
-
-
0026441194
-
Quelling: Transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences
-
Romano N, Macino G. Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences. Mol Microbiol 1992;6:3343-53.
-
(1992)
Mol Microbiol
, vol.6
, pp. 3343-3353
-
-
Romano, N.1
Macino, G.2
-
3
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-11.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
4
-
-
0035942736
-
Duplexes of 21-nucleotide RNA5 mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNA5 mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
5
-
-
0034877670
-
RNA interference: Listening to the sound of silence
-
Zamore PD. RNA interference: listening to the sound of silence. Nat Struct Biol 2001;8:746-50.
-
(2001)
Nat Struct Biol
, vol.8
, pp. 746-750
-
-
Zamore, P.D.1
-
6
-
-
0035795428
-
RNA Interference and Small Interfering RNAs. Chembiochem Europ
-
Tuschl T. RNA Interference and Small Interfering RNAs. Chembiochem Europ J Chem Biol 2001;2:239-45.
-
(2001)
J Chem Biol
, vol.2
, pp. 239-245
-
-
Tuschl, T.1
-
7
-
-
0037062951
-
RNA interference
-
Hannon GJ. RNA interference. Nature 2002;418:244-51.
-
(2002)
Nature
, vol.418
, pp. 244-251
-
-
Hannon, G.J.1
-
8
-
-
0346848758
-
RNA Interference: Biology, Mechanism, and Applications
-
Agrawal N, Dasaradhi PVN, Mohmmed A, Malhotra P, Bhatnagar RK, Mukherjee SK. RNA Interference: Biology, Mechanism, and Applications. Microbiol Mol Biol Rev 2003;67:657-85.
-
(2003)
Microbiol Mol Biol Rev
, vol.67
, pp. 657-685
-
-
Agrawal, N.1
Dasaradhi, P.V.N.2
Mohmmed, A.3
Malhotra, P.4
Bhatnagar, R.K.5
Mukherjee, S.K.6
-
9
-
-
0035859929
-
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
-
Caplen NJ, Parrish S, Imani F, Fire A, Morgan RA. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci U S A 2001;98:9742-7.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 9742-9747
-
-
Caplen, N.J.1
Parrish, S.2
Imani, F.3
Fire, A.4
Morgan, R.A.5
-
10
-
-
11244328982
-
RNA interference and the use of small interfering RNA to study gene function in mammalian systems
-
Bantounas I, Phylactou LA, Uney JB. RNA interference and the use of small interfering RNA to study gene function in mammalian systems. J Mol Endocrinol 2004;33:545-57.
-
(2004)
J Mol Endocrinol
, vol.33
, pp. 545-557
-
-
Bantounas, I.1
Phylactou, L.A.2
Uney, J.B.3
-
11
-
-
0037019339
-
Gene expression: RNA interference in adult mice
-
McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. Gene expression: RNA interference in adult mice. Nature 2002;418:38-9.
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
Meuse, L.2
Pham, T.T.3
Conklin, D.S.4
Hannon, G.J.5
Kay, M.A.6
-
12
-
-
0037804642
-
Whither RNAi?
-
Anonymous
-
Anonymous. Whither RNAi? Nat Cell Biol 2003;5:489-90.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 489-490
-
-
-
13
-
-
11344255740
-
Defining and assaying RNAi in mammalian cells
-
Huppi K, Martin SE, Caplen NJ. Defining and assaying RNAi in mammalian cells. Mol Cell 2004;17:1-10.
-
(2004)
Mol Cell
, vol.17
, pp. 1-10
-
-
Huppi, K.1
Martin, S.E.2
Caplen, N.J.3
-
14
-
-
10744225153
-
Unexpected Asymmetry in the assembly of the RNAi Enzyme Complex
-
Schwarz DS, Hutvagner G, Du T, Xu Z, Aronin N, Zamore PD. Unexpected Asymmetry in the assembly of the RNAi Enzyme Complex. Cell 2003;115:199-208.
-
(2003)
Cell
, vol.115
, pp. 199-208
-
-
Schwarz, D.S.1
Hutvagner, G.2
Du, T.3
Xu, Z.4
Aronin, N.5
Zamore, P.D.6
-
15
-
-
0142165224
-
-
Khvorova A, Reynolds A, Jayasena S. Functional siRNAs and miRNAs exhibit strand bias. Cell 2003;115:209-16. 16 Reynolds A, Leake D, Scaringe S, Marshall WS, Boese Q, Khvorova A. Rational siRNA design for RNA interference. Nat Biotech 2004;22:326-30.
-
Khvorova A, Reynolds A, Jayasena S. Functional siRNAs and miRNAs exhibit strand bias. Cell 2003;115:209-16. 16 Reynolds A, Leake D, Scaringe S, Marshall WS, Boese Q, Khvorova A. Rational siRNA design for RNA interference. Nat Biotech 2004;22:326-30.
-
-
-
-
16
-
-
1642273831
-
An algorithm for selection of functional siRNA sequences
-
Amarzguioui M, Prydz H. An algorithm for selection of functional siRNA sequences. Biochem Biophys Res Commun 2004;316:1050-8.
-
(2004)
Biochem Biophys Res Commun
, vol.316
, pp. 1050-1058
-
-
Amarzguioui, M.1
Prydz, H.2
-
17
-
-
1642346273
-
Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference
-
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A et al. Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res 2004;32:936-48.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 936-948
-
-
Ui-Tei, K.1
Naito, Y.2
Takahashi, F.3
Haraguchi, T.4
Ohki-Hamazaki, H.5
Juni, A.6
-
18
-
-
0038798081
-
Genome-wide view of gene silencing by small interfering RNAs
-
Chi J-T, Chang HY, Wang NN, Chang DS, Dunphy N, Brown PO. Genome-wide view of gene silencing by small interfering RNAs. Proc Natl Acad Sci U S A 2003;100:6343-6.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 6343-6346
-
-
Chi, J.-T.1
Chang, H.Y.2
Wang, N.N.3
Chang, D.S.4
Dunphy, N.5
Brown, P.O.6
-
19
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotech 2003;21:635-7.
-
(2003)
Nat Biotech
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
Kobayashi, S.V.4
Burchard, J.5
Mao, M.6
-
20
-
-
4744373229
-
Noise amidst the silence: Off-target effects of siRNAs?
-
Jackson AL, Linsley PS. Noise amidst the silence: off-target effects of siRNAs? Trends Genet 2004;20:521-4.
-
(2004)
Trends Genet
, vol.20
, pp. 521-524
-
-
Jackson, A.L.1
Linsley, P.S.2
-
21
-
-
33745608078
-
Off-target effects by siRNA can induce toxic phenotype
-
Fedorov Y, Anderson EM, Birmingham A, Reynolds A, Karpilow J, Robinson K et al. Off-target effects by siRNA can induce toxic phenotype. RNA 2006;12:1188-96.
-
(2006)
RNA
, vol.12
, pp. 1188-1196
-
-
Fedorov, Y.1
Anderson, E.M.2
Birmingham, A.3
Reynolds, A.4
Karpilow, J.5
Robinson, K.6
-
22
-
-
0142173075
-
Small RNAs with imperfect match to endogenous mRNA repress translation: Implications for off-target activity of small inhibitory RNA in mammalian cells
-
Saxena S, Jónsson ZO, Dutta A. Small RNAs with imperfect match to endogenous mRNA repress translation: implications for off-target activity of small inhibitory RNA in mammalian cells. J Biol Chem 2003;278:44312-9.
-
(2003)
J Biol Chem
, vol.278
, pp. 44312-44319
-
-
Saxena, S.1
Jónsson, Z.O.2
Dutta, A.3
-
23
-
-
0347623204
-
Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
-
Persengiev SP, Zhu X, Green MR. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA 2004;10:12-8.
-
(2004)
RNA
, vol.10
, pp. 12-18
-
-
Persengiev, S.P.1
Zhu, X.2
Green, M.R.3
-
24
-
-
0038121109
-
Specificity of short interfering RNA determined through gene expression signatures
-
Semizarov D, Frost L, Sarthy A, Kroeger P, Halbert DN, Fesik SW. Specificity of short interfering RNA determined through gene expression signatures. Proc Natl Acad Sci U S A 2003;100:6347-52.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 6347-6352
-
-
Semizarov, D.1
Frost, L.2
Sarthy, A.3
Kroeger, P.4
Halbert, D.N.5
Fesik, S.W.6
-
25
-
-
10744219688
-
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells
-
Scacheri PC, Rozenblatt-Rosen O, Caplen NJ, Wolfsberg TG, Umayam L, Lee JC et al. Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A 2004;101:1892-7.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 1892-1897
-
-
Scacheri, P.C.1
Rozenblatt-Rosen, O.2
Caplen, N.J.3
Wolfsberg, T.G.4
Umayam, L.5
Lee, J.C.6
-
26
-
-
17844387370
-
A computational study of off-target effects of RNA interference
-
Qiu S, Adema CM, Lane T. A computational study of off-target effects of RNA interference. Nucleic Acids Res 2005;33:1834-47.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 1834-1847
-
-
Qiu, S.1
Adema, C.M.2
Lane, T.3
-
27
-
-
23344438420
-
siRNA-mediated off-target gene silencing triggered by a 7 nt complementation
-
Lin X, Ruan X, Anderson MG, McDowell JA, Kroeger PE, Fesik SW et al. siRNA-mediated off-target gene silencing triggered by a 7 nt complementation. Nucleic Acids Res 2005;33:4527-35.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 4527-4535
-
-
Lin, X.1
Ruan, X.2
Anderson, M.G.3
McDowell, J.A.4
Kroeger, P.E.5
Fesik, S.W.6
-
28
-
-
23144436831
-
dsCheck: Highly sensitive off-target search software for double-stranded RNA-mediated RNA interference
-
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S. dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference. Nucleic Acids Res 2005;33:W589-91.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Naito, Y.1
Yamada, T.2
Matsumiya, T.3
Ui-Tei, K.4
Saigo, K.5
Morishita, S.6
-
29
-
-
33646188259
-
3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets
-
Birmingham A, Anderson EM, Reynolds A, Ilsley-Tyree D, Leake D, Fedorov Y et al. 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat Meth 2006;3:199-204.
-
(2006)
Nat Meth
, vol.3
, pp. 199-204
-
-
Birmingham, A.1
Anderson, E.M.2
Reynolds, A.3
Ilsley-Tyree, D.4
Leake, D.5
Fedorov, Y.6
-
30
-
-
48349100076
-
Position-specific chemical modification increases specificity of siRNA-mediated gene silencing
-
Jackson AL, Burchard J, Leake D, Reynolds A, Schelter J, Guo J et al. Position-specific chemical modification increases specificity of siRNA-mediated gene silencing. RNA 2006;12:1188-96.
-
(2006)
RNA
, vol.12
, pp. 1188-1196
-
-
Jackson, A.L.1
Burchard, J.2
Leake, D.3
Reynolds, A.4
Schelter, J.5
Guo, J.6
-
31
-
-
42449152837
-
Experimental validation of the importance of seed complement frequency to siRNA specificity
-
Anderson EM, Birmingham A, Baskerville S, Reynolds A, Maksimova F, Leake D et al. Experimental validation of the importance of seed complement frequency to siRNA specificity. RNA 2008;14:853-61.
-
(2008)
RNA
, vol.14
, pp. 853-861
-
-
Anderson, E.M.1
Birmingham, A.2
Baskerville, S.3
Reynolds, A.4
Maksimova, F.5
Leake, D.6
-
32
-
-
24144465745
-
Cloning of short hairpin RNAs for gene knockdown in mammalian cells
-
Paddison PJ, Cleary M, Silva JM, Chang K, Sheth N, Sachidanandam R et al. Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Meth 2004;1:163-7.
-
(2004)
Nat Meth
, vol.1
, pp. 163-167
-
-
Paddison, P.J.1
Cleary, M.2
Silva, J.M.3
Chang, K.4
Sheth, N.5
Sachidanandam, R.6
-
33
-
-
27644436787
-
Second-generation shRNA libraries covering the mouse and human genomes
-
Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ et al. Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet 2005;37:1281-8.
-
(2005)
Nat Genet
, vol.37
, pp. 1281-1288
-
-
Silva, J.M.1
Li, M.Z.2
Chang, K.3
Ge, W.4
Golding, M.C.5
Rickles, R.J.6
-
34
-
-
24944560377
-
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
-
Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A 2005;102:13212-7.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 13212-13217
-
-
Stegmeier, F.1
Hu, G.2
Rickles, R.J.3
Hannon, G.J.4
Elledge, S.J.5
-
35
-
-
38849192515
-
Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening
-
Silva JM, Marran K, Parker JS, Silva J, Golding M, Schlabach MR et al. Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening. Science 2008;319:617-20.
-
(2008)
Science
, vol.319
, pp. 617-620
-
-
Silva, J.M.1
Marran, K.2
Parker, J.S.3
Silva, J.4
Golding, M.5
Schlabach, M.R.6
-
36
-
-
35548953686
-
An elaborate pathway required for Ras-mediated epigenetic silencing
-
Gazin C, Wajapeyee N, Gobeil S, Virbasius CM, Green MR. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 2007;449:1073-7.
-
(2007)
Nature
, vol.449
, pp. 1073-1077
-
-
Gazin, C.1
Wajapeyee, N.2
Gobeil, S.3
Virbasius, C.M.4
Green, M.R.5
-
37
-
-
38849098442
-
Cancer Proliferation Gene Discovery Through Functional Genomics
-
Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ et al. Cancer Proliferation Gene Discovery Through Functional Genomics. Science 2008;319:620-4.
-
(2008)
Science
, vol.319
, pp. 620-624
-
-
Schlabach, M.R.1
Luo, J.2
Solimini, N.L.3
Hu, G.4
Xu, Q.5
Li, M.Z.6
-
38
-
-
27644582893
-
Probing tumor phenotypes using stable and regulated synthetic microRNA precursore
-
Dickins RA, Hemann MT, Zilfou JT, Simpson DR, Ibarra I, Hannon GJ et al. Probing tumor phenotypes using stable and regulated synthetic microRNA precursore. Nat Genet 2005;37:1289.
-
(2005)
Nat Genet
, vol.37
, pp. 1289
-
-
Dickins, R.A.1
Hemann, M.T.2
Zilfou, J.T.3
Simpson, D.R.4
Ibarra, I.5
Hannon, G.J.6
-
39
-
-
20444376939
-
A genetic screen for candidate tumor suppressors identifies REST
-
Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 2005;121:837-8.
-
(2005)
Cell
, vol.121
, pp. 837-838
-
-
Westbrook, T.F.1
Martin, E.S.2
Schlabach, M.R.3
Leng, Y.4
Liang, A.C.5
Feng, B.6
-
40
-
-
34147198467
-
Synthetic lethal screen identification of chemosensitizer loci in cancer cells
-
Whitehurst AW, Bodemann BO, Cardenas J, Ferguson D, Girard L, Peyton M et al. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 2007;446:815-9.
-
(2007)
Nature
, vol.446
, pp. 815-819
-
-
Whitehurst, A.W.1
Bodemann, B.O.2
Cardenas, J.3
Ferguson, D.4
Girard, L.5
Peyton, M.6
-
41
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN et al. RNAi-mediated gene silencing in non-human primates. Nature 2006;441:111-4.
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
-
42
-
-
43049176170
-
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
-
Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol 2008;26:561-9.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 561-569
-
-
Akinc, A.1
Zumbuehl, A.2
Goldberg, M.3
Leshchiner, E.S.4
Busini, V.5
Hossain, N.6
|