Uncertainties in biologically-based modeling of formaldehyde-induced respiratory cancer risk: Identification of key issues

Risk Analysis

Volumn 28, Issue 4, 2008, Pages 907-923

  Subramaniam, Ravi P ^a   Chen, Chao ^a   Crump, Kenny S ^b   DeVoney, Danielle ^a   Fox, John F ^a   Portier, Christopher J ^c   Schlosser, Paul M ^a   Thompson, Chad M ^a   White, Paul ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b LOUISIANA TECH UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Biologically based dose response; Formaldehyde; Two stage cancer model

Indexed keywords

ANIMAL CELL CULTURE; COMPUTATIONAL METHODS; ENVIRONMENTAL PROTECTION; ESTIMATION; EXTRAPOLATION; FORMALDEHYDE; HEALTH RISKS; LABELING; NUCLEIC ACIDS; ORGANIC ACIDS; PARAMETER ESTIMATION; RISK ASSESSMENT; RISK MANAGEMENT; RISK PERCEPTION; SAFETY ENGINEERING;

BIOLOGICAL INTERPRETATIONS; BIOLOGICALLY-BASED DOSE RESPONSE; CALIFORNIA; CANCER RISKS; CELL REPLICATIONS; CONCEPTUAL FRAMEWORKS; ESTIMATED PARAMETERS; HUMAN EXPOSURES; HUMAN RISK; INITIATED CELLS; MECHANISTIC INFORMATION; MODEL PARAMETERS; MODEL SPECIFICATIONS; MODELING UNCERTAINTIES; PARAMETER VALUES; REGULATORY BODIES; RISK ASSESSMENT REPORT; SCALE-UP; STATISTICAL UNCERTAINTIES; TOXICOKINETIC; TWO-STAGE CANCER MODEL; TWO-STAGE CLONAL EXPANSION;

UNCERTAINTY ANALYSIS;

DEOXYRIBONUCLEOPROTEIN; FORMALDEHYDE;

CANCER; ESTIMATION METHOD; FORMALDEHYDE; HEALTH RISK; MODELING; RESPIRATORY DISEASE; RISK ASSESSMENT; UNCERTAINTY ANALYSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CANCER RISK; CELL DIVISION; CROSS LINKING; DRUG INDUCED DISEASE; ENVIRONMENTAL EXPOSURE; GENE MUTATION; MALE; NONHUMAN; RAT; RESPIRATORY TRACT CANCER; UNCERTAINTY;

CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; HUMANS; MODELS, THEORETICAL; RESPIRATORY TRACT NEOPLASMS; RISK ASSESSMENT; UNCERTAINTY;

ANIMALIA;

EID: 48349118361     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2008.01083.x     Document Type: Article

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