The application of normal, SV40 T-antigen-immortalised and tumour-derived oral keratinocytes, under serum-free conditions, to the study of the probability of cancer progression as a result of environmental exposure to chemicals

Alternatives to Laboratory Animals

Volumn 35, Issue 6, 2007, Pages 621-639

  Ceder, Rebecca ^a   Merne, Marina ^a,b   Staab, Claudia A ^a   Nilsson, Jan Anders ^a   Höög, Jan Olov ^a   Dressler, Dirk ^c   Engelhart, Karin ^c   Grafström, Roland C ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF TURKU   (Finland)

^c BIOTESYS GMBH   (Germany)

Author keywords

Carcinogenicity; Chemical testing; Genotoxicity versus cytotoxicity; Immortality; Oral epithelium; Terminal differentiation

Indexed keywords

PROTEIN P53; RETINOID DERIVATIVE; TOXIC SUBSTANCE; VIRUS T ANTIGEN;

APOPTOSIS; CANCER CELL CULTURE; CANCER GROWTH; CANCER RISK; CARCINOGENESIS; CELL DEATH; CELL DENSITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMOSOME DAMAGE; CYTOTOXICITY; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MOUTH CANCER; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; PROTEIN FUNCTION; REVIEW; SIMIAN VIRUS 40; SQUAMOUS CELL CARCINOMA;

ANIMALIA;

EID: 38649137974     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290703500603     Document Type: Review

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