Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx

Inhalation Toxicology

Volumn 10, Issue 5, 1998, Pages 473-502

  Subramaniam, Ravi P ^a   Richardson, Regina B ^a   Morgan, Kevin T ^a,c   Kimbell, Julia S ^a   Guilmette, Raymond A ^b  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0031811345     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/089583798197637     Document Type: Article

References (40)

1. Andersen, I., and Proctor, D. F. 1982. The fate and effects of inhaled materials. In The nose, upper airway physiology and the atmospheric environment, eds. D. F. Proctor and I. Andersen, pp. 423-455. New York: Elsevier Biomedical Press.
2. Bridger, G. P., and Proctor, D. F. 1970. Maximum nasal inspiratory flow and nasal resistance. Ann. Otol. Rhinol. Laryngol. 79:481-488.
3. Brin, L., Huband, J., Miller, J., Potter, L. K., Price, M., Kimbell, J. S., and Kepler, G. M. 1997. Shapebased mathematical modeling of the human nasal passages. Proceedings, NCSU 1996 Industrial Mathematics Modeling Workshop For Graduate Students, CRSC-TR97-8 37-66.
4. Cole, P. 1982. Upper respiratory airflow. In The nose, upper airway physiology and the atmospheric environment, eds. D. F. Proctor and I. Andersen, pp. 163-183. New York: Elsevier Biomedical Press.
5. Cole, P. 1993. The respiratory role of the upper airways. St. Louis, MO: Mosby Year Book.
6. Elad, D., Liebenthal, R., Wenig, B. L., and Einav, S. 1993. Analysis of airflow patterns in the human nose. Med. Biol. Eng Comput. 31:585-592.
7. Fluid Dynamics International. 1991. FIDAP. Fluid dynamics analysis package: Theory manual. Evanston, IL: Fluid Dynamics International (now Fluent Inc., Lebanon, NH).
8. Fluid Dynamics International. 1996. FIDAP. Fluid dynamics analysis package: User's manual. Evanston, IL: Fluid Dynamics International (now Fluent Inc., Lebanon, NH).
9. Frederick, C. B., Morris, J. B., Kimbell, J. S., Morgan, K. T., and Scherer, P. S. 1994. Comparison of four biologically based dosimetry models for the deposition of rapidly metabolized vapors in the rodent nasal cavity. Inhal. Toxicol. 6(suppl.):135-157.
10. Girardin, M., Bilgen, E., and Arbour, P. 1983. Experimental studies of velocity fields in a human nasal fossa by laser anemometry. Ann. Otol. Rhinol. Laryngol. 92:231-236.
11. Godo, M. N., Morgan, K. T., Richardson, R. B., and Kimbell, J. S. 1995. Reconstruction of complex passageways for simulations of transport phenomena: Development of a graphical user interface for biological applications. Comp. Meth. Prog. Biomed. 47:97-112.
12. Guilmette, R. A., Cheng, Y. S., Yeh, H. C., and Swift, D. L. 1994. Deposition of 0.005-12 μm monodisperse particles in a computer-milled MR-imaging based nasal airway replica. Inhal. Toxicol. 6(suppl. 1):395-399.
13. Hahn, I., Scherer, P. W., and Mozel, M. M. 1993. Velocity profiles measured for airflow through a large-scale model of the human nasal cavity. J. Appl. Physiol. 75:2273-2287.
14. Haight, S. J., and Cole, P. 1983. Site and function of the nasal valve. Laryngoscope. 93:49-55.
15. Hirschberg, A., Roithmann, R., Parikh, S., Miljeteig, H., and Cole, P. 1995. The airflow resistance profile of healthy nasal cavities. Rhinology 33:10-13.
16. Hornung, D. E., Leopold, D. A., Youngentob, S. L., Sheehe, P. R., Gagne, G. M., Thomas, F. D., and Mozell, M. M. 1987. Airflow patterns in a human nasal model. Arch. Otolaryngol. Head Neck Surg. 113:169-172.
17. International Commission on Radiological Protection. 1975. Report on the task group on Reference Man. Oxford: Pergamon Press.
18. Keyhani, K., Scherer, P. W., and Mozell, M. M. 1995. Numerical simulation of airflow in the human nasal cavity. J. Biomech. Eng. 117:429-441.
19. Kimbell, J. S., Gross, E. A., Joyner, D. R., Godo, M. N., and Morgan, K. T. 1993. Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol. Appl. Pharmacol. 121:253-263.
20. Lang, J. 1989. Clinical anatomy of the nose, nasal cavity and paranasal sinuses. New York: Thieme Medical.
21. Lanza, D. C., and Clerico, D. M. 1995. Anatomy of the human nasal passages. In Handbook of olfaction and gustation, ed. R. L. Doty, pp. 53-73. New York: Marcel Dekker.
22. Masing, H. 1967. Expermentelle untersuchungen über den strömungsverlauf im nasenmodell. Arch. Klin. Exp. Ohren. Nasen Kehlkopfheilk 189:371-381.
23. Miller, F. J., ed. 1995. Nasal toxicity and dosimetry of inhaled xenobiotics. Washington, DC: Taylor & Francis.
24. Morgan, K. T., and Monticello, T. M. 1990. Airflow, gas deposition, and lesion distribution in the nasal passages. Environ. Health Perspect. 85:209-218.
25. Morgan, K. T., Kimbell, J. S., Monticello, T. M., Patra, A. L., and Fleishman, A. 1991. Studies of inspiratory airflow patterns in the nasal passages of the F344 rat and rhesus monkey using nasal molds: Relevance to formaldehyde toxicity. Toxicol. Appl. Pharmacol. 110:223-240.
26. Negus, V. 1958. The comparative anatomy and physiology of the nose and paranasal sinuses. London: Livingstone.
27. Olsen, J. H., and Asnaes, S. 1985. Formaldehyde and the risk of squamous cell carcinoma of the sinonasal cavities. Br. J. Ind. Hyg. 43:769-774.
28. Pedley, T. J., Schroter, R. C., and Sudlow, M. F. 1977. Gas flow and mixing in airways. In Bioengineering aspects of the lung, ed. J. B. West, pp. 229-233. New York: Marcel Dekker.
29. Proctor, D. F. 1982. The upper airway. In The nose, upper airway physiology and the atmospheric environment, eds. D. F. Proctor and I. Andersen, pp. 23-43. New York: Elsevier Biomedical Press.
30. Proetz, A. W. 1951. Air currents in the upper respiratory tract and their clinical importance. Ann. Otol Rhinol. Laryngol. 60:439-467.
31. Roush, G. C., Walrath, J., Stayner, L. T., Kaplan, S. A., Flannery, J. T., and Blair, A. 1987. Nasopharyngeal cancer, sinonasal cancer, and occupations related to formaldehyde: A case-control study. JNCI 79(6):1221-1224.
32. Scherer, P. W., Yang, C. G., and Keyhani, K. 1996. Finite element modeling of gaseous pollutant uptake in the human nasal cavity. Ann. Biomed. Eng. 24(suppl. 1):S-80.
33. Schreck, S., Sullivan, K. J., Ho, C. M., and Chang, H. K. 1993. Correlations between flow resistance and geometry in a model of the human nose. J. Appl. Physiol. 75:1767-1775.
34. Subramaniam, R. P., Morgan, K. T., and Kimbell, J. S. 1996. Modeling airflow in the upper respiratory tract: Delivery of xenobiotics to the nasopharynx. Ann. Biomed. Eng. 1996. 24(suppl.): S-82.
35. Swift, D. L., and Proctor, D. F. 1977. Access of air to the respiratory tract. In Respiratory defense mechanisms, eds. J. D. Brain, D. F. Proctor, and L. M. Reid, pp. 63-91. New York: Marcel Dekker.
36. Tarabichi, M., and Fanous, N. 1993. Finite element analysis of airflow in the nasal valve. Arch. Otolaryngol. Head Neck Surg. 119:638-642.
37. Torjussen, W. 1983. Nasal cancer in nickel workers. Histopathological findings and nickel concentrations in the nasal mucosa of nickel workers, and a short review of chromium and arsenic. In Nasal tumors in animals and man: Tumor pathology, eds. G. Reznik and S. F. Stipson, pp. 33-53. Boca Raton, FL: CRC Press.
38. Virtue, J. A. 1972. The relationship between the refining of nickel and cancer of the nasal cavity. Can. J. Otolaryngol. 1:37.
39. Vogel, S. 1994. Life in moving fluids, 2nd ed. Princeton, NJ: Princeton University Press.
40. Zienkiewicz, O. C. 1977. The finite element method, 3rd ed. London: McGraw-Hill.