The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-κB, is dispensable for T cell development and/or T cell effector functions

Molecular Immunology

Volumn 45, Issue 14, 2008, Pages 3756-3766

  Young, Jennifer A ^a   Becker, Amy M ^a   Medeiros, Jennifer J ^a   Shapiro, Virginia S ^b   Wang, Andrew ^a   Farrar, J David ^a   Quill, Timothy A ^c   van Huijsduijnen, Rob Hooft ^d   van Oers, Nicolai S C ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d MERCK SERONO S A   (Switzerland)

Author keywords

Cell differentiation; Protein kinases phosphatases; Signal transduction; T cells; Transgenic knockout

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN SUBUNIT; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 4; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; IMMUNE RESPONSE; KNOCKOUT MOUSE; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; JURKAT CELLS; KIDNEY; MICE; NF-KAPPA B; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 4; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TRANSFECTION;

ANIMALIA; LISTERIA MONOCYTOGENES; MUS;

EID: 48049090916     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.05.023     Document Type: Article

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