-
1
-
-
0001639195
-
Some speculations on the myeloproliferative syndromes
-
Dameshek W: Some speculations on the myeloproliferative syndromes. Blood 1951;6:372-375.
-
(1951)
Blood
, vol.6
, pp. 372-375
-
-
Dameshek, W.1
-
2
-
-
0036720398
-
The roles of FLT3 in hematopoiesis and leukemia
-
Gilliland DG, Griffin JD: The roles of FLT3 in hematopoiesis and leukemia. Blood 2002;100:1532-1542.
-
(2002)
Blood
, vol.100
, pp. 1532-1542
-
-
Gilliland, D.G.1
Griffin, J.D.2
-
3
-
-
34548042964
-
Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: Recommendations from an ad hoc international expert panel
-
Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, Barosi G, Verstovsek S, Birgegard G, Mesa R, Reilly JT, Gisslinger H, Vannucchi AM, Cervantes F, Finazzi G, Hoffman R, Gilliland DG, Bloomfield CD, Vardiman JW: Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood 2007;110:1092-1097.
-
(2007)
Blood
, vol.110
, pp. 1092-1097
-
-
Tefferi, A.1
Thiele, J.2
Orazi, A.3
Kvasnicka, H.M.4
Barbui, T.5
Hanson, C.A.6
Barosi, G.7
Verstovsek, S.8
Birgegard, G.9
Mesa, R.10
Reilly, J.T.11
Gisslinger, H.12
Vannucchi, A.M.13
Cervantes, F.14
Finazzi, G.15
Hoffman, R.16
Gilliland, D.G.17
Bloomfield, C.D.18
Vardiman, J.W.19
-
5
-
-
0017653321
-
Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/ macrophage
-
Fialkow PJ, Jacobson RJ, Papayannopoulou T: Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/ macrophage. Am J Med 1977;63:125-130.
-
(1977)
Am J Med
, vol.63
, pp. 125-130
-
-
Fialkow, P.J.1
Jacobson, R.J.2
Papayannopoulou, T.3
-
6
-
-
0017174101
-
Polycythemia vera: Stem-cell and probable clonal origin of the disease
-
Adamson JW, Fialkow PJ, Murphy S, Prchal JF, Steinmann L: Polycythemia vera: stem-cell and probable clonal origin of the disease. N Engl J Med 1976;295:913-916.
-
(1976)
N Engl J Med
, vol.295
, pp. 913-916
-
-
Adamson, J.W.1
Fialkow, P.J.2
Murphy, S.3
Prchal, J.F.4
Steinmann, L.5
-
7
-
-
0026075627
-
Clonality in myeloproliferative disorders: Analysis by means of the polymerase chain reaction
-
Gilliland DG, Blanchard KL, Levy J, Perrin S, Bunn HF: Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci USA 1991;88:6848-6852.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 6848-6852
-
-
Gilliland, D.G.1
Blanchard, K.L.2
Levy, J.3
Perrin, S.4
Bunn, H.F.5
-
8
-
-
0000286732
-
A minute chromosome in human chronic granulocytic leukemia
-
Nowell PC, Hungerford DA: A minute chromosome in human chronic granulocytic leukemia. Science 1960;132:1497-1498.
-
(1960)
Science
, vol.132
, pp. 1497-1498
-
-
Nowell, P.C.1
Hungerford, D.A.2
-
9
-
-
0015694748
-
A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
Rowley JD: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973;243:290-293.
-
(1973)
Nature
, vol.243
, pp. 290-293
-
-
Rowley, J.D.1
-
10
-
-
0020972979
-
Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
-
Heisterkamp N, Stephenson JR, Groffen J, Hansen PF, de Klein A, Bartram CR, Grosveld G: Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature 1983;306:239-242.
-
(1983)
Nature
, vol.306
, pp. 239-242
-
-
Heisterkamp, N.1
Stephenson, J.R.2
Groffen, J.3
Hansen, P.F.4
de Klein, A.5
Bartram, C.R.6
Grosveld, G.7
-
11
-
-
0025117392
-
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
-
Daley GQ, Van Etten RA, Baltimore D: Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990;247:824-830.
-
(1990)
Science
, vol.247
, pp. 824-830
-
-
Daley, G.Q.1
Van Etten, R.A.2
Baltimore, D.3
-
12
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker B, Tamura S, Buchdunger E, Ohno S, Segal G, Fanning S, Zimmermann J, Lydon N: Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996;2:561-566.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.5
Fanning, S.6
Zimmermann, J.7
Lydon, N.8
-
13
-
-
0035810142
-
Activity of a specific inhibitor of the BCRABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M: Activity of a specific inhibitor of the BCRABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001;344:1038-1042.
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
Capdeville, R.7
Talpaz, M.8
-
14
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001;344:1031-1037.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
15
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, Kutok J, Clark J, Galinsky I, Griffin JD, Cross NC, Tefferi A, Malone J, Alam R, Schrier SL, Schmid J, Rose M, Vandenberghe P, Verhoef G, Boogaerts M, Wlodarska I, Kantarjian H, Marynen P, Coutre SE, Stone R, Gilliland DG: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003;348:1201-1214.
-
(2003)
N Engl J Med
, vol.348
, pp. 1201-1214
-
-
Cools, J.1
DeAngelo, D.J.2
Gotlib, J.3
Stover, E.H.4
Legare, R.D.5
Cortes, J.6
Kutok, J.7
Clark, J.8
Galinsky, I.9
Griffin, J.D.10
Cross, N.C.11
Tefferi, A.12
Malone, J.13
Alam, R.14
Schrier, S.L.15
Schmid, J.16
Rose, M.17
Vandenberghe, P.18
Verhoef, G.19
Boogaerts, M.20
Wlodarska, I.21
Kantarjian, H.22
Marynen, P.23
Coutre, S.E.24
Stone, R.25
Gilliland, D.G.26
more..
-
16
-
-
0009013631
-
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm
-
Longley BJ, Tyrrell L, Lu SZ, Ma YS, Langley K, Ding TG, Duffy T, Jacobs P, Tang LH, Modlin I: Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet 1996;12:312-314.
-
(1996)
Nat Genet
, vol.12
, pp. 312-314
-
-
Longley, B.J.1
Tyrrell, L.2
Lu, S.Z.3
Ma, Y.S.4
Langley, K.5
Ding, T.G.6
Duffy, T.7
Jacobs, P.8
Tang, L.H.9
Modlin, I.10
-
17
-
-
0028224348
-
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
-
Golub TR, Barker GF, Lovett M, Gilliland DG: Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994;77:307-316.
-
(1994)
Cell
, vol.77
, pp. 307-316
-
-
Golub, T.R.1
Barker, G.F.2
Lovett, M.3
Gilliland, D.G.4
-
18
-
-
0034656066
-
Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera
-
Temerinac S, Klippel S, Strunck E, Roder S, Lubbert M, Lange W, Azemar M, Meinhardt G, Schaefer HE, Pahl HL: Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. Blood 2000;95:2569-2576.
-
(2000)
Blood
, vol.95
, pp. 2569-2576
-
-
Temerinac, S.1
Klippel, S.2
Strunck, E.3
Roder, S.4
Lubbert, M.5
Lange, W.6
Azemar, M.7
Meinhardt, G.8
Schaefer, H.E.9
Pahl, H.L.10
-
19
-
-
0036191941
-
Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera
-
Kralovics R, Guan Y, Prchal JT: Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera. Exp Hematol 2002;30:229-236.
-
(2002)
Exp Hematol
, vol.30
, pp. 229-236
-
-
Kralovics, R.1
Guan, Y.2
Prchal, J.T.3
-
20
-
-
0032568003
-
Expression of Bcl-x in erythroid precursors from patients with polycythemia vera
-
Silva M, Richard C, Benito A, Sanz C, Olalla I, Fernandez-Luna J: Expression of Bcl-x in erythroid precursors from patients with polycythemia vera. N Engl J Med 1998;338:564-571.
-
(1998)
N Engl J Med
, vol.338
, pp. 564-571
-
-
Silva, M.1
Richard, C.2
Benito, A.3
Sanz, C.4
Olalla, I.5
Fernandez-Luna, J.6
-
21
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C, Garcon L, Raslova H, Berger R, Bennaceur-Griscelli A, Villeval JL, Constantinescu SN, Casadevall N, Vainchenker W: A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005;434:1144-1148.
-
(2005)
Nature
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
Garcon, L.7
Raslova, H.8
Berger, R.9
Bennaceur-Griscelli, A.10
Villeval, J.L.11
Constantinescu, S.N.12
Casadevall, N.13
Vainchenker, W.14
-
22
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R, Passamonti F, Buser AS, Teo S, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda R: A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 2005;352:1779-1790.
-
(2005)
N Engl J Med
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.9
-
23
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, Vassiliou GS, Bench AJ, Boyd EM, Curtin N, Scott MA, Erber WN, Green AR: Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005;365:1054-1061.
-
(2005)
Lancet
, vol.365
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
Vassiliou, G.S.7
Bench, A.J.8
Boyd, E.M.9
Curtin, N.10
Scott, M.A.11
Erber, W.N.12
Green, A.R.13
-
24
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Frohling S, Dohner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG: Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005;7:387-397.
-
(2005)
Cancer Cell
, vol.7
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.6
Boggon, T.J.7
Wlodarska, I.8
Clark, J.J.9
Moore, S.10
Adelsperger, J.11
Koo, S.12
Lee, J.C.13
Gabriel, S.14
Mercher, T.15
D'Andrea, A.16
Frohling, S.17
Dohner, K.18
Marynen, P.19
Vandenberghe, P.20
Mesa, R.A.21
Tefferi, A.22
Griffin, J.D.23
Eck, M.J.24
Sellers, W.R.25
Meyerson, M.26
Golub, T.R.27
Lee, S.J.28
Gilliland, D.G.29
more..
-
25
-
-
22144452197
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
Ugo V, James C, Vainchenker W: A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Med Sci (Paris) 2005;21:669-670.
-
(2005)
Med Sci (Paris)
, vol.21
, pp. 669-670
-
-
Ugo, V.1
James, C.2
Vainchenker, W.3
-
26
-
-
33646546386
-
The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
-
Jamieson CH, Gotlib J, Durocher JA, Chao MP, Mariappan MR, Lay M, Jones C, Zehnder JL, Lilleberg SL, Weissman IL: The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci USA 2006;103:6224-6229.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6224-6229
-
-
Jamieson, C.H.1
Gotlib, J.2
Durocher, J.A.3
Chao, M.P.4
Mariappan, M.R.5
Lay, M.6
Jones, C.7
Zehnder, J.L.8
Lilleberg, S.L.9
Weissman, I.L.10
-
27
-
-
4544324306
-
Blasts from the past: New lessons in stem cell biology from chronic myelogenous leukemia
-
Huntly BJ, Gilliland DG: Blasts from the past: new lessons in stem cell biology from chronic myelogenous leukemia. Cancer Cell 2004;6:199-201.
-
(2004)
Cancer Cell
, vol.6
, pp. 199-201
-
-
Huntly, B.J.1
Gilliland, D.G.2
-
28
-
-
25844447519
-
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia-chromosome-negative CML and megakaryocytic leukemia
-
Jelinek J, Oki Y, Gharibyan V, Bueso-Ramos C, Prchal JT, Verstovsek S, Beran M, Estey E, Kantarjian HM, Issa JP: JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia-chromosome-negative CML and megakaryocytic leukemia. Blood 2005;106:3370-3373.
-
(2005)
Blood
, vol.106
, pp. 3370-3373
-
-
Jelinek, J.1
Oki, Y.2
Gharibyan, V.3
Bueso-Ramos, C.4
Prchal, J.T.5
Verstovsek, S.6
Beran, M.7
Estey, E.8
Kantarjian, H.M.9
Issa, J.P.10
-
29
-
-
33645400695
-
X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveals a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis
-
Levine RL, Belisle C, Wadleigh M, Zahrieh D, Lee S, Chagnon P, Gilliland DG, Busque L: X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveals a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood 2006;107:4139-4141.
-
(2006)
Blood
, vol.107
, pp. 4139-4141
-
-
Levine, R.L.1
Belisle, C.2
Wadleigh, M.3
Zahrieh, D.4
Lee, S.5
Chagnon, P.6
Gilliland, D.G.7
Busque, L.8
-
30
-
-
33749325187
-
Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation
-
Szpurka H, Tiu R, Murugesan G, Aboudola S, Hsi ED, Theil KS, Sekeres MA, Maciejewski JP: Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation. Blood 2006;108:2173-2181.
-
(2006)
Blood
, vol.108
, pp. 2173-2181
-
-
Szpurka, H.1
Tiu, R.2
Murugesan, G.3
Aboudola, S.4
Hsi, E.D.5
Theil, K.S.6
Sekeres, M.A.7
Maciejewski, J.P.8
-
31
-
-
33745213401
-
The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow
-
Ingram W, Lea NC, Cervera J, Germing U, Fenaux P, Cassinat B, Kiladjian JJ, Varkonyi J, Antunovic P, Westwood NB, Arno MJ, Mohamedali A, Gaken J, Kontou T, Czepulkowski BH, Twine NA, Tamaska J, Csomer J, Benedek S, Gattermann N, Zipperer E, Giagounidis A, Garcia-Casado Z, Sanz G, Mufti GJ: The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow. Leukemia 2006;20:1319-1321.
-
(2006)
Leukemia
, vol.20
, pp. 1319-1321
-
-
Ingram, W.1
Lea, N.C.2
Cervera, J.3
Germing, U.4
Fenaux, P.5
Cassinat, B.6
Kiladjian, J.J.7
Varkonyi, J.8
Antunovic, P.9
Westwood, N.B.10
Arno, M.J.11
Mohamedali, A.12
Gaken, J.13
Kontou, T.14
Czepulkowski, B.H.15
Twine, N.A.16
Tamaska, J.17
Csomer, J.18
Benedek, S.19
Gattermann, N.20
Zipperer, E.21
Giagounidis, A.22
Garcia-Casado, Z.23
Sanz, G.24
Mufti, G.J.25
more..
-
32
-
-
25844518265
-
The JAK2-V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
-
Levine RL, Loriaux M, Huntly BJ, Loh ML, Beran M, Stoffregen E, Berger R, Clark JJ, Willis SG, Nguyen KT, Flores NJ, Estey E, Gattermann N, Armstrong S, Look AT, Griffin JD, Bernard OA, Heinrich MC, Gilliland DG, Druker B, Deininger MW: The JAK2-V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood 2005;106:3377-3379.
-
(2005)
Blood
, vol.106
, pp. 3377-3379
-
-
Levine, R.L.1
Loriaux, M.2
Huntly, B.J.3
Loh, M.L.4
Beran, M.5
Stoffregen, E.6
Berger, R.7
Clark, J.J.8
Willis, S.G.9
Nguyen, K.T.10
Flores, N.J.11
Estey, E.12
Gattermann, N.13
Armstrong, S.14
Look, A.T.15
Griffin, J.D.16
Bernard, O.A.17
Heinrich, M.C.18
Gilliland, D.G.19
Druker, B.20
Deininger, M.W.21
more..
-
34
-
-
31544474025
-
Rare occurrence of the JAK2 V617F mutation in AML subtypes M5, M6, and M7
-
Frohling S, Lipka DB, Kayser S, Scholl C, Schlenk RF, Dohner H, Gilliland DG, Levine RL, Dohner K: Rare occurrence of the JAK2 V617F mutation in AML subtypes M5, M6, and M7. Blood 2006;107:1242-1243.
-
(2006)
Blood
, vol.107
, pp. 1242-1243
-
-
Frohling, S.1
Lipka, D.B.2
Kayser, S.3
Scholl, C.4
Schlenk, R.F.5
Dohner, H.6
Gilliland, D.G.7
Levine, R.L.8
Dohner, K.9
-
35
-
-
33749358349
-
Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia
-
Scott LM, Scott MA, Campbell PJ, Green AR: Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia. Blood 2006;108:2435-2437.
-
(2006)
Blood
, vol.108
, pp. 2435-2437
-
-
Scott, L.M.1
Scott, M.A.2
Campbell, P.J.3
Green, A.R.4
-
36
-
-
43249084493
-
Ratio of mutant JAK2-V617F to wild type JAK2 determines the MPD phenotypes in transgenic mice
-
Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, Schwaller J, Skoda RC: Ratio of mutant JAK2-V617F to wild type JAK2 determines the MPD phenotypes in transgenic mice. Blood 2008;111:3931-3940.
-
(2008)
Blood
, vol.111
, pp. 3931-3940
-
-
Tiedt, R.1
Hao-Shen, H.2
Sobas, M.A.3
Looser, R.4
Dirnhofer, S.5
Schwaller, J.6
Skoda, R.C.7
-
37
-
-
46749137278
-
-
Xing S, Ho WT, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ: Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood 2008, Epub ahead of print.
-
Xing S, Ho WT, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ: Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood 2008, Epub ahead of print.
-
-
-
-
38
-
-
0027179365
-
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
-
Argetsinger LS, Campbell GS, Yang X, Witthuhn BA, Silvennoinen O, Ihle JN, Carter-Su C: Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 1993;74:237-244.
-
(1993)
Cell
, vol.74
, pp. 237-244
-
-
Argetsinger, L.S.1
Campbell, G.S.2
Yang, X.3
Witthuhn, B.A.4
Silvennoinen, O.5
Ihle, J.N.6
Carter-Su, C.7
-
39
-
-
0032076542
-
JAK2 is essential for signaling through a variety of cytokine receptors
-
Parganas E, Wang D, Stravopodis D, Topham DJ, Marine J, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN: JAK2 is essential for signaling through a variety of cytokine receptors. Cell 1998;93:385-395.
-
(1998)
Cell
, vol.93
, pp. 385-395
-
-
Parganas, E.1
Wang, D.2
Stravopodis, D.3
Topham, D.J.4
Marine, J.5
Teglund, S.6
Vanin, E.F.7
Bodner, S.8
Colamonici, O.R.9
van Deursen, J.M.10
Grosveld, G.11
Ihle, J.N.12
-
40
-
-
30144436273
-
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
-
Lucet IS, Fantino E, Styles M, Bamert R, Patel O, Broughton SE, Walter M, Burns CJ, Treutlein H, Wilks AF, Rossjohn J: The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood 2006;107:176-183.
-
(2006)
Blood
, vol.107
, pp. 176-183
-
-
Lucet, I.S.1
Fantino, E.2
Styles, M.3
Bamert, R.4
Patel, O.5
Broughton, S.E.6
Walter, M.7
Burns, C.J.8
Treutlein, H.9
Wilks, A.F.10
Rossjohn, J.11
-
41
-
-
23044495944
-
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog
-
Boggon TJ, Li Y, Manley PW, Eck MJ: Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood 2005;106:996-1002.
-
(2005)
Blood
, vol.106
, pp. 996-1002
-
-
Boggon, T.J.1
Li, Y.2
Manley, P.W.3
Eck, M.J.4
-
42
-
-
0035045092
-
Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation
-
Lindauer K, Loerting T, Liedl KR, Kroemer RT: Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation. Protein Eng 2001;14:27-37.
-
(2001)
Protein Eng
, vol.14
, pp. 27-37
-
-
Lindauer, K.1
Loerting, T.2
Liedl, K.R.3
Kroemer, R.T.4
-
43
-
-
0037033012
-
The pseudokinase domain is required for suppression of basal activity of JAK2 and JAK3 tyrosine kinases and for cytokine-inducible activation of signal transduction
-
Saharinen P, Silvennoinen O: The pseudokinase domain is required for suppression of basal activity of JAK2 and JAK3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem 2002;277:47954-47963.
-
(2002)
J Biol Chem
, vol.277
, pp. 47954-47963
-
-
Saharinen, P.1
Silvennoinen, O.2
-
44
-
-
20744460045
-
Identification of an acquired JAK2 mutation in polycythemia vera
-
Zhao R, Xing S, Li Z, Fu X, Li Q, Krantz SB, Zhao ZJ: Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem 2005;280:22788- 22792.
-
(2005)
J Biol Chem
, vol.280
, pp. 22788-22792
-
-
Zhao, R.1
Xing, S.2
Li, Z.3
Fu, X.4
Li, Q.5
Krantz, S.B.6
Zhao, Z.J.7
-
45
-
-
30044437118
-
Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
-
Lu X, Levine R, Tong W, Wernig G, Pikman Y, Zarnegar S, Gilliland DG, Lodish H: Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation. Proc Natl Acad Sci USA 2005;102:18962-18967.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 18962-18967
-
-
Lu, X.1
Levine, R.2
Tong, W.3
Wernig, G.4
Pikman, Y.5
Zarnegar, S.6
Gilliland, D.G.7
Lodish, H.8
-
46
-
-
33744490974
-
Expression of JAK2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
-
Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG: Expression of JAK2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 2006;107:349-353.
-
(2006)
Blood
, vol.107
, pp. 349-353
-
-
Wernig, G.1
Mercher, T.2
Okabe, R.3
Levine, R.L.4
Lee, B.H.5
Gilliland, D.G.6
-
47
-
-
33745721197
-
JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
-
Lacout C, Pisani DF, Tulliez M, Gachelin FM, Vainchenker W, Villeval JL: JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood 2006;108:1652-1660.
-
(2006)
Blood
, vol.108
, pp. 1652-1660
-
-
Lacout, C.1
Pisani, D.F.2
Tulliez, M.3
Gachelin, F.M.4
Vainchenker, W.5
Villeval, J.L.6
-
48
-
-
34447642422
-
-
Zaleskas VM, Krause DS, Lazarides K, Patel N, Hu Y, Li S, Van Etten RA: Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PLoS ONE 2006;1:e18.
-
Zaleskas VM, Krause DS, Lazarides K, Patel N, Hu Y, Li S, Van Etten RA: Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PLoS ONE 2006;1:e18.
-
-
-
-
49
-
-
33845798378
-
Characterization of murine JAK2V617F-positive myeloproliferative disease
-
Bumm TG, Elsea C, Corbin AS, Loriaux M, Sherbenou D, Wood L, Deininger J, Silver RT, Druker BJ, Deininger MW: Characterization of murine JAK2V617F-positive myeloproliferative disease. Cancer Res 2006;66:11156-11165.
-
(2006)
Cancer Res
, vol.66
, pp. 11156-11165
-
-
Bumm, T.G.1
Elsea, C.2
Corbin, A.S.3
Loriaux, M.4
Sherbenou, D.5
Wood, L.6
Deininger, J.7
Silver, R.T.8
Druker, B.J.9
Deininger, M.W.10
-
50
-
-
33846660947
-
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
-
Scott LM, Tong W, Levine RL, Scott MA, Beer PA, Stratton MR, Futreal PA, Erber WN, McMullin MF, Harrison CN, Warren AJ, Gilliland DG, Lodish HF, Green AR: JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med 2007;356:459-468.
-
(2007)
N Engl J Med
, vol.356
, pp. 459-468
-
-
Scott, L.M.1
Tong, W.2
Levine, R.L.3
Scott, M.A.4
Beer, P.A.5
Stratton, M.R.6
Futreal, P.A.7
Erber, W.N.8
McMullin, M.F.9
Harrison, C.N.10
Warren, A.J.11
Gilliland, D.G.12
Lodish, H.F.13
Green, A.R.14
-
51
-
-
38949160429
-
Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders
-
Pietra D, Li S, Brisci A, Passamonti F, Rumi E, Theocharides A, Ferrari M, Gisslinger H, Kralovics R, Cremonesi L, Skoda R, Cazzola M: Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders. Blood 2008;111:1686-1689.
-
(2008)
Blood
, vol.111
, pp. 1686-1689
-
-
Pietra, D.1
Li, S.2
Brisci, A.3
Passamonti, F.4
Rumi, E.5
Theocharides, A.6
Ferrari, M.7
Gisslinger, H.8
Kralovics, R.9
Cremonesi, L.10
Skoda, R.11
Cazzola, M.12
-
52
-
-
35448963775
-
Phenotypic variations and new mutations in JAK2 V617F-negative polycythemia vera, erythrocytosis, and idiopathic myelofibrosis
-
Williams DM, Kim AH, Rogers O, Spivak JL, Moliterno AR: Phenotypic variations and new mutations in JAK2 V617F-negative polycythemia vera, erythrocytosis, and idiopathic myelofibrosis. Exp Hematol 2007;35:1641-1646.
-
(2007)
Exp Hematol
, vol.35
, pp. 1641-1646
-
-
Williams, D.M.1
Kim, A.H.2
Rogers, O.3
Spivak, J.L.4
Moliterno, A.R.5
-
53
-
-
49449100990
-
TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation-negative patients
-
Epub ahead of print
-
Lasho TL, Tefferi A, Hood JD, Verstovsek S, Gilliland DG, Pardanani A: TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation-negative patients. Leukemia 2008, Epub ahead of print.
-
(2008)
Leukemia
-
-
Lasho, T.L.1
Tefferi, A.2
Hood, J.D.3
Verstovsek, S.4
Gilliland, D.G.5
Pardanani, A.6
-
54
-
-
46749132374
-
-
Kiladjian JJ, Cervantes F, Leebeek FW, Marzac C, Cassinat B, Chevret S, Cazals-Hatem D, Plessier A, Garcia-Pagan JC, Darwish Murad S, Raffa S, Janssen HL, Gardin C, Cereja S, Tonetti C, Giraudier S, Condat B, Casadevall N, Fenaux P, Valla DC: The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis. A report on 241 cases. Blood 2008, Epub ahead of print.
-
Kiladjian JJ, Cervantes F, Leebeek FW, Marzac C, Cassinat B, Chevret S, Cazals-Hatem D, Plessier A, Garcia-Pagan JC, Darwish Murad S, Raffa S, Janssen HL, Gardin C, Cereja S, Tonetti C, Giraudier S, Condat B, Casadevall N, Fenaux P, Valla DC: The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis. A report on 241 cases. Blood 2008, Epub ahead of print.
-
-
-
-
55
-
-
15444339209
-
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
-
Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M, Berthou C, Lessard M, Berger R, Ghysdael J, Bernard OA: A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 1997;278:1309-1312.
-
(1997)
Science
, vol.278
, pp. 1309-1312
-
-
Lacronique, V.1
Boureux, A.2
Valle, V.D.3
Poirel, H.4
Quang, C.T.5
Mauchauffe, M.6
Berthou, C.7
Lessard, M.8
Berger, R.9
Ghysdael, J.10
Bernard, O.A.11
-
56
-
-
0030852328
-
-
Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P, Monpoux F, Van Rompaey L, Baens M, Van den Berghe H, Marynen P: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 1997;90:2535-2540.
-
Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P, Monpoux F, Van Rompaey L, Baens M, Van den Berghe H, Marynen P: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 1997;90:2535-2540.
-
-
-
-
57
-
-
33847393317
-
Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia
-
Malinge S, Ben-Abdelali R, Settegrana C, Radford-Weiss I, Debre M, Beldjord K, Macintyre EA, Villeval JL, Vainchenker W, Berger R, Bernard OA, Delabesse E, Penard-Lacronique V: Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia. Blood 2007;109:2202-2204.
-
(2007)
Blood
, vol.109
, pp. 2202-2204
-
-
Malinge, S.1
Ben-Abdelali, R.2
Settegrana, C.3
Radford-Weiss, I.4
Debre, M.5
Beldjord, K.6
Macintyre, E.A.7
Villeval, J.L.8
Vainchenker, W.9
Berger, R.10
Bernard, O.A.11
Delabesse, E.12
Penard-Lacronique, V.13
-
58
-
-
33750627651
-
JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model
-
Mercher T, Wernig G, Moore SA, Levine RL, Gu TL, Frohling S, Cullen D, Polakiewicz RD, Bernard OA, Boggon TJ, Lee BH, Gilliland DG: JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. Blood 2006;108:2770-2779.
-
(2006)
Blood
, vol.108
, pp. 2770-2779
-
-
Mercher, T.1
Wernig, G.2
Moore, S.A.3
Levine, R.L.4
Gu, T.L.5
Frohling, S.6
Cullen, D.7
Polakiewicz, R.D.8
Bernard, O.A.9
Boggon, T.J.10
Lee, B.H.11
Gilliland, D.G.12
-
59
-
-
33746437130
-
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
-
Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, Cuker A, Wernig G, Moore S, Galinsky I, Deangelo DJ, Clark JJ, Lee SJ, Golub TR, Wadleigh M, Gilliland DG, Levine RL: MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 2006;3:e270.
-
(2006)
PLoS Med
, vol.3
-
-
Pikman, Y.1
Lee, B.H.2
Mercher, T.3
McDowell, E.4
Ebert, B.L.5
Gozo, M.6
Cuker, A.7
Wernig, G.8
Moore, S.9
Galinsky, I.10
Deangelo, D.J.11
Clark, J.J.12
Lee, S.J.13
Golub, T.R.14
Wadleigh, M.15
Gilliland, D.G.16
Levine, R.L.17
-
60
-
-
33750534561
-
MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
-
Pardanani AD, Levine RL, Lasho T, Pikman Y, Mesa RA, Wadleigh M, Steensma DP, Elliott MA, Wolanskyj AP, Hogan WJ, McClure RF, Litzow MR, Gilliland DG, Tefferi A: MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 2006;108:3472-3476.
-
(2006)
Blood
, vol.108
, pp. 3472-3476
-
-
Pardanani, A.D.1
Levine, R.L.2
Lasho, T.3
Pikman, Y.4
Mesa, R.A.5
Wadleigh, M.6
Steensma, D.P.7
Elliott, M.A.8
Wolanskyj, A.P.9
Hogan, W.J.10
McClure, R.F.11
Litzow, M.R.12
Gilliland, D.G.13
Tefferi, A.14
-
61
-
-
34447627350
-
TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/k mutations
-
Pardanani A, Hood J, Lasho T, Levine RL, Martin MB, Noronha G, Finke C, Mak CC, Mesa R, Zhu H, Soll R, Gilliland DG, Tefferi A: TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/k mutations. Leukemia 2007;21:1658-1668.
-
(2007)
Leukemia
, vol.21
, pp. 1658-1668
-
-
Pardanani, A.1
Hood, J.2
Lasho, T.3
Levine, R.L.4
Martin, M.B.5
Noronha, G.6
Finke, C.7
Mak, C.C.8
Mesa, R.9
Zhu, H.10
Soll, R.11
Gilliland, D.G.12
Tefferi, A.13
-
62
-
-
0033639119
-
STAT5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2
-
Schwaller J, Parganas E, Wang D, Cain D, Aster JC, Williams IR, Lee CK, Gerthner R, Kitamura T, Frantsve J, Anastasiadou E, Loh ML, Levy DE, Ihle JN, Gilliland DG: STAT5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. Mol Cell 2000;6:693-704.
-
(2000)
Mol Cell
, vol.6
, pp. 693-704
-
-
Schwaller, J.1
Parganas, E.2
Wang, D.3
Cain, D.4
Aster, J.C.5
Williams, I.R.6
Lee, C.K.7
Gerthner, R.8
Kitamura, T.9
Frantsve, J.10
Anastasiadou, E.11
Loh, M.L.12
Levy, D.E.13
Ihle, J.N.14
Gilliland, D.G.15
-
63
-
-
0035036625
-
Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation
-
Frantsve J, Schwaller J, Sternberg DW, Kutok J, Gilliland DG: Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol Cell Biol 2001;21:3547-3557.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3547-3557
-
-
Frantsve, J.1
Schwaller, J.2
Sternberg, D.W.3
Kutok, J.4
Gilliland, D.G.5
-
64
-
-
34249728880
-
The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
-
Hookham MB, Elliott J, Suessmuth Y, Staerk J, Ward AC, Vainchenker W, Percy MJ, McMullin MF, Constantinescu SN, Johnston JA: The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3. Blood 2007;109:4924-4929.
-
(2007)
Blood
, vol.109
, pp. 4924-4929
-
-
Hookham, M.B.1
Elliott, J.2
Suessmuth, Y.3
Staerk, J.4
Ward, A.C.5
Vainchenker, W.6
Percy, M.J.7
McMullin, M.F.8
Constantinescu, S.N.9
Johnston, J.A.10
-
65
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition
-
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N: BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006;439:358-362.
-
(2006)
Nature
, vol.439
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
Sawai, A.4
Getz, G.5
Basso, A.6
Ye, Q.7
Lobo, J.M.8
She, Y.9
Osman, I.10
Golub, T.R.11
Sebolt-Leopold, J.12
Sellers, W.R.13
Rosen, N.14
-
66
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukaemia and acute lymphoblastic leukaemia with the Philadelphia chromosome
-
Druker B, Sawyers C, Kantarjian H, Resta D, Reese S, Ford J, Capdeville R, Talpaz M: Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukaemia and acute lymphoblastic leukaemia with the Philadelphia chromosome. N Engl J Med 2001;344:1038-1042.
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.1
Sawyers, C.2
Kantarjian, H.3
Resta, D.4
Reese, S.5
Ford, J.6
Capdeville, R.7
Talpaz, M.8
-
67
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukaemia
-
Druker B, Talpaz M, Resta D, Peng B, Buchdunger E, Ford J, Lydon N, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers C: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukaemia. N Engl J Med 2001;344:1031-1037.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.1
Talpaz, M.2
Resta, D.3
Peng, B.4
Buchdunger, E.5
Ford, J.6
Lydon, N.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.11
-
68
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL: Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004;305:399-401.
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
69
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
Kantarjian H, Giles F, Wunderle L, Bhalla K, O'Brien S, Wassmann B, Tanaka C, Manley P, Rae P, Mietlowski W, Bochinski K, Hochhaus A, Griffin JD, Hoelzer D, Albitar M, Dugan M, Cortes J, Alland L, Ottmann OG: Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006;354:2542-2551.
-
(2006)
N Engl J Med
, vol.354
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
Bhalla, K.4
O'Brien, S.5
Wassmann, B.6
Tanaka, C.7
Manley, P.8
Rae, P.9
Mietlowski, W.10
Bochinski, K.11
Hochhaus, A.12
Griffin, J.D.13
Hoelzer, D.14
Albitar, M.15
Dugan, M.16
Cortes, J.17
Alland, L.18
Ottmann, O.G.19
-
70
-
-
41249099841
-
Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera
-
Wernig G, Kharas MG, Okabe R, Moore SA, Leeman DS, Cullen DE, Gozo M, McDowell EP, Levine RL, Doukas J, Mak CC, Noronha G, Martin M, Ko YD, Lee BH, Soll R, Tefferi A, Hood JD, Gilliland DG: Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell 2008;13:311-320.
-
(2008)
Cancer Cell
, vol.13
, pp. 311-320
-
-
Wernig, G.1
Kharas, M.G.2
Okabe, R.3
Moore, S.A.4
Leeman, D.S.5
Cullen, D.E.6
Gozo, M.7
McDowell, E.P.8
Levine, R.L.9
Doukas, J.10
Mak, C.C.11
Noronha, G.12
Martin, M.13
Ko, Y.D.14
Lee, B.H.15
Soll, R.16
Tefferi, A.17
Hood, J.D.18
Gilliland, D.G.19
-
71
-
-
33845897463
-
-
Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H: Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 2006;25:745-755.
-
Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H: Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 2006;25:745-755.
-
-
-
-
72
-
-
0028857954
-
Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
-
Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, Migone TS, Noguchi M, Markert ML, Buckley RH, O'Shea JJ, Leonard WJ: Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995;270:797-800.
-
(1995)
Science
, vol.270
, pp. 797-800
-
-
Russell, S.M.1
Tayebi, N.2
Nakajima, H.3
Riedy, M.C.4
Roberts, J.L.5
Aman, M.J.6
Migone, T.S.7
Noguchi, M.8
Markert, M.L.9
Buckley, R.H.10
O'Shea, J.J.11
Leonard, W.J.12
-
73
-
-
0029164841
-
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
-
Macchi P, Villa A, Giliani S, Sacco MG, Frattini A, Porta F, Ugazio AG, Johnston JA, Candotti F, O'Shea JJ, Vezzoni P, Notarangelo LD: Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995;377:65-68.
-
(1995)
Nature
, vol.377
, pp. 65-68
-
-
Macchi, P.1
Villa, A.2
Giliani, S.3
Sacco, M.G.4
Frattini, A.5
Porta, F.6
Ugazio, A.G.7
Johnston, J.A.8
Candotti, F.9
O'Shea, J.J.10
Vezzoni, P.11
Notarangelo, L.D.12
-
74
-
-
33749434271
-
Mutation of JAK2 in the myeloproliferative disorders: Timing, clonality studies, cytogenetic associations, and role in leukemic transformation
-
Campbell PJ, Baxter EJ, Beer PA, Scott LM, Bench AJ, Huntly BJ, Erber WN, Kusec R, Larsen TS, Giraudier S, Le Bousse-Kerdiles MC, Griesshammer M, Reilly JT, Cheung BY, Harrison CN, Green AR: Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation. Blood 2006;108:3548-3555.
-
(2006)
Blood
, vol.108
, pp. 3548-3555
-
-
Campbell, P.J.1
Baxter, E.J.2
Beer, P.A.3
Scott, L.M.4
Bench, A.J.5
Huntly, B.J.6
Erber, W.N.7
Kusec, R.8
Larsen, T.S.9
Giraudier, S.10
Le Bousse-Kerdiles, M.C.11
Griesshammer, M.12
Reilly, J.T.13
Cheung, B.Y.14
Harrison, C.N.15
Green, A.R.16
-
75
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, Sawyers CL: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001;293:876-880.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Rao, P.N.6
Sawyers, C.L.7
-
76
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J, Sawyers CL: Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002;2:117-125.
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
Gorre, M.E.4
Paquette, R.L.5
Kuriyan, J.6
Sawyers, C.L.7
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