Integrin is essential for teratoma growth and angiogenesis

Journal of Cell Biology

Volumn 139, Issue 1, 1997, Pages 265-278

  Bloch, Wilhelm ^a   Forsberg, Erik ^b   Lentini, Sylvia ^a   Brakebusch, Cord ^b   Martin, Karl ^b   Krell, Hans W ^c   Weidle, Ulrich H ^c   Addicks, Klaus ^a   Fässler, Reinhard ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; ENTACTIN; FIBRONECTIN; INTEGRIN; BETA1 INTEGRIN; CD51 ANTIGEN; ENDOTHELIAL CELL GROWTH FACTOR; LEUKOCYTE ANTIGEN; LYMPHOKINE; VASCULOTROPIN; VASCULOTROPIN A;

ADOLESCENT; ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOCHEMISTRY; MALE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TERATOMA; TUMOR GROWTH; TUMOR VASCULARIZATION; ANIMAL; APOPTOSIS; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; EMBRYO; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; STEM CELL; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD29; APOPTOSIS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; EMBRYO; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; INTEGRIN ALPHAV; LYMPHOKINES; MALE; MICE; NEOVASCULARIZATION, PATHOLOGIC; STEM CELLS; TERATOMA; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0030608876     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.139.1.265     Document Type: Article

References (48)

1. Alexander, C.M., and Z. Werb. 1991. Degradation of extracellular matrix. In Cell Biology of Extracellular Matrix. E. Hay, editor. Plenum Press, New York. pp. 255-294.
2. Bagutti, C., A.M. Wobus, R. Fässler, and F.M. Watt. 1996. Differentiation of embryonal stem cells into keratinocytes: comparison of wild-type and β1 integrin-deficient cells. Dev. Biol. 179:184-196.
3. Boudreau, N., C.J. Sympson, Z. Werb, and M.J. Bissel. 1995. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science (Wash. DC). 267:891-893.
4. Brooks, P.C., R.A.F. Clark, and D.A. Cheresch. 1994a. Requirement of vascular integrin αvβ3 for angiogenesis. Science (Wash. DC). 264:569-571.
5. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 79:1157-1164.
6. Coucouvanis, E., and G.R. Martin. 1995. Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell. 83:279-287.
7. Damjanov, I, 1978. Teratoma and teratocarcinoma in experimental animals. Natl. Cancer Inst. Monogr. 49:305-306.
8. Damjanov, I., and D. Solter. 1974. Experimental teratoma. Curr. Top. Pathol. 59:69-130.
9. Dike, L.E., and S.R. Farmer. 1988. Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts. Proc. Natl. Acad. Sci. USA. 85:6792-6796.
10. DiPersio, C.M., K.M. Hodivila-Dilke, R. Jaenisch, J.A. Kreidberg, and R.O. Hynes. 1997. α3β1 integrin is required for normal development of the epidermal basement membrane. J. Cell Biol. 137:729-742.
11. Doetschman, T.C., H. Eistetter, M. Katz, W. Schmidt, and R. Kemler. 1985. The in vitro development of blastocyst derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morph. 87:27-45.
12. Dziadek, M., R. Clements, K. Mitrangas, H. Reiter, and K. Fowler. 1988. Analysis of degradation of the basement membrane protein nidogen, using a specific monoclonal antibody. Eur. J. Biochem. 172:219-225.
13. Fässler, R., and M. Meyer. 1995. Consequences of lack of β1 integrin gene expression in mice. Genes Dev. 9:1896-1908.
14. Fässler, R., M. Pfaff, J. Murphy, A. Noegel, S. Johansson, R. Timpl, and R. Albrecht. 1995. Lack of β1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts. J. Cell Biol. 128:979-988.
15. Fässler, R., J. Rohwedel, V. Maltsev, W. Bloch, S. Lentini, K. Guan, D. Gullberg, J. Hescheler, K. Addicks, and A.M. Wobus. 1996. Differentiation and integrity of cardiac muscle cells are impaired in the absence of β1 integrin. J. Cell Sci. 109:2989-2999.
16. Folkman, J. 1996. Fighting cancer by attacking its blood supply. Sci. Am. 275: 150-154.
17. Folkman, J., and A. Moscona. 1978. Role of cell shape in growth control. Nature (Lond.). 273:345-349.
18. Friedlander, M., P.C. Brooks, R.W. Shaffer, C.M. Kincaid, J.A. Varner, and D.A. Cheresh. 1995. Definition of two angiogenetic pathways by distinct αv integrins. Science (Wash. DC). 270:1500-1502.
19. Giancotti, F.G., and E. Ruoslahti. 1990. Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cell variants. Cell. 60:849-859.
20. Guadagno, T.M., M. Ohtsubo, J.M. Roberts, and R.K. Assoian. 1993. A link between cyclin A expression and adhesion-dependent cell cycle progression. Science (Wash. DC). 262:1572-1575.
21. Guan, J.L., and D. Shalloway. 1992. Regulation of focal adhesion associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature (Lond.). 358:690-692.
22. Haas, T.A., and E.F. Plow. 1994. Integrin-ligand interactions: a year in review. Curr. Opinion Cell Biol. 6:656-662.
23. Hannigan, G.E., C. Leung-Hagesteijn, L. Fitz-Gibbon, M.G. Coppolino, G. Radeva, J. Filmus, J.C. Bell, and S. Dedhar. 1996. Regulation of cell adhesion and anchorage-dependent growth by a new β1 integrin-linked protein kinase. Nature (Lond.). 379:91-96.
24. Hirsch, E., A. Iglesias, A.J. Potocnik, U. Hartmann, and R. Fässler. 1996. Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins. Nature (Lond.). 380:171-175.
25. Hirst, R., A. Horwitz, C. Buck, and L. Rohrschneider. 1986. Phosphorylation of the fibronectin receptor y oncogenes that encode tyrosine kinases. Proc. Natl. Acad. Sci. USA. 83:6470-6474.
26. Hynes, R.O. 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 69:11-25.
27. Ingber, D. 1991. Integrins as mechanochemical transducers. Curr. Opin. Cell Biol. 3:841-848.
28. Johansson, S., and M. Höök. 1984. Substrate adhesion of rat hepatocytes: on the mechanism of attachment to fibronectin. J. Cell Biol. 98:810-817.
29. Kreidberg, J.A., M.J. Donovan, S.L Goldstein, H. Renke, K. Shepherd, R.C. Jones, and R. Jaenisch. 1996. α3β1 integrin has a crucial role in kidney and lung organogenesis. Development (Camb.). 122:3537-3547.
30. McNamee, H.P., D.E. Ingber, and M.A. Schwartz. 1993. Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J. Cell Biol. 121:673-678.
31. Meredith, J.E., B. Fazeli, and M.A. Schwartz. 1993. The extracellular matrix as a cell survival factor. Mol. Biol. Cell. 4:953-961.
32. Morino, N., T. Mimura, K. Hamasaki, K. Tobe, K. Ueki, K. Kikuchi, K. Takehara, T. Kadowaki, Y. Yazaki, and Y. Nojima. 1995. Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2. J. Biol. Chem. 270:269-273.
33. Nathan, C., and M. Sporn. 1991. Cytokines in context. J. Cell Biol. 113:981-986.
34. Plantefaber, L.C., and R.O. Hynes. 1990. Changes in integrin receptors on oncogenically transformed cells. Cell. 56:281-290.
35. Risau, W., H. Sariola, H.G. Zerwes, J. Sasse, P. Ekblom, R. Kemler, and T. Doetschman. 1988. Vasculogenesis and angiogenesis in embryonic stem cell-derived embryoid bodies. Development (Camb.). 102:471-478.
36. Ruoslanti, E., and J.C. Reed. 1994. Anchorage dependence, integrins and apoptosis. Cell. 77:477-478.
37. Schaller, M.D., C.A. Otey, J.D. Hildebrand, and J.T. Parsons. 1995. Focal adhesion kinase and paxillin bind to peptides mimicking β integrin cytoplasmic domains. J. Cell Biol. 130:1181-1187.
38. Schwartz, M.A. 1993. Signaling by integrins: implications for tumorigenesis. Cancer Res. 53:1503-1506.
39. Schwartz, M.A., G. Both, and C. Lechene. 1989. Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts. Proc. Natl. Acad. Sci. USA. 86:4525-4529.
40. Schwartz, M.A., E.J. Cragoe, Jr., and C.P. Lechene. 1990. pH regulation in spread cells and round cells. J. Biol. Chem. 265:1327-1332.
41. Varner, J.A., D.A. Emerson, and R.L. Juliano. 1995. Integrin α5β1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol. Biol. Cell 6:725-740.
42. Varner, J.A., and D.A. Cheresh. 1996. Integrins and cancer. Curr. Opin. Cell. Biol. 8:724-730.
43. Vecchi, A., C. Garlanda, M.G. Lampugnani, M. Resnati, C. Matteucci, A. Stoppacciaro, H. Schnurch, W. Risau, L. Ruco, A. Mantovani, et al. 1994. Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur. J. Cell Biol. 63:247-254.
44. Vittet, D., M.H. Prandini, R. Berthier, A. Schweitzer, H. Martin-Sisteron, G. Uzan, and E. Dejana. 1996. Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps. Blood. 88:3424-3431.
45. Vuori, K., and E. Ruoslahti. 1993. Activation of protein kinase C precedes α5β1 integrin-mediated cell spreading on fibronectin. J. Biol. Chem. 268:21459-21462.
46. Yebra, M., E.J. Filardo, E.M. Bayna, E. Kawahara, J.C. Becker, and D.A. Cheresh. 1995. Induction of carcinoma cell migration on vitronectin by NF-κ B-dependent gene expression. Mol. Biol. Cell. 6:841-850.
47. Zhang, Z., K. Vuori, J.C. Reed, and E. Ruoslahti. 1995. The α5β1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc. Natl. Acad. Sci. USA. 92:6161-6165.
48. Zutter, M.M., S.A. Santoro, W.D. Staatz, and Y.L. Tsung. 1995. Re-expression of the α2β1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc. Natl. Acad. Sci. USA. 92:7411-7415.