메뉴 건너뛰기




Volumn 110, Issue 7, 2002, Pages 933-941

Inhibition of endothelial cell survival and angiogenesis by protein kinase A

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 INTEGRIN; BETA1 INTEGRIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE;

EID: 0036792466     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0214268     Document Type: Article
Times cited : (165)

References (46)
  • 1
    • 0030635917 scopus 로고    scopus 로고
    • The role of vascular cell integrin αvβ3 and αvβ5 in angiogenesis
    • Varner, J.A. 1997. The role of vascular cell integrin αvβ3 and αvβ5 in angiogenesis. EXS. 79:361-390.
    • (1997) EXS , vol.79 , pp. 361-390
    • Varner, J.A.1
  • 2
    • 0033565540 scopus 로고    scopus 로고
    • VEGF contributes to postnatal neovascularization by mobilizing bone marrow derived endothelial progenitor cells
    • Asahara, T., et al. 1999. VEGF contributes to postnatal neovascularization by mobilizing bone marrow derived endothelial progenitor cells. EMBO J. 18:3964-3972.
    • (1999) EMBO J. , vol.18 , pp. 3964-3972
    • Asahara, T.1
  • 4
    • 0028670833 scopus 로고
    • Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis ofangiogenic blood vessels
    • Brooks, P.C., et al. 1994. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis ofangiogenic blood vessels. Cell. 79:1157-1164.
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1
  • 5
    • 0028927484 scopus 로고
    • Suppression of ICE and apoptosis in mammary epithelial cells by ECM
    • Boudreau, N., Sympson, C.J., Werb, Z., and Bissell, M. 1995. Suppression of ICE and apoptosis in mammary epithelial cells by ECM. Science. 267:891-893.
    • (1995) Science , vol.267 , pp. 891-893
    • Boudreau, N.1    Sympson, C.J.2    Werb, Z.3    Bissell, M.4
  • 6
    • 0030038229 scopus 로고    scopus 로고
    • Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin αvβ3 during angiogenesis
    • Stromblad, S., Becker, J.C., Yebra, M., Brooks, P.C., and Cheresh, D.A. 1996. Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin αvβ3 during angiogenesis. J. Clin. Invest. 98:426-433.
    • (1996) J. Clin. Invest. , vol.98 , pp. 426-433
    • Stromblad, S.1    Becker, J.C.2    Yebra, M.3    Brooks, P.C.4    Cheresh, D.A.5
  • 7
    • 0029965462 scopus 로고    scopus 로고
    • Transient functional expression of αvβ3 on vascular cells during wound repair
    • Clark, R.A.F., Tonneson, M.G., Gailit, J., and Cheresh, D.A. 1996. Transient functional expression of αvβ3 on vascular cells during wound repair. Am. J. Path. 148:1407-1421.
    • (1996) Am. J. Path. , vol.148 , pp. 1407-1421
    • Clark, R.A.F.1    Tonneson, M.G.2    Gailit, J.3    Cheresh, D.A.4
  • 8
    • 0029610677 scopus 로고
    • Definition of two angiogenic pathways by distinct alpha v integrins
    • Friedlander, M., et al. 1995. Definition of two angiogenic pathways by distinct alpha v integrins. Science. 270:1500-1502.
    • (1995) Science , vol.270 , pp. 1500-1502
    • Friedlander, M.1
  • 9
    • 0032535999 scopus 로고    scopus 로고
    • Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
    • Arap, W., Pasqualini, R., and Ruoslahti, E. 1997. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science. 279:377-380.
    • (1997) Science , vol.279 , pp. 377-380
    • Arap, W.1    Pasqualini, R.2    Ruoslahti, E.3
  • 10
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • Brooks, P.C., Clark, R.A., and Cheresh, D.A. 1994. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 264:569-571.
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 11
    • 0032080854 scopus 로고    scopus 로고
    • A peptidomimetic antagonist of the integrin αvβ3 inhibits Leydig cell tumor growth and development of hypercalcemia of malignancy
    • Carron, C.P., et al. 1998. A peptidomimetic antagonist of the integrin αvβ3 inhibits Leydig cell tumor growth and development of hypercalcemia of malignancy. Cancer Res. 58:1930-1955.
    • (1998) Cancer Res. , vol.58 , pp. 1930-1955
    • Carron, C.P.1
  • 12
    • 0030759955 scopus 로고    scopus 로고
    • Expression and function of endothelial cell αv integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras
    • Christofidou-Solomidou, M., Bridges, M., Murphy, G., Albelda, S., and DeLisser, H.M. 1997. Expression and function of endothelial cell αv integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras. Am. J. Path. 151:975-983.
    • (1997) Am. J. Path. , vol.151 , pp. 975-983
    • Christofidou-Solomidou, M.1    Bridges, M.2    Murphy, G.3    Albelda, S.4    DeLisser, H.M.5
  • 13
    • 0028981497 scopus 로고
    • An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization
    • Drake, C.J., Cheresh, D.A., and Little, C.D. 1995. An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization. J. Cell Sci. 108:2655-2661.
    • (1995) J. Cell Sci. , vol.108 , pp. 2655-2661
    • Drake, C.J.1    Cheresh, D.A.2    Little, C.D.3
  • 14
    • 0029843947 scopus 로고    scopus 로고
    • Involvement ofintegrin αvβ3 and αvβ5 in ocular neovascular diseases
    • Friedlander, M., et al. 1996. Involvement ofintegrin αvβ3 and αvβ5 in ocular neovascular diseases. Proc. Natl. Acad. Sci. USA. 93:9764-9769.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9764-9769
    • Friedlander, M.1
  • 15
    • 0002588527 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro™)
    • Varner, J.A., Nakata, M.T., Jordan, R.E., and Coller, B.S. 1999. Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro™). Angiogenesis. 3:53-61.
    • (1999) Angiogenesis , vol.3 , pp. 53-61
    • Varner, J.A.1    Nakata, M.T.2    Jordan, R.E.3    Coller, B.S.4
  • 16
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins
    • Bader, B.L., Rayburn, H., Crowley, D., and Hynes, R.O. 1998. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins. Cell. 95:507-520.
    • (1998) Cell , vol.95 , pp. 507-520
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 17
    • 0033843942 scopus 로고    scopus 로고
    • Regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell binding domain of fibronectin
    • Kim, S., Bell, K., Mousa, S., and Varner, J.A. 2000. Regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell binding domain of fibronectin. Am. J. Path. 156:1345-1362.
    • (2000) Am. J. Path. , vol.156 , pp. 1345-1362
    • Kim, S.1    Bell, K.2    Mousa, S.3    Varner, J.A.4
  • 18
    • 0033575752 scopus 로고    scopus 로고
    • Integrin family of cell adhesion molecules in the injured brain: Regulation and cellular localization in the normal and regenerating mouse facial motor nucleus
    • Kloss, C., et al. 1999. Integrin family of cell adhesion molecules in the injured brain: regulation and cellular localization in the normal and regenerating mouse facial motor nucleus. J. Comp. Neurol. 411:162-178.
    • (1999) J. Comp. Neurol. , vol.411 , pp. 162-178
    • Kloss, C.1
  • 19
    • 0034721888 scopus 로고    scopus 로고
    • Regulation of integrin αvβ3-mediated endothelial cell migration and angiogenesis by integrin α5β1 and protein kinase A.J
    • Kim, S., Harris, M., and Varnet, J.A. 2000. Regulation of integrin αvβ3-mediated endothelial cell migration and angiogenesis by integrin α5β1 and protein kinase A.J. Biol Chem. 275:33920-33928.
    • (2000) Biol. Chem. , vol.275 , pp. 33920-33928
    • Kim, S.1    Harris, M.2    Varnet, J.A.3
  • 20
    • 0028979701 scopus 로고
    • Integrin α5β1 expression negatively regulates cell growth: Reversal by attachment to fibronectin
    • Varner, J.A., Emerson, D.A., and Juliano, R.L. 1995. Integrin α5β1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol. Biol. Cell. 6:725-740.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 725-740
    • Varner, J.A.1    Emerson, D.A.2    Juliano, R.L.3
  • 21
    • 0025214421 scopus 로고
    • Elevated levels of alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells
    • Giancotti, F.G., and Ruoslahti, E. 1990. Elevated levels of alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell. 60:849-859.
    • (1990) Cell , vol.60 , pp. 849-859
    • Giancotti, F.G.1    Ruoslahti, E.2
  • 22
    • 0034683576 scopus 로고    scopus 로고
    • A novel function for the tumor suppressor p16INK4a: Induction of anoikis via upregulation of the α5β1 fibronectin receptor
    • Plath, T., et al. 2000. A novel function for the tumor suppressor p16INK4a: induction of anoikis via upregulation of the α5β1 fibronectin receptor. J. Cell. Biol. 150:1467-1477.
    • (2000) J. Cell. Biol. , vol.150 , pp. 1467-1477
    • Plath, T.1
  • 23
    • 0027379724 scopus 로고
    • Defects in mesodermal migration and vascular development in fibronectin-deficient mice
    • George, E. L., Georges, E.N., Patel-King, R.S., Rayburn, H., and Hynes, R.O. 1993. Defects in mesodermal migration and vascular development in fibronectin-deficient mice. Development 119:1079-1091.
    • (1993) Development , vol.119 , pp. 1079-1091
    • George, E.L.1    Georges, E.N.2    Patel-King, R.S.3    Rayburn, H.4    Hynes, R.O.5
  • 24
    • 0027371908 scopus 로고
    • Embryonic mesodermal defects in α5 integrin-deficient mice
    • Yang, J.T., Rayburn, H., and Hynes, R.O. 1993. Embryonic mesodermal defects in α5 integrin-deficient mice. Development. 119:1093-1105.
    • (1993) Development , vol.119 , pp. 1093-1105
    • Yang, J.T.1    Rayburn, H.2    Hynes, R.O.3
  • 25
    • 0030700763 scopus 로고    scopus 로고
    • Mesodermal defects and cranial neural crest apoptosis in α5 integrin-null embryos
    • Goh, K.L., Yang, J.T., and Hynes, R.O. 1997. Mesodermal defects and cranial neural crest apoptosis in α5 integrin-null embryos. Development. 124:4309-4319.
    • (1997) Development , vol.124 , pp. 4309-4319
    • Goh, K.L.1    Yang, J.T.2    Hynes, R.O.3
  • 26
    • 0024059120 scopus 로고
    • Novel purification of vitronectin from human plasma by heparin affinity chromatography
    • Yatohgo, T., Izumi, M., Kashiwagi, H., and Hayashi, M. 1988. Novel purification of vitronectin from human plasma by heparin affinity chromatography. Cell Struct. Funct 13:281-292.
    • (1988) Cell Struct. Funct. , vol.13 , pp. 281-292
    • Yatohgo, T.1    Izumi, M.2    Kashiwagi, H.3    Hayashi, M.4
  • 27
    • 0028625746 scopus 로고
    • A rapid and simple method for the isolation of apoptotic DNA fragments
    • Herrmann, M., et al. 1994. A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res. 22:5506-5507.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5506-5507
    • Herrmann, M.1
  • 28
    • 0034791297 scopus 로고    scopus 로고
    • NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelialcell spreading, migration and angiogenesis
    • Dormond, O., Foletti, A., Paroz, C., and Rüegg, C. 2001. NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelialcell spreading, migration and angiogenesis. Nat. Med. 7:1041-1047.
    • (2001) Nat. Med. , vol.7 , pp. 1041-1047
    • Dormond, O.1    Foletti, A.2    Paroz, C.3    Rüegg, C.4
  • 29
    • 0028324464 scopus 로고
    • Annexins: The problem of assessing the biological role for a gene family of multifunctional calcium and phospholipid-binding proteins
    • Raynal, P., and Pollard, H. B. 1994. Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium and phospholipid-binding proteins. Biochem. Biophys. Acta. 1197:63-93.
    • (1994) Biochem. Biophys. Acta , vol.1197 , pp. 63-93
    • Raynal, P.1    Pollard, H.B.2
  • 30
    • 0029068871 scopus 로고
    • Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    • Nicholson, D.W., et al. 1995. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 376:37-43.
    • (1995) Nature , vol.376 , pp. 37-43
    • Nicholson, D.W.1
  • 31
    • 0029927422 scopus 로고    scopus 로고
    • The role of protease during apoptosis
    • Partel, T., Gores, G.J., and Kaufmann, S.H. 1996. The role of protease during apoptosis. FASEB J. 10:587-597.
    • (1996) FASEB J. , vol.10 , pp. 587-597
    • Partel, T.1    Gores, G.J.2    Kaufmann, S.H.3
  • 32
    • 0027513593 scopus 로고
    • Integrin β1 and β3-mediated endothelial cell migration is triggered through distinct mechanisms
    • Leaveley, D.I., Schwartz, M.A., Rosenfeld, M., and Cheresh, D.A. 1993. Integrin β1 and β3-mediated endothelial cell migration is triggered through distinct mechanisms. J. Cell Biol. 121:163-170.
    • (1993) J. Cell Biol. , vol.121 , pp. 163-170
    • Leaveley, D.I.1    Schwartz, M.A.2    Rosenfeld, M.3    Cheresh, D.A.4
  • 33
    • 0033999220 scopus 로고    scopus 로고
    • Caspase-3 and -6 expression and enzyme activity in hen granulosa cells
    • Johnson, A.L., and Bridgham, J.T. 2000. Caspase-3 and -6 expression and enzyme activity in hen granulosa cells. Biol. Reprod. 62:589-598.
    • (2000) Biol. Reprod. , vol.62 , pp. 589-598
    • Johnson, A.L.1    Bridgham, J.T.2
  • 34
    • 0028670298 scopus 로고
    • Integrin αvβ3 rescues melanoma from apoptosis in a three-dimensional dermal collagen
    • Montgomery, A.M.P, Reisfeld, R.A., and Cheresh, D.A. 1994. Integrin αvβ3 rescues melanoma from apoptosis in a three-dimensional dermal collagen. Proc. Natl. Acad. Sci. USA. 91:8856-8860.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8856-8860
    • Montgomery, A.M.P.1    Reisfeld, R.A.2    Cheresh, D.A.3
  • 35
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi, A., and Dixit, V.M. 1998. Death receptors: signaling and modulation. Science. 281:1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 36
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry, N., and Lazebik, Y. 1998. Caspases: enemies within. Science. 281:1312-1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.1    Lazebik, Y.2
  • 37
    • 0030661566 scopus 로고    scopus 로고
    • Integrins, oncogenes and anchorage independence
    • Schwartz, M.A. 1997. Integrins, oncogenes and anchorage independence. J. Cell Biol. 139:575-578.
    • (1997) J. Cell Biol. , vol.139 , pp. 575-578
    • Schwartz, M.A.1
  • 38
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch, S.M., and Francis, H. 1994. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell. Biol. 124:619-626.
    • (1994) J. Cell. Biol. , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 39
    • 0033598145 scopus 로고    scopus 로고
    • Involvement of FADD and caspase 8 signaling in detachment induced apoptosis
    • Rytomaa, M., Martins, L.M., and Downward,J. 1999. Involvement of FADD and caspase 8 signaling in detachment induced apoptosis. Curr. Biol. 9:1043-1046.
    • (1999) Curr. Biol. , vol.9 , pp. 1043-1046
    • Rytomaa, M.1    Martins, L.M.2    Downward, J.3
  • 40
    • 0031713365 scopus 로고    scopus 로고
    • Fibronectin: Structure, assembly, and cardiovascular implications
    • Magnusson, M.K., and Mosher, D.F. 1998. Fibronectin: structure, assembly, and cardiovascular implications. Arterioscler. Thromb. Vasc. Biol. 18:1363-1370.
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 1363-1370
    • Magnusson, M.K.1    Mosher, D.F.2
  • 42
    • 0030947318 scopus 로고    scopus 로고
    • Inhibition of Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells
    • Weissinger, E., et al. 1997. Inhibition of Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells. Mol. Cell. Biol. 17:3229-3241.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3229-3241
    • Weissinger, E.1
  • 43
    • 0030664140 scopus 로고    scopus 로고
    • CAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation
    • D'Angelo, G., Lee, H., and Weiner, R.I. 1997. CAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation. J. Cell. Biochem. 67:353-366.
    • (1997) J. Cell. Biochem. , vol.67 , pp. 353-366
    • D'Angelo, G.1    Lee, H.2    Weiner, R.I.3
  • 44
    • 0031813790 scopus 로고    scopus 로고
    • Involvement of microtubules in the regulation of Bcl-2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase
    • Srivastava, R.K., et al. 1998. Involvement of microtubules in the regulation of Bcl-2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol. Cell. Biol. 18:3509-3517.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 3509-3517
    • Srivastava, R.K.1
  • 45
    • 0001322994 scopus 로고
    • The α5β1 integrin supports survival of cells on fibronectin and upregulates bcl-2 expression
    • Zhang, Z., Vuori, K., Reed,J.C., and Ruoslahti, E. 1995. The α5β1 integrin supports survival of cells on fibronectin and upregulates bcl-2 expression. Mol. Biol. Cell. 6:841-850.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 841-850
    • Zhang, Z.1    Vuori, K.2    Reed, J.C.3    Ruoslahti, E.4
  • 46
    • 0035918149 scopus 로고    scopus 로고
    • Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1
    • Kim, S., Jee, K., Kim, D., Koh, H., and Chung, J. 2001. Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. J. Biol. Chem. 276:12864-12870.
    • (2001) J. Biol. Chem. , vol.276 , pp. 12864-12870
    • Kim, S.1    Jee, K.2    Kim, D.3    Koh, H.4    Chung, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.