Neuropathological stageing of Alzheimer-related changes

Acta Neuropathologica

Volumn 82, Issue 4, 1991, Pages 239-259

  Braak, H ^a   Braak, E ^a  

^a Zentrum der Morphologie ^*  (Germany)

Author keywords

Alzheimer's disease; Amyloid; Dementia; Neurofibrillary changes; Stageing

Indexed keywords

AMYLOID;

ADULT; AGED; ALZHEIMER DISEASE; DEMENTIA; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PRIORITY JOURNAL; REVIEW;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID; BRAIN; FEMALE; HISTOCYTOCHEMISTRY; HUMAN; MALE; MIDDLE AGE; NEURITES; NEUROFIBRILLARY TANGLES;

EID: 0025863618     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/BF00308809     Document Type: Review

References (63)

1. Neurofibrillary degeneration and neuronal loss in Alzheimer's disease
2. Architectonics of the human telecephalic cortex
3. On areas of transition between entorhinal allocortex and temporal isocortex in the human brain. Normal morphology and lamina-specific pathology in Alzheimer's disease
4. Morphology of the human isocortex in young and aged individuals: qualitative and quantitative findings
5. Neuropil threads occur in dendrites of tangle-bearing nerve cells
6. Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia
7. Alzheimer's disease: striatal amyloid deposits and neurofibrillary changes
8. Morphology of the cerebral cortex in relation to Alzheimer's dementia
9. Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia
10. Alzheimer's disease affects limbic nuclci of the thalamus
11. Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections
12. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
13. Silver impregnation of Alzheimer's neurofibrillary changes counterstained for basophilic material and lipofuscin pigment
14. Alzheimer's disease: areal and laminar pathology in the occipital isocortex
15. Alzheimer's disease: mismatch between amyloid plaques and neuritic plaques
16. Alzheimer's disease: amyloid plaques in the cerebellum
17. Alzheimer's plaques and tangles: a controlled and enhanced silver-staining method
18. Biology of disease. Human amyloidosis, Alzheimer's disease and related disorders
19. A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques
20. Quantitative histological studies on the aged human brain. I. Senile plaques and neurofibrillary tangles in normal patients
21. Large amounts of neocortical βA4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person
22. Does amyloid precede paired helical filaments in the senile plaques? A study of 15 cases with graded intellectual status in aging and Alzheimer's disease
23. Rating of lesions in senile dementia of the Alzheimer type: concordance between laboratories. A European multicenter study under the auspices of EURAGE
24. The cortex of the primary auditory area in Alzheimer's disease
25. Silver staining of Alzheimer's neurofibrillary changes by means of physical development
26. Metal-catalyzed oxidation renders silver intensification selective. Applications for the histochemistry of diaminobenzidine and neurofibrillary changes
27. Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques
28. Die pathologische Anatomie der senilen Demenz und der Alzheimerschen Krankheit
29. A quantitative histological study of early clinical and preclinical Alzheimer's disease
30. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation
31. Validation of diagnostic criteria for Alzheimer's disease
32. The presubicular region in Alzheimer's disease: topography of amyloid deposits and neurofibrillary changes
33. Senile dementia: a focal disease in the temporal lobe
34. Diagnosis of Alzheimer's disease
35. What are the early and late clinical manifestations of the disease?
36. Clinical diagnosis of Alzheimer's disease: DSM-III-R, ICD-10 — what else?
37. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices
38. The neuropathology of Alzheimer's disease: a review with pathogenetic, aetiological and therapeutic considerations
39. The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease
40. Diffuse plaques do not accentuate synapse loss in Alzheimer's disease
41. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA-work group under the auspices of department of health and human services, task force on Alzheimer's disease
42. β-Protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease
43. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer's disease
44. Functional staging of dementia of the Alzheimer type
45. Senile dementia of the Alzheimer type: diagnostic and differential diagnostic features with special reference to functional assessment staging (FAST)
46. The stage specific temporal course of Alzheimer's disease: functional and behavioral concomitants based upon cross-sectional and longitudinal observation
47. Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease
48. Histologische Studien über die senile Demenz
49. Morbus Alzheimer and Morbus Pick
50. Polyethylene glycol embedding: a technique compatible with immunocytochemistry, enzyme histochemistry, histofluorescence and intracellular staining
51. The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition
52. Alzheimer's disease
53. The NINCDS-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases
54. The neuropathology of Alzheimer's disease — Issues in need of resolution
55. Ageing and the dementias
56. Alz-50 immunoreactivity in the thalamic reticular nucleus in Alzheimer's disease
57. Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease
58. Alterserkrankungen des Zentralnervensystems. Senile Involution. Senile Demenz. Alzheimersche Krankheit
59. Plaques, tangles and dementia. A quantitative study
60. Neuropathological diagnosis of Alzheimer's disease
61. A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by β protein immunostaining
62. Ultrastructure of neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques