Alteration of substrate specificity of rat neurolysin from matrix metalloproteinase-2/9-type to -3-type specificity by comprehensive mutation

Protein Engineering, Design and Selection

Volumn 21, Issue 8, 2008, Pages 507-513

  Kadonosono, Tetsuya ^a   Kato Murai, Michiko ^a   Ueda, Mitsuyoshi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Matrix metalloproteinase; Molecular display; Neurolysin; Peptidase; Substrate specificity

Indexed keywords

BINDING EFFICIENCY; DISPLAY SYSTEMS; GLUTAMIC ACID (GLU); KINETIC ANALYSES; MATRIX METALLOPROTEINASE (MT1 MMP); OXFORD UNIVERSITY; PEPTIDE BONDS; PROTEIN LIBRARIES; RAT BRAIN; SCISSILE BOND; SUBSTRATE SPECIFICITY; YEAST CELL SURFACES;

ACIDS; AMINATION; AMINES; AMINO ACIDS; CELL MEMBRANES; HEALTH; MATRIX ALGEBRA; ORGANIC ACIDS; QUENCHING; ULSI CIRCUITS; YEAST;

SUBSTRATES;

ALANINE; ARGININE; ASPARTIC ACID; GELATINASE A; GELATINASE B; GLUTAMIC ACID; NEUROLYSIN; STROMELYSIN; TYROSINE;

ANIMAL TISSUE; ARTICLE; CELL SCREENING; CELL SURFACE; CONTROLLED STUDY; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME SUBSTRATE; MUTATION; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID SUBSTITUTION; ANIMALS; CLONING, MOLECULAR; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MUTATION; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

RATTUS;

EID: 47649126144     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzn026     Document Type: Article

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