메뉴 건너뛰기




Volumn 64, Issue 1, 2004, Pages 1-15

Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic Hepatitis B virus infection

Author keywords

Hepatitis B, Viral persistence, Viral resistance, Viral clearance, Nucleosides, Nucleotides, Immunopathology

Indexed keywords

ADEFOVIR; ADEFOVIR DIPIVOXIL; ALPHA INTERFERON; ANTIVIRUS AGENT; CLEVUDINE; CYTIDINE DERIVATIVE; ELVUCITABINE; EMTRICITABINE; ENTECAVIR; FAMCICLOVIR; GAMMA INTERFERON; LAMIVUDINE; NUCLEOSIDE ANALOG; PEGINTERFERON; PENCICLOVIR; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TELBIVUDINE; TENOFOVIR; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 4744354693     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2004.07.003     Document Type: Review
Times cited : (162)

References (143)
  • 3
    • 0035132220 scopus 로고    scopus 로고
    • Does a cdc2 kinase-like recognition motif on the core protein of hepadnaviruses regulate assembly and disintegration of capsids
    • M.I. Barrasa, J.T. Guo, J. Saputelli, W.S. Mason, and C. Seeger Does a cdc2 kinase-like recognition motif on the core protein of hepadnaviruses regulate assembly and disintegration of capsids J. Virol. 75 4 2001 2024 2028
    • (2001) J. Virol. , vol.75 , Issue.4 , pp. 2024-2028
    • Barrasa, M.I.1    Guo, J.T.2    Saputelli, J.3    Mason, W.S.4    Seeger, C.5
  • 4
    • 0030882376 scopus 로고    scopus 로고
    • Mutations in the hepatitis B virus polymerase gene that are associated with resistance to famciclovir and lamivudine
    • A. Bartholomeusz, and S. Locarnini Mutations in the hepatitis B virus polymerase gene that are associated with resistance to famciclovir and lamivudine Int. Antivir. News 5 1997 123 124
    • (1997) Int. Antivir. News , vol.5 , pp. 123-124
    • Bartholomeusz, A.1    Locarnini, S.2
  • 5
    • 2342433984 scopus 로고    scopus 로고
    • Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations
    • A. Bartholomeusz, B.G. Tehan, and D.K. Chalmers Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations Antivir. Ther. 9 2 2004 149 160
    • (2004) Antivir. Ther. , vol.9 , Issue.2 , pp. 149-160
    • Bartholomeusz, A.1    Tehan, B.G.2    Chalmers, D.K.3
  • 6
    • 0038310759 scopus 로고    scopus 로고
    • Translation of immunological knowledge into better treatments of chronic hepatitis B
    • A. Bertoletti, and N.V. Naoumov Translation of immunological knowledge into better treatments of chronic hepatitis B J. Hepatol. 39 1 2003 115 124
    • (2003) J. Hepatol. , vol.39 , Issue.1 , pp. 115-124
    • Bertoletti, A.1    Naoumov, N.V.2
  • 7
    • 0035737942 scopus 로고    scopus 로고
    • Iminosugars as possible broad spectrum anti hepatitis virus agents: The glucovirs and alkovirs
    • T.M. Block, and R. Jordan Iminosugars as possible broad spectrum anti hepatitis virus agents: the glucovirs and alkovirs Antivir. Chem. Chemother. 12 6 2001 317 325
    • (2001) Antivir. Chem. Chemother. , vol.12 , Issue.6 , pp. 317-325
    • Block, T.M.1    Jordan, R.2
  • 8
  • 11
    • 0343147172 scopus 로고    scopus 로고
    • Peptides that block hepatitis B virus assembly: Analysis by cryomicroscopy, mutagenesis and transfection
    • B. Böttcher, N. Tsuji, H. Takahashi, M. Dyson, S. Zhao, R.A. Crowther, and K. Murray Peptides that block hepatitis B virus assembly: analysis by cryomicroscopy, mutagenesis and transfection EMBO J. 17 1998 6839 6845
    • (1998) EMBO J. , vol.17 , pp. 6839-6845
    • Böttcher, B.1    Tsuji, N.2    Takahashi, H.3    Dyson, M.4    Zhao, S.5    Crowther, R.A.6    Murray, K.7
  • 12
    • 0028808367 scopus 로고
    • Use of novel b-L(-)-nucleoside analogues for treatment and prevention of chronic hepatitis B virus infection and hepatocellular carcinoma
    • E. Bridges, and Y. Cheng Use of novel b-L(-)-nucleoside analogues for treatment and prevention of chronic hepatitis B virus infection and hepatocellular carcinoma Progress in Liver Diseases 1995
    • (1995) Progress in Liver Diseases
    • Bridges, E.1    Cheng, Y.2
  • 13
    • 0030997139 scopus 로고    scopus 로고
    • Interleukine-12 inhibits hepatitis B virus replication in transgenic mice
    • V.J. Cavanaugh, L. Guidotti, and F.V. Chisari Interleukine-12 inhibits hepatitis B virus replication in transgenic mice J. Virol. 71 1997 3236 3243
    • (1997) J. Virol. , vol.71 , pp. 3236-3243
    • Cavanaugh, V.J.1    Guidotti, L.2    Chisari, F.V.3
  • 15
    • 0029148749 scopus 로고
    • Hepatitis B virus transgenic mice: Insights into the virus and the disease
    • F. Chisari Hepatitis B virus transgenic mice: insights into the virus and the disease Hepatology 22 1995 1316 1325
    • (1995) Hepatology , vol.22 , pp. 1316-1325
    • Chisari, F.1
  • 16
    • 0029866581 scopus 로고    scopus 로고
    • Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU)
    • J. Colacino Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU) Antivir. Res. 29 1996 125 139
    • (1996) Antivir. Res. , vol.29 , pp. 125-139
    • Colacino, J.1
  • 17
    • 0033999389 scopus 로고    scopus 로고
    • In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir [in process citation]
    • D. Colledge, G. Civitico, S. Locarnini, and T. Shaw In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir [in process citation] Antimicrob. Agents Chemother. 44 3 2000 551 560
    • (2000) Antimicrob. Agents Chemother. , vol.44 , Issue.3 , pp. 551-560
    • Colledge, D.1    Civitico, G.2    Locarnini, S.3    Shaw, T.4
  • 18
    • 0030926706 scopus 로고    scopus 로고
    • Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro
    • D. Colledge, S. Locarnini, and T. Shaw Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro Hepatology 26 1997 216 225
    • (1997) Hepatology , vol.26 , pp. 216-225
    • Colledge, D.1    Locarnini, S.2    Shaw, T.3
  • 19
    • 0030032268 scopus 로고    scopus 로고
    • (-)-Cis-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes
    • L. Condreay, J. Condreay, R. Jansen, M. Paff, and D. Averett (-)-Cis-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes Antimicrob. Agents Chemother. 40 1996 520 523
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 520-523
    • Condreay, L.1    Condreay, J.2    Jansen, R.3    Paff, M.4    Averett, D.5
  • 21
    • 0035041976 scopus 로고    scopus 로고
    • Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC)
    • K. Das, X. Xiong, H. Yang, C.E. Westland, C.S. Gibbs, S.G. Sarafianos, and E. Arnold Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC) J. Virol. 75 10 2001 4771 4779
    • (2001) J. Virol. , vol.75 , Issue.10 , pp. 4771-4779
    • Das, K.1    Xiong, X.2    Yang, H.3    Westland, C.E.4    Gibbs, C.S.5    Sarafianos, S.G.6    Arnold, E.7
  • 22
    • 0033027137 scopus 로고    scopus 로고
    • Perspectives for the treatment of hepatitis B virus infections
    • E. De Clercq Perspectives for the treatment of hepatitis B virus infections Int. J. Antimicrob. Agents 12 2 1999 81 95
    • (1999) Int. J. Antimicrob. Agents , vol.12 , Issue.2 , pp. 81-95
    • De Clercq, E.1
  • 23
    • 0034966673 scopus 로고    scopus 로고
    • Antiviral drugs: Current state of the art
    • E. De Clercq Antiviral drugs: current state of the art J. Clin. Virol. 22 1 2001 73 89
    • (2001) J. Clin. Virol. , vol.22 , Issue.1 , pp. 73-89
    • De Clercq, E.1
  • 24
    • 0031684393 scopus 로고    scopus 로고
    • Hepatitis B virus replication in human HepG2 cells mediated by hepatitis B virus recombinant baculovirus
    • W.E. Delaney, and H.C. Isom Hepatitis B virus replication in human HepG2 cells mediated by hepatitis B virus recombinant baculovirus Hepatology 28 1998 1134 1146
    • (1998) Hepatology , vol.28 , pp. 1134-1146
    • Delaney, W.E.1    Isom, H.C.2
  • 25
    • 0036721178 scopus 로고    scopus 로고
    • Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro
    • W.E.t. Delaney, R. Edwards, D. Colledge, T. Shaw, P. Furman, G. Painter, and S. Locarnini Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro Antimicrob. Agents Chemother. 46 9 2002 3057 3060
    • (2002) Antimicrob. Agents Chemother. , vol.46 , Issue.9 , pp. 3057-3060
    • Delaney, W.E.T.1    Edwards, R.2    Colledge, D.3    Shaw, T.4    Furman, P.5    Painter, G.6    Locarnini, S.7
  • 27
    • 0142092372 scopus 로고    scopus 로고
    • The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro
    • W.E.t Delaney, H. Yang, C.E. Westland, K. Das, E. Arnold, C.S. Gibbs, M.D. Miller, and S. Xiong The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro J. Virol. 77 21 2003 11833 11841
    • (2003) J. Virol. , vol.77 , Issue.21 , pp. 11833-11841
    • Delaney, W.E.T.1    Yang, H.2    Westland, C.E.3    Das, K.4    Arnold, E.5    Gibbs, C.S.6    Miller, M.D.7    Xiong, S.8
  • 28
    • 0036148731 scopus 로고    scopus 로고
    • Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro
    • J. Delmas, O. Schorr, C. Jamard, C. Gibbs, C. Trepo, O. Hantz, and F. Zoulim Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro Antimicrob. Agents Chemother. 46 2 2002 425 433
    • (2002) Antimicrob. Agents Chemother. , vol.46 , Issue.2 , pp. 425-433
    • Delmas, J.1    Schorr, O.2    Jamard, C.3    Gibbs, C.4    Trepo, C.5    Hantz, O.6    Zoulim, F.7
  • 31
    • 0028987482 scopus 로고
    • Mutations in the e sequences of human hepatitis B virus affect both RNA encapsidation and reverse transcription
    • D. Fallows, and S. Goff Mutations in the e sequences of human hepatitis B virus affect both RNA encapsidation and reverse transcription J. Virol. 69 1995 3067 3073
    • (1995) J. Virol. , vol.69 , pp. 3067-3073
    • Fallows, D.1    Goff, S.2
  • 33
    • 0027979816 scopus 로고
    • The carbocyclic analog of 2′-deoxyguanosine induces a prolonged inhibition of duck hepatitis B virus DNA synthesis in primary hepatocyte cultures and in the liver
    • I. Fourel, J. Saputelli, P. Schaffer, and W.S. Mason The carbocyclic analog of 2′-deoxyguanosine induces a prolonged inhibition of duck hepatitis B virus DNA synthesis in primary hepatocyte cultures and in the liver J. Virol. 68 1994 1059 1065
    • (1994) J. Virol. , vol.68 , pp. 1059-1065
    • Fourel, I.1    Saputelli, J.2    Schaffer, P.3    Mason, W.S.4
  • 34
    • 0032525030 scopus 로고    scopus 로고
    • Role of additional mutations outside the YMDD motif of hepatitis B virus polymerase in L(-)SddC (3TC) resistance
    • L. Fu, and Y.-C. Cheng Role of additional mutations outside the YMDD motif of hepatitis B virus polymerase in L(-)SddC (3TC) resistance Biochem. Pharmacol. 55 1998 1567 1572
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1567-1572
    • Fu, L.1    Cheng, Y.-C.2
  • 35
    • 0034423384 scopus 로고    scopus 로고
    • Characterization of novel human hepatoma cell lines with stable hepatitis B virus secretion for evaluating new compounds against lamivudine- and penciclovir-resistant virus [in process citation]
    • L. Fu, and Y.-C. Cheng Characterization of novel human hepatoma cell lines with stable hepatitis B virus secretion for evaluating new compounds against lamivudine- and penciclovir-resistant virus [in process citation] Antimicrob. Agents Chemother. 44 12 2000 3402 3407
    • (2000) Antimicrob. Agents Chemother. , vol.44 , Issue.12 , pp. 3402-3407
    • Fu, L.1    Cheng, Y.-C.2
  • 36
    • 0032951562 scopus 로고    scopus 로고
    • Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues
    • L. Fu, S.H. Liu, and Y.-C. Cheng Sensitivity of L-(-)2,3- dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues Biochem. Pharmacol. 57 12 1999 1351 1359
    • (1999) Biochem. Pharmacol. , vol.57 , Issue.12 , pp. 1351-1359
    • Fu, L.1    Liu, S.H.2    Cheng, Y.-C.3
  • 37
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B virus infection - Natural history and clinical consequences
    • D. Ganem, and A.M. Prince Hepatitis B virus infection - natural history and clinical consequences N. Engl. J. Med. 350 11 2004 1118 1129
    • (2004) N. Engl. J. Med. , vol.350 , Issue.11 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 38
    • 0032751727 scopus 로고    scopus 로고
    • Quantitation of Hepatitis B viremia and emergence of YMDD variants in patients with chronic Hepatitis B treated with lamivudine
    • J. Gauthier, E.J. Bourne, M.W. Lutz, L.M. Crowther, J.L. Dienstag, N.A. Brown, and L.D. Condreay Quantitation of Hepatitis B viremia and emergence of YMDD variants in patients with chronic Hepatitis B treated with lamivudine J. Infect. Dis. 180 6 1999 1757 1762
    • (1999) J. Infect. Dis. , vol.180 , Issue.6 , pp. 1757-1762
    • Gauthier, J.1    Bourne, E.J.2    Lutz, M.W.3    Crowther, L.M.4    Dienstag, J.L.5    Brown, N.A.6    Condreay, L.D.7
  • 41
    • 0033577852 scopus 로고    scopus 로고
    • Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte
    • L.G. Guidotti, P. Borrow, A. Brown, H. McClary, R. Koch, and F.V. Chisari Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte J. Exp. Med. 189 10 1999 1555 1564
    • (1999) J. Exp. Med. , vol.189 , Issue.10 , pp. 1555-1564
    • Guidotti, L.G.1    Borrow, P.2    Brown, A.3    McClary, H.4    Koch, R.5    Chisari, F.V.6
  • 42
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • L.G. Guidotti, R. Rochford, J. Chung, M. Shapiro, R. Purcell, and F.V. Chisari Viral clearance without destruction of infected cells during acute HBV infection Science 284 5415 1999 825 829
    • (1999) Science , vol.284 , Issue.5415 , pp. 825-829
    • Guidotti, L.G.1    Rochford, R.2    Chung, J.3    Shapiro, M.4    Purcell, R.5    Chisari, F.V.6
  • 44
    • 0029082116 scopus 로고
    • A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients
    • S. Günther, B.-C. Li, S. Miska, D. Kruger, H. Meisel, and H. Will A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients J. Virol. 69 1995 5437 5444
    • (1995) J. Virol. , vol.69 , pp. 5437-5444
    • Günther, S.1    Li, B.-C.2    Miska, S.3    Kruger, D.4    Meisel, H.5    Will, H.6
  • 45
    • 0033965482 scopus 로고    scopus 로고
    • Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections [in process citation]
    • J.T. Guo, H. Zhou, C. Liu, C. Aldrich, J. Saputelli, T. Whitaker, M.I. Barrasa, W.S. Mason, and C. Seeger Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections [in process citation] J. Virol. 74 3 2000 1495 1505
    • (2000) J. Virol. , vol.74 , Issue.3 , pp. 1495-1505
    • Guo, J.T.1    Zhou, H.2    Liu, C.3    Aldrich, C.4    Saputelli, J.5    Whitaker, T.6    Barrasa, M.I.7    Mason, W.S.8    Seeger, C.9
  • 46
  • 47
    • 0031018112 scopus 로고    scopus 로고
    • Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids
    • J. Hu, D. Toft, and C. Seeger Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids EMBO J. 16 1997 59 68
    • (1997) EMBO J. , vol.16 , pp. 59-68
    • Hu, J.1    Toft, D.2    Seeger, C.3
  • 50
    • 0027941175 scopus 로고
    • Woodchuck hepatitis virus infections: Very rapid recovery after a prolonged viremia and infection of virtually every hepatocyte
    • K. Kajino, A. Jilbert, J. Saputelli, C. Aldrich, J. Cullen, and W. Mason Woodchuck hepatitis virus infections: very rapid recovery after a prolonged viremia and infection of virtually every hepatocyte J. Virol. 68 1994 5792 5803
    • (1994) J. Virol. , vol.68 , pp. 5792-5803
    • Kajino, K.1    Jilbert, A.2    Saputelli, J.3    Aldrich, C.4    Cullen, J.5    Mason, W.6
  • 51
    • 84983726628 scopus 로고    scopus 로고
    • Hepatitis B genotypes and the response to interferon therapy
    • J.H. Kao, N.H. Wu, P.J. Chen, M.Y. Lai, and D.S. Chen Hepatitis B genotypes and the response to interferon therapy J. Hepatol. 33 6 2000 998 1002
    • (2000) J. Hepatol. , vol.33 , Issue.6 , pp. 998-1002
    • Kao, J.H.1    Wu, N.H.2    Chen, P.J.3    Lai, M.Y.4    Chen, D.S.5
  • 52
    • 0031758695 scopus 로고    scopus 로고
    • Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)b-L-2′, 3′-dideoxy-3′-thiacytidine
    • R.W. King, S.K. Ladner, T.J. Miller, K. Zaifert, R.B. Perni, S.C. Conway, and M.J. Otto Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)b-L-2′, 3′-dideoxy-3′-thiacytidine Antimicrob. Agents Chemother. 42 1998 3179 3186
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 3179-3186
    • King, R.W.1    Ladner, S.K.2    Miller, T.J.3    Zaifert, K.4    Perni, R.B.5    Conway, S.C.6    Otto, M.J.7
  • 54
    • 17144440717 scopus 로고    scopus 로고
    • Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes
    • J. Kock, T.F. Baumert, W.E.t. Delaney, H.E. Blum, H.E. Blum, and F. von Weizsacker Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes Hepatology 38 6 2003 1410 1418
    • (2003) Hepatology , vol.38 , Issue.6 , pp. 1410-1418
    • Kock, J.1    Baumert, T.F.2    Delaney, W.E.T.3    Blum, H.E.4    Blum, H.E.5    Von Weizsacker, F.6
  • 55
    • 0029983056 scopus 로고    scopus 로고
    • In vitro evaluation of combination therapies against hepatitis B virus replication
    • B.E. Korba In vitro evaluation of combination therapies against hepatitis B virus replication Antivir. Res. 29 1 1996 49 51
    • (1996) Antivir. Res. , vol.29 , Issue.1 , pp. 49-51
    • Korba, B.E.1
  • 56
    • 0033955317 scopus 로고    scopus 로고
    • Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks
    • B.E. Korba, P. Cote, W. Hornbuckle, R. Schinazi, J.L. Gerin, and B.C. Tennant Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks Antivir. Res. 45 1 2000 19 32
    • (2000) Antivir. Res. , vol.45 , Issue.1 , pp. 19-32
    • Korba, B.E.1    Cote, P.2    Hornbuckle, W.3    Schinazi, R.4    Gerin, J.L.5    Tennant, B.C.6
  • 57
    • 0031927319 scopus 로고    scopus 로고
    • The M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2′-deoxy-3′-thiacytidine and a reduced ability to synthesize viral DNA
    • S. Ladner, T.J. Miller, and R.W. King The M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2′-deoxy-3′- thiacytidine and a reduced ability to synthesize viral DNA Antimicrob. Agents Chemother. 42 1998 2128 2131
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2128-2131
    • Ladner, S.1    Miller, T.J.2    King, R.W.3
  • 58
    • 0030842540 scopus 로고    scopus 로고
    • Inducible expression of human hepatitis B virus (HBV) instably transfected hepatoblastoma cells: A novel system for screening potential inhibitors of HBV replication
    • S.K. Ladner, M.J. Otto, C.S. Barker, K. Zaifert, G.-H. Wang, J.-T. Guo, C. Seeger, and R.W. King Inducible expression of human hepatitis B virus (HBV) instably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication Antimicrob. Agents Chemother. 41 1997 1715 1720
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1715-1720
    • Ladner, S.K.1    Otto, M.J.2    Barker, C.S.3    Zaifert, K.4    Wang, G.-H.5    Guo, J.-T.6    Seeger, C.7    King, R.W.8
  • 60
    • 0028978938 scopus 로고
    • Nucleotide priming and reverse transcriptase activity of hepatitis B virus polymerase expressed in insect cells
    • R. Lanford, L. Notvall, and B. Beames Nucleotide priming and reverse transcriptase activity of hepatitis B virus polymerase expressed in insect cells J. Virol. 69 1995 4431 4439
    • (1995) J. Virol. , vol.69 , pp. 4431-4439
    • Lanford, R.1    Notvall, L.2    Beames, B.3
  • 63
    • 0033854069 scopus 로고    scopus 로고
    • Combination therapy with lamivudine and famciclovir for chronic hepatitis B-infected Chinese patients: A viral dynamics study [see comments]
    • G.K. Lau, M. Tsiang, J. Hou, S. Yuen, W.F. Carman, L. Zhang, C.S. Gibbs, and S. Lam Combination therapy with lamivudine and famciclovir for chronic hepatitis B-infected Chinese patients: a viral dynamics study [see comments] Hepatology 32 2 2000 394 399
    • (2000) Hepatology , vol.32 , Issue.2 , pp. 394-399
    • Lau, G.K.1    Tsiang, M.2    Hou, J.3    Yuen, S.4    Carman, W.F.5    Zhang, L.6    Gibbs, C.S.7    Lam, S.8
  • 66
    • 0035173806 scopus 로고    scopus 로고
    • Molecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agents
    • K. Lee, and C.K. Chu Molecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agents Antimicrob. Agents Chemother. 45 1 2001 138 144
    • (2001) Antimicrob. Agents Chemother. , vol.45 , Issue.1 , pp. 138-144
    • Lee, K.1    Chu, C.K.2
  • 67
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • W.M. Lee Hepatitis B virus infection N. Engl. J. Med. 337 1997 1733 1745
    • (1997) N. Engl. J. Med. , vol.337 , pp. 1733-1745
    • Lee, W.M.1
  • 68
    • 0028145857 scopus 로고
    • Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes
    • R. Lenhoff, and J. Summers Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes J. Virol. 68 1994 5706 5713
    • (1994) J. Virol. , vol.68 , pp. 5706-5713
    • Lenhoff, R.1    Summers, J.2
  • 69
    • 0028334395 scopus 로고
    • Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus
    • R. Lenhoff, and J. Summers Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus J. Virol. 68 1994 4565 4571
    • (1994) J. Virol. , vol.68 , pp. 4565-4571
    • Lenhoff, R.1    Summers, J.2
  • 70
    • 0035991863 scopus 로고    scopus 로고
    • Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro
    • S. Levine, D. Hernandez, G. Yamanaka, S. Zhang, R. Rose, S. Weinheimer, and R.J. Colonno Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro Antimicrob. Agents Chemother. 46 8 2002 2525 2532
    • (2002) Antimicrob. Agents Chemother. , vol.46 , Issue.8 , pp. 2525-2532
    • Levine, S.1    Hernandez, D.2    Yamanaka, G.3    Zhang, S.4    Rose, R.5    Weinheimer, S.6    Colonno, R.J.7
  • 71
    • 0034756599 scopus 로고    scopus 로고
    • Analysis of hepatitis B viral load decline under potent therapy: Complex decay profiles observed
    • S.R. Lewin, R.M. Ribeiro, T. Walters, G.K. Lau, S. Bowden, S. Locarnini, and A.S. Perelson Analysis of hepatitis B viral load decline under potent therapy: complex decay profiles observed Hepatology 34 5 2001 1012 1020
    • (2001) Hepatology , vol.34 , Issue.5 , pp. 1012-1020
    • Lewin, S.R.1    Ribeiro, R.M.2    Walters, T.3    Lau, G.K.4    Bowden, S.5    Locarnini, S.6    Perelson, A.S.7
  • 72
    • 0036133073 scopus 로고    scopus 로고
    • Woodchuck gamma interferon upregulates major histocompatibility complex class I transcription but is unable to deplete woodchuck hepatitis virus replication intermediates and RNAs in persistently infected woodchuck primary hepatocytes
    • M. Lu, B. Lohrengel, G. Hilken, T. Kemper, and M. Roggendorf Woodchuck gamma interferon upregulates major histocompatibility complex class I transcription but is unable to deplete woodchuck hepatitis virus replication intermediates and RNAs in persistently infected woodchuck primary hepatocytes J. Virol. 76 1 2002 58 67
    • (2002) J. Virol. , vol.76 , Issue.1 , pp. 58-67
    • Lu, M.1    Lohrengel, B.2    Hilken, G.3    Kemper, T.4    Roggendorf, M.5
  • 75
    • 0019133611 scopus 로고
    • Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus
    • W.S. Mason, G. Seal, and J. Summers Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus J. Virol. 36 1980 829 836
    • (1980) J. Virol. , vol.36 , pp. 829-836
    • Mason, W.S.1    Seal, G.2    Summers, J.3
  • 76
    • 0036788304 scopus 로고    scopus 로고
    • Gene silencing in mammals by small interfering RNAs
    • M.T. McManus, and P.A. Sharp Gene silencing in mammals by small interfering RNAs Nat. Rev. Genet. 3 10 2002 737 747
    • (2002) Nat. Rev. Genet. , vol.3 , Issue.10 , pp. 737-747
    • McManus, M.T.1    Sharp, P.A.2
  • 77
    • 0036098137 scopus 로고    scopus 로고
    • Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection
    • S. Menne, C.A. Roneker, B.E. Korba, J.L. Gerin, B.C. Tennant, and P.J. Cote Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection J. Virol. 76 11 2002 5305 5314
    • (2002) J. Virol. , vol.76 , Issue.11 , pp. 5305-5314
    • Menne, S.1    Roneker, C.A.2    Korba, B.E.3    Gerin, J.L.4    Tennant, B.C.5    Cote, P.J.6
  • 78
    • 0021180942 scopus 로고
    • Hepatitis B virus DNA in nuclear and cytoplasmic fractions of infected human liver
    • R.H. Miller, and W.S. Robinson Hepatitis B virus DNA in nuclear and cytoplasmic fractions of infected human liver Virology 137 1984 390 399
    • (1984) Virology , vol.137 , pp. 390-399
    • Miller, R.H.1    Robinson, W.S.2
  • 79
    • 0030776176 scopus 로고    scopus 로고
    • Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus
    • G. Moraleda, J. Saputelli, C.E. Aldrich, D. Averett, L. Condreay, and W.S. Mason Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus J. Virol. 71 1997 9392 9399
    • (1997) J. Virol. , vol.71 , pp. 9392-9399
    • Moraleda, G.1    Saputelli, J.2    Aldrich, C.E.3    Averett, D.4    Condreay, L.5    Mason, W.S.6
  • 80
    • 0023005611 scopus 로고
    • Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks
    • T. Moroy, A. Marchio, J. Etiemble, C. Trepo, P. Tiollais, and M. Buendia Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks Nature 324 1986 276 279
    • (1986) Nature , vol.324 , pp. 276-279
    • Moroy, T.1    Marchio, A.2    Etiemble, J.3    Trepo, C.4    Tiollais, P.5    Buendia, M.6
  • 82
    • 0033761078 scopus 로고    scopus 로고
    • Early detection of viral resistance by determination of Hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic Hepatitis B
    • S. Nafa, S. Ahmed, D. Tavan, C. Pichoud, F. Berby, L. Stuyver, M. Johnson, P. Merle, H. Abidi, C. Trepo, and F. Zoulim Early detection of viral resistance by determination of Hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic Hepatitis B Hepatology 32 5 2000 1078 1088
    • (2000) Hepatology , vol.32 , Issue.5 , pp. 1078-1088
    • Nafa, S.1    Ahmed, S.2    Tavan, D.3    Pichoud, C.4    Berby, F.5    Stuyver, L.6    Johnson, M.7    Merle, P.8    Abidi, H.9    Trepo, C.10    Zoulim, F.11
  • 84
    • 0027528518 scopus 로고
    • In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides
    • W. Offensperger, S. Offensperger, E. Walter, K. Teubner, G. Igloi, H. Blum, and W. Gerok In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides EMBO J. 12 1993 1257 1262
    • (1993) EMBO J. , vol.12 , pp. 1257-1262
    • Offensperger, W.1    Offensperger, S.2    Walter, E.3    Teubner, K.4    Igloi, G.5    Blum, H.6    Gerok, W.7
  • 85
    • 0031916237 scopus 로고    scopus 로고
    • Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma
    • J. Petersen, M. Dandri, S. Gupta, and C.E. Rogler Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma Proc. Natl. Acad. Sci. U.S.A. 95 1 1998 310 315
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , Issue.1 , pp. 310-315
    • Petersen, J.1    Dandri, M.2    Gupta, S.3    Rogler, C.E.4
  • 86
    • 0032897955 scopus 로고    scopus 로고
    • Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance
    • C. Pichoud, B. Seignères, Z. Wang, C. Trepo, and F. Zoulim Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance Hepatology 29 1999 230 237
    • (1999) Hepatology , vol.29 , pp. 230-237
    • Pichoud, C.1    Seignères, B.2    Wang, Z.3    Trepo, C.4    Zoulim, F.5
  • 88
    • 0035154880 scopus 로고    scopus 로고
    • Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors
    • S. Ren, and M. Nassal Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors J. Virol. 75 3 2001 1104 1116
    • (2001) J. Virol. , vol.75 , Issue.3 , pp. 1104-1116
    • Ren, S.1    Nassal, M.2
  • 89
    • 0033798292 scopus 로고    scopus 로고
    • The impact of drug resistance on the effectiveness of chemotherapy for chronic hepatitis B
    • D.D. Richman The impact of drug resistance on the effectiveness of chemotherapy for chronic hepatitis B Hepatology 32 4 Pt. 1 2000 866 867
    • (2000) Hepatology , vol.32 , Issue.41 , pp. 866-867
    • Richman, D.D.1
  • 92
    • 0031964879 scopus 로고    scopus 로고
    • Inhibition of human and duck hepatitis B virus by 2′,3′- dideoxy-3′-fluoroguanosine in vitro
    • I. Schroder, B. Holmgren, M. Oberg, and B. Lofgren Inhibition of human and duck hepatitis B virus by 2′,3′-dideoxy-3′-fluoroguanosine in vitro Antivir. Res. 37 1 1998 57 66
    • (1998) Antivir. Res. , vol.37 , Issue.1 , pp. 57-66
    • Schroder, I.1    Holmgren, B.2    Oberg, M.3    Lofgren, B.4
  • 93
    • 0033046767 scopus 로고    scopus 로고
    • Recombinant duck interferon gamma inhibits duck hepatitis B virus replication in primary hepatocytes
    • U. Schultz, and F.V. Chisari Recombinant duck interferon gamma inhibits duck hepatitis B virus replication in primary hepatocytes J. Virol. 73 4 1999 3162 3168
    • (1999) J. Virol. , vol.73 , Issue.4 , pp. 3162-3168
    • Schultz, U.1    Chisari, F.V.2
  • 94
    • 0033056684 scopus 로고    scopus 로고
    • Elimination of duck hepatitis B virus RNA-containing capsids in duck interferon-alpha-treated hepatocytes [in process citation]
    • U. Schultz, J. Summers, P. Staeheli, and F.V. Chisari Elimination of duck hepatitis B virus RNA-containing capsids in duck interferon-alpha-treated hepatocytes [in process citation] J. Virol. 73 7 1999 5459 5465
    • (1999) J. Virol. , vol.73 , Issue.7 , pp. 5459-5465
    • Schultz, U.1    Summers, J.2    Staeheli, P.3    Chisari, F.V.4
  • 95
    • 0022502287 scopus 로고
    • Biochemical and genetic evidence for the hepatitis B virus replication strategy
    • C. Seeger, D. Ganem, and H.E. Varmus Biochemical and genetic evidence for the hepatitis B virus replication strategy Science 232 1986 477 484
    • (1986) Science , vol.232 , pp. 477-484
    • Seeger, C.1    Ganem, D.2    Varmus, H.E.3
  • 96
    • 0025176761 scopus 로고
    • Identification and characterization of the woodchuck hepatitis virus origin of DNA replication
    • C. Seeger, and J. Maragos Identification and characterization of the woodchuck hepatitis virus origin of DNA replication J. Virol. 64 1990 16 23
    • (1990) J. Virol. , vol.64 , pp. 16-23
    • Seeger, C.1    Maragos, J.2
  • 98
    • 0031761652 scopus 로고    scopus 로고
    • In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir
    • M. Seifer, R.K. Hamatake, R.J. Colonno, and D.N. Standring In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir Antimicrob. Agents Chemother. 42 1998 3200 3208
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 3200-3208
    • Seifer, M.1    Hamatake, R.K.2    Colonno, R.J.3    Standring, D.N.4
  • 99
    • 0035136133 scopus 로고    scopus 로고
    • Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo
    • B. Seigneres, S. Aguesse-Germon, C. Pichoud, I. Vuillermoz, C. Jamard, C. Trepo, and F. Zoulim Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo J. Hepatol. 34 1 2001 114 122
    • (2001) J. Hepatol. , vol.34 , Issue.1 , pp. 114-122
    • Seigneres, B.1    Aguesse-Germon, S.2    Pichoud, C.3    Vuillermoz, I.4    Jamard, C.5    Trepo, C.6    Zoulim, F.7
  • 101
    • 0034062371 scopus 로고    scopus 로고
    • Evolution of Hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic Hepatitis B
    • B. Seigneres, C. Pichoud, S.S. Ahmed, O. Hantz, C. Trepo, and F. Zoulim Evolution of Hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic Hepatitis B J. Infect. Dis. 181 4 2000 1221 1233
    • (2000) J. Infect. Dis. , vol.181 , Issue.4 , pp. 1221-1233
    • Seigneres, B.1    Pichoud, C.2    Ahmed, S.S.3    Hantz, O.4    Trepo, C.5    Zoulim, F.6
  • 102
    • 0036725346 scopus 로고    scopus 로고
    • Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses
    • B. Seigneres, C. Pichoud, P. Martin, P. Furman, C. Trepo, and F. Zoulim Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses Hepatology 36 3 2002 710 722
    • (2002) Hepatology , vol.36 , Issue.3 , pp. 710-722
    • Seigneres, B.1    Pichoud, C.2    Martin, P.3    Furman, P.4    Trepo, C.5    Zoulim, F.6
  • 103
    • 0000934401 scopus 로고
    • Production of hepatitis B virus particles in hepG2 cells transfected with cloned hepatitis B virus DNA
    • M.A. Sells, M. Chen, and G. Acs Production of hepatitis B virus particles in hepG2 cells transfected with cloned hepatitis B virus DNA Proc. Natl. Acad. Sci. U.S.A. 84 1987 1005 1009
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 1005-1009
    • Sells, M.A.1    Chen, M.2    Acs, G.3
  • 104
    • 0029031381 scopus 로고
    • Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-b-L-2′,3′-dideoxy-3′-thyacytidine
    • A. Severini, X.-Y. Liu, J. Wilson, and D. Tyrell Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-b-L-2′,3′-dideoxy- 3′-thyacytidine Antimicrob. Agents Chemother. 39 1995 1430 1435
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1430-1435
    • Severini, A.1    Liu, X.-Y.2    Wilson, J.3    Tyrell, D.4
  • 105
    • 0037382795 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus expression and replication by RNA interference
    • A. Shlomai, and Y. Shaul Inhibition of hepatitis B virus expression and replication by RNA interference Hepatology 37 4 2003 764 770
    • (2003) Hepatology , vol.37 , Issue.4 , pp. 764-770
    • Shlomai, A.1    Shaul, Y.2
  • 106
    • 0023803399 scopus 로고
    • Isolation and characterization of a hepatitis B virus endemic in herons
    • R. Sprengel, E.F. Kaleta, and H. Will Isolation and characterization of a hepatitis B virus endemic in herons J. Virol. 62 1988 3832 3839
    • (1988) J. Virol. , vol.62 , pp. 3832-3839
    • Sprengel, R.1    Kaleta, E.F.2    Will, H.3
  • 109
    • 0018084546 scopus 로고
    • A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks
    • J. Summers, J.M. Smolec, and R. Snyder A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks Proc. Natl. Acad. Sci. U.S.A. 75 1978 4533 4537
    • (1978) Proc. Natl. Acad. Sci. U.S.A. , vol.75 , pp. 4533-4537
    • Summers, J.1    Smolec, J.M.2    Snyder, R.3
  • 110
    • 0023013770 scopus 로고
    • Production of hepatitis B virus by a differentiated human hepatoma cell line after transfection with cloned circular HBV DNA
    • C. Sureau, J. Romet-Lemonne, J.I. Mullins, and M. Essex Production of hepatitis B virus by a differentiated human hepatoma cell line after transfection with cloned circular HBV DNA Cell 47 1987 37 47
    • (1987) Cell , vol.47 , pp. 37-47
    • Sureau, C.1    Romet-Lemonne, J.2    Mullins, J.I.3    Essex, M.4
  • 112
    • 0037213545 scopus 로고    scopus 로고
    • CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • R. Thimme, S. Wieland, C. Steiger, J. Ghrayeb, K.A. Reimann, R.H. Purcell, and F.V. Chisari CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection J. Virol. 77 1 2003 68 76
    • (2003) J. Virol. , vol.77 , Issue.1 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3    Ghrayeb, J.4    Reimann, K.A.5    Purcell, R.H.6    Chisari, F.V.7
  • 113
    • 0033029334 scopus 로고    scopus 로고
    • Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy
    • M. Tsiang, J.F. Rooney, J.J. Toole, and C.S. Gibbs Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy Hepatology 29 6 1999 1863 1869
    • (1999) Hepatology , vol.29 , Issue.6 , pp. 1863-1869
    • Tsiang, M.1    Rooney, J.F.2    Toole, J.J.3    Gibbs, C.S.4
  • 114
    • 1642308939 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by APOBEC3G
    • P. Turelli, B. Mangeat, S. Jost, S. Vianin, and D. Trono Inhibition of hepatitis B virus replication by APOBEC3G Science 303 5665 2004 1829
    • (2004) Science , vol.303 , Issue.5665 , pp. 1829
    • Turelli, P.1    Mangeat, B.2    Jost, S.3    Vianin, S.4    Trono, D.5
  • 115
    • 0023028191 scopus 로고
    • Formation of the pool of covalently closed circular viral DNA in hepadnavirus infected cells
    • J. Tuttleman, C. Pourcel, and J. Summers Formation of the pool of covalently closed circular viral DNA in hepadnavirus infected cells Cell 47 1986 451 460
    • (1986) Cell , vol.47 , pp. 451-460
    • Tuttleman, J.1    Pourcel, C.2    Summers, J.3
  • 116
    • 0035942275 scopus 로고    scopus 로고
    • Efficient pyrophosphorolysis by a hepatitis B virus polymerase may be a primer-unblocking mechanism
    • S. Urban, K.P. Fischer, and D.L. Tyrrell Efficient pyrophosphorolysis by a hepatitis B virus polymerase may be a primer-unblocking mechanism Proc. Natl. Acad. Sci. U.S.A. 98 9 2001 4984 4989
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , Issue.9 , pp. 4984-4989
    • Urban, S.1    Fischer, K.P.2    Tyrrell, D.L.3
  • 117
    • 0036146250 scopus 로고    scopus 로고
    • Inhibition of duck hepatitis B virus infection by a myristoylated pre-S peptide of the large viral surface protein
    • S. Urban, and P. Gripon Inhibition of duck hepatitis B virus infection by a myristoylated pre-S peptide of the large viral surface protein J. Virol. 76 4 2002 1986 1990
    • (2002) J. Virol. , vol.76 , Issue.4 , pp. 1986-1990
    • Urban, S.1    Gripon, P.2
  • 119
    • 0032996593 scopus 로고    scopus 로고
    • Dominant negative mutants of the duck hepatitis B virus core protein interfere with RNA pregenome packaging and viral DNA synthesis
    • F. von Weizsacker, J. Kock, S. Wieland, W.B. Offensperger, and H.E. Blum Dominant negative mutants of the duck hepatitis B virus core protein interfere with RNA pregenome packaging and viral DNA synthesis Hepatology 30 1 1999 308 315
    • (1999) Hepatology , vol.30 , Issue.1 , pp. 308-315
    • Von Weizsacker, F.1    Kock, J.2    Wieland, S.3    Offensperger, W.B.4    Blum, H.E.5
  • 121
    • 0029890346 scopus 로고    scopus 로고
    • Hepatitis B virus infection of tupaia hepatocytes in vitro and in vivo
    • E. Walter, R. Keist, B. Niederöst, I. Pult, and H. Blum Hepatitis B virus infection of tupaia hepatocytes in vitro and in vivo Hepatology 24 1996 1 5
    • (1996) Hepatology , vol.24 , pp. 1-5
    • Walter, E.1    Keist, R.2    Niederöst, B.3    Pult, I.4    Blum, H.5
  • 122
    • 0028004062 scopus 로고
    • The role of RNA in enzymatic activity of the reverse transcriptase of hepatitis B viruses
    • G. Wang, F. Zoulim, E. Leber, J. Kitson, and C. Seeger The role of RNA in enzymatic activity of the reverse transcriptase of hepatitis B viruses J. Virol. 68 1994 8437 8442
    • (1994) J. Virol. , vol.68 , pp. 8437-8442
    • Wang, G.1    Zoulim, F.2    Leber, E.3    Kitson, J.4    Seeger, C.5
  • 123
    • 0026493753 scopus 로고
    • The reverse transcriptase of hepatitis B virus acts a protein primer for viral DNA synthesis
    • G.H. Wang, and C. Seeger The reverse transcriptase of hepatitis B virus acts a protein primer for viral DNA synthesis Cell 71 1992 633 670
    • (1992) Cell , vol.71 , pp. 633-670
    • Wang, G.H.1    Seeger, C.2
  • 124
    • 2442682870 scopus 로고    scopus 로고
    • Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy
    • G.J. Webster, S. Reignat, D. Brown, G.S. Ogg, L. Jones, S.L. Seneviratne, R. Williams, G. Dusheiko, and A. Bertoletti Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy J. Virol. 78 11 2004 5707 5719
    • (2004) J. Virol. , vol.78 , Issue.11 , pp. 5707-5719
    • Webster, G.J.1    Reignat, S.2    Brown, D.3    Ogg, G.S.4    Jones, L.5    Seneviratne, S.L.6    Williams, R.7    Dusheiko, G.8    Bertoletti, A.9
  • 125
    • 1242337438 scopus 로고    scopus 로고
    • Evolution of hepatitis B viral load and viral genome sequence during adefovir dipivoxil therapy
    • B. Werle, K. Cinquin, P. Marcellin, S. Pol, M. Maynard, C. Trepo, and F. Zoulim Evolution of hepatitis B viral load and viral genome sequence during adefovir dipivoxil therapy J. Viral Hepat. 11 1 2004 74 83
    • (2004) J. Viral Hepat. , vol.11 , Issue.1 , pp. 74-83
    • Werle, B.1    Cinquin, K.2    Marcellin, P.3    Pol, S.4    Maynard, M.5    Trepo, C.6    Zoulim, F.7
  • 128
    • 0035991456 scopus 로고    scopus 로고
    • Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B
    • L.M. Wolters, B.E. Hansen, H.G. Niesters, D. DeHertogh, and R.A. de Man Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B J. Hepatol. 37 1 2002 137 144
    • (2002) J. Hepatol. , vol.37 , Issue.1 , pp. 137-144
    • Wolters, L.M.1    Hansen, B.E.2    Niesters, H.G.3    Dehertogh, D.4    De Man, R.A.5
  • 129
    • 0027378724 scopus 로고
    • Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis [see comments]
    • D.K. Wong, A.M. Cheung, K. O'Rourke, C.D. Naylor, A.S. Detsky, and J. Heathcote Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis [see comments] Ann. Intern. Med. 119 4 1993 312 323
    • (1993) Ann. Intern. Med. , vol.119 , Issue.4 , pp. 312-323
    • Wong, D.K.1    Cheung, A.M.2    O'Rourke, K.3    Naylor, C.D.4    Detsky, A.S.5    Heathcote, J.6
  • 130
    • 0031793849 scopus 로고    scopus 로고
    • Mutations in hepatitis B DNA polymerase asssociated with resistance to lamivudine do not confer resistance to adefovir in vitro
    • X. Xiong, C. Flores, H. Yang, J.J. Toole, and C.S. Gibbs Mutations in hepatitis B DNA polymerase asssociated with resistance to lamivudine do not confer resistance to adefovir in vitro Hepatology 28 1998 1669 1673
    • (1998) Hepatology , vol.28 , pp. 1669-1673
    • Xiong, X.1    Flores, C.2    Yang, H.3    Toole, J.J.4    Gibbs, C.S.5
  • 131
    • 0036147464 scopus 로고    scopus 로고
    • Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2′-fluoro-5-methyl-beta-L- arabinofuranosyluracil
    • T. Yamamoto, S. Litwin, T. Zhou, Y. Zhu, L. Condreay, P. Furman, and W.S. Mason Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2′-fluoro-5-methyl-beta-L- arabinofuranosyluracil J. Virol. 76 3 2002 1213 1223
    • (2002) J. Virol. , vol.76 , Issue.3 , pp. 1213-1223
    • Yamamoto, T.1    Litwin, S.2    Zhou, T.3    Zhu, Y.4    Condreay, L.5    Furman, P.6    Mason, W.S.7
  • 132
    • 0344304757 scopus 로고    scopus 로고
    • In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector
    • H. Yang, C. Westland, S. Xiong, and Delaney In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector W. E. t. 61 1 2004 27 36
    • (2004) W. E. T. , vol.61 , Issue.1 , pp. 27-36
    • Yang, H.1    Westland, C.2    Xiong, S.3    Delaney4
  • 133
    • 0029078179 scopus 로고
    • Illegitimate replication of linear hepadnavirus DNA through nonhomologous recombination
    • W. Yang, and J. Summers Illegitimate replication of linear hepadnavirus DNA through nonhomologous recombination J. Virol. 69 1995 4029 4036
    • (1995) J. Virol. , vol.69 , pp. 4029-4036
    • Yang, W.1    Summers, J.2
  • 134
    • 0021934431 scopus 로고
    • Changes of hepatitis B virus DNA in liver and serum caused by recombinant leukocyte interferon treatment: Analysis of intrahepatic replicative hepatitis B virus DNA
    • O. Yokosuka, M. Omata, F. Imazeki, K. Okuda, and J. Summers Changes of hepatitis B virus DNA in liver and serum caused by recombinant leukocyte interferon treatment: analysis of intrahepatic replicative hepatitis B virus DNA Hepatology 5 5 1985 728 734
    • (1985) Hepatology , vol.5 , Issue.5 , pp. 728-734
    • Yokosuka, O.1    Omata, M.2    Imazeki, F.3    Okuda, K.4    Summers, J.5
  • 135
    • 0028358552 scopus 로고
    • Multiple functions of capsid protein phosphorylation in duck hepatitis B virus replication
    • M. Yu, and J. Summers Multiple functions of capsid protein phosphorylation in duck hepatitis B virus replication J. Virol. 68 1994 4341 4348
    • (1994) J. Virol. , vol.68 , pp. 4341-4348
    • Yu, M.1    Summers, J.2
  • 136
    • 0030004556 scopus 로고    scopus 로고
    • Analysis of hepatitis B virus genotypes and pre-core region variability during interferon treatment of HBe antigen negative chronic hepatitis B
    • X. Zhang, F. Zoulim, F. Habersetzer, S. Xiong, and C. Trépo Analysis of hepatitis B virus genotypes and pre-core region variability during interferon treatment of HBe antigen negative chronic hepatitis B J. Med. Virol. 48 1996 8 16
    • (1996) J. Med. Virol. , vol.48 , pp. 8-16
    • Zhang, X.1    Zoulim, F.2    Habersetzer, F.3    Xiong, S.4    Trépo, C.5
  • 138
    • 0032817797 scopus 로고    scopus 로고
    • Emergence of drug-resistant populations of woodchuck hepatitis virus in woodchucks treated with the antiviral nucleoside lamivudine [in process citation]
    • T. Zhou, J. Saputelli, C.E. Aldrich, M. Deslauriers, L.D. Condreay, and W.S. Mason Emergence of drug-resistant populations of woodchuck hepatitis virus in woodchucks treated with the antiviral nucleoside lamivudine [in process citation] Antimicrob. Agents Chemother. 43 8 1999 1947 1954
    • (1999) Antimicrob. Agents Chemother. , vol.43 , Issue.8 , pp. 1947-1954
    • Zhou, T.1    Saputelli, J.2    Aldrich, C.E.3    Deslauriers, M.4    Condreay, L.D.5    Mason, W.S.6
  • 139
    • 0034987304 scopus 로고    scopus 로고
    • Detection of hepatitis B virus resistance to antivirals
    • F. Zoulim Detection of hepatitis B virus resistance to antivirals J. Clin. Virol. 21 3 2001 243 253
    • (2001) J. Clin. Virol. , vol.21 , Issue.3 , pp. 243-253
    • Zoulim, F.1
  • 140
    • 0036311880 scopus 로고    scopus 로고
    • A preliminary benefit-risk assessment of Lamivudine for the treatment of chronic hepatitis B virus infection
    • F. Zoulim A preliminary benefit-risk assessment of Lamivudine for the treatment of chronic hepatitis B virus infection Drug Saf. 25 7 2002 497 510
    • (2002) Drug Saf. , vol.25 , Issue.7 , pp. 497-510
    • Zoulim, F.1
  • 142
    • 0030032079 scopus 로고    scopus 로고
    • 2′,3′-Dideoxy-b-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo
    • F. Zoulim, E. Dannaoui, C. Borel, O. Hantz, T.-S. Lin, S.-H. Liu, C. Trépo, and Y.-C. Cheng 2′,3′-Dideoxy-b-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo Antimicrob. Agents Chemother. 40 1996 448 453
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 448-453
    • Zoulim, F.1    Dannaoui, E.2    Borel, C.3    Hantz, O.4    Lin, T.-S.5    Liu, S.-H.6    Trépo, C.7    Cheng, Y.-C.8
  • 143
    • 0028091053 scopus 로고
    • Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase
    • F. Zoulim, and C. Seeger Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase J. Virol. 68 1994 6 13
    • (1994) J. Virol. , vol.68 , pp. 6-13
    • Zoulim, F.1    Seeger, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.