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Volumn 42, Issue 8, 1998, Pages 2128-2131

The M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2'-Deoxy-3'-thiacytidine and a reduced ability to synthesize viral DNA

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA POLYMERASE; ISOLEUCINE; LAMIVUDINE; METHIONINE; VALINE; VIRUS DNA; VIRUS ENZYME; VIRUS RNA;

EID: 0031927319     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.8.2128     Document Type: Article
Times cited : (39)

References (12)
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  • 4
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    • Gao, Q., Z. Gu, J. Hiscott, G. Dionne, and M. A. Wainberg. 1993. Generation of drug-resistant variants of human immunodeficiency virus type 1 by in vitro passage in increasing concentrations of 2′,3′-dideoxycytidine and 2′,3′-dideoxythiacytidine. Antimicrob. Agents Chemother. 37:130-133.
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    • Gao, Q.1    Gu, Z.2    Hiscott, J.3    Dionne, G.4    Wainberg, M.A.5
  • 6
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    • Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: A novel system for screening potential inhibitors of HBV replication
    • Ladner, S. K., M. J. Otto, C. S. Barker, K. Zaifert, G.-H. Wang, J.-T. Guo, C. Seeger, and R. W. King. 1997. Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication. Antimicrob. Agents Chemother. 41:1715-1720.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1715-1720
    • Ladner, S.K.1    Otto, M.J.2    Barker, C.S.3    Zaifert, K.4    Wang, G.-H.5    Guo, J.-T.6    Seeger, C.7    King, R.W.8
  • 7
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    • The M539V polymerase variation responsible for 3TC-resistance also confers cross-resistance to other nucleoside analogs
    • Ladner, S. K., T. J. Miller, M. J. Otto, and R. W. King. 1998. The M539V polymerase variation responsible for 3TC-resistance also confers cross-resistance to other nucleoside analogs. Antiviral Chem. Chemother. 9:65-72.
    • (1998) Antiviral Chem. Chemother. , vol.9 , pp. 65-72
    • Ladner, S.K.1    Miller, T.J.2    Otto, M.J.3    King, R.W.4
  • 8
    • 0031021902 scopus 로고    scopus 로고
    • 3TC is effective in suppressing hepatitis B virus DNa in Chinese hepatitis B surface antigen carriers: A placebo-controlled trial
    • Lai, C.-H., C.-K. Ching, A. K.-M. Tung, E. Li, J. Young, A. Hill, B. C.-Y. Wong, J. Dent, and P.-C. Wu. 1997. 3TC is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: a placebo-controlled trial. Hepatology 25:241-244.
    • (1997) Hepatology , vol.25 , pp. 241-244
    • Lai, C.-H.1    Ching, C.-K.2    Tung, A.K.-M.3    Li, E.4    Young, J.5    Hill, A.6    Wong, B.C.-Y.7    Dent, J.8    Wu, P.-C.9
  • 9
    • 0029815110 scopus 로고    scopus 로고
    • Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with 3TC
    • Ling, R., D. Mutimer, M. Ahmed, E. Boxall, E. Elias, M. Dusheiko, and T. J. Harrison. 1996. Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with 3TC. Hepatology 24:711-713.
    • (1996) Hepatology , vol.24 , pp. 711-713
    • Ling, R.1    Mutimer, D.2    Ahmed, M.3    Boxall, E.4    Elias, E.5    Dusheiko, M.6    Harrison, T.J.7
  • 12
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    • Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
    • Tisdale, M., S. D. Kemp, N. M. Parry, and B. A. Ladner. 1993. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc. Natl. Acad. Sci. USA 90:5633-5656.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.