Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking

Nature Medicine

Volumn 4, Issue 5, 1998, Pages 610-614

  Block, Timothy M ^a   Lu, Xuanyong ^a   Mehta, Anand S ^b   Blumberg, Baruch S ^b,c   Tennant, Bud ^d   Ebling, Mathew ^a   Korba, Brent ^e   Lansky, David M ^f   Jacob, Gary S ^f   Dwek, Raymond A ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c FOX CHASE CANCER CENTER   (United States)

^d Department of Obstetrics Gynecology   (United States)

^e GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXYNOJIRIMYCIN DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; GLYCAN; GLYCOPROTEIN; PLACEBO; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA VIRUS; DRUG MECHANISM; DRUG SENSITIVITY; ENDOPLASMIC RETICULUM; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN GLYCOSYLATION; PROTEIN TRANSPORT; VIREMIA; VIRUS INFECTION; WOODCHUCK;

1-DEOXYNOJIRIMYCIN; ALPHA-GLUCOSIDASES; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; GLUCOSIDES; GLYCOSYLATION; HEPATITIS B VIRUS, WOODCHUCK; HEPATITIS B, CHRONIC; MANNOSIDES; MARMOTA; OLIGOSACCHARIDES; PROTEIN FOLDING; RODENT DISEASES; VIRUS REPLICATION;

ANIMALIA; DNA VIRUSES; HEPADNAVIRIDAE; HEPATITIS B VIRUS; MARMOTA MONAX; WOODCHUCK HEPATITIS B VIRUS;

EID: 0031809225     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0598-610     Document Type: Article

References (23)

1. Mehta, A., Lu, X., Block, T.M., Blumberg, B.S. & Dwek, R.A. Hepatitis B virus envelope proteins vary drastically in their sensitivity to glycan processing. Proc. Natl. Acad. Sci. USA 94, 1822-1827 (1997).
2. Lu, X. et al. Aberrant trafficking of hepatitis B virus glycoproteins in cells in which N-glycan processing is inhibited. Proc. Natl. Acad. Sci. USA 94, 2380-2385 (1997).
3. Sherker, A. & Marion, P. Hepadnaviruses and hepatocellular carcinoma. Ann Revs. Microb. 45, 475-508 (1991).
4. Tipples, G.A. et al. Mutations in the HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo. Hepatology 24, 714-717 (1996).
5. Tennant, B.C. & Gerin, J.L. The woodchuck model of hepatitis B virus infection. In; The Liver: Biology and pathobiology. 3rd edition. Eds. Aries, I.M. et al. Raven press, Publisher (NY, NY) pp. 1455-1466 (1994).
6. Hoofnagle, J.H. & DiBisceglie, A.M. Drug Therapy: The treatment of chronic viral hepatitis. New Engl. J. Med. 336, 347-356 (1997).
7. Wong, D.C., Shi, J.W.K., Purcell, R.H., Gerin, J.L. & London, W.T. Natural and experimental infection of woodchucks with woodchuck hepatitis virus, as measured by new, specific assays for woodchuck hepatitis surface antigen and antibody. J. Clin. Microb. 15, 484-490 (1982).
8. Lu, X., Mehta, A., Butters, T., Dwek, R. & Block, T. Evidence that N-linked glycosylation is necessary for hepatitis B virus secretion. Virol. 213, 660-665 (1995).
9. Cullen, J.M. et al. In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethly)-1,3-oxathiolan-5-yl] cytosine in woodchuck hepatitis virus-infected woodchucks. Antimicro. Agents Chemo. 41, 2076-2082 (1997).
10. Nowak, M.A. et al. Viral dynamics in hepatitis B virus infection. Proc. Natl. Acad. Sci. USA 93, 4398-4402 (1996).
11. Ueda, K., Tsurimoto, T. & Matsubara, K., Three Envelope Proteins of Hepatitis B virus: Large S, Middle S, and Major S needed for the formation of Dane particles J. Virol. 65, 3521-3529 (1991).
12. Seifer, M., Heermann, K.H. & Gerlich, W.J. Replication of hepatitis B virus in transfected nonhepatic cells. Virol. 179, 300-311 (1990).
13. Wei, Y., Tavis, J.E. & Ganem, D. Relationship between viral DNA synthesis and virion envelopment in hepatitis B virus. J. Virol. 70, 6455-6458 (1997).
14. Abe, K., Kurata, T. & Shikata, T. Localization of woodchuck hepatitis virus in the liver. Hepatology 8, 88-92 (1988).
15. Moore, S.E. & Spiro, R.G. Demonstration that Golgi endo - D-mannosidase provides a glucosidase independent pathway for the formation of complex N-linked oligosaccharides of glycoproteins. J. Biol. Chem. 265, 13104-13112 (1990).
16. Werr, M. & Prange, R. Role for calnexin and N-linked glycosylation in the assembly and secretion of hepatitis B virus middle envelope protein particles. J. Virol. 7, 778-782
17. Jacob, G.S. Glycosylation inhibitors in biology and medicine. Curr. Opin Struct. Biol. 5, 605-611 (1995).
18. Karpas, A. et al. Amino sugar derivatives as potential anti-HIV agents. Proc. Natl. Acad. Sci. USA 85, 9229-9233 (1988).
19. Fontana, R.J. & Lok, A.S.F. Combination therapy for chronic hepatitis B. Hepatology 26, 234-236 (1997).
20. Korba, A.B. et al. Liver-targeted antiviral nucleosides: Enhanced antiviral activity of phosphatidyl-dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo. Hepatology 23, No. 6, 958-963 (1996).
21. Lee, W.M. et al. Antibodies to polymerized albumin in woodchuck hepatitis virus infection. Viral Immuno. 6, 13-19 (1993).
22. Guile, G.R., Rudd, P., Wing, D., Prime, S.B. & Dwek, R.A. A rapid high-resolution high-performance liquid chromatographic method for separating glycan mixtures and analyzing oligosaccharide profiles. Anal. Biochem. 240, 210-226 (1996).
23. Rudd, P.M. et al. Oligosaccharide Sequence Technology. Nature 388, 205-208 (1997).