Influence of Bcl-2 overexpression on Na+/K+-ATPase pump activity: Correlation with radiation-induced programmed cell death

Journal of Cellular Physiology

Volumn 171, Issue 3, 1997, Pages 299-304

  Gilbert, Mark ^a   Knox, Susan ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BUTHIONINE SULFOXIMINE; OUABAIN; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CELL LINE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IMMUNOBLOTTING; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INJURY;

APOPTOSIS; HUMANS; LYMPHOMA, B-CELL; MEMBRANE POTENTIALS; NA(+)-K(+)-EXCHANGING ATPASE; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0030922646     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199706)171:3<299::AID-JCP8>3.0.CO;2-J     Document Type: Article

References (16)

1. Allard, J., Lennon, D.P., Greenwood, M.R., Buckenham, A.J., and Hawthorne, J.N. (1993) Reduced sodium pump activity in inositol-deficient HL-60 cells: No evidence of control by protein kinase C. Biochim. Biophys. Acta, 1220:66-68.
2. Borner, C., Martinou, I., Mattmann, C., Irmler, M., Schaerer, E., Martinou, J.-C., and Tschopp, J. (1994) The protein bcl-2α does not require membrane attachment, but two conserved domains to supress apoptosis. J. Cell Biol., 126:1059-1068.
3. Clausen, T., Everts, M.E., and Kjeldsen, K. (1987) Quantification of the maximum capacity for active sodium-potassium transport in rat skeletal muscle. J. Physiol. (Lond.), 388:163-181.
4. Cotter, F.E. (1990) The role of the bcl-2 gene in lymphoma. Br. J. Haematol., 75:449-453.
5. Duvall, E., and Wyllie, A.M. (1986) Death and the cell. Immunol. Today, 7:115-119.
6. Gilbert, M.S., Rupnow, B.A., Ramirez, D.A., Trisler, K.D., and Knox, S.J. (1996a) Over-expression of Bcl-2 protects against apoptosis induced by the bioreductive cytotoxic drug SR4233 (Tirapazamine). J. Cell Death Differentiation, 3:215-222.
7. Gilbert, M.S., Saad, A.H., Rupnow, B.A., and Knox, S.J. (1996b) Association of Bel-2 overexpression with membrane hyperpolarization and radioresistance. J. Cell Physiol., 168:114-122.
8. Hitschke, K., Buhler, R., Apell, H.J., and Stark, G. (1994) Inactivation of the Na, K-ATPase by radiation-induced free radicals. Evidence for a radical-chain mechanism. FEBS Lett, 353:297-300.
9. Hockenbery, D.M., Oltvai, Z.N., Yin, X.M., Milliman, C.L., and Korsmeyer, S.J. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell, 75:241-251.
10. Kane, D.J., Sarafian, T.A., Anton, R., Hahn, H., Gralla, E.B., Valentine, J.S., Ord, T., and Bredesen, D.E. (1993) Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science, 262:1274-1277.
11. +-pump, Part B: Cellular aspects. In: Progress in Clinical and Biological Research. J.C. Skou, J.G. Noy, A.B. Maunsbach, and M. Esmann (eds.) Alan R. Liss, New York, pp. 171-194.
12. Macklis, R.M., Lin, J.Y., Beresford, B., Atcher, R.W., Hines, J.J., and Humm, J.L. (1992) Cellular kinetics, dosimetry, and radiobiology of alpha-particle radioimmunotherapy: Induction of apoptosis. Radiat. Res., 130:220-226.
13. Sellins, K.S., and Cohen, J.J. (1987) Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J. Immunol., 139:3199-3206.
14. +-ATPase. Biochim. Biophys. Acta, 1154:201-222.
15. Vaux, D.L., Aguila, H.L., and Weissman, I.L. (1992) Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing. Int. Immunol., 4:821-824.
16. +-ATPase. J. Mol. Cell. Cardiol., 24:465-470.