Bcl-2 prevents TNF- and Fas-induced cell death but does not inhibit initial processing of caspase-3

Biomedical Research

Volumn 18, Issue 6, 1997, Pages 405-411

  Shiraiwa, Nobuko ^a   Okano, Hideyuki ^a,b,c   Miura, Masayuki ^a,b,c  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CYSTEINE PROTEINASE; FAS ANTIGEN; PROTEIN BCL 2; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HELA CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PROCESSING;

EID: 0031425807     PISSN: 03886107     EISSN: None     Source Type: Journal    
DOI: 10.2220/biomedres.18.405     Document Type: Article

References (32)

1. ALLSOPP T. E., WYATT S., PATERSON H. F. and DAVIS A. M. (1993) The protooncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73, 295-307
2. ARMSTRONG R. C., AJA T., XIANG J., GAUR S., KREBS J. F., HOANG K., BAI X., KORSMEYER S. J., KARANEWSKY D. S., FRITZ L. C. and TOMASELLI K. J. (1996) Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors. J. Biol. Chem. 271, 16850-16855
3. BOISE L. H., GONZALEZ-GARCIA M., POSTEMA C. E., DING L., LINDSTEN T., TURKA L., MAO X., NUNEZ G. and THOMPSON C. B. (1993) Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608
4. BOLDIN M. P., GONCHAROV T. M., GOLTSEV Y. V. and WALLACH D. (1996) Involvement of MACH, a novel MORTI/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85, 803-815
5. CHINNAIYAN A. M., ORTH K., O'ROURKE K., DUAN H., POIRIER G. G. and DIXIT V. M. (1996) Molecular ordering of the cell death pathway: Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J. Biol. Chem. 271, 4573-4576
6. DBAIBO G. S., PERRY D. K., GAMARD C. J., PLATT R., POIRIER G. G., OBEID L. M. and HANNUN Y. A. (1997) Cytokine responese modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-α: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J. Exp. Med. 185, 481-490
7. DUBREZ L., SAVOY I., HAMMAN A. and SOLARY E. (1996) Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways. EMBO J. 15, 5504-5512
8. ELLIS R. E., YUAN J. and HORVITZ H. R. (1991) Mechanisms and functions of cell death. Annu. Rev. Cell Biol. 7, 663-698
9. ENARI M., HASE A. and NAGATA S. (1995) Apoptosis by a cytosolic extract from Fas-activated cells. EMBO J. 14, 5201-5208
10. ENARI M., HUG H. and NAGATA S. (1995) Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375, 78-81
11. FRASER A. and EVAN G. (1996) A license to kill. Cell 85, 781-784
12. GAGLIARDINI V, FERNANDES P. A., LEE R. K. K., DREXLER H. C. A., ROTELLO R. J., FISHMAN M. C. and YUAN J. (1994) Prevention of vertebrate neuronal death by the crmA gene. Science 263, 826-828
13. HISAHARA S., SHOJI S., OKANO H. and MIURA M. (1997) ICE/CED-3 family executes oligodendrocyte apoptosis by tumor necrosis factor. J. Neurochem. 69, 10-20
14. HOCKENBERRY D. M., NUNEZ G., MILLIMAN C., SCREIBER R. D. and KORSMEYER S. J. (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348, 334-336
15. JUO P., KUO C. J., REYNOLDS S. E., KONZ R. F., RAINGEAUD J., DAVIS R. J., BIEMANN H.-P. and BLENIS J. (1996) Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Mol. Cell. Biol. 17, 24-35
16. LOS M., VAN DE CRAEN M., PENNING L. C., SCHENK H., WESTENDORP M., BAEUERLE P. A., DROGE W., KRAMMER P. H., FIERS W. and SCHULZE-OSTHOFF K. (1995) Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 375, 81-83
17. MARTIN S. J., AMARANTE-MENDES G. P., SHI L., CHUANG T.-H., CASIANO C. A., GERALDINE A. O., FITZGERALD P., TAN E. M., BOKOCH G. M., GREENBERG A. H. and GREEN D. R. (1996) The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism. EMBO J. 15, 2407-2416
18. MASHIMA T, NAITO M., KATAOKA S., KAWAI H. and TSURUO T. (1995) Aspartate-based inhibitor of interleukin-1β-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells. Biochem. Biophys. Res. Commun. 209, 907-915
19. MIURA M., FRIEDLANDER R. M. and YUAN J. (1995) Tumor necrosis factor-induced apoptosis is mediated by a crmA-sensitive cell death pathway. Proc. Nail. Acad. Sci. USA 92, 8318-8322
20. MIURA M., ZHU H., ROTELLO R., HARTWEIG E. A. and YUAN J. (1993) Induction of apoptosis in fibroblasts by IL1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75, 653-660
21. MONNEY L., OTTER I., OLIVIER R., RAVN U., MIRZASALEH H., FELLAY I., POIRIER G. G. and BORNER C. (1996) Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain. Biochem. Biophys. Res. Commun. 221, 340-345
22. MUZIO M., SALVESEN G. S. and DIXIT V. M. (1997) FLICE induced apoptosis in a cell free system. J. Biol. Chem. 272, 2952-2956
23. NICHOLSON D. W., ALI A., THORNBERRY N. A., VAILLANCOURT J. P., DING C. K., GALLANT M., GAREAU Y, GRIFFIN P. R., LABELLE M., LAZEBNIK Y. A., MUNDAY N. A., RAJU S. M., SMULSON M. E., YAMIN T.-T., YU V. L. and MILLER D. K. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43
24. ROSETTE C. and KARIN M. (1996) Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274, 1194-1197
25. SHIMIZU S., EGUCHI Y, KAMIIKE W., WAGRI S., UCHIYAMA Y, MATSUDA H. and TSUJIMOTO Y. (1996). Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. Oncogene 13, 21-29
26. TEPPER C. G., JAYADEV S., LIU B., BIELAWSKA A., WOLFF R., YONEHARA S., HANNUN Y. A. and SELDEN M. F. (1995) Role for ceramide as an endogenous mediator of Fasinduced cytotoxicity. Proc. Natl. Acad. Sci. USA 92, 8443-8447
27. TEWARI M. and DIXIT V. M. (1995) Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Boil. Chem. 270, 3255-3260
28. TEWARI M., QUAN L. T., O'ROURKE K., DESNOYERS S., ZENG Z., BEIDLER D. R., POIRIER G. G., SALVESEN G. S. and DIXIT V. M. (1995) Yama/CPP32B, a mammalian homolog of Ced-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 81, 801-809
29. VAUX D. L., CORY S. and ADAMS J. M. (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335, 440-442
30. WALLACH D. (1984) Preparations of lymphotoxin induce resistance to their own cytotoxic effect. J. Immunol. 132, 2464-2469
31. WANG L., MIURA M., BERGERON L., ZHU H. and YUAN J. (1994) Ich-I, an Ice/Ced-3 related gene, encodes both positive and negative regulators of programmed cell death. Cell 78, 739-750
32. YUAN J., SHAHAM S., LEDNOX S., ELLIS H. M. and HORVITZ H. R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β converting enzyme. Cell 75, 641-652