Decrease in age-adjusted cerebrospinal fluid β-secretase activity in Alzheimer's subjects

Clinical Biochemistry

Volumn 41, Issue 12, 2008, Pages 986-996

  Wu, Guoxin ^a   Sankaranarayanan, Sethu ^a   Tugusheva, Kate ^a   Kahana, Jason ^a   Seabrook, Guy ^a   Shi, Xiao ping ^a   King, Elizabeth ^b   Devanarayan, Viswanath ^a   Cook, Jacquelynn J ^a   Simon, Adam J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Alzheimer's; Assay development; BACE; Biomarker; CSF

Indexed keywords

ANTIBODY; BETA SECRETASE; BETA SECRETASE INHIBITOR; BIOLOGICAL MARKER; EPITOPE; RECOMBINANT ENZYME;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; FEMALE; HUMAN; MALE; PH; PRIORITY JOURNAL; RHESUS MONKEY; TEMPERATURE DEPENDENCE; TIME; WESTERN BLOTTING;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MACACA MULATTA; MALE; MIDDLE AGED; PEPSTATINS; PROTEASE INHIBITORS; SENSITIVITY AND SPECIFICITY;

EID: 47049087497     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2008.04.022     Document Type: Article

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