CYP3A4 active site volume modification by mutagenesis of leucine 211

Drug Metabolism and Disposition

Volumn 30, Issue 4, 2002, Pages 452-456

  Fowler, Stephen M ^a   Taylor, John M ^a   Friedberg, Thomas ^b   Roland Wolf, C ^b   Riley, Robert J ^a  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 BENZYLOXY 4 TRIFLUOROMETHYLCOUMARIN; BROMOCRIPTINE; COUMARIN DERIVATIVE; CYCLOSPORIN A; CYTOCHROME P450 3A4; CYTOCHROME P450 REDUCTASE; DIAZEPAM; DILTIAZEM; ERYTHROMYCIN; HALOPERIDOL; LEUCINE; NIFEDIPINE; PHENYLALANINE; PROGESTERONE; TESTOSTERONE; TROLEANDOMYCIN; TYROSINE; UNCLASSIFIED DRUG; VINBLASTINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; MOLECULAR SIZE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANTI-ANXIETY AGENTS; ANTI-BACTERIAL AGENTS; BINDING SITES; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; DIAZEPAM; ENZYME ACTIVATION; ENZYME INHIBITORS; ERYTHROMYCIN; HYDROXYLATION; KINETICS; LEUCINE; MIXED FUNCTION OXYGENASES; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TESTOSTERONE; TROLEANDOMYCIN;

ESCHERICHIA COLI;

EID: 0036207628     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.4.452     Document Type: Article

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