메뉴 건너뛰기




Volumn 11, Issue 3, 2004, Pages 699-705

Determination of the in vivo effects of cladribine alone and its combination with cyclophosphamide or cyclophosphamide and mitoxantrone on Bax and Bcl-2 protein expression in B-CLL cells

Author keywords

B cell chronic lymphocytic leukemia (B CLL); Bax; Bax Bcl 2 ratio; Bcl 2; DNA fragmentation; Drug induced apoptosis; Western blot

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CLADRIBINE; CYCLOPHOSPHAMIDE; DNA FRAGMENT; MITOXANTRONE; ONCOPROTEIN; PROTEIN BAX; PROTEIN BCL 2;

EID: 4644229322     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.11.3.699     Document Type: Article
Times cited : (5)

References (56)
  • 2
    • 0034520470 scopus 로고    scopus 로고
    • Dissecting the pathways to death
    • Daniel PT: Dissecting the pathways to death. Leukemia 14: 2035-2044, 2000.
    • (2000) Leukemia , vol.14 , pp. 2035-2044
    • Daniel, P.T.1
  • 4
    • 0034057320 scopus 로고    scopus 로고
    • Apoptosis in cancer
    • Lowe SM and Lin AW: Apoptosis in cancer. Carcinogenesis 21: 485-495, 2000.
    • (2000) Carcinogenesis , vol.21 , pp. 485-495
    • Lowe, S.M.1    Lin, A.W.2
  • 5
    • 0033839403 scopus 로고    scopus 로고
    • Bcl-2 and Bax expression and chlorambucil-induced apoptosis in the T-cells and leukemic B-cells of untreated B-cell chronic lymphocytic leukemia patients
    • Thomas A, Pepper C, Hoy T and Bentley P: Bcl-2 and Bax expression and chlorambucil-induced apoptosis in the T-cells and leukemic B-cells of untreated B-cell chronic lymphocytic leukemia patients. Leuk Res 24: 813-821, 2000.
    • (2000) Leuk Res , vol.24 , pp. 813-821
    • Thomas, A.1    Pepper, C.2    Hoy, T.3    Bentley, P.4
  • 9
    • 0242583769 scopus 로고    scopus 로고
    • Combination strategies for purine nucleoside analogs
    • Cheson BD (ed). Marcel Dekker, Inc., Basel, New York
    • Gandhi V and Plunkett W: Combination strategies for purine nucleoside analogs. In: Chronic Lymphoid Leukemias. Cheson BD (ed). Marcel Dekker, Inc., Basel, New York, pp195-208, 2001.
    • (2001) Chronic Lymphoid Leukemias , pp. 195-208
    • Gandhi, V.1    Plunkett, W.2
  • 10
    • 0035158357 scopus 로고    scopus 로고
    • Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts
    • Wieder T, Prokop A, Bagci B, et al: Piceatanol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary leukemic lymphoblasts. Leukemia 15: 1735-1742, 2001. (Pubitemid 33061841)
    • (2001) Leukemia , vol.15 , Issue.11 , pp. 1735-1742
    • Wieder, T.1    Prokop, A.2    Bagci, B.3    Essmann, F.4    Bernicke, D.5    Schulze-Osthoff, K.6    Dorken, B.7    Schmalz, H.-G.8    Daniel, P.T.9    Henze, G.10
  • 11
    • 0035283079 scopus 로고    scopus 로고
    • Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3
    • DOI 10.1182/blood.V97.5.1378
    • Wieder T, Essmann F, Prokop A, et al: Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD 95/Fas receptor-ligand interaction and occurs downstream of caspase-3. Blood 97: 1378-1387, 2001. (Pubitemid 32183762)
    • (2001) Blood , vol.97 , Issue.5 , pp. 1378-1387
    • Wieder, T.1    Essmann, F.2    Prokop, A.3    Schmelz, K.4    Schulze-Osthoff, K.5    Beyaert, R.6    Dorken, B.7    Daniel, P.T.8
  • 12
    • 0033007405 scopus 로고    scopus 로고
    • Cytotoxity of 2-chlorodeoxyadenosine (cladribine, 2-CdA) in combination with other chemotherapy drugs against two lymphoma cell lines
    • Hoffman M, Xu JC, Lesser M and Rai K: Cytotoxity of 2- chlorodeoxyadenosine (cladribine, 2-CdA) in combination with other chemotherapy drugs against two lymphoma cell lines. Leuk Lymph 33: 14-15, 1999.
    • (1999) Leuk Lymph , vol.33 , pp. 14-15
    • Hoffman, M.1    Xu, J.C.2    Lesser, M.3    Rai, K.4
  • 13
    • 0032830965 scopus 로고    scopus 로고
    • In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia
    • Bellosillo B, Villamor N, Colomer D, Pons G, Montserrat E and Gil J: In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood 94: 2836-2843, 1999. (Pubitemid 29477312)
    • (1999) Blood , vol.94 , Issue.8 , pp. 2836-2843
    • Bellosillo, B.1    Villamor, N.2    Colomer, D.3    Pons, G.4    Montserrat, E.5    Gil, J.6
  • 14
    • 0028038136 scopus 로고
    • Recent progress in chronic lymphocytic leukemia
    • International Workshop on Chronic Lymphocytic Leukemia.
    • Gale RP, Caligaris-Carpio F, Dighiero G, Keating M, Montserrat E and Rai K: Recent progress in chronic lymphocytic leukemia. International Workshop on Chronic Lymphocytic Leukemia. Leukemia 8: 1610-1614, 1994.
    • (1994) Leukemia , vol.8 , pp. 1610-1614
    • Gale, R.P.1    Caligaris-Carpio, F.2    Dighiero, G.3    Keating, M.4    Montserrat, E.5    Rai, K.6
  • 15
    • 0031815977 scopus 로고    scopus 로고
    • Molecular biology of chronic lymphocytic leukemia: Implications for therapy
    • Reed JC: Molecular biology of chronic lymphocytic leukemia: implications for therapy. Semin Hematol 35: 3-13, 1998.
    • (1998) Semin Hematol , vol.35 , pp. 3-13
    • Reed, J.C.1
  • 16
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 17
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl-2 family: Regulators of the cellular life - or - death switch
    • Corry S and Adams JA: The Bcl-2 family: regulators of the cellular life - or - death switch. Nat Rev Cancer 2: 647-656, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 647-656
    • Corry, S.1    Adams, J.A.2
  • 18
    • 0036087028 scopus 로고    scopus 로고
    • Role of BCL-2 family of proteins in malignancy
    • DOI 10.1002/hon.685
    • Baliga BC and Kumar S: Role of Bcl-2 family of proteins in malignancy. Hematol Oncol 20: 63-74, 2002. (Pubitemid 34654300)
    • (2002) Hematological Oncology , vol.20 , Issue.2 , pp. 63-74
    • Baliga, B.C.1    Kumar, S.2
  • 19
    • 0036245045 scopus 로고    scopus 로고
    • To die or not to die, the role of apoptosis in normal and abnormal mammalian development
    • Mirkes PE: To die or not to die, the role of apoptosis in normal and abnormal mammalian development. Teratology 65: 228-239, 2002.
    • (2002) Teratology , vol.65 , pp. 228-239
    • Mirkes, P.E.1
  • 20
    • 35448965686 scopus 로고    scopus 로고
    • Cloning and analysis of Bcl-2 family genes
    • Cepero E, Johnson BW and Boise LH: Cloning and analysis of Bcl-2 family genes. Cell Biol 66: 24-47, 2001.
    • (2001) Cell Biol , vol.66 , pp. 24-47
    • Cepero, E.1    Johnson, B.W.2    Boise, L.H.3
  • 21
    • 0021821903 scopus 로고
    • Involvement of the bcl-2 gene in human follicular lymphoma
    • Tsujimoto Y, Crossman J, Jaffe E and Croce CM: Involvement of the bcl-2 gene in human follicular lymphoma. Science 228: 1440-1443, 1985. (Pubitemid 15041322)
    • (1985) Science , vol.228 , Issue.4706 , pp. 1440-1443
    • Tsujimoto, Y.1    Cossman, J.2    Jaffe, E.3    Croce, C.M.4
  • 22
    • 0027362667 scopus 로고
    • Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
    • Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W and Reed JC: Investigation of the subcelluler distribution of the Bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial mambranes. Cancer Res 53: 4701-4714, 1993. (Pubitemid 23304404)
    • (1993) Cancer Research , vol.53 , Issue.18 , pp. 4701-4714
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.J.4    Fenton, W.5    Reed, J.C.6
  • 23
    • 0032451930 scopus 로고    scopus 로고
    • Ubiquitous expression of bcl-2 protein in mitotic nuclei and chromosomes
    • Nakano A, Morikawa S and Harada T: Ubiqitous expression of Bcl-2 protein in mitotic nuclei and chromosomes. Acta Histochem Cytochem 31: 475-483, 1998. (Pubitemid 29125999)
    • (1998) Acta Histochemica et Cytochemica , vol.31 , Issue.6 , pp. 475-483
    • Nakano, A.1    Morikawa, S.2    Harada, T.3
  • 24
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124: 1-6, 1994.
    • (1994) J Cell Biol , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 25
    • 0030752756 scopus 로고    scopus 로고
    • Bcl-2/Bax ratios in chronic lymphocytic leukemia and their correlation with in vitro apoptosis and clinical resistance
    • Pepper C, Hoy T and Bentley DP: Bcl-2/Bax ratios in chronic lymphocytic leukemia and their correlation with in vitro apoptosis and clinical resistance. Br J Cancer 76: 935-958, 1997.
    • (1997) Br J Cancer , vol.76 , pp. 935-958
    • Pepper, C.1    Hoy, T.2    Bentley, D.P.3
  • 26
    • 0035049735 scopus 로고    scopus 로고
    • Bcl-2 mediates chemoresistance in matched pairs of primary Emu-myc lymphomas in vivo
    • DOI 10.1006/bcmd.2000.0372
    • Schmitt CA and Lowe SW: Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)myc lymphomas in vivo. Blood Cells Mol Dis 27: 206-216, 2001. (Pubitemid 32299776)
    • (2001) Blood Cells, Molecules, and Diseases , vol.27 , Issue.1 , pp. 206-216
    • Schmitt, C.A.1    Lowe, S.W.2
  • 28
    • 0033981577 scopus 로고    scopus 로고
    • Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
    • DOI 10.1128/MCB.20.3.929-935.2000
    • Eskes R, Desagher S, Antonsson B and Martinou JC: Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol 20: 929-935, 2000. (Pubitemid 30044230)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.3 , pp. 929-935
    • Eskes, R.1    Desagher, S.2    Antonsson, B.3    Martinou, J.-C.4
  • 29
    • 0034885639 scopus 로고    scopus 로고
    • Subcellular redistribution of BAX during apoptosis induced by anticancer drugs
    • DOI 10.1097/00001813-200108000-00008
    • Godlewski MM, Motyl MA, Gajkowska B, Wareski P, Koronkiewicz M and Motyl T: Subcellular redistribution of Bax during apoptosis induced by anticancer drugs. Anticancer Drugs 12: 607-617, 2001. (Pubitemid 32762808)
    • (2001) Anti-Cancer Drugs , vol.12 , Issue.7 , pp. 607-617
    • Godlewski, M.M.1    Motyl, M.A.2    Gajkowska, B.3    Wareski, P.4    Koronkiewicz, M.5    Motyl, T.6
  • 31
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
    • DOI 10.1016/0092-8674(93)90509-O
    • Oltvai Z and Korsmayer S: Bcl-2 heterodimerizes in vivo with conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993. (Pubitemid 23259742)
    • (1993) Cell , vol.74 , Issue.4 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 32
    • 0033832590 scopus 로고    scopus 로고
    • Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontanous caspase-3 processing in vivo
    • Prokop A, Wieder T, Sturm I, et al: Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontanous caspase-3 processing in vivo. Leukemia 14: 1606-1613, 2000.
    • (2000) Leukemia , vol.14 , pp. 1606-1613
    • Prokop, A.1    Wieder, T.2    Sturm, I.3
  • 33
    • 0026799508 scopus 로고
    • Drug profiles. Cladribine (2-chlorodeoxyadenosine)
    • Beutler E: Drug profiles. Cladribine (2-chlorodeoxyadenosine). Lancet 340: 952-956, 1992.
    • (1992) Lancet , vol.340 , pp. 952-956
    • Beutler, E.1
  • 34
    • 0031840834 scopus 로고    scopus 로고
    • Cladribine for the treatment of hairy cell leukemia and chronic lymphocytic leukemia
    • Rai KR: Cladribine for the treatment of hairy cell leukemia and chronic lymphocytic leukemia. Semin Oncol (Suppl. 7) 25: 19-22, 1998.
    • (1998) Semin Oncol , vol.25 , Issue.SUPPL. 7 , pp. 19-22
    • Rai, K.R.1
  • 35
    • 0035048303 scopus 로고    scopus 로고
    • Cladribine in treatment of chronic lymphocytic leukemia
    • Robak T: Cladribine in treatment of chronic lymphocytic leukemia. Leuk Lymph 40: 561-564, 2001.
    • (2001) Leuk Lymph , vol.40 , pp. 561-564
    • Robak, T.1
  • 36
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson BD, Bennett JM, Grever M, Kay N, Keating MJ, O'Brieu S and Rai KR: National Cancer Institute - sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 87: 4990-4997, 1996. (Pubitemid 26189840)
    • (1996) Blood , vol.87 , Issue.12 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3    Kay, N.4    Keating, M.J.5    O'Brien, S.6    Rai, K.R.7
  • 38
    • 0034667537 scopus 로고    scopus 로고
    • Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: Report of a prospective, randomized, multicenter trial
    • Robak T, Blonski JZ, Kasznicki M, et al: Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: report of a prospective, randomized, multicenter trial. Blood 96: 2723-2729, 2000.
    • (2000) Blood , vol.96 , pp. 2723-2729
    • Robak, T.1    Blonski, J.Z.2    Kasznicki, M.3
  • 41
    • 0014385564 scopus 로고
    • Isolation of mononuclear cells and granulocytes from human blood
    • Böyum A: Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21: 77-89, 1968.
    • (1968) Scand J Clin Lab Invest , vol.21 , pp. 77-89
    • Böyum, A.1
  • 42
    • 0033049597 scopus 로고    scopus 로고
    • Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells
    • Fadeel B, Hassan Z, Hellstrom-Lindberg E, Heuter J, Orrenius S and Zhivotovsky B: Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells. Leukemia 13: 719-728, 1999. (Pubitemid 29243623)
    • (1999) Leukemia , vol.13 , Issue.5 , pp. 719-728
    • Fadeel, B.1    Hassan, Z.2    Hellstrom-Lindberg, E.3    Henter, J.-I.4    Orrenius, S.5    Zhivotovsky, B.6
  • 43
    • 37049251145 scopus 로고
    • Nuclei from rat liver: Isolation method that combines purity with high yield
    • Blobel G and Potter VR: Nuclei from rat liver: isolation method that combines purity with high yield. Science 154: 1662-1665, 1966.
    • (1966) Science , vol.154 , pp. 1662-1665
    • Blobel, G.1    Potter, V.R.2
  • 44
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 46
    • 0020794694 scopus 로고
    • Rapid biotin labelled DNA probes hybrized to DNA or RNA immobilized on nitrocellulose: Bio-blots
    • Leary JJ, Brigati JJ and Ward DC: Rapid biotin labelled DNA probes hybrized to DNA or RNA immobilized on nitrocellulose: Bio-blots. Proc Natl Acad Sci USA 80: 4045-4049, 1983.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4045-4049
    • Leary, J.J.1    Brigati, J.J.2    Ward, D.C.3
  • 48
    • 0002538655 scopus 로고
    • Sample preparation from paraffin-embedded tissues
    • Innis MA, Gelfand DH, Sninsky JJ and White TJ (eds). Academic Press, Inc.
    • Wright DK and Manos MM: Sample preparation from paraffin-embedded tissues. In: PCR Protocols: A Guide to Methods and Applications. Innis MA, Gelfand DH, Sninsky JJ and White TJ (eds). Academic Press, Inc., pp153-158, 1990.
    • (1990) PCR Protocols: A Guide to Methods and Applications , pp. 153-158
    • Wright, D.K.1    Manos, M.M.2
  • 49
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • Lowry OH, Rosebrough NJ and Farr AL: Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3
  • 50
    • 0033061417 scopus 로고    scopus 로고
    • Chlorambucil resistance in B-cell chronic lymphocytic leukaemia is mediated through failed Bax induction and selection of high Bcl-2-expressing subclones
    • Pepper C, Thomas A, Hoy T and Bentley P: Chlorambucil resistance in B-cell chronic lymphocytic leukemia is mediated through failed Bax induction and selection of high Bcl2 expressing subclones. Br J Haematol 104: 581-588, 1999. (Pubitemid 29119285)
    • (1999) British Journal of Haematology , vol.104 , Issue.3 , pp. 581-588
    • Pepper, C.1    Thomas, A.2    Hoy, T.3    Bentley, P.4
  • 51
    • 0029558583 scopus 로고
    • Bcl-2 family proteins: Regulators of chemiresistance in cancer
    • Reed J: Bcl-2 family proteins: regulators of chemiresistance in cancer. Toxicol Lett 82/83: 155-158, 1995.
    • (1995) Toxicol Lett , vol.82-83 , pp. 155-158
    • Reed, J.1
  • 52
    • 0029871942 scopus 로고    scopus 로고
    • Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome
    • Robertson LE, Plunkett W, McConnell K, Keating MJ and McDonnel TJ: Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia 10: 456-459, 1996. (Pubitemid 26128784)
    • (1996) Leukemia , vol.10 , Issue.3 , pp. 456-459
    • Robertson, L.E.1    Plunkett, W.2    McConnell, K.3    Keating, M.J.4    McDonnell, T.J.5
  • 53
    • 0031904716 scopus 로고    scopus 로고
    • Bcl-2 and bax protein expression in indolent versus aggressive b-cell non-hodgkin's lymphomas
    • DOI 10.1016/S0046-8177(98)90451-8
    • Wheaton S, Netser J, Guinee D, Rahm M and Perkins S: Bcl-2 and Bax protein in indolent versus aggressive B-cell non-Hodgkin's lymphomas. Hum Pathol 29: 820-825, 1998. (Pubitemid 28375988)
    • (1998) Human Pathology , vol.29 , Issue.8 , pp. 820-825
    • Wheaton, S.1    Netser, J.2    Guinee, D.3    Rahn, M.4    Perkins, S.5
  • 54
    • 0037079699 scopus 로고    scopus 로고
    • Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release
    • DOI 10.1182/blood.V99.2.655
    • Chandra J, Mansson E, Gogvadze V, Kaufmann SH, Albertioni F and Orrenius S: Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release. Blood 99: 655-663, 2002. (Pubitemid 34533105)
    • (2002) Blood , vol.99 , Issue.2 , pp. 655-663
    • Chandra, J.1    Mansson, E.2    Gogvadze, V.3    Kaufmann, S.H.4    Albertioni, F.5    Orrenius, S.6
  • 55
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induced programmed cell death in chronic lymphocytic leukemia by damaging the DNA and by directly affecting the mitochondria
    • Genini D, Adachi S, Chao Q, et al: Deoxyadenosine analogs induced programmed cell death in chronic lymphocytic leukemia by damaging the DNA and by directly affecting the mitochondria. Blood 96: 3537-3543, 2000.
    • (2000) Blood , vol.96 , pp. 3537-3543
    • Genini, D.1    Adachi, S.2    Chao, Q.3
  • 56
    • 0035503898 scopus 로고    scopus 로고
    • Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria
    • DOI 10.1042/0264-6021:3590537
    • Marzo I, Perez-Galan P, Giraldo P, Rubio-Felix D, Anel A and Naval J: Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria. Biochem J 359: 537-546, 2001. (Pubitemid 33063377)
    • (2001) Biochemical Journal , vol.359 , Issue.3 , pp. 537-546
    • Marzo, I.1    Perez-Galan, P.2    Giraldo, P.3    Rubio-Felix, D.4    Anel, A.5    Naval, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.