Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts

Leukemia

Volumn 15, Issue 11, 2001, Pages 1735-1742

  Wieder, T ^a   Prokop, A ^a   Bagci, B ^a   Essmann, F ^a   Bernicke, D ^b   Schulze Osthoff, K ^c   Dorken B ^a   Schmalz, H G ^b   Daniel, P T ^a   Henze, G ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Apoptosis; Caspase 3 processing; Childhood acute lymphoblastic leukemia; DNA fragmentation; Mitochondrial activation; Polyhydroxystilbenes

Indexed keywords

ADAPTOR PROTEIN; CASPASE 3; DRUG ANALOG; FAS ANTIGEN; PICEATANNOL; RESVERATROL; STILBENE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASSAY; BURKITT LYMPHOMA; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; EXPERIMENT; FEMALE; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; LYMPHOBLAST; LYMPHOMA CELL; LYMPHOMA CELL LINE; MALE; MITOCHONDRION; PERMEABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0035158357     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402284     Document Type: Article

References (49)

1. Plants used against cancer. A survey
2. Biological effects of resveratrol
3. Use of potato disc and brine shrimp bioassays to detect activity and isolate piceatannol as the antileukemic principle from the seeds of Euphorbia lagascae
4. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction
5. Review of moderate alcohol consumption and reduced risk of coronary heart disease: Is the effect due to beer, wine, or spirits
6. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
7. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells
8. Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway
9. Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells
10. Apoptosis: Mechanisms and roles in pathology
11. Dissecting the pathways to death
12. Apoptosis and chemotherapy resistance
13. Apoptosis and the dilemma of cancer chemotherapy
14. Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2-ratio and loss of spontaneous caspase-3 processing in vivo
15. Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release
16. Piceatannol (3,4,3′,5′-tetrahydroxytrans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor
17. Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol
18. Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity
19. Genetic and pharmacological analyses of Syk function in alphallb-beta3 signaling in platelets
20. Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol
21. Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol
22. Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3
23. Proposals for the immunological classification of acute leukemias
24. Prevention of CNS recurrence in childhood ALL: Results with reduced radiotherapy combined with CNS-directed chemotherapy in four consecutive ALL-BFM trials
25. TEL-AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia
26. Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia
27. Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis
28. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocline
29. GDP dissociation inhibition D4-GDI (Rho-GDI 2), but not the homologous Rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis
30. Measurement of protein using bicinchoninic acid
31. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
32. Identification of a putative membrane-interacting domain of CTP: Phosphocholine cytidylyltransferase from rat liver
33. Membrane potential, anion and cation conductances in Ehrlich ascites tumor cells
34. Mitochondrial membrane potential monitored by JC-1 dye
35. Caspases: The executioners of apoptosis
36. The role of caspases in development, immunity, and apoptotic signal transduction: Lessons from knockout mice
37. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
38. Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood
39. Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia
40. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation
41. Piceatannol, a stilbene phytochemical, inhibits mitochondrial FOF1-ATPase activity by targeting the F1 complex
42. Inhibition of mitochondrial proton FOF1-ATPase/ATP synthase by polyphenolic phytochemicals
43. Mitochondrial control of cell death
44. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
45. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells
46. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2
47. Deactivation of cultured human liver myofibroblasts by trans-resveratrol, a grapevine-derived polyphenol
48. Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance
49. Resveratrol selectively inhibits leukemia cells: A prospective agent for ex vivo bone marrow purging