Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3

Blood

Volumn 97, Issue 5, 2001, Pages 1378-1387

  Wieder, Thomas ^b   Essmann, Frank ^b   Prokop, Aram ^b   Schmelz, Karin ^b   Schulze Osthoff, Klaus ^b   Beyaert, Rudi ^b   Dörken, Bernd ^b   Daniel, Peter T ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CYTOTOXIC AGENT; DNA FRAGMENT; EPIRUBICIN; FAS ANTIGEN; PACLITAXEL;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; LIGAND BINDING; LYMPHOMA CELL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0035283079     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.5.1378     Document Type: Article

References (50)

1. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
2. Regulation of apoptosis in the immune system
3. Mechanisms and functions of cell death
4. Caspases: Enemies within
5. Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia
6. Apoptosis and the dilemma of cancer chemotherapy
7. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
8. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
9. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
10. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloidbeta
11. Involvement of the CD95 (APO-1/FAS) receptor/Ligand system in drug-induced apoptosis in leukemia cells
12. Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells
13. Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/Ligand interaction
14. Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling: Implications for cancer therapy
15. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
16. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
17. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
18. Apotosis of mature B cells
19. Activation and activation-induced death of human tonsillar B cells and Burkitt lymphoma cells: Lack of CD95 (Fas/APO-1) ligand expression and function
20. Critical role for mitochondria in B cell receptor-mediated apoptosis
21. Coupling cell division and cell death to microtubule dynamics
22. Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis
23. Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2-ratio and loss of spontaneous caspase-3 processing in vivo
24. Proposals for the immunological classification of acute leukemias: European Group for the Immunological Characterization of Leukemias (EGIL)
25. Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens
26. Two new sphingomyelin analogues inhibit phosphatidylcholine biosynthesis by decreasing membrane-bound CTP: Phosphooholine cytidylyltransferase levels in HaCaT cells
27. GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous Rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis
28. Measurement of protein using bicinchoninic acid
29. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
30. Identification of a putative membrane-interacting domain of CTP: Phosphocholine cytidylyltransferase from rat liver
31. Target protease specificity of the viral serpin CrmA: Analysis of five caspases
32. 1α,25-dihydroxyvitamin D3 induces sphingomyelin hydrolysis in HaCaT cells via tumor necrosis factor alpha
33. Membrane potential, anion and cation conductances in Ehrlich ascites tumor cells
34. Mitochondrial membrane potential monitored by JC-1 dye
35. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
36. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
37. Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin
38. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
39. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: A potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release
40. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
41. Comparison of apoptosis in wild-type and Fas-resistant cells: Chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions
42. Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling
43. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
44. Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)
45. Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells
46. Regulation of germinal center B cell differentiation: Role of the human APO-1/Fas (CD95) molecule
47. Chemotherapeutic drugs sensitize pre-BALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis
48. Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release
49. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
50. Modulation of clinical drug resistance in a B cell lymphoma patient by the protein kinase inhibitor 7-hydroxystaurosporine: Presentation of a novel therapeutic paradigm